98
Views
42
CrossRef citations to date
0
Altmetric
Research Article

Evidence for Cytokine Dysregulation in Multiple Sclerosis: Peripheral Blood Mononuclear Cell Production of Pro-inflammatory and Anti-inflammatory Cytokines During Relapse and Remission

, , &
Pages 133-141 | Received 08 May 2002, Accepted 15 Jan 2003, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

H. Reginald McDaniel, Christopher LaGanke, Laura Bloom, Sharon Goldberg, Lucas C. Lages, Laura A. Lantigua, Steven E. Atlas, Judi M. Woolger & John E. Lewis. (2020) The Effect of a Polysaccharide-Based Multinutrient Dietary Supplementation Regimen on Infections and Immune Functioning in Multiple Sclerosis. Journal of Dietary Supplements 17:2, pages 184-199.
Read now
Anastasiya Georgieva Trenova, Georgi Svetoslavov Slavov, Maria Georgieva Manova, Milena Nenkova Draganaova-Filipova, Nonka Georgieva Mateva, Lyuba Dineva Miteva & Spaska Angelova Stanilova. (2017) Alterations in serum levels of IL-17 in contrast to TNF-alpha correspond to disease-modifying treatment in relapsing-remitting multiple sclerosis. Scandinavian Journal of Clinical and Laboratory Investigation 77:4, pages 283-288.
Read now
Kara E. O'Connell, Tzehow Mok, Brian Sweeney, Aisling M. Ryan & Kumlesh K. Dev. (2014) The use of cytokine signature patterns: separating drug naïve, interferon and natalizumab-treated multiple sclerosis patients. Autoimmunity 47:8, pages 505-511.
Read now

Articles from other publishers (39)

Abbas F. Almulla, Al-Karrar Kais Abdul Jaleel, Ali Abbas Abo Algon, Chavit Tunvirachaisakul, Hayder K. Hassoun, Hussein K. Al-Hakeim & Michael Maes. (2023) Mood Symptoms and Chronic Fatigue Syndrome Due to Relapsing-Remitting Multiple Sclerosis Are Associated with Immune Activation and Aberrations in the Erythron. Brain Sciences 13:7, pages 1073.
Crossref
Mohamed S. Attia, Heba A. Ewida, Mohamed Aly Abdel Hafez, Shohda A. El-Maraghy & Maha M. El-Sawalhi. (2023) Altered Lnc-EGFR, SNHG1, and LincRNA-Cox2 Profiles in Patients with Relapsing-Remitting Multiple Sclerosis: Impact on Disease Activity and Progression. Diagnostics 13:8, pages 1448.
Crossref
Kouichi Ito, Naoko Ito, Sudhir K Yadav, Shradha Suresh, Yong Lin & Suhayl Dhib-Jalbut. (2021) Effect of switching glatiramer acetate formulation from 20 mg daily to 40 mg three times weekly on immune function in multiple sclerosis. Multiple Sclerosis Journal - Experimental, Translational and Clinical 7:3, pages 205521732110323.
Crossref
Hadi Atabati, Esmaeil Yazdanpanah, Hamed Mortazavi, Saeed Gharibian bajestani, Amir Raoofi, Seyed-Alireza Esmaeili, Azad Khaledi, Ehsan Saburi, Jalil Tavakol Afshari, Thozhukat Sathyapalan, Abbas Shapouri Moghaddam & Amirhossein Sahebkar. 2021. Reviews on New Drug Targets in Age-Related Disorders. Reviews on New Drug Targets in Age-Related Disorders 87 105 .
Dimitris Tsoukalas, Vassileios Fragoulakis, Evangelos Papakonstantinou, Maria Antonaki, Athanassios Vozikis, Aristidis Tsatsakis, Ana Maria Buga, Mihaela Mitroi & Daniela Calina. (2020) Prediction of Autoimmune Diseases by Targeted Metabolomic Assay of Urinary Organic Acids. Metabolites 10:12, pages 502.
Crossref
Carlo CervellatiAlessandro TrentiniAlessandra PecorelliGiuseppe Valacchi. (2020) Inflammation in Neurological Disorders: The Thin Boundary Between Brain and Periphery. Antioxidants & Redox Signaling 33:3, pages 191-210.
Crossref
Maziar Ganji, Arezou Sayad, Mir Davood Omrani, Shahram Arsang-Jang, Mehrdokht Mazdeh & Mohammad Taheri. (2019) Expression analysis of long non-coding RNAs and their target genes in multiple sclerosis patients. Neurological Sciences 40:4, pages 801-811.
Crossref
Janine Schlöder, Carsten Berges, Felix Luessi & Helmut Jonuleit. (2017) Dimethyl Fumarate Therapy Significantly Improves the Responsiveness of T Cells in Multiple Sclerosis Patients for Immunoregulation by Regulatory T Cells. International Journal of Molecular Sciences 18:2, pages 271.
Crossref
Roham Parsa, Harald Lund, Ivana Tosevski, Xing-Mei Zhang, Ursula Malipiero, Jan Beckervordersandforth, Doron Merkler, Marco Prinz, Alexandra Gyllenberg, Tojo James, Andreas Warnecke, Jan Hillert, Lars Alfredsson, Ingrid Kockum, Tomas Olsson, Adriano Fontana, Tobias Suter & Robert A. Harris. (2016) TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells. Glia 64:11, pages 1925-1937.
Crossref
Zahra Tolou-Ghamari & Hamid Mazdak. (2016) Fingolimod for Multiple Sclerosis; Mechanism of Action, Safety and Toxicity. Archives of Neuroscience 3:3.
Crossref
Georgi Sv. Slavov, Maria G. Manova, Anastasia G. Trenova, Ivanka I. Kostadinova, Pavel I. Pavlov, Nonka G. Mateva & Zahari I. Zahariev. (2016) 25 Hydroxyvitamin D and Cytokines in Multiple Sclerosis. Folia Medica 57:3-4, pages 200-206.
Crossref
Zhaoqiang Zhang, Lei Wang, Xiao Sun, Li Zhang & Lianyuan Lu. (2016) Association of IL4 and IL4R polymorphisms with multiple sclerosis susceptibility in Caucasian population: A meta-analysis. Journal of the Neurological Sciences 363, pages 107-113.
Crossref
Anna M. Witkowska, Katarzyna Socha, Jan Kochanowicz, Elżbieta Karpińska, Marta Jakoniuk, Małgorzata E. Zujko, Marianna WilkielMaria H. Borawska & Zenon Mariak. (2015) Serum Levels of Biomarkers of Immune Activation and Associations With Neurological Impairment in Relapsing-Remitting Multiple Sclerosis Patients During Remission. Biological Research For Nursing 18:1, pages 113-119.
Crossref
A. Tsakiri, S. Ravanidis, R. Lagoudaki, K.-N. Poulatsidou, I. M. Svane, J. L. Frederiksen & N. Grigoriadis. (2015) Neuroprotective and anti-inflammatory mechanisms are activated early in Optic Neuritis. Acta Neurologica Scandinavica 131:5, pages 305-312.
Crossref
Lena Dietz, Friederike Frommer, Anna-Lena Vogel, Martin Vaeth, Edgar Serfling, Ari Waisman, Mathias Buttmann & Friederike Berberich-Siebelt. (2015) NFAT1 deficit and NFAT2 deficit attenuate EAE via different mechanisms. European Journal of Immunology 45:5, pages 1377-1389.
Crossref
S. Simpson, N. Stewart, I. van der Mei, P. Otahal, J. Charlesworth, A.-L. Ponsonby, L. Blizzard, T. Dwyer, F. Pittas, P. Gies & B. Taylor. (2014) Stimulated PBMC-produced IFN-  and TNF-  are associated with altered relapse risk in multiple sclerosis: results from a prospective cohort study. Journal of Neurology, Neurosurgery & Psychiatry 86:2, pages 200-207.
Crossref
Shih-Heng Chen, Esteban A. Oyarzabal, Janine Santos, Qingshan Wang, Lulu Jiang & Jau-Shyong Hong. 2015. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders 385 407 .
Francesco Girolamo, Cristiana Coppola, Domenico Ribatti & Maria Trojano. (2014) Angiogenesis in multiple sclerosis and experimental autoimmune encephalomyelitis. Acta Neuropathologica Communications 2:1.
Crossref
Thais B. Ferreira, Priscila O. Barros, Bruna Teixeira, Tatiane Cassano, Newton Centurião, Taissa M. Kasahara, Joana Hygino, Claudia Cristina F. Vasconcelos, Helcio Alvarenga Filho, Regina Alvarenga, Ana Cristina Wing, Regis M. Andrade, Arnaldo F. Andrade & Cleonice A.M. Bento. (2014) Dopamine favors expansion of glucocorticoid-resistant IL-17-producing T cells in multiple sclerosis. Brain, Behavior, and Immunity 41, pages 182-190.
Crossref
Anastasiya G. Trenova, Georgy S. Slavov, Maria G. Manova & Ivanka I. Kostadinova. (2014) Cytokines and Disability in Interferon-β-1b Treated and Untreated Women with Multiple Sclerosis. Archives of Medical Research 45:6, pages 495-500.
Crossref
Regina Berkovich & Mark A. Agius. (2014) Mechanisms of action of ACTH in the management of relapsing forms of multiple sclerosis. Therapeutic Advances in Neurological Disorders 7:2, pages 83-96.
Crossref
Bruna Teixeira, Vera Carolina B. Bittencourt, Thais B. Ferreira, Taissa M. Kasahara, Priscila O. Barros, Regina Alvarenga, Joana Hygino, Regis M. Andrade, Arnaldo F. Andrade & Cleonice A.M. Bento. (2013) Low sensitivity to glucocorticoid inhibition of in vitro Th17-related cytokine production in multiple sclerosis patients is related to elevated plasma lipopolysaccharide levels. Clinical Immunology 148:2, pages 209-218.
Crossref
D. Pisa, R. Alonso, F. J. Jiménez-Jiménez & L. Carrasco. (2013) Fungal infection in cerebrospinal fluid from some patients with multiple sclerosis. European Journal of Clinical Microbiology & Infectious Diseases 32:6, pages 795-801.
Crossref
Francesco Girolamo, Giovanni Ferrara, Maurizio Strippoli, Marco Rizzi, Mariella Errede, Maria Trojano, Roberto Perris, Luisa Roncali, Maria Svelto, Tiziana Mennini & Daniela Virgintino. (2011) Cerebral cortex demyelination and oligodendrocyte precursor response to experimental autoimmune encephalomyelitis. Neurobiology of Disease 43:3, pages 678-689.
Crossref
L. S. Harbige, E. Pinto, M. Xiang & M. K. Shareif. (2011) Circulating plasma cytokines, zinc, copper, vitamins A and E in multiple sclerosis patients and healthy controls. Proceedings of the Nutrition Society 70:OCE2.
Crossref
Maryam Izad, Mohammed Vodjgani, Mohammed Hossein Niknam, Aliakbar Amirzargar, Amir Behzad Heidari, Saeed Shahbeigi & Mohammad Keramatipour. (2010) Cytokines Genes Polymorphisms and Risk of Multiple Sclerosis. The American Journal of the Medical Sciences 339:4, pages 327-331.
Crossref
M. Liu, X. Hu, Y. Wang, F. Peng, Y. Yang, X. Chen, Z. Lu & X. Zheng. (2009) Effect of high-dose methylprednisolone treatment on Th17 cells in patients with multiple sclerosis in relapse. Acta Neurologica Scandinavica 120:4, pages 235-241.
Crossref
Johann Sellner, Isabell Greeve, Oliver Findling, Christian P. Kamm, Carsten Minten, Britta Engelhardt, Denis Grandgirard, Stephen L. Leib & Heinrich P. Mattle. (2008) Effect of interferon-β and atorvastatin on Th1/Th2 cytokines in multiple sclerosis. Neurochemistry International 53:1-2, pages 17-21.
Crossref
Laureline Berthelot, David‐Axel Laplaud, Ségolène Pettré, Caroline Ballet, Laure Michel, Sophie Hillion, Cécile Braudeau, Francine Connan, Fabienne Lefrère, Sandrine Wiertlewski, Jean‐Gérard Guillet, Sophie Brouard, Jeannine Choppin & Jean‐Paul Soulillou. (2008) Blood CD8 + T cell responses against myelin determinants in multiple sclerosis and healthy individuals . European Journal of Immunology 38:7, pages 1889-1899.
Crossref
L. S. Harbige, E. Pinto, M. Xiang, M. Leach & M. K. Sharief. (2008) PUFA in the pathogenesis and treatment of patients with multiple sclerosis. Proceedings of the Nutrition Society 67:OCE1.
Crossref
Laurence S. Harbige & Mohammad K. Sharief. (2007) Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis. British Journal of Nutrition 98:S1, pages S46-S53.
Crossref
Sarah A. Imam, Mary K. Guyton, Azizul Haque, Arthur Vandenbark, William R. Tyor, Swapan K. Ray & Naren L. Banik. (2007) Increased calpain correlates with Th1 cytokine profile in PBMCs from MS patients. Journal of Neuroimmunology 190:1-2, pages 139-145.
Crossref
Jeffrey T. La Belle, Kinjal Bhavsar, Aaron Fairchild, Anusuya Das, James Sweeney, T.L. Alford, Joseph Wang, Veer P. Bhavanandan & Lokesh Joshi. (2007) A cytokine immunosensor for multiple sclerosis detection based upon label-free electrochemical impedance spectroscopy. Biosensors and Bioelectronics 23:3, pages 428-431.
Crossref
Niall Stewart, Bruce Taylor, Anne-Louise Ponsonby, Fotini Pittas, Ingrid van der Mei, Greg Woods & Haydn Walters. (2007) The effect of season on cytokine expression in multiple sclerosis and healthy subjects. Journal of Neuroimmunology 188:1-2, pages 181-186.
Crossref
H. TremlettS. SeemüllerY. ZhaoE. M. YoshidaJ. OgerJ. Petkau. (2006) Liver test abnormalities in multiple sclerosis: Findings from placebo-treated patients. Neurology 67:7, pages 1291-1293.
Crossref
M. Comabella, C. Romera, M. Camiña, H. Perkal, M. A. Moro, J. C. Leza, I. Lizasoain, M. Castillo & X. Montalban. (2006) TNF–α converting enzyme (TACE) protein expression in different clinical subtypes of multiple sclerosis. Journal of Neurology 253:6, pages 701-706.
Crossref
Tove Christensen. (2005) Association of human endogenous retroviruses with multiple sclerosis and possible interactions with herpes viruses. Reviews in Medical Virology 15:3, pages 179-211.
Crossref
Yu-Min HuangXuan Liu, Knut Steffensen, Alessandra Sanna, Giannina Arru, Maria Laura Fois, Giulio Rosati, Stefano Sotgiu & Hans Link. (2016) Immunological heterogeneity of multiple sclerosis in Sardinia and Sweden. Multiple Sclerosis Journal 11:1, pages 16-23.
Crossref
Helen Tremlett & Joel Oger. (2004) Hepatic injury, liver monitoring and the beta-interferons for multiple sclerosis. Journal of Neurology 251:11, pages 1297-1303.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.