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Inhalation Toxicology
International Forum for Respiratory Research
Volume 20, 2008 - Issue 1
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Research Article

A Controlled Inhalation Diesel Exhaust Exposure Facility with Dynamic Feedback Control of PM Concentration

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Pages 49-52 | Received 14 May 2007, Accepted 19 Sep 2007, Published online: 06 Oct 2008

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Read on this site (7)

David A. Morgott. (2014) Factors and Trends Affecting the Identification of a Reliable Biomarker for Diesel Exhaust Exposure. Critical Reviews in Environmental Science and Technology 44:16, pages 1795-1864.
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Chad S. Weldy, Ian P. Luttrell, Collin C. White, Vicki Morgan-Stevenson, David P. Cox, Christopher M. Carosino, Timothy V. Larson, James A. Stewart, Joel D. Kaufman, Francis Kim, Kanchan Chitaley & Terrance J. Kavanagh. (2013) Glutathione (GSH) and the GSH synthesis gene Gclm modulate plasma redox and vascular responses to acute diesel exhaust inhalation in mice. Inhalation Toxicology 25:8, pages 444-454.
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Ni Bai, Erin M. Tranfield, Terrance J. Kavanagh, Joel D. Kaufman, Michael E. Rosenfeld & Stephan F. van Eeden. (2012) Exposure to diesel exhaust upregulates COX-2 expression in ApoE knockout mice. Inhalation Toxicology 24:8, pages 518-527.
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Chad S. Weldy, Collin C. White, Hui-Wen Wilkerson, Timothy V. Larson, James A. Stewart, Sean E. Gill, William C. Parks & Terrance J. Kavanagh. (2011) Heterozygosity in the glutathione synthesis gene Gclm increases sensitivity to diesel exhaust particulate induced lung inflammation in mice. Inhalation Toxicology 23:12, pages 724-735.
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Takashi Kido, Ni Bai, Kazuhiro Yatera, Hisashi Suzuki, Anna Meredith, Hiroshi Mukae, Michael E. Rosenfeld & Stephan F. van Eeden. (2011) Diesel exhaust inhalation induces heat shock protein 70 expression in vivo. Inhalation Toxicology 23:10, pages 593-601.
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Nicholas Birger, Timothy Gould, James Stewart, Mark R. Miller, Timothy Larson & Chris Carlsten. (2011) The Air Pollution Exposure Laboratory (APEL) for controlled human exposure to diesel exhaust and other inhalants: characterization and comparison to existing facilities. Inhalation Toxicology 23:4, pages 219-225.
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C. Carlsten, J. D. Kaufman, C. A. Trenga, J. Allen, A. Peretz & J. H. Sullivan. (2008) Thrombotic Markers in Metabolic Syndrome Subjects Exposed to Diesel Exhaust. Inhalation Toxicology 20:10, pages 917-921.
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Articles from other publishers (29)

Jacqueline M. Garrick, Toby B. Cole, Khoi Dao, Ashley Phillips & Lucio G. Costa. (2023) Perinatal diesel exhaust exposure causes persistent changes in the brains of aged mice: An assessment of behavioral and biochemical endpoints related to neurodegenerative disease. Environmental Toxicology 38:4, pages 899-913.
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Jay W. Rutherford, Timothy V. Larson, Timothy Gould, Edmund Seto, Igor V. Novosselov & Jonathan D. Posner. (2021) Source apportionment of environmental combustion sources using excitation emission matrix fluorescence spectroscopy and machine learning. Atmospheric Environment 259, pages 118501.
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Kristen E. Cosselman, Jason Allen, Karen L. Jansen, Patricia Stapleton, Carol A. Trenga, Timothy V. Larson & Joel D. Kaufman. (2020) Acute exposure to traffic-related air pollution alters antioxidant status in healthy adults. Environmental Research 191, pages 110027.
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Gaurav Mahamuni, Jay Rutherford, Justin Davis, Eric Molnar, Jonathan D. Posner, Edmund Seto, Gregory Korshin & Igor Novosselov. (2020) Excitation–Emission Matrix Spectroscopy for Analysis of Chemical Composition of Combustion Generated Particulate Matter. Environmental Science & Technology 54:13, pages 8198-8209.
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Lara P. Clark, V. Sreekanth, Bujin Bekbulat, Michael Baum, Songlin Yang, Pao Baylon, Timothy R. Gould, Timothy V. Larson, Edmund Y. W. Seto, Chris D. Space & Julian D. Marshall. (2020) Developing a Low-Cost Passive Method for Long-Term Average Levels of Light-Absorbing Carbon Air Pollution in Polluted Indoor Environments. Sensors 20:12, pages 3417.
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Jay W. Rutherford, Neal Dawson-Elli, Anne M. Manicone, Gregory V. Korshin, Igor V. Novosselov, Edmund Seto & Jonathan D. Posner. (2020) Excitation emission matrix fluorescence spectroscopy for combustion generated particulate matter source identification. Atmospheric Environment 220, pages 117065.
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Jamie M. Goodson, James W. MacDonald, Theo K. Bammler, Wei-Ming Chien & Michael T. Chin. (2019) In utero exposure to diesel exhaust is associated with alterations in neonatal cardiomyocyte transcription, DNA methylation and metabolic perturbation. Particle and Fibre Toxicology 16:1.
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Keith Morris-Schaffer, Alyssa K. Merrill, Candace Wong, Katrina Jew, Marissa Sobolewski & Deborah A. Cory-Slechta. (2019) Limited developmental neurotoxicity from neonatal inhalation exposure to diesel exhaust particles in C57BL/6 mice. Particle and Fibre Toxicology 16:1.
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Fen Yin, Rajat Gupta, Laurent Vergnes, Will S. Driscoll, Jerry Ricks, Gajalakshmi Ramanathan, James A. Stewart, Diana M. Shih, Kym F. Faull, Simon W. Beaven, Aldons J. Lusis, Karen Reue, Michael E. Rosenfeld & Jesús A. Araujo. (2019) Diesel Exhaust Induces Mitochondrial Dysfunction, Hyperlipidemia, and Liver Steatosis. Arteriosclerosis, Thrombosis, and Vascular Biology 39:9, pages 1776-1786.
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Yu-Chi Chang, Ray Daza, Robert Hevner, Lucio G. Costa & Toby B. Cole. (2019) Prenatal and early life diesel exhaust exposure disrupts cortical lamina organization: Evidence for a reelin-related pathogenic pathway induced by interleukin-6. Brain, Behavior, and Immunity 78, pages 105-115.
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Yu-Chi Chang, Toby B. Cole & Lucio G. Costa. (2018) Prenatal and early-life diesel exhaust exposure causes autism-like behavioral changes in mice. Particle and Fibre Toxicology 15:1.
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Jacki L. Coburn, Toby B. Cole, Khoi T. Dao & Lucio G. Costa. (2018) Acute exposure to diesel exhaust impairs adult neurogenesis in mice: prominence in males and protective effect of pioglitazone. Archives of Toxicology 92:5, pages 1815-1829.
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Jamie M. Goodson, Chad S. Weldy, James W. MacDonald, Yonggang Liu, Theo K. Bammler, Wei‐Ming Chien & Michael T. Chin. (2017) In utero exposure to diesel exhaust particulates is associated with an altered cardiac transcriptional response to transverse aortic constriction and altered DNA methylation . The FASEB Journal 31:11, pages 4935-4945.
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Lucio G. Costa, Toby B. Cole, Jacki Coburn, Yu-Chi Chang, Khoi Dao & Pamela J. Roqué. (2017) Neurotoxicity of traffic-related air pollution. NeuroToxicology 59, pages 133-139.
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Toby B. Cole, Jacki Coburn, Khoi Dao, Pam Roqué, Yu-Chi Chang, Vrinda Kalia, Tomas R. Guilarte, Jennifer Dziedzic & Lucio G. Costa. (2016) Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain. Toxicology 374, pages 1-9.
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Pamela J. Roqué, Khoi Dao & Lucio G. Costa. (2016) Microglia mediate diesel exhaust particle-induced cerebellar neuronal toxicity through neuroinflammatory mechanisms. NeuroToxicology 56, pages 204-214.
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Cora S. Sack, Karen L. Jansen, Kristen E. Cosselman, Carol A. Trenga, Pat L. Stapleton, Jason Allen, Alon Peretz, Casey Olives & Joel D. Kaufman. (2016) Pretreatment with Antioxidants Augments the Acute Arterial Vasoconstriction Caused by Diesel Exhaust Inhalation. American Journal of Respiratory and Critical Care Medicine 193:9, pages 1000-1007.
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Julie Richman Fox, David P. Cox, Bertram E. Drury, Timothy R. Gould, Terrance J. Kavanagh, Michael H. Paulsen, Lianne Sheppard, Christopher D. Simpson, James A. Stewart, Timothy V. Larson & Joel D. Kaufman. (2014) Chemical characterization and in vitro toxicity of diesel exhaust particulate matter generated under varying conditions. Air Quality, Atmosphere & Health 8:5, pages 507-519.
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Chad S. Weldy, Yonggang Liu, H. Denny Liggitt & Michael T. Chin. (2014) In Utero Exposure to Diesel Exhaust Air Pollution Promotes Adverse Intrauterine Conditions, Resulting in Weight Gain, Altered Blood Pressure, and Increased Susceptibility to Heart Failure in Adult Mice. PLoS ONE 9:2, pages e88582.
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Chris Carlsten, Assaf P. Oron, Heidi Curtiss, Sara Jarvis, William Daniell & Joel D. Kaufman. (2013) Symptoms in Response to Controlled Diesel Exhaust More Closely Reflect Exposure Perception Than True Exposure. PLoS ONE 8:12, pages e83573.
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Chad S Weldy, Yonggang Liu, Yu-Chi Chang, Ivan O Medvedev, Julie R Fox, Timothy V Larson, Wei-Ming Chien & Michael T Chin. (2013) In utero and early life exposure to diesel exhaust air pollution increases adult susceptibility to heart failure in mice. Particle and Fibre Toxicology 10:1.
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Yonggang Liu, Wei-Ming Chien, Ivan O Medvedev, Chad S Weldy, Daniel L Luchtel, Michael E Rosenfeld & Michael T Chin. (2013) Inhalation of diesel exhaust does not exacerbate cardiac hypertrophy or heart failure in two mouse models of cardiac hypertrophy. Particle and Fibre Toxicology 10:1.
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Ranjini M Krishnan, Jeffrey H Sullivan, Chris Carlsten, Hui-Wen Wilkerson, Richard P Beyer, Theo Bammler, Fred Farin, Alon Peretz & Joel D Kaufman. (2013) A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans. Particle and Fibre Toxicology 10:1, pages 7.
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Kristen E. CosselmanRanjini M. KrishnanAssaf P. OronKaren JansenAlon PeretzJeffrey H. SullivanTimothy V. LarsonJoel D. Kaufman. (2012) Blood Pressure Response to Controlled Diesel Exhaust Exposure in Human Subjects. Hypertension 59:5, pages 943-948.
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Chad S. Weldy, Hui-Wen Wilkerson, Timothy V. Larson, James A. Stewart & Terrance J. Kavanagh. (2011) DIESEL particulate exposed macrophages alter endothelial cell expression of eNOS, iNOS, MCP1, and glutathione synthesis genes. Toxicology in Vitro 25:8, pages 2064-2073.
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Ni Bai, Takashi Kido, Terrance J. Kavanagh, Joel D. Kaufman, Michael E. Rosenfeld, Cornelis van Breemen & Stephan F. van Eeden. (2011) Exposure to diesel exhaust up-regulates iNOS expression in ApoE knockout mice. Toxicology and Applied Pharmacology 255:2, pages 184-192.
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Ni Bai, Takashi Kido, Hisashi Suzuki, Grace Yang, Terrance J. Kavanagh, Joel D. Kaufman, Michael E. Rosenfeld, Cornelis van Breemen & Stephan F. van Eeden. (2011) Changes in atherosclerotic plaques induced by inhalation of diesel exhaust. Atherosclerosis 216:2, pages 299-306.
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Jeremy P. Langrish, Mark W. Frampton & Anders Blomberg. 2011. Cardiovascular Effects of Inhaled Ultrafine and Nanosized Particles. Cardiovascular Effects of Inhaled Ultrafine and Nanosized Particles 217 239 .
Alon Peretz, Jeffrey H. Sullivan, Daniel F. LeottaCarol A. Trenga, Fiona N. Sands, Jason Allen, Chris Carlsten, Charles W. Wilkinson, Edward A. Gill & Joel D. Kaufman. (2008) Diesel Exhaust Inhalation Elicits Acute Vasoconstriction in Vivo . Environmental Health Perspectives 116:7, pages 937-942.
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