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Gynecological Endocrinology Volume 22, 2006 - Issue 1
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Original

Metformin administration modulates neurosteroids secretion in non-obese amenorrhoic patients with polycystic ovary syndrome

Alessandro D. Genazzani Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, ItalyCorrespondence[email protected]
,
Claudia Strucchi Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, Italy
,
Michele Luisi Department of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
,
Elena Casarosa Department of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
,
Chiara Lanzoni Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, Italy
,
Enrica Baraldi Laboratory of Endocrinology, Azienda Policlinico, Modena, Italy
,
Federica Ricchieri Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, Italy
,
Hilda Mehmeti Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, Modena, Italy
&
Andrea R. Genazzani Department of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
 show all
Pages 36-43 | Received 12 Aug 2005, Accepted 12 Dec 2005, Published online: 07 Jul 2009

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Sahruh Turkmen, Lotta Andreen & Yucel Cengiz. (2015) Effects of Roux-en-Y gastric bypass surgery on eating behaviour and allopregnanolone levels in obese women with polycystic ovary syndrome. Gynecological Endocrinology 31:4, pages 301-305.
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Alessandro D. Genazzani, Elisa Chierchia, Erika Rattighieri, Susanna Santagni, Elena Casarosa, Michele Luisi & Andrea R. Genazzani. (2010) Metformin administration restores allopregnanolone response to adrenocorticotropic hormone (ACTH) stimulation in overweight hyperinsulinemic patients with PCOS. Gynecological Endocrinology 26:9, pages 684-689.
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Evangelia Billa, Niki Kapolla, Stamatina C. Nicopoulou, Eftychia Koukkou, Evangelia Venaki, Spyros Milingos, Aristides Antsaklis & Dimitrios A. Adamopoulos. (2009) Metformin administration was associated with a modification of LH, prolactin and insulin secretion dynamics in women with polycystic ovarian syndrome. Gynecological Endocrinology 25:7, pages 427-434.
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Toru Takeuchi, Osamu Tsutsumi & Yuji Taketani. (2008) Abnormal response of insulin to glucose loading and assessment of insulin resistance in non-obese patients with polycystic ovary syndrome. Gynecological Endocrinology 24:7, pages 385-391.
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Articles from other publishers (23)

Antonella Rosario Ramona Cáceres, Fiorella Campo Verde Arboccó, Daniela Alejandra Cardone, María de los Ángeles Sanhueza, Marilina Casais, Adriana Soledad Vega Orozco & Myriam Raquel Laconi. (2021) Superior mesenteric ganglion neural modulation of ovarian angiogenesis, apoptosis and proliferation by the neuroactive steroid allopregnanolone. Journal of Neuroendocrinology 34:2.
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Lindsay R. Standeven, Elizabeth Olson, Nicole Leistikow, Jennifer L. Payne, Lauren M. Osborne & Liisa Hantsoo. (2021) Polycystic Ovary Syndrome, Affective Symptoms, and Neuroactive Steroids: a Focus on Allopregnanolone. Current Psychiatry Reports 23:6.
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Shaimaa Nasr Amin, Shaimaa Abdalaleem Abdalgeleel, Mubarak Ali Algahtany, Sherif Ahmed Shaltout, Walaa Bayoumie El Gazzar & Dalia Azmy Elberry. (2021) Effect of Allopregnanolone on Spatial Memory and Synaptic Proteins in Animal Model of Metabolic Syndrome. Brain Sciences 11:5, pages 644.
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E. Holmberg, J. Sjöstedt, E. Malinina, M. Johansson, S. Turkmen, G. Ragagnin, A. Lundqvist, M. Löfgren, L. Jaukkuri, M. Bixo & T. Bäckström. (2018) Allopregnanolone involvement in feeding regulation, overeating and obesity. Frontiers in Neuroendocrinology 48, pages 70-77.
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Alessandro D. Genazzani, Alessia Prati & Giulia Despini. 2018. Pre-Menopause, Menopause and Beyond. Pre-Menopause, Menopause and Beyond 141 152 .
Fan Wang, Shaobing Wang, Zhenghong Zhang, Qingqiang Lin, Yiping Liu, Yijun Xiao, Kaizhuan Xiao & Zhengchao Wang. (2017) Defective insulin signaling and the protective effects of dimethyldiguanide during follicular development in the ovaries of polycystic ovary syndrome. Molecular Medicine Reports 16:6, pages 8164-8170.
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Sahruh Turkmen, Marie Bixo, Helena Hedström, Ida Gideonsson, Sigrid Nyberg, Mingde Wang & Torbjörn Bäckström. (2016) The author's reply: Blood allopregnanolone levels in women with polycystic ovary syndrome. Clinical Endocrinology 85:1, pages 152-154.
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Feifei Cheng, Lu Zhao, Yuanyuan Wu, Tiantian Huang, Gangyi Yang, Zhanyu Zhang, Yijia Wu, Fang Jia, Jinlin Wu, Chen Chen & Dongfang Liu. (2015) Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment. Clinical Endocrinology 84:3, pages 386-393.
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Sahruh Turkmen, Alebtekin Ahangari & Torbjörn Bäckstrom. (2015) Roux-en-Y Gastric Bypass Surgery in Patients with Polycystic Ovary Syndrome and Metabolic Syndrome. Obesity Surgery 26:1, pages 111-118.
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Helena Hedström, Torbjörn Bäckström, Marie Bixo, Sigrid Nyberg, Mingde Wang, Ida Gideonsson & Sahruh Turkmen. (2015) Women with polycystic ovary syndrome have elevated serum concentrations of and altered GABA A receptor sensitivity to allopregnanolone . Clinical Endocrinology 83:5, pages 643-650.
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Susan L. Samson & Alan J. Garber. 2015. International Textbook of Diabetes Mellitus. International Textbook of Diabetes Mellitus 641 656 .
Mariagrazia Stracquadanio & Lilliana CiottaMariagrazia Stracquadanio & Lilliana Ciotta. 2015. Metabolic Aspects of PCOS. Metabolic Aspects of PCOS 89 137 .
Susanna Santagni, Erika Rattighieri, Elisa Chierchia, Giulia Despini, Alessia Prati & Alessandro D. Genazzani. 2015. Frontiers in Gynecological Endocrinology. Frontiers in Gynecological Endocrinology 143 153 .
Alison V. Roland & Suzanne M. Moenter. (2014) Reproductive neuroendocrine dysfunction in polycystic ovary syndrome: Insight from animal models. Frontiers in Neuroendocrinology 35:4, pages 494-511.
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Luciana Tock, Gláucia Carneiro, Andrea Z. Pereira, Sérgio Tufik & Maria Teresa Zanella. (2014) Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome. International Journal of Endocrinology 2014, pages 1-7.
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Julia JohanssonLeanne RedmanPaula P. VeldhuisAntonina SazonovaFernand LabrieGöran HolmGudmundur Johannsson & Elisabet Stener-Victorin. (2013) Acupuncture for ovulation induction in polycystic ovary syndrome: a randomized controlled trial. American Journal of Physiology-Endocrinology and Metabolism 304:9, pages E934-E943.
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Julia Johansson & Elisabet Stener-Victorin. (2013) Polycystic Ovary Syndrome: Effect and Mechanisms of Acupuncture for Ovulation Induction. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-16.
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Bachir Abi Salloum, Carol Herkimer, James S. Lee, Almudena Veiga-Lopez & Vasantha Padmanabhan. (2012) Developmental Programming: Prenatal and Postnatal Contribution of Androgens and Insulin in the Reprogramming of Estradiol Positive Feedback Disruptions in Prenatal Testosterone-Treated Sheep. Endocrinology 153:6, pages 2813-2822.
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Maria F. Gangale, Luca Miele, Antonio Lanzone, Francesca Sagnella, Daniela Martinez, Anna Tropea, Francesca Moro, Andrea Morciano, Andrea Ciardulli, Carola Palla, Maurizio Pompili, Consuelo Cefalo, Antonio Grieco & Rosanna Apa. (2011) Long‐term metformin treatment is able to reduce the prevalence of metabolic syndrome and its hepatic involvement in young hyperinsulinaemic overweight patients with polycystic ovarian syndrome. Clinical Endocrinology 75:4, pages 520-527.
Crossref
Alessandro D Genazzani, Federica Ricchieri & Chiara Lanzoni. (2010) Use of Metformin in the Treatment of Polycystic Ovary Syndrome. Women's Health 6:4, pages 577-593.
Crossref
Stefano Palomba, Angela Falbo, Fulvio Zullo & Francesco OrioJr.Jr.. (2009) Evidence-Based and Potential Benefits of Metformin in the Polycystic Ovary Syndrome: A Comprehensive Review. Endocrine Reviews 30:1, pages 1-50.
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. (2007) Current World Literature. Current Opinion in Obstetrics & Gynecology 19:4, pages 402-410.
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. (2007) Current World Literature. Current Opinion in Endocrinology, Diabetes & Obesity 14:2, pages 170-196.
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