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Platelets Volume 16, 2005 - Issue 7
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Original Article

Glycoprotein IIb/IIIa and P2Y12 receptor antagonists yield additive inhibition of platelet aggregation, granule secretion, soluble CD40L release and procoagulant responses

Heather M. Judge Cardiovascular Research Unit, Clinical Sciences Centre, Northern General Hospital, Sheffield S5 7AU, UKCorrespondence[email protected]
,
Robert J. Buckland Cardiovascular Research Unit, Clinical Sciences Centre, Northern General Hospital, Sheffield S5 7AU, UK
,
Carol E. Holgate Cardiovascular Research Unit, Clinical Sciences Centre, Northern General Hospital, Sheffield S5 7AU, UK
&
Robert F. Storey Cardiovascular Research Unit, Clinical Sciences Centre, Northern General Hospital, Sheffield S5 7AU, UK
Pages 398-407 | Received 10 Jan 2005, Accepted 07 Feb 2005, Published online: 07 Jul 2009

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Paul M Haller, Stefan Stojkovic, Edita Piackova, Tijana Andric, Lukas Wisgrill, Andreas Spittler, Johann Wojta, Kurt Huber & Bernhard Jäger. (2020) The association of P2Y12 inhibitors with pro-coagulatory extracellular vesicles and microRNAs in stable coronary artery disease. Platelets 31:4, pages 497-504.
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Aleksandra Gasecka, Anita N. Böing, Krzysztof J. Filipiak & Rienk Nieuwland. (2017) Platelet extracellular vesicles as biomarkers for arterial thrombosis. Platelets 28:3, pages 228-234.
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Robert F. Storey & Akanksha Sinha. (2016) Cangrelor for the management and prevention of arterial thrombosis. Expert Review of Cardiovascular Therapy 14:9, pages 991-999.
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Milladur Rahman, David Gustafsson, Yongzhi Wang, Henrik Thorlacius & Oscar Ö Braun. (2014) Ticagrelor reduces neutrophil recruitment and lung damage in abdominal sepsis. Platelets 25:4, pages 257-263.
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Alexander O. Spiel, Florian B. Mayr, Nathalie Ladani, Patricia G. Wagner, Robert G. Schaub, James C. Gilbert & Bernd Jilma. (2009) The aptamer ARC1779 is a potent and specific inhibitor of von willebrand factor mediated ex vivo platelet function in acute myocardial infarction. Platelets 20:5, pages 334-340.
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Heather M. Judge, Robert J. Buckland, Atsuhiro Sugidachi, Joseph A. Jakubowski & Robert F. Storey. (2008) The active metabolite of prasugrel effectively blocks the platelet P2Y12 receptor and inhibits procoagulant and pro-inflammatory platelet responses. Platelets 19:2, pages 125-133.
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Cezary Watala, Joanna Wzorek, Agnieszka Palma & Magdalena Boncler. (2022) A comparison of different regression models for the quantitative analysis of the combined effect of P2Y12 and P2Y1 receptor antagonists on ADP-induced platelet activation. Thrombosis Research 211, pages 88-97.
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Sarah Schmidt, Wilfried Reichardt, Beat Kaufmann, Carolin Wadle, Dominik von Elverfeldt, Peter Stachon, Ingo Hilgendorf, Dennis Wolf, Timo Heidt, Daniel Duerschmied, Karlheinz Peter, Christoph Bode, Constantin von zur Mühlen & Alexander Maier. (2021) P2Y12 Inhibition in Murine Myocarditis Results in Reduced Platelet Infiltration and Preserved Ejection Fraction. Cells 10:12, pages 3414.
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Zhi-Jiang Xie, Shuan-Li Xin, Chao Chang, Hai-Jing Zhou, Xiu-Feng Zhao, Feng-Hui Jiao, Chuan Chen & Tao Li. (2021) Combined glycoprotein IIb/IIIa inhibitor therapy with ticagrelor for patients with acute coronary syndrome. PLOS ONE 16:2, pages e0246166.
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Aleksandra Gąsecka, Sylwester Rogula, Ceren Eyileten, Marek Postuła, Miłosz J. Jaguszewski, Janusz Kochman, Tomasz Mazurek, Rienk Nieuwland & Krzysztof J. Filipiak. (2020) Role of P2Y Receptors in Platelet Extracellular Vesicle Release. International Journal of Molecular Sciences 21:17, pages 6065.
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Tianwei Zhan, Taofeng Wei, Lingjun Dong, Qi Wang, Zixiang Wu, Qihang Yan, Weiping Zhang, Yunbi Lu & Ming Wu. (2020) Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice. Molecular Immunology 120, pages 83-92.
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Aleksandra Gasecka, Rienk Nieuwland, Monika Budnik, Françoise Dignat‐George, Ceren Eyileten, Paul Harrison, Romaric Lacroix, Aurélie Leroyer, Grzegorz Opolski, Kinga Pluta, Edwin van der Pol, Marek Postuła, Pia Siljander, Jolanta M. Siller‐Matula & Krzysztof J. Filipiak. (2020) Ticagrelor attenuates the increase of extracellular vesicle concentrations in plasma after acute myocardial infarction compared to clopidogrel. Journal of Thrombosis and Haemostasis 18:3, pages 609-623.
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Francesco Taus, Alessandra Meneguzzi, Marco Castelli & Pietro Minuz. (2019) Platelet-Derived Extracellular Vesicles as Target of Antiplatelet Agents. What Is the Evidence?. Frontiers in Pharmacology 10.
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Ivelin I. Ivanov, Bonita H. R. Apta, Arkadiusz M. Bonna & Matthew T. Harper. (2019) Platelet P-selectin triggers rapid surface exposure of tissue factor in monocytes. Scientific Reports 9:1.
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Diana A. Gorog & Gregory Y.H. Lip. (2019) Impaired Spontaneous/Endogenous Fibrinolytic Status as New Cardiovascular Risk Factor?. Journal of the American College of Cardiology 74:10, pages 1366-1375.
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Ying Gao, Cheng Yu, Shulan Pi, Ling Mao & Bo Hu. (2018) The role of P2Y12 receptor in ischemic stroke of atherosclerotic origin. Cellular and Molecular Life Sciences 76:2, pages 341-354.
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Hitesh Shukla, Jessica Louise Mason & Abdullah Sabyah. (2018) A Literature Review of Genetic Markers Conferring Impaired Response to Cardiovascular Drugs. American Journal of Cardiovascular Drugs 18:4, pages 259-269.
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Mariusz Tomaniak, Aleksandra Gąsecka & Krzysztof J. Filipiak. (2017) Cell-derived microvesicles in cardiovascular diseases and antiplatelet therapy monitoring — A lesson for future trials? Current evidence, recent progresses and perspectives of clinical application. International Journal of Cardiology 226, pages 93-102.
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Yuichi J. Shimada, Sameer Bansilal, Stephen D. Wiviott, Richard C. Becker, Robert A. Harrington, Anders Himmelmann, Benjamin Neely, Steen Husted, Stefan K. James, Hugo A. Katus, Renato D. Lopes, Ph. Gabriel Steg, Robert F. Storey, Lars Wallentin & Christopher P. Cannon. (2016) Impact of glycoprotein IIb/IIIa inhibitors on the efficacy and safety of ticagrelor compared with clopidogrel in patients with acute coronary syndromes: Analysis from the Platelet Inhibition and Patient Outcomes (PLATO) Trial. American Heart Journal 177, pages 1-8.
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Marco Roffi, Carlo Patrono, Jean-Philippe Collet, Christian Mueller, Marco Valgimigli, Felicita Andreotti, Jeroen J. Bax, Michael A. Borger, Carlos Brotons, Derek P. Chew, Baris Gencer, Gerd Hasenfuss, Keld Kjeldsen, Patrizio Lancellotti, Ulf Landmesser, Julinda Mehilli, Debabrata Mukherjee, Robert F. Storey & Stephan Windecker. (2016) 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. European Heart Journal 37:3, pages 267-315.
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Mark Thomas & Robert Storey. (2017) Effect of P2Y12 inhibitors on inflammation and immunity. Thrombosis and Haemostasis 114:09, pages 490-497.
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Karin Müller, Madhumita Chatterjee, Dominik Rath & Tobias Geisler. (2017) Platelets, inflammation and anti-inflammatory effects of antiplatelet drugs in ACS and CAD. Thrombosis and Haemostasis 114:09, pages 498-518.
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Michelle A. Berny‐Lang, Joseph A. Jakubowski, Atsuhiro Sugidachi, Marc R. Barnard, Alan D. Michelson & Andrew L. FrelingerIIIIII. (2013) P2Y 12 Receptor Blockade Augments Glycoprotein IIb‐IIIa Antagonist Inhibition of Platelet Activation, Aggregation, and Procoagulant Activity . Journal of the American Heart Association 2:3.
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Wei Yin & David A Rubenstein. (2012) Differences between mainstream and sidestream tobacco smoke extracts and nicotine in the activation and aggregation of platelets subjected to cardiovascular conditions in diabetes. Diabetes and Vascular Disease Research 10:1, pages 57-64.
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Piotr P. Buszman, Wojciech Wojakowski, Krzysztof Milewski, Marcin Dębiński, Jacek Pająk, Michael S. Aboodi, Wanda Jackiewicz, Magdalena Kawka, Andrzej Bochenek, Jayne Prats, Juan F. Granada, Greg L. Kałuża & Pawel E. Buszman. (2012) Controlled Reperfusion with Intravenous Bivalirudin and Intracoronary Abciximab Combination Therapy in the Porcine Myocardial Infarction Model. Thrombosis Research 130:2, pages 265-272.
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Shankar B. PatilLaura E. JackmanSheila E. FrancisHeather M. JudgeSven NylanderRobert F. Storey. (2010) Ticagrelor Effectively and Reversibly Blocks Murine Platelet P2Y 12 -Mediated Thrombosis and Demonstrates a Requirement for Sustained P2Y 12 Inhibition to Prevent Subsequent Neointima . Arteriosclerosis, Thrombosis, and Vascular Biology 30:12, pages 2385-2391.
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Hans-Joerg Weig, Lorenz Bott-Flügel, Christian Städele, Kerstin Winter, Roland Schmidt, Meinrad Gawaz, Karl-Ludwig Laugwitz & Melchior Seyfarth. (2008) Impaired platelet function reduces myocardial infarct size in Gαq knock-out mice in vivo. Journal of Molecular and Cellular Cardiology 44:1, pages 143-150.
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H Zhang, P M Nimmer, S K Tahir, J Chen, R M Fryer, K R Hahn, L A Iciek, S J Morgan, M C Nasarre, R Nelson, L C Preusser, G A Reinhart, M L Smith, S H Rosenberg, S W Elmore & C Tse. (2007) Bcl-2 family proteins are essential for platelet survival. Cell Death & Differentiation 14:5, pages 943-951.
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