Glycoprotein IIb/IIIa and P2Y₁₂ receptor antagonists yield additive inhibition of platelet aggregation, granule secretion, soluble CD40L release and procoagulant responses

References

• Shattil SJ, Gao J, Kashiwagi H. Not just another pretty face: Regulation of platelet function at the cytoplasmic face of integrin aIIbfi3. Thrombosis and Haemostasis 1997;78:220–225.
   PubMed Web of Science ®Google Scholar
• Massberg S, Mueller I, Besta F, Thomas P, Gawaz M. Effects of 2 different antiplatelet regimens with abciximab or tirofiban on platelet function in patients undergoing coronary stenting. American Heart Journal 2003;146:E19.
   PubMedGoogle Scholar
• Nannizzi-Alaimo L, Alves VL, Phillips DR. Inhibitory effects of glycoprotein IIb/IIIa antagonists and aspirin on the release of soluble CD40 ligand during platelet stimulation. Circulation 2003;107:1123–1128.
   PubMed Web of Science ®Google Scholar
• Savi P, Labouret C, Delesque N, Guette F, Lupker J, Herbert JM. P2Y12, a new platelet ADP receptor, target of clopidogrel. Biochemical and Biophysical Research Communications 2001; 283:379–383.
   PubMed Web of Science ®Google Scholar
• Storey RF, Wilcox RG, Heptinstall S. Comparison of the pharmacodynamic effects of the platelet ADP receptor antagonists clopidogrel and AR-C69931MX in patients with ischaemic heart disease. Platelets 2003;13:407–413.
   Google Scholar
• Storey RF, Sanderson HM, White AE, May JA, Cameron KE, Heptinstall S. The central role of the P2T receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity. British Journal of Haematology 2000;110:925–934.
   PubMed Web of Science ®Google Scholar
• Storey RF, Oldroyd KG, Wilcox RG. Open multicentre study of the P2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes. Thrombosis and Haemostasis 2001;85:401–407.
   PubMed Web of Science ®Google Scholar
• Storey RF, Wilcox RD, Heptinstall S. Differential effects of glycoprotein IIb/IIIa antagonists on platelet microaggregate and macroaggregate formation and effect of anticoagulant and antagonist potency. Circulation 1998;98:1616–1621.
   PubMedGoogle Scholar
• Matzdorff AC, Kuhnel G, Kemkes-Matthes B, Pralle H, Voss R, Fareed J. Effect of glycoprotein IIb/IIIa inhibitors on CD62P expression, platelet aggregates and microparticles in vitro. Journal of Laboratory and Clinical Medicine 2000;135:247–255.
   PubMedGoogle Scholar
• Dachery-Prigent J, Freyssinet JM, Pasquet JM, Carron JC, Nurden AT. Annexin V as a probe of aminophospholipid exposure and platelet membrane vesiculation: A flow cytometry study showing a role for free sulfhydryl groups. Blood 1993;81(10):2554–2565.
   PubMedGoogle Scholar
• Trumel C, Payraste B, Plantavid M, Hechler B, Viala C, Presek P, Martinson EA, Cazenave J, Chap H, Gachet C. A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase. Blood 1999;94(12):4156–4165.
   PubMed Web of Science ®Google Scholar
• Cho MJ, Liu J, Pestina TI, Steward SA, Thomas DW, Coffman TM, Wang D, Jackson CW, Gartner TK. The roles of aIIbfi3-mediated outside–in signal transduction, throm- boxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. Blood 2003;101:2646–2651.
   PubMed Web of Science ®Google Scholar
• Gawaz M, Ruf A, Pogatsa-Murray G, Dickfield T, Rudiger S, Taubitz W, Fischer J, Muller I, Meier D, Patscheke H, Schomig A. Incomplete inhibition of platelet aggregation and glycoprotein IIb–IIIa receptor blockade by abciximab: Importance of internal pool of glycoprotein IIb–IIIa receptors. Thrombosis and Haemostasis 2000;83:915–922.
   PubMedGoogle Scholar
• Tsao PW, Forsythe MS, Mousa SA. Dissociation between the anti-aggregatory and anti-secretory effects of platelet integrin aIIbfi3 (GPIIb/IIIa) antagonists, c7E3 and DMP728. Thrombosis Research 1997;88(2):137–146.
   PubMedGoogle Scholar
• Xiao Z, Theroux P. Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome. Journal of the American College of Cardiology 2004;43(11):1982–1988.
   PubMedGoogle Scholar
• Furman MI, Krueger LA, Linden MD, Barnard MR, Frelinger AL, Michelson AD. Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization. Journal of the American College of Cardiology 2004;43(12):2319–2325.
   PubMed Web of Science ®Google Scholar
• Anand SX, Viles-Gonzalez JF, Badimon JJ, Cavusoglu E, Marmur JD. Membrane-associated CD40L and sCD40L in atherothrombotic disease. Thrombosis and Haemostasis 2003;90:377–384.
   PubMed Web of Science ®Google Scholar
• Scho¨nbeck U, Libby P. CD40 signalling and plaque stability. Circulation Research 2001;89:1092–1103.
   PubMed Web of Science ®Google Scholar
• Aukrust P, Mu¨ ller F, Ueland T, Berget T, Aaser E, Brunsvig A, Solum NO, Forgang K, Froland SS, Gullestad L. Enhanced levels of soluble and membrane- bound CD40 ligand in patients with unstable angina. Circulation 1999;100:614–620.
   Google Scholar
• Andre´ P, Srinivasa KS, Denis CV, He M, Papalia JM, Hynes RO, Phillips DR, Wagner DD. CD40L stabilizes arterial thrombi by a b3 integrin-dependent mechanism. Nature Medicine 2002;8(3):247–252.
   PubMed Web of Science ®Google Scholar
• VanWijk MJ, VanBavel E, Sturk A, Nieuwland R. Microparticles in cardiovascular disease. Cardiovascular Research 2003;59:277–287.
   PubMed Web of Science ®Google Scholar
• Forlow SB, McEver RP, Nollert MU. Leukocyte-leukocyte interactions mediated by platelet microparticles under flow. Blood 2000;95:1317–1323.
   PubMed Web of Science ®Google Scholar
• Barry OP, Pratico D, Savani RC, FitzGerald GA. Modulation of monocyte-endothelial cell interactions by platelet micro- particles. Journal of Clinical Investigation 1998;102:136–144.
   PubMed Web of Science ®Google Scholar
• Biro´ E´, Sturk-Maquelin KN, Vogel GMT, Meuleman DG, Smit MJ, Hack CE, Sturk, Nieuwland R. Human cell-derived microparticles promote thrombus formation in vivo in a tissue-factor-dependent manner. Journal of Thrombosis and Haemostasis 2003;1:2561–2568.
   Google Scholar
• Storey RF, Judge HM, Wilcox RG, Heptinstall S. Inhibition of ADP-induced P selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin. Thrombosis and Haemostasis 2002;88:488–494.
   PubMed Web of Science ®Google Scholar
• Shattil SJ, Kashiwagi H, Pampori N. Integrin signaling: The platelet paradigm. Blood 1998;91(8):2645–2657.
   PubMed Web of Science ®Google Scholar
• Cazes E, Nurden P, Nurden AT. Abciximab binding to glycoprotein IIb–IIIa and protein tyrosine phosphorylation in human platelets. Blood 1999;93(11): 4019–4027.
   PubMedGoogle Scholar