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Original Article

Structure-activity Relationships in the Development of Hypoxic Cell Radiosensitizers

III. Effects of Basic Substituents in Nitroimidazole Sidechains

, , , , , , , & show all
Pages 613-626 | Received 07 Mar 1980, Accepted 15 Jun 1980, Published online: 03 Jul 2009

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Read on this site (4)

L. Santos, M.C. Lopez Zumel, M.V. Alvarez & M.C. Izquierdo. (1989) Radiosensitization by Quaternary Salts of 5-nitroimidazole Derivatives. International Journal of Radiation Biology 55:6, pages 983-991.
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M.F. Dennis, M.R.L. Stratford, P. Wardman & M.E. Watts. (1985) Cellular Uptake of Misonidazole and Analogues with Acidic or Basic Functions. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 47:6, pages 629-643.
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C. Murayama, Y. Nagao, E. Fujita, T. Asao, M. Yasumoto & T. Mori. (1983) Radiosensitization of Hypoxic HeLa S3 Cells in Vitro by a New Type of Radiosensitizer: Spermine and Spermidine Amides with Nitro Groups. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 44:5, pages 497-503.
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D.J. Chaplin, P.W. Sheldon, I.J. Stratford, I. Ahmed & G.E. Adams. (1983) Radiosensitization in Vivo: A Study with an Homologous Series of 2-nitroimidazoles. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 44:4, pages 387-398.
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Narimantas Čėnas, Aušra Nemeikaitė-Čėnienė & Lidija Kosychova. (2021) Single- and Two-Electron Reduction of Nitroaromatic Compounds by Flavoenzymes: Mechanisms and Implications for Cytotoxicity. International Journal of Molecular Sciences 22:16, pages 8534.
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Peter Wardman. (2018) Nitroimidazoles as hypoxic cell radiosensitizers and hypoxia probes: misonidazole, myths and mistakes. The British Journal of Radiology, pages 20170915.
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Kaijie Zhao, Wendong Ke, Wei Yin, Junjie Li, Ming Qiang & Zhishen Ge. (2017) Facile Preparation and Radiotherapy Application of an Amphiphilic Block Copolymer Radiosensitizer. ACS Macro Letters 6:5, pages 556-560.
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Piyush Kumar, Hassan R. H. Elsaidi, Bohdarianna Zorniak, Evelyn Laurens, Jennifer Yang, Veena Bacchu, Monica Wang & Leonard I. Wiebe. (2016) Synthesis and Biological Evaluation of Iodoglucoazomycin (I-GAZ), an Azomycin-Glucose Adduct with Putative Applications in Diagnostic Imaging and Radiotherapy of Hypoxic Tumors. ChemMedChem 11:15, pages 1638-1645.
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Wei Long, Xiao-dong Zhang, Hao Wang, Xiu Shen, Hong-zong Si, Sai-jun Fan, Ze-wei Zhou & Pei-xun Liu. (2013) Prediction of enhancement effect of nitroimidazoles on irradiation by gene expression programming. Chemical Research in Chinese Universities 29:3, pages 519-525.
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Wei LONG & Peixun LIU. (2010) Quantitative Structure Activity Relationship Modeling for Predicting Radiosensitization Effectiveness of Nitroimidazole Compounds. Journal of Radiation Research 51:5, pages 563-572.
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P WARDMAN. (2009) The importance of radiation chemistry to radiation and free radical biology (The 2008 Silvanus Thompson Memorial Lecture). The British Journal of Radiology 82:974, pages 89-104.
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P. Wardman. 2001. Radiation Chemistry - Present Status and Future Trends. Radiation Chemistry - Present Status and Future Trends 623 655 .
Harukazu Mashiba, Keiko Matsunaga & Kazuo Hata. (1991) Enhancement of radiosensitizing effect of the nitroimidazole derivative RK28 on the proliferation of MethA tumor cells in combined use with diethyldithiocarbamate. Life Sciences 49:19, pages 1419-1425.
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T. C. Jenkins. 1990. The Chemistry of Antitumour Agents. The Chemistry of Antitumour Agents 342 369 .
D. H. Picker. 1988. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 355 366 .
J.M. Walling, I.J. Stratford, G.E. Adams, A.R.J. Silver, I. Ahmed, T.C. Jenkins & E.M. Fielden. (1986) Studies on the mechanisms of the radiosensitizing and cytotoxic properties of RSU-1069 and its analogues. International Journal of Radiation Oncology*Biology*Physics 12:7, pages 1083-1086.
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Krishna C. Agrawal, Cynthia A. Larroquette & Pradeep K. Garg. (1984) Pharmacokinetic studies of amino acid analogues of 2-nitroimidazole, new hypoxic cell radiosensitizers. International Journal of Radiation Oncology*Biology*Physics 10:8, pages 1301-1305.
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Peter Wardman. (1984) Radiation chemistry in the clinic: Hypoxic cell radiosensitizers for radiotherapy. Radiation Physics and Chemistry (1977) 24:3-4, pages 293-305.
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John Butler, Edward J. Land & A.John Swallow. (1984) Chemical mechanisms of the effects of high energy radiation on biological systems. Radiation Physics and Chemistry (1977) 24:3-4, pages 273-282.
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. 1983. Flash Photolysis and Pulse Radiolysis. Flash Photolysis and Pulse Radiolysis 209 229 .
Krishna C. Agrawal, Masakazu Sakaguchi & Sara Rockwell. (1982) A new potent radiosensitizer: 1-(2′, 3′-dideoky-α-d-erythro-hex-2′-enopyranosyl)-2-nitroimidazole (RA-263). International Journal of Radiation Oncology*Biology*Physics 8:3-4, pages 403-407.
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P. Wardman, R.F. Anderson, R.J. Hodgkiss, J. Parrick, C.E. Smithen, R.G. Wallace & M.E. Watts. (1982) Radiosensitization by non-nitro compounds. International Journal of Radiation Oncology*Biology*Physics 8:3-4, pages 399-401.
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Ian J. Stratford. (1982) Mechanisms of hypoxic cell radiosensitization and the development of new sensitizers. International Journal of Radiation Oncology*Biology*Physics 8:3-4, pages 391-398.
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Peter Wardman. 1982. Advanced Topics on Radiosensitizers of Hypoxic Cells. Advanced Topics on Radiosensitizers of Hypoxic Cells 49 75 .
C. E. Smithen & C. R. Hardy. 1982. Advanced Topics on Radiosensitizers of Hypoxic Cells. Advanced Topics on Radiosensitizers of Hypoxic Cells 1 47 .
Hugh Monney, Jojn Parrick & Raymond G. Wallace. (1981) Nitroimidazole radiosensitizers: Approaches to their chemical synthesis. Pharmacology & Therapeutics 14:2, pages 197-216.
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