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Original Articles

Therapeutic and nutraceutical potential of rosmarinic acid—Cytoprotective properties and pharmacokinetic profile

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Ana Raquel Madureira, Sara Nunes, Débora A Campos, João C Fernandes, Cláudia Marques, Monica Zuzarte, Beatriz Gullón, Luís M Rodríguez-Alcalá, Conceição Calhau, Bruno Sarmento, Ana Maria Gomes, Maria Manuela Pintado & Flávio Reis. (2016) Safety profile of solid lipid nanoparticles loaded with rosmarinic acid for oral use: in vitro and animal approaches. International Journal of Nanomedicine 11, pages 3621-3640.
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Md Shamsuddin Sultan Khan, Muhammad Adnan Iqbal & Amin Malik Shah Abdul Majid. (2016) Effect of crystallization of caffeic acid enhanced stability and dual biological efficacy. Cogent Biology 2:1.
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Pooja Ravaria, Priyanka Saxena, Shruti Laksmi BS, Vikas Ranjan, Syed Wasfi Fatma Abidi, Priyanka Saha, Siva Ramamoorthy, Faraz Ahmad & Sandeep Singh Rana. (2023) Molecular mechanisms of neuroprotective offerings by rosmarinic acid against neurodegenerative and other CNS pathologies. Phytotherapy Research 37:5, pages 2119-2143.
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Irina Georgiana Munteanu, Vasile Robert Grădinaru & Constantin Apetrei. (2022) Sensitive Detection of Rosmarinic Acid Using Peptide-Modified Graphene Oxide Screen-Printed Carbon Electrode. Nanomaterials 12:19, pages 3292.
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Saba Noor, Taj Mohammad, Malik Abdul Rub, Ali Raza, Naved Azum, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan & Abdullah M. Asiri. (2022) Biomedical features and therapeutic potential of rosmarinic acid. Archives of Pharmacal Research 45:4, pages 205-228.
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Gilnei Bruno da Silva, Milena Ayumi Yamauchi, Daniela Zanini & Margarete Dulce Bagatini. (2021) Novel possibility for cutaneous melanoma treatment by means of rosmarinic acid action on purinergic signaling. Purinergic Signalling 18:1, pages 61-81.
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Dariusz Dziki. (2021) Current Trends in Enrichment of Wheat Pasta: Quality, Nutritional Value and Antioxidant Properties. Processes 9:8, pages 1280.
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Ivanka K. Koycheva, Liliya V. Vasileva, Kristiana M. Amirova, Andrey S. Marchev, Zhivka P. Balcheva-Sivenova & Milen I. Georgiev. (2021) Biotechnologically Produced Lavandula angustifolia Mill. Extract Rich in Rosmarinic Acid Resolves Psoriasis-Related Inflammation Through Janus Kinase/Signal Transducer and Activator of Transcription Signaling. Frontiers in Pharmacology 12.
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Yuanlian Zeng, Junyu Liu, Qiang Zhang, Xuhua Qin, Zulun Li, Guojuan Sun & Shenrui Jin. (2021) The Traditional Uses, Phytochemistry and Pharmacology of Sarcandra glabra (Thunb.) Nakai, a Chinese Herb With Potential for Development: Review. Frontiers in Pharmacology 12.
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Amparo Olivares, Miguel Alcaraz-Saura, Daniel Gyingiri Achel, Juan de Dios Berná-Mestre & Miguel Alcaraz. (2021) Radiation-Induced Bystander Effect: Loss of Radioprotective Capacity of Rosmarinic Acid In Vivo and In Vitro. Antioxidants 10:2, pages 231.
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Tina Blažević, Gottfried Reznicek, Limin Ding, Gangqiang Yang, Patricia Haiss, Elke H. Heiss, Verena M. Dirsch & Rongxia Liu. (2021) Short Chain (≤C4) Esterification Increases Bioavailability of Rosmarinic Acid and Its Potency to Inhibit Vascular Smooth Muscle Cell Proliferation. Frontiers in Pharmacology 11.
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Yun Ju Kang, Chul Haeng Lee, Soo-Jin Park, Hye Suk Lee, Min-Koo Choi & Im-Sook Song. (2021) Involvement of Organic Anion Transporters in the Pharmacokinetics and Drug Interaction of Rosmarinic Acid. Pharmaceutics 13:1, pages 83.
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Amparo Olivares, Miguel Alcaraz-Saura, Daniel Gyingiri Achel & Miguel Alcaraz. (2020) Effect of Rosmarinic Acid and Ionizing Radiation on Glutathione in Melanoma B16F10 Cells: A Translational Opportunity. Antioxidants 9:12, pages 1291.
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Xiaoqi Pan, Xiao Ma, Yinxiao Jiang, Jianxia Wen, Lian Yang, Dayi Chen, Xiaoyu Cao & Cheng Peng. (2020) A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-19.
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Anna Berim & David R. Gang. (2020) Extractability, stability, and accumulation of nepetoidins in Ocimum basilicum L. leaves and cell cultures. Plant Cell, Tissue and Organ Culture (PCTOC) 143:1, pages 75-85.
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Alexandra C. Sevastre-Berghian, Irina Ielciu, Andrei Otto Mitre, Gabriela A. Filip, Ilioara Oniga, Laurian Vlase, Daniela Benedec, Ana-Maria Gheldiu, Vlad A. Toma, Bianca Mihart, Andra Mihuţ, Ioana Bâldea, Diana Olteanu, Irina C. Chis, Simona V. Clichici & Daniela Hanganu. (2020) Targeting Oxidative Stress Reduction and Inhibition of HDAC1, MECP2, and NF-kB Pathways in Rats With Experimentally Induced Hyperglycemia by Administration of Thymus marshallianus Willd. Extracts. Frontiers in Pharmacology 11.
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Sotirios Kiokias, Charalampos Proestos & Vassiliki Oreopoulou. (2020) Phenolic Acids of Plant Origin—A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties. Foods 9:4, pages 534.
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N. V. Petrova, K. V. Sazanova, N. A. Medvedeva & A. L. Shavarda. (2020) Features of Metabolomic Profiles in Different Stages of Ontogenesis in Prunella vulgaris (Lamiaceae) Grown in a Climate Chamber. Russian Journal of Bioorganic Chemistry 45:7, pages 906-912.
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Kleyton Santos Veras, Flávia Nathiely Silveira Fachel, Maria Gabriele Delagustin, Helder Ferreira Teixeira, Thiago Barcellos, Amélia Teresinha Henriques, Valquíria Linck Bassani & Letícia Scherer Koester. (2019) Complexation of rosmarinic acid with hydroxypropyl-β-cyclodextrin and methyl-β-cyclodextrin: Formation of 2:1 complexes with improved antioxidant activity. Journal of Molecular Structure 1195, pages 582-590.
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Amit Kumar Singh, Célia Cabral, Ramesh Kumar, Risha Ganguly, Harvesh Kumar Rana, Ashutosh Gupta, Maria Rosaria Lauro, Claudia Carbone, Flávio Reis & Abhay K. Pandey. (2019) Beneficial Effects of Dietary Polyphenols on Gut Microbiota and Strategies to Improve Delivery Efficiency. Nutrients 11:9, pages 2216.
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Niculae, Hanganu, Oniga, Benedec, Ielciu, Giupana, Sandru, Ciocârlan & Spinu. (2019) Phytochemical Profile and Antimicrobial Potential of Extracts Obtained from Thymus marschallianus Willd. Molecules 24:17, pages 3101.
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Swarnalata Joardar, Saikat Dewanjee, Shovonlal Bhowmick, Tarun K. Dua, Sonjit Das, Achintya Saha & Vincenzo De Feo. (2019) Rosmarinic Acid Attenuates Cadmium-Induced Nephrotoxicity via Inhibition of Oxidative Stress, Apoptosis, Inflammation and Fibrosis. International Journal of Molecular Sciences 20:8, pages 2027.
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Silvia Bittner Fialová, Martin Kello, Matúš Čoma, Lívia Slobodníková, Eva Drobná, Ivana Holková, Mária Garajová, Martin Mrva, Vlastimil Zachar & Miloš Lukáč. (2019) Derivatization of Rosmarinic Acid Enhances its in vitro Antitumor, Antimicrobial and Antiprotozoal Properties. Molecules 24:6, pages 1078.
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Maria Zych, Ilona Kaczmarczyk-Sedlak, Weronika Wojnar & Joanna Folwarczna. (2019) Effect of Rosmarinic Acid on the Serum Parameters of Glucose and Lipid Metabolism and Oxidative Stress in Estrogen-Deficient Rats. Nutrients 11:2, pages 267.
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Jianbin Min, Hao Chen, Zipeng Gong, Xian Liu, Tian Wu, Weirong Li, Jiansong Fang, Tianlai Huang, Yingfeng Zhang, Wei Zhao, Chenchen Zhu, Qi Wang, Suiqing Mi & Ningsheng Wang. (2018) Pharmacokinetic and Pharmacodynamic Properties of Rosmarinic Acid in Rat Cholestatic Liver Injury. Molecules 23:9, pages 2287.
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Justyna Krzyżanowska-Kowalczyk, Łukasz Pecio, Jarosław Mołdoch, Agnieszka Ludwiczuk & Mariusz Kowalczyk. (2018) Novel Phenolic Constituents of Pulmonaria officinalis L. LC-MS/MS Comparison of Spring and Autumn Metabolite Profiles. Molecules 23:9, pages 2277.
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Kitty S.C. Tang, Izabela Konczak & Jian Zhao. (2017) Phenolic compounds of the Australian native herb Prostanthera rotundifolia and their biological activities. Food Chemistry 233, pages 530-539.
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Ana Raquel Madureira, Débora A. Campos, Ana Oliveira, Bruno Sarmento, Maria Manuela Pintado & Ana Maria Gomes. (2016) Insights into the protective role of solid lipid nanoparticles on rosmarinic acid bioactivity during exposure to simulated gastrointestinal conditions. Colloids and Surfaces B: Biointerfaces 139, pages 277-284.
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Xiang Liu, Yun Liu, Yang Yang, Jiadai Xu, Deshu Dai, Chao Yan, Xiangyang Li, Renxian Tang, Chen Yu & Hongqi Ren. (2016) Antioxidative Stress Effects of <b><i>Salvia przewalskii</i></b> Extract in Experimentally Injured Podocytes. Nephron 134:4, pages 253-271.
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Kristina Ramanauskiene, Raimondas Raudonis & Daiva Majiene. (2016) Rosmarinic Acid and Melissa officinalis Extracts Differently Affect Glioblastoma Cells . Oxidative Medicine and Cellular Longevity 2016, pages 1-9.
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