1,279
Views
43
CrossRef citations to date
0
Altmetric
Reviews

Lactoferrin: an overview of its main functions, immunomodulatory and antimicrobial role, and clinical significance

, , &

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Wusun Li, Biao Liu, Yingying Lin, Peng Xue, Yao Lu, Sijia Song, Yixuan Li, Ignatius Man-Yau Szeto, Fazheng Ren & Huiyuan Guo. (2022) The application of lactoferrin in infant formula: The past, present and future. Critical Reviews in Food Science and Nutrition 0:0, pages 1-20.
Read now

Articles from other publishers (42)

Ying Li, Lezhen Dong, Yahui Liu, Qin Chen, Zufang Wu, Lingyi Liu, Mohamed A. Farag & Lianliang Liu. (2024) Ultrasound and enzyme assisted preparation of novel lactoferrin-cereal phenolic acid conjugates: structural, physicochemical and functional properties. Food Chemistry 435, pages 137572.
Crossref
Michał Sienkiewicz, Marta Zielińska, Damian Jacenik, Weronika Machelak, Katarzyna Owczarek & Jakub Fichna. (2023) Lactoferrin improves symptoms of dextran sulfate sodium-induced colitis in mice through modulation of cellular senescence. Nutrition Research 120, pages 58-71.
Crossref
Nannan Wang, Tingting Cai, Xia Liu & Wanping Zhu. (2023) Bovine lactoferrin inhibits resistant Helicobacter pylori in vitro and protects gastric mucosal injury in vivo. International Dairy Journal 147, pages 105770.
Crossref
Clara-Sophie Jugert, Andrea Didier & Nadja Jessberger. (2023) Lactoferrin-based food supplements trigger toxin production of enteropathogenic Bacillus cereus. Frontiers in Microbiology 14.
Crossref
Hassan M. Hassan, Usama D. Souka, Salma M. Hassan & Hosam M. Habib. (2023) Use of 4-D proteomics to differentiate between bovine and camel lactoferrin. Food Chemistry 427, pages 136682.
Crossref
Michał Sienkiewicz, Kamila Sroka, Agata Binienda, Diana Jurk & Jakub Fichna. (2023) A new face of old cells: An overview about the role of senescence and telomeres in inflammatory bowel diseases. Ageing Research Reviews 91, pages 102083.
Crossref
Inam Ullah & Minglin Lang. (2023) Key players in the regulation of iron homeostasis at the host-pathogen interface. Frontiers in Immunology 14.
Crossref
Lucile Yart, Andy Wiranata Wijaya, Maria João Lima, Corinne Haller, Eline M. van der Beek, Ryan S. Carvalho, Marine R.-C. Kraus & Omid Mashinchian. (2023) Cellular agriculture for milk bioactive production. Nature Reviews Bioengineering 1:11, pages 858-874.
Crossref
Changhui Zhao, Nan Chen & Tolulope Joshua Ashaolu. (2023) Prebiotic and modulatory evidence of lactoferrin on gut health and function. Journal of Functional Foods 108, pages 105741.
Crossref
Agnieszka Paziewska-Nowak, Marcin Urbanowicz, Kamila Sadowska & Dorota Genowefa Pijanowska. (2023) DNA-based molecular recognition system for lactoferrin biosensing. International Journal of Biological Macromolecules, pages 126747.
Crossref
Mélanie Pereira, Ana Rita O. Rodrigues, Leslie Amaral, Manuela Côrte-Real, Cátia Santos-Pereira & Elisabete M. S. Castanheira. (2023) Bovine Lactoferrin-Loaded Plasmonic Magnetoliposomes for Antifungal Therapeutic Applications. Pharmaceutics 15:8, pages 2162.
Crossref
Hojjat Allah Yami, Mojtaba Tahmoorespur, Ali Javadmanesh, Abbas Tazarghi & Mohammad Hadi Sekhavati. (2023) The immunomodulatory effects of lactoferrin and its derived peptides on NF‐κB signaling pathway: A systematic review and meta‐analysis. Immunity, Inflammation and Disease 11:8.
Crossref
Michał Ostrówka, Anna Duda-Madej, Filip Pietluch, Paweł Mackiewicz & Przemysław Gagat. (2023) Testing Antimicrobial Properties of Human Lactoferrin-Derived Fragments. International Journal of Molecular Sciences 24:13, pages 10529.
Crossref
Rirong Chen, Yizhe Tie, Xi Zhang, Li Li, Minhu Chen & Shenghong Zhang. (2023) Fecal lactoferrin early predicts long‐term outcomes in ulcerative colitis: A post‐hoc analysis of the UNIFI and PURSUIT trials. United European Gastroenterology Journal.
Crossref
Zhen-Shu Liu & Po-Wen Chen. (2023) Featured Prebiotic Agent: The Roles and Mechanisms of Direct and Indirect Prebiotic Activities of Lactoferrin and Its Application in Disease Control. Nutrients 15:12, pages 2759.
Crossref
Xiao Ma, Duoyi Zhao, Yubo Xiang, Yingqi Hua, Wei Zhao, Yan Cui & Zhiyu Zhang. (2023) Layer-by-layer self-assembly and clinical application in orthopedics. Journal of Materials Science & Technology 147, pages 241-268.
Crossref
Xuanxuan Ma, Ya Hao, Ruoyu Mao, Na Yang, Xueling Zheng, Bing Li, Zhenlong Wang, Qingjuan Zhang, Da Teng & Jianhua Wang. (2022) Effects of dietary supplementation of bovine lactoferrin on growth performance, immune function and intestinal health in weaning piglets. BioMetals 36:3, pages 587-601.
Crossref
Ray Ong, Jillian Cornish & Jingyuan Wen. (2022) Nanoparticular and other carriers to deliver lactoferrin for antimicrobial, antibiofilm and bone-regenerating effects: a review. BioMetals 36:3, pages 709-727.
Crossref
Jeffrey K. Actor, Thao K. T. Nguyen, Agnieszka Wasik-Smietana & Marian L. Kruzel. (2022) Modulation of TDM-induced granuloma pathology by human lactoferrin: a persistent effect in mice. BioMetals 36:3, pages 603-615.
Crossref
Luigi Rosa, Antimo Cutone, Maria Pia Conte, Elena Campione, Luca Bianchi & Piera Valenti. (2022) An overview on in vitro and in vivo antiviral activity of lactoferrin: its efficacy against SARS-CoV-2 infection. BioMetals 36:3, pages 417-436.
Crossref
Parminder Singh, Roberto Hernandez‐Rauda & Oscar Peña‐Rodas. (2023) Preventative and therapeutic potential of animal milk components against COVID‐19: A comprehensive review. Food Science & Nutrition 11:6, pages 2547-2579.
Crossref
Wang-Jing Liu, Yun-Shiang Chang, Kou-Chun Tseng & Meng-Hua Yu. (2023) Activity of bovine lactoferrin in resistance to white spot syndrome virus infection in shrimp. Developmental & Comparative Immunology 142, pages 104651.
Crossref
Tuan Hiep Tran, Phuong Thi Thu Tran & Duy Hieu Truong. (2023) Lactoferrin and Nanotechnology: The Potential for Cancer Treatment. Pharmaceutics 15:5, pages 1362.
Crossref
Emile Levy, Valérie Marcil, Sarah Tagharist Ép Baumel, Noam Dahan, Edgard Delvin & Schohraya Spahis. (2023) Lactoferrin, Osteopontin and Lactoferrin–Osteopontin Complex: A Critical Look on Their Role in Perinatal Period and Cardiometabolic Disorders. Nutrients 15:6, pages 1394.
Crossref
Jianing FU, Liu YANG, Dehong TAN & Ling LIU. (2023) Iron transport mechanism of lactoferrin and its application in food processing. Food Science and Technology 43.
Crossref
Alexandra Wilhelmina Carla Einerhand, Carolien Annika van Loo-Bouwman, Gisela Adrienne Weiss, Caiyun Wang, Genna Ba, Qicheng Fan, Baoping He & Gerrit Smit. (2022) Can Lactoferrin, a Natural Mammalian Milk Protein, Assist in the Battle against COVID-19?. Nutrients 14:24, pages 5274.
Crossref
Thao K. T. Nguyen, Zainab Niaz, Marian L. Kruzel & Jeffrey K. Actor. (2022) Recombinant Human Lactoferrin Reduces Inflammation and Increases Fluoroquinolone Penetration to Primary Granulomas During Mycobacterial Infection of C57Bl/6 Mice. Archivum Immunologiae et Therapiae Experimentalis 70:1.
Crossref
V. S. Shini, Chinthu Tharayil Udayarajan & P. Nisha. (2022) A comprehensive review on lactoferrin: a natural multifunctional glycoprotein. Food & Function 13:23, pages 11954-11972.
Crossref
Vibeke Videm, Ingrid Sæther Houge, Marthe Halsan Liff & Mari Hoff. (2022) Inflammation mediates approximately one quarter of excess relative all-cause mortality in persons with rheumatoid arthritis: the Trøndelag Health Study. Scientific Reports 12:1.
Crossref
Julie A. Talbert, Jacky Lu, Sabrina K. Spicer, Rebecca E. Moore, Steven D. Townsend & Jennifer A. Gaddy. (2022) Ameliorating adverse perinatal outcomes with Lactoferrin: An intriguing chemotherapeutic intervention. Bioorganic & Medicinal Chemistry 74, pages 117037.
Crossref
Antimo Cutone, Luigi Rosa, Maria Carmela Bonaccorsi di Patti, Federico Iacovelli, Maria Pia Conte, Giusi Ianiro, Alice Romeo, Elena Campione, Luca Bianchi, Piera Valenti, Mattia Falconi & Giovanni Musci. (2022) Lactoferrin Binding to SARS-CoV-2 Spike Glycoprotein Blocks Pseudoviral Entry and Relieves Iron Protein Dysregulation in Several In Vitro Models. Pharmaceutics 14:10, pages 2111.
Crossref
Ying Li, Lezhen Dong, Zhishen Mu, Lingyi Liu, Junsi Yang, Zufang Wu, Daodong Pan & Lianliang Liu. (2022) Research Advances of Lactoferrin in Electrostatic Spinning, Nano Self-Assembly, and Immune and Gut Microbiota Regulation. Journal of Agricultural and Food Chemistry 70:33, pages 10075-10089.
Crossref
Prokopis Konstanti, Marloes van Splunter, Erik van den Brink, Clara Belzer, Arjen Nauta, R. van Neerven & Hauke Smidt. (2022) The Effect of Nutritional Intervention with Lactoferrin, Galactooligosacharides and Vitamin D on the Gut Microbiota Composition of Healthy Elderly Women. Nutrients 14:12, pages 2468.
Crossref
Zehan Pang, Ruolan Hu, Lili Tian, Fuxing Lou, Yangzhen Chen, Shuqi Wang, Shiting He, Shaozhou Zhu, Xiaoping An, Lihua Song, Feitong Liu, Yigang Tong & Huahao Fan. (2022) Overview of Breastfeeding Under COVID-19 Pandemic. Frontiers in Immunology 13.
Crossref
Iwona Bukowska-Ośko, Dorota Sulejczak, Katarzyna Kaczyńska, Patrycja Kleczkowska, Karol Kramkowski, Marta Popiel, Ewa Wietrak & Paweł Kowalczyk. (2022) Lactoferrin as a Human Genome “Guardian”—An Overall Point of View. International Journal of Molecular Sciences 23:9, pages 5248.
Crossref
Fernando Bartolomé, Luigi Rosa, Piera Valenti, Francisco Lopera, Jesús Hernández-Gallego, José Luis Cantero, Gorka Orive & Eva Carro. (2022) Lactoferrin as Immune-Enhancement Strategy for SARS-CoV-2 Infection in Alzheimer’s Disease Patients. Frontiers in Immunology 13.
Crossref
Yu. A. Rudnichenko, S. A. Novakovskaya & V. S. Lukashevich. (2022) Long-Term Intake of Recombinant Human Lactoferrin Corrects Changes in Serum Biochemical Parameters and Liver Injuries Induced by Chronic Alcohol Intoxication in Rats. Journal of Evolutionary Biochemistry and Physiology 58:2, pages 457-464.
Crossref
Maria Björmsjö, Olle Hernell, Bo Lönnerdal & Staffan K. Berglund. (2022) Immunological Effects of Adding Bovine Lactoferrin and Reducing Iron in Infant Formula: A Randomized Controlled Trial. Journal of Pediatric Gastroenterology & Nutrition 74:3, pages e65-e72.
Crossref
Xiya Zhao, Xu Zhang, Teng Xu, Junjie Luo, Yongting Luo & Peng An. (2022) Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials. Nutrients 14:3, pages 543.
Crossref
Jolanta Artym & Michał Zimecki. (2021) Antimicrobial and Prebiotic Activity of Lactoferrin in the Female Reproductive Tract: A Comprehensive Review. Biomedicines 9:12, pages 1940.
Crossref
Aleksandra Tarasiuk, Marcin Talar, Kamila Bulak & Jakub Fichna. (2021) Ghee Butter from Bovine Colostrum Reduces Inflammation in the Mouse Model of Acute Pancreatitis with Potential Involvement of Free Fatty Acid Receptors. Nutrients 13:9, pages 3271.
Crossref
Fahad Dhafer Algahtani, Mohamed Tharwat Elabbasy, Mai A. Samak, Adeniyi A. Adeboye, Rafeek A. Yusuf & Mohamed E. Ghoniem. (2021) The Prospect of Lactoferrin Use as Adjunctive Agent in Management of SARS-CoV-2 Patients: A Randomized Pilot Study. Medicina 57:8, pages 842.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.