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Research Article

Mode of Action: Oxalate Crystal-Induced Renal Tubule Degeneration and Glycolic Acid-Induced Dysmorphogenesis—Renal and Developmental Effects of Ethylene Glycol

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Pages 691-702 | Published online: 10 Oct 2008

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Robert G. Ellis-Hutchings, Reza J. Rasoulpour, Claire Terry, Edward W. Carney & Richard Billington. (2014) Human relevance framework evaluation of a novel rat developmental toxicity mode of action induced by sulfoxaflor. Critical Reviews in Toxicology 44:sup2, pages 45-62.
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Cristoforo Pomara, Carmela Fiore, Stefano D'Errico, Irene Riezzo & Vittorio Fineschi. (2008) Calcium oxalate crystals in acute ethylene glycol poisoning: A confocal laser scanning microscope study in a fatal case. Clinical Toxicology 46:4, pages 322-324.
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Alan R. Boobis, John E. Doe, Barbara Heinrich-Hirsch, M. E. (Bette) Meek, Sharon Munn, Mathuros Ruchirawat, Josef Schlatter, Jennifer Seed & Carolyn Vickers. (2008) IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans. Critical Reviews in Toxicology 38:2, pages 87-96.
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Zijian Zhou, Dexiang Feng, Donghui Shi, Peng Gao, Lujia Wang & Zhong Wu. (2023) Untargeted and targeted metabolomics reveal bile acid profile changes in rats with ethylene glycol-induced calcium oxalate nephrolithiasis. Chemico-Biological Interactions 381, pages 110570.
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Szabina A. Stice & Edward W. Carney. 2022. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 803 814 .
Faik GÖKALP. (2021) The effective ethanol rate against the toxicity of ethylene glycol. Turkish Computational and Theoretical Chemistry 5:1, pages 20-26.
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Nahla E. El-Ashmawy, Hoda A. El-Bahrawy, Heba H. Ashmawy & Eman G. Khedr. (2021) Amelioration of lithiatic injury to renal tissue by candesartan and sodium thiosulfate in a rat model of nephrolithiasis. PLOS ONE 16:5, pages e0251408.
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Edward W. Carney & Szabina A. Stice. 2017. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 797 809 .
William M. Snellings, Richard A. Corley, Kenneth E. McMartin, Christopher R. Kirman & Sol M. Bobst. (2013) Oral Reference Dose for ethylene glycol based on oxalate crystal-induced renal tubule degeneration as the critical effect. Regulatory Toxicology and Pharmacology 65:2, pages 229-241.
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Ali NoorafshanSaied Karbalay-DoustFatemeh Karimi. (2013) Diosmin Reduces Calcium Oxalate Deposition and Tissue Degeneration in Nephrolithiasis in Rats: A Stereological Study. Korean Journal of Urology 54:4, pages 252.
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Rejane Barbosa de Oliveira, Eduardo Barbosa Coelho, Marina Rezende Rodrigues, Ana Rita de Mello Costa-Machado, João Paulo Barreto de Sousa, Andresa A. Berretta & Jairo Kenupp Bastos. (2013) Effect of the Copaifera langsdorffii Desf. Leaf Extract on the Ethylene Glycol-Induced Nephrolithiasis in Rats . Evidence-Based Complementary and Alternative Medicine 2013, pages 1-10.
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Abu Nasim Nizami, Md Atiar Rahman, Nazim Uddin Ahmed & Md Shahidul Islam. (2012) Whole Leea macrophylla ethanolic extract normalizes kidney deposits and recovers renal impairments in an ethylene glycol–induced urolithiasis model of rats. Asian Pacific Journal of Tropical Medicine 5:7, pages 533-538.
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Fred Reyers & Theuns W. Naudé. 2012. Veterinary Toxicology. Veterinary Toxicology 1128 1139 .
R.A. Corley, S.A. Saghir, M.J. Bartels, S.C. Hansen, J. Creim, K.E. McMartin & W.M. Snellings. (2011) Extension of a PBPK model for ethylene glycol and glycolic acid to include the competitive formation and clearance of metabolites associated with kidney toxicity in rats and humans. Toxicology and Applied Pharmacology 250:3, pages 229-244.
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Edward W. Carney, Belen Tornesi, Ashley B. Liberacki, Daniel A. Markham, Karl K. Weitz, Teressa M. Luders, Kristine G. Studniski, John C. Blessing, Richard A. Gies & Richard A. Corley. (2011) The Impact of Dose Rate on Ethylene Glycol Developmental Toxicity and Pharmacokinetics in Pregnant CD Rats. Toxicological Sciences 119:1, pages 178-188.
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Edward W. Carney. 2011. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 607 615 .
Edward A. Lock. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Edward W. Carney, Belen Tornesi, Daniel A. Markham, Reza J. Rasoulpour & Nigel Moore. (2008) Species‐specificity of ethylene glycol‐induced developmental toxicity: toxicokinetic and whole embryo culture studies in the rabbit. Birth Defects Research Part B: Developmental and Reproductive Toxicology 83:6, pages 573-581.
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Swapna Upadhyay, Joern Carstens, Dominik Klein, Thomas H. Faller, Stephan Halbach, Werner Kirchinger, Winfried Kessler, György A. Csanády & Johannes G. Filser. (2008) Inhalation and epidermal exposure of volunteers to ethylene glycol: Kinetics of absorption, urinary excretion, and metabolism to glycolate and oxalate. Toxicology Letters 178:2, pages 131-141.
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Hua-Chang Fang, Po-Tsang Lee, Pei-Jung Lu, Chien-Liang Chen, Tsu-Yuan Chang, Chih-Yang Hsu, Hsiao-Min Chung & Kang-Ju Chou. (2008) Mechanisms of star fruit-induced acute renal failure. Food and Chemical Toxicology 46:5, pages 1744-1752.
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Sheldon C. Chaffer & Jules B. Puschett. 2008. Clinical Nephrotoxins. Clinical Nephrotoxins 495 509 .
Chungang Guo, Troy A. Cenac, Yan Li & Kenneth E. McMartin. (2007) Calcium oxalate, and not other metabolites, is responsible for the renal toxicity of ethylene glycol. Toxicology Letters 173:1, pages 8-16.
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Chungang Guo & Kenneth E. McMartin. (2007) Aluminum citrate inhibits cytotoxicity and aggregation of oxalate crystals. Toxicology 230:2-3, pages 117-125.
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Theuns W. Naudé & V. Naidoo. 2007. Veterinary Toxicology. Veterinary Toxicology 880 891 .
Fazlul Huq & Deena Ababneh. (2006) Molecular Modelling Analysis of the Metabolic Activation of Ethylene Glycol. Journal of Pharmacology and Toxicology 2:1, pages 54-62.
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