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Research Article

Mode of Action: Impaired Fetal Leydig Cell Function—Effects on Male Reproductive Development Produced by Certain Phthalate Esters

Pages 713-719 | Published online: 10 Oct 2008

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Jan L. Lyche, Arno C. Gutleb, Åke Bergman, Gunnar S. Eriksen, AlberTinka J. Murk, Erik Ropstad, Margaret Saunders & Janneche U. Skaare. (2009) Reproductive and Developmental Toxicity of Phthalates. Journal of Toxicology and Environmental Health, Part B 12:4, pages 225-249.
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Ju Young Ryu, Ena Lee, Tae Hyung Kim, Young Jun Lee, Jaewon Lee, Byung Mu Lee, Seung Jun Kwack, Ki Kyung Jung, Soon Young Han, Seung Hee Kim, Sam Kacew & Hyung Sik Kim. (2008) Time-Response Effects of Testicular Gene Expression Profiles in Sprague-Dawley Male Rats Treated with Di(n-Butyl) Phthalate. Journal of Toxicology and Environmental Health, Part A 71:23, pages 1542-1549.
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Julia J. Wirth, Mary G. Rossano, Rachel Potter, Elizabeth Puscheck, Douglas C. Daly, Nigel Paneth, Stephen A. Krawetz, Bridget M. Protas & Michael P. Diamond. (2008) A Pilot Study Associating Urinary Concentrations of Phthalate Metabolites and Semen Quality. Systems Biology in Reproductive Medicine 54:3, pages 143-154.
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Alan R. Boobis, John E. Doe, Barbara Heinrich-Hirsch, M. E. (Bette) Meek, Sharon Munn, Mathuros Ruchirawat, Josef Schlatter, Jennifer Seed & Carolyn Vickers. (2008) IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans. Critical Reviews in Toxicology 38:2, pages 87-96.
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Maryam Zare Jeddi, Leila Janani, Amir Hossein Memari, Shahin Akhondzadeh & Masud yunesian. (2016) The role of phthalate esters in autism development: A systematic review. Environmental Research 151, pages 493-504.
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V. Cruciani, C. Iovine, J.-P. Thomé & C. Joaquim-Justo. (2015) Impact of three phthalate esters on the sexual reproduction of the Monogonont rotifer, Brachionus calyciflorus. Ecotoxicology 25:1, pages 192-200.
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Thaddeus T. SchugAshley M. Blawas, Kimberly GrayJerrold J. HeindelCindy P. Lawler. (2015) Elucidating the Links Between Endocrine Disruptors and Neurodevelopment. Endocrinology 156:6, pages 1941-1951.
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Crossref
Sushil K. Khetan. 2014. Endocrine Disruptors in the Environment. Endocrine Disruptors in the Environment 91 110 .
Hueiwang Anna Jeng. (2014) Exposure to Endocrine Disrupting Chemicals and Male Reproductive Health. Frontiers in Public Health 2.
Crossref
Virginie Cuvillier-Hot, Karine Salin, Séverine Devers, Aurélie Tasiemski, Pauline Schaffner, Raphaël Boulay, Sylvain Billiard & Alain Lenoir. (2014) Impact of ecological doses of the most widespread phthalate on a terrestrial species, the ant Lasius niger. Environmental Research 131, pages 104-110.
Crossref
Sheela Sathyanarayana, Emily Barrett, Samantha Butts, Christina Wang & Shanna Helen Swan. (2014) Phthalate exposure and reproductive hormone concentrations in pregnancy. REPRODUCTION 147:4, pages 401-409.
Crossref
I-Ling Tseng, Ying-Fei Yang, Chan-Wei Yu, Wen-Hsuan Li & Vivian Hsiu-Chuan Liao. (2013) Phthalates Induce Neurotoxicity Affecting Locomotor and Thermotactic Behaviors and AFD Neurons through Oxidative Stress in Caenorhabditis elegans. PLoS ONE 8:12, pages e82657.
Crossref
Joanna Jurewicz, Michał Radwan, Wojciech Sobala, Danuta Ligocka, Paweł Radwan, Michał Bochenek, Wanda Hawuła, Lucjusz Jakubowski & Wojciech Hanke. (2013) Human urinary phthalate metabolites level and main semen parameters, sperm chromatin structure, sperm aneuploidy and reproductive hormones. Reproductive Toxicology 42, pages 232-241.
Crossref
Uta Enke, Ekkehard Schleussner, Claudia Pälmke, Lydia Seyfarth & Holger Martin Koch. (2013) Phthalate exposure in pregnant women and newborns – The urinary metabolite excretion pattern differs distinctly. International Journal of Hygiene and Environmental Health 216:6, pages 735-742.
Crossref
Susan L. Makris, Susan Y. Euling, L. Earl GrayJr.Jr., Robert Benson & Paul M.D. Foster. (2013) Use of genomic data in risk assessment case study: I. Evaluation of the dibutyl phthalate male reproductive development toxicity data set. Toxicology and Applied Pharmacology 271:3, pages 336-348.
Crossref
S. Magdouli, R. Daghrir, S.K. Brar, P. Drogui & R.D. Tyagi. (2013) Di 2-ethylhexylphtalate in the aquatic and terrestrial environment: A critical review. Journal of Environmental Management 127, pages 36-49.
Crossref
Jens P.E. Bonde. (2013) Occupational causes of male infertility. Current Opinion in Endocrinology, Diabetes & Obesity 20:3, pages 234-239.
Crossref
Jure Knez. (2013) Endocrine-disrupting chemicals and male reproductive health. Reproductive BioMedicine Online 26:5, pages 440-448.
Crossref
. (2013) Scientific Opinion on the hazard assessment of endocrine disruptors: Scientific criteria for identification of endocrine disruptors and appropriateness of existing test methods for assessing effects mediated by these substances on human health and the environment. EFSA Journal 11:3.
Crossref
Hermann Fromme, Ludwig Gruber, Ralph Schuster, Martin Schlummer, Mandy Kiranoglu, Gabriele Bolte & Wolfgang Völkel. (2013) Phthalate and di-(2-ethylhexyl) adipate (DEHA) intake by German infants based on the results of a duplicate diet study and biomonitoring data (INES 2). Food and Chemical Toxicology 53, pages 272-280.
Crossref
A.R. Ndhlala, B. Ncube & J. Van Staden. (2012) Ensuring quality in herbal medicines: Toxic phthalates in plastic-packaged commercial herbal products. South African Journal of Botany 82, pages 60-66.
Crossref
Mei Chen, Lin Tao, Erin M. Collins, Christine Austin & Chensheng Lu. (2012) Simultaneous determination of multiple phthalate metabolites and bisphenol-A in human urine by liquid chromatography–tandem mass spectrometry. Journal of Chromatography B 904, pages 73-80.
Crossref
Holger Martin Koch, Andreas Haller, Tobias Weiß, Heiko-Udo Käfferlein, Joachim Stork & Thomas Brüning. (2012) Phthalate exposure during cold plastisol application—a human biomonitoring study. Toxicology Letters 213:1, pages 100-106.
Crossref
Katherine E. Kelley, Sonia Hernández-Díaz, Erica L. Chaplin, Russ Hauser & Allen A. Mitchell. (2012) Identification of Phthalates in Medications and Dietary Supplement Formulations in the United States and Canada. Environmental Health Perspectives 120:3, pages 379-384.
Crossref
C.J. Borgert, E.V. Sargent, G. Casella, D.R. Dietrich, L.S. McCarty & R.J. Golden. (2012) The human relevant potency threshold: Reducing uncertainty by human calibration of cumulative risk assessments. Regulatory Toxicology and Pharmacology 62:2, pages 313-328.
Crossref
Ronald D. HoodSusan L. Makris. 2011. Developmental and Reproductive Toxicology: A Practical Approach. Developmental and Reproductive Toxicology: A Practical Approach 675 707 .
Thaddeus T. Schug, Amanda Janesick, Bruce Blumberg & Jerrold J. Heindel. (2011) Endocrine disrupting chemicals and disease susceptibility. The Journal of Steroid Biochemistry and Molecular Biology 127:3-5, pages 204-215.
Crossref
Rosario Planelló, Oscar Herrero, José Luis Martínez-Guitarte & Gloria Morcillo. (2011) Comparative effects of butyl benzyl phthalate (BBP) and di(2-ethylhexyl) phthalate (DEHP) on the aquatic larvae of Chironomus riparius based on gene expression assays related to the endocrine system, the stress response and ribosomes. Aquatic Toxicology 105:1-2, pages 62-70.
Crossref
Jan L. Lyche. 2011. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 637 655 .
A. Kortenkamp & M. Faust. (2010) Combined exposures to anti-androgenic chemicals: steps towards cumulative risk assessment. International Journal of Andrology 33:2, pages 463-474.
Crossref
Matthew Lorber, Jürgen Angerer & Holger M Koch. (2009) A simple pharmacokinetic model to characterize exposure of Americans to Di-2-ethylhexyl phthalate. Journal of Exposure Science & Environmental Epidemiology 20:1, pages 38-53.
Crossref
Matthias Wittassek, Juergen Angerer, Marike Kolossa-Gehring, Sebastian Daniel Schäfer, Walter Klockenbusch, Lorenz Dobler, Andreas K. Günsel, Antje Müller & Gerhard Andreas Wiesmüller. (2009) Fetal exposure to phthalates – a pilot study. International Journal of Hygiene and Environmental Health 212:5, pages 492-498.
Crossref
François ChauvignéArnaud MenuetLaurianne LesnéMarie-Christine ChagnonCécile ChevrierJean-François RegnierJürgen Angerer & Bernard Jégou. (2009) Time- and Dose-Related Effects of Di-(2-ethylhexyl) Phthalate and Its Main Metabolites on the Function of the Rat Fetal Testis in Vitro . Environmental Health Perspectives 117:4, pages 515-521.
Crossref
. (2008) Urinary Phthalate Metabolite Concentrations among Workers in Selected Industries: A Pilot Biomonitoring Study. The Annals of Occupational Hygiene.
Crossref
Thomas M. Onorato, Petrice W. Brown & Patricia L. Morris. (2013) Mono‐(2‐ethylhexyl) Phthalate Increases Spermatocyte Mitochondrial Peroxiredoxin 3 and Cyclooxygenase 2. Journal of Andrology 29:3, pages 293-303.
Crossref
Nadeem Rezaq Janjua, Hanne Frederiksen, Niels E. Skakkebæk, Hans Christian Wulf & Anna-Maria Andersson. (2008) Urinary excretion of phthalates and paraben after repeated whole-body topical application in humans. International Journal of Andrology 31:2, pages 118-130.
Crossref
Giuseppe Latini, Egeria Scoditti, Alberto Verrotti, Claudio De Felice & Marika Massaro. (2008) Peroxisome Proliferator-Activated Receptors as Mediators of Phthalate-Induced Effects in the Male and Female Reproductive Tract: Epidemiological and Experimental Evidence. PPAR Research 2008, pages 1-13.
Crossref
Matthias Wittassek, Gerhard Andreas Wiesmüller, Holger Martin Koch, Rolf Eckard, Lorenz Dobler, Johannes Müller, Jürgen Angerer & Christoph Schlüter. (2007) Internal phthalate exposure over the last two decades – A retrospective human biomonitoring study. International Journal of Hygiene and Environmental Health 210:3-4, pages 319-333.
Crossref
Matthias Wittassek, Wolfgang Heger, Holger M. Koch, Kerstin Becker, Jürgen Angerer & Marike Kolossa-Gehring. (2007) Daily intake of di(2-ethylhexyl)phthalate (DEHP) by German children – A comparison of two estimation models based on urinary DEHP metabolite levels. International Journal of Hygiene and Environmental Health 210:1, pages 35-42.
Crossref
Simone W. Grande, Anderson J.M. Andrade, Chris E. Talsness, Konstanze Grote, Andrea Golombiewski, Anja Sterner-Kock & Ibrahim Chahoud. (2007) A dose–response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): Reproductive effects on adult female offspring rats. Toxicology 229:1-2, pages 114-122.
Crossref
Vassilios Papadopoulos. 2007. The Leydig Cell in Health and Disease. The Leydig Cell in Health and Disease 393 413 .
Peter Kovacic & Ratnasamy Somanathan. (2006) Mechanism of teratogenesis: Electron transfer, reactive oxygen species, and antioxidants. Birth Defects Research Part C: Embryo Today: Reviews 78:4, pages 308-325.
Crossref
Antonia M. Calafat & Richard H. McKee. (2006) Integrating Biomonitoring Exposure Data into the Risk Assessment Process: Phthalates [Diethyl Phthalate and Di(2-ethylhexyl) Phthalate] as a Case Study. Environmental Health Perspectives 114:11, pages 1783-1789.
Crossref
Giuseppe Latini, Antonio Del Vecchio, Marika Massaro, Alberto Verrotti & Claudio De Felice. (2006) Phthalate exposure and male infertility. Toxicology 226:2-3, pages 90-98.
Crossref

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