625
Views
201
CrossRef citations to date
0
Altmetric
Research Article

Modes of Action and Species-Specific Effects of Di-(2-ethylhexyl)Phthalate in the Liver

, &
Pages 459-479 | Published online: 10 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

Joseph Apau, Wilfred Sefah & Eric Adua. (2020) Human contact with phthalates during early life stages leads to weight gain and obesity. Cogent Chemistry 6:1.
Read now
Yangcai Wang, Bailin Chen, Tao Lin, Shengde Wu & Guanghui Wei. (2017) Protective effects of vitamin E against reproductive toxicity induced by di(2-ethylhexyl) phthalate via PPAR-dependent mechanisms. Toxicology Mechanisms and Methods 27:7, pages 551-559.
Read now
Pınar Erkekoglu & Belma Kocer-Gumusel. (2014) Genotoxicity of phthalates. Toxicology Mechanisms and Methods 24:9, pages 616-626.
Read now
J. Christopher Corton, Michael L. Cunningham, B. Timothy Hummer, Christopher Lau, Bette Meek, Jeffrey M. Peters, James A. Popp, Lorenz Rhomberg, Jennifer Seed & James E. Klaunig. (2014) Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study. Critical Reviews in Toxicology 44:1, pages 1-49.
Read now
Pınar Erkekoglu, Belma Kocer Giray, Murat Kızilgün, Walid Rachidi, Isabelle Hininger-Favier, Anne-Marie Roussel, Alain Favier & Filiz Hincal. (2012) Di(2-ethylhexyl)phthalate-induced renal oxidative stress in rats and protective effect of selenium. Toxicology Mechanisms and Methods 22:6, pages 415-423.
Read now
Pınar Erkekoglu, N. Dilara Zeybek, Belma Giray, Esin Asan, Josiane Arnaud & Filiz Hincal. (2011) Reproductive toxicity of di(2-ethylhexyl) phthalate in selenium-supplemented and selenium-deficient rats. Drug and Chemical Toxicology 34:4, pages 379-389.
Read now
P. Robinan Gentry, Harvey J. Clewell$suffix/text()$suffix/text(), Rebecca Clewell, Jerry Campbell, Cynthia Van Landingham & Annette M. Shipp. (2011) Challenges in the application of quantitative approaches in risk assessment: a case study with di-(2-ethylhexyl)phthalate. Critical Reviews in Toxicology 41:sup2, pages 1-72.
Read now
Na Young Kim, Tae Hyung Kim, Ena Lee, Nabanita Patra, Jaewon Lee, Mi Ok Shin, Seung Jun Kwack, Kui Lea Park, Soon Young Han, Tae Seok Kang, Seung Hee Kim, Byung Mu Lee & Hyung Sik Kim. (2010) Functional Role of Phospholipase D (PLD) in Di(2-Ethylhexyl) Phthalate-Induced Hepatotoxicity in Sprague-Dawley Rats. Journal of Toxicology and Environmental Health, Part A 73:21-22, pages 1560-1569.
Read now
Joseph V. Rodricks, James A. Swenberg, Joseph F. Borzelleca, Robert R. Maronpot & Annette M. Shipp. (2010) Triclosan: A critical review of the experimental data and development of margins of safety for consumer products. Critical Reviews in Toxicology 40:5, pages 422-484.
Read now
Jan L. Lyche, Arno C. Gutleb, Åke Bergman, Gunnar S. Eriksen, AlberTinka J. Murk, Erik Ropstad, Margaret Saunders & Janneche U. Skaare. (2009) Reproductive and Developmental Toxicity of Phthalates. Journal of Toxicology and Environmental Health, Part B 12:4, pages 225-249.
Read now
Mathieu Vinken, Tatyana Doktorova, Elke Decrock, Luc Leybaert, Tamara Vanhaecke & Vera Rogiers. (2009) Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity. Critical Reviews in Biochemistry and Molecular Biology 44:4, pages 201-222.
Read now

Articles from other publishers (190)

Silvia Abdelmalak, Ningning Yang & Sidhartha D. Ray. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 399 407 .
Jana Růžičková, Helena Raclavská, Marek Kucbel, Christoph Pfeifer, Dagmar Juchelková, Jitka Hrbek, Michal Šafář, Karolina Slamová, Barbora Švédová & Pavel Kantor. (2023) Incidence and spread of additives from co-combustion of plastic waste in domestic boilers in indoor and outdoor environments around the family house. Energy 285, pages 129357.
Crossref
Pablo A. Pérez, Jonathan Toledo, Facundo Vitellini, Victoria Navall Cuello, Verónica Cantarelli, Marina Ponzio, Jorge H. Mukdsi & Silvina Gutiérrez. (2023) Environmentally relevant DEHP exposure during gestational and lactational period inhibits filamin a testicular expression. Journal of Molecular Histology.
Crossref
Guangxing Li, Yang Chen, Menglin Wu, Kaiting Chen, Di Zhang, Ruili Zhang, Guijun Yang & Xiaodan Huang. (2023) Di (2-ethyl) hexyl phthalate induces liver injury in chickens by regulating PTEN/PI3K/AKT signaling pathway via reactive oxygen species. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 270, pages 109639.
Crossref
Tetyana Kobets & Gary M. Williams. 2003. Patty's Toxicology. Patty's Toxicology 1 22 .
A. O. Sedova & V. B. Сhernykh. (2023) The negative impact of phthalates on male reproductive system and fertility. Andrology and Genital Surgery 24:2, pages 19-30.
Crossref
Mhasen Khalifa, R.H. Fayed, Ahmed A. Sedik & Heba M.A. Khalil. (2023) Dose-dependent toxic effects of di-(2-ethylhexyl) phthalate in male rats: Focus on behavioral alterations and inducing TLR4/NF-κB signaling pathway. Toxicology and Applied Pharmacology 468, pages 116515.
Crossref
Linyan Zhu, Parvaneh Hajeb, Patrik Fauser & Katrin Vorkamp. (2023) Endocrine disrupting chemicals in indoor dust: A review of temporal and spatial trends, and human exposure. Science of The Total Environment 874, pages 162374.
Crossref
Annamaria Colacci, Raffaella Corvi, Kyomi Ohmori, Martin Paparella, Stefania Serra, Iris Da Rocha Carrico, Paule Vasseur & Miriam Naomi Jacobs. (2023) The Cell Transformation Assay: A Historical Assessment of Current Knowledge of Applications in an Integrated Approach to Testing and Assessment for Non-Genotoxic Carcinogens. International Journal of Molecular Sciences 24:6, pages 5659.
Crossref
Meenakshi Soni, Mohd. Zahoor ul haq Shah & Vinoy Kumar Shrivastava. (2023) The hypoglycemic and anti-hyperlipidemic activity of vitamin C in di(2-ethylhexyl) phthalate-induced toxicity in female mice, Mus musculus. Comparative Clinical Pathology 32:4, pages 575-585.
Crossref
Yiyun Liu, Zhiling Guo, Ruihong Zhu, Dongzhi Gou, Pan-Pan Jia & De-Sheng Pei. (2023) An insight into sex-specific neurotoxicity and molecular mechanisms of DEHP: A critical review. Environmental Pollution 316, pages 120673.
Crossref
Andrea Garolla, Andrea Di Nisio, Luca De Toni, Alberto Ferlin & Carlo Foresta. 2023. Environment Impact on Reproductive Health. Environment Impact on Reproductive Health 131 151 .
Ozan GÜLBOY, Emine ALTIN & Ali ERTEKİN. (2022) Di (2-Etilhekzil) Fitalatın Ratlarda Doku Lipid Peroksidasyonu ve Antioksidan Düzeylerine Etkisi. Van Sağlık Bilimleri Dergisi 15:3, pages 301-311.
Crossref
Wentao Wu, Yun Teng, Miao Tian, Bingxin Huang, Yuhang Deng, Huili Li, Haiyun Yuan, Jimei Chen, Xiaohong Li & Chengbin Zhou. (2022) Tissue-specific metabolomic profiling after cardiopulmonary bypass in fetal sheep. Frontiers in Cardiovascular Medicine 9.
Crossref
Wei Chen, Caidie He, Xiang Liu, Songlin An, Xia Wang, Lin Tao, Haonan Zhang, Yingkuan Tian, Nian Wu, Pei Xu, Dengqing Liao, Juan Liao, Linglu Wang, Derong Fang, Shimin Xiong, Yijun Liu, Kunming Tian, Quan Li, Jingyi Huang, Hongyu Yuan, Xiaoshan Chen, Li Zhang, Xubo Shen & Yuanzhong Zhou. (2022) Effects of exposure to phthalate during early pregnancy on gestational diabetes mellitus: a nested case–control study with propensity score matching. Environmental Science and Pollution Research 30:12, pages 33555-33566.
Crossref
Shuichi Hamada, Miyuki Shigano, Yumi Wako, Kazufumi Kawasako, Kensuke Satomoto, Tatsuya Mitsumoto, Takayuki Fukuda, Wakako Ohyama, Takeshi Morita & Makoto Hayashi. (2022) Detection of hepatocarcinogens by combination of liver micronucleus assay and histopathological examination in 2-week or 4-week repeated dose studies. Genes and Environment 44:1.
Crossref
Xiangjuan Wei, Daqian Yang, Boya Zhang, Xingpei Fan, Haining Du, Ruijiao Zhu, Xiaotong Sun, Meimei Zhao & Ning Gu. (2022) Di-(2-ethylhexyl) phthalate increases plasma glucose and induces lipid metabolic disorders via FoxO1 in adult mice. Science of The Total Environment 842, pages 156815.
Crossref
Angel D. Davalos, Lidia Mínguez-Alarcón, Thomas J. van t’ Erve, Alexander P. Keil, Paige L. Williams, John D. Meeker, Ginger L. Milne, Shanshan Zhao, Russ Hauser & Kelly K. Ferguson. (2022) Associations between mixtures of urinary phthalate metabolite concentrations and oxidative stress biomarkers among couples undergoing fertility treatment. Environmental Research 212, pages 113342.
Crossref
Leila Lemos, Laura Gantiva, Catherine Kaylor, Alessandra Sanchez & Natalia Quinete. (2022) American oysters as bioindicators of emerging organic contaminants in Florida, United States. Science of The Total Environment 835, pages 155316.
Crossref
Ivan Rusyn, Weihsueh A. Chiu & Fred A. Wright. (2022) Model systems and organisms for addressing inter- and intra-species variability in risk assessment. Regulatory Toxicology and Pharmacology 132, pages 105197.
Crossref
Yue-Qiang Huang, Yi-Xi Tang, Bai-Hao Qiu, Milton Talukder, Xue-Nan Li & Jin-Long Li. (2022) Di-2-ethylhexyl phthalate (DEHP) induced lipid metabolism disorder in liver via activating the LXR/SREBP-1c/PPARα/γ and NF-κB signaling pathway. Food and Chemical Toxicology 165, pages 113119.
Crossref
Qian Chen, Qingmin Kong, Peijun Tian, Yufeng He, Jianxin Zhao, Hao Zhang, Gang Wang & Wei Chen. (2022) Lactic acid bacteria alleviate di-(2-ethylhexyl) phthalate-induced liver and testis toxicity via their bio-binding capacity, antioxidant capacity and regulation of the gut microbiota. Environmental Pollution 305, pages 119197.
Crossref
Soheila Safarpour, Maryam Ghasemi-Kasman, Samaneh Safarpour & Yasaman Mahdizadeh Darban. (2022) Effects of Di-2-Ethylhexyl Phthalate on Central Nervous System Functions: A Narrative Review. Current Neuropharmacology 20:4, pages 766-776.
Crossref
E. A. Lozovskaya, S. B. Nikiforov, A. G. Enikeev, K. Yu. Kostyunin, N. P. Sudakov & A. A. Semenov. (2022) Complexes of ortho-Phthalic Acid in Spontaneous Animal Tumors. Doklady Biochemistry and Biophysics 503:1, pages 112-114.
Crossref
Shiting Xiang, Jie Dong, Xun Li & Chao Li. (2022) Urine Phthalate Levels and Liver Function in US Adolescents: Analyses of NHANES 2007–2016. Frontiers in Public Health 10.
Crossref
Silke Schmidt. (2022) Targeting the Macrophage: Immune Cells May Be the Key to Phthalate-Induced Liver Toxicity. Environmental Health Perspectives 130:3.
Crossref
Denis Baranenko, Mohamed Said Boulkrane, Irina Borisova, Bazhena Astafyeva, Weihong Lu & A. M. Abd El-Aty. (2022) Translocation of Phthalates From Food Packaging Materials Into Minced Beef. Frontiers in Nutrition 8.
Crossref
Miao Xu, Yongning Li, Xiaohong Wang, Qiannan Zhang, Lei Wang, Xin Zhang, Wenming Cui, Xiaomin Han, Ning Ma, Haishan Li, Hongyun Fang, Song Tang, Jingguang Li, Zhaoping Liu, Hui Yang & Xudong Jia. (2022) Role of Hepatocyte- and Macrophage-Specific PPARγ in Hepatotoxicity Induced by Diethylhexyl Phthalate in Mice. Environmental Health Perspectives 130:1.
Crossref
David Hala, Lene H. Petersen, Duane B. Huggett, Michelle A. Puchowicz, Henri Brunengraber & Guo-Fang Zhang. (2021) Overcompensation of CoA Trapping by Di(2-ethylhexyl) Phthalate (DEHP) Metabolites in Livers of Wistar Rats. International Journal of Molecular Sciences 22:24, pages 13489.
Crossref
Huan Liu, Wenna Han, Siyu Zhu, Zhongyi Li & Chunhong Liu. (2021) Effect of DEHP and DnOP on mitochondrial damage and related pathways of Nrf2 and SIRT1/PGC-1α in HepG2 cells. Food and Chemical Toxicology 158, pages 112696.
Crossref
Gang Li, Chen-Yang Zhao, Qian Wu, Si-yuan Guan, Hong-Wei Jin, Xiao-Lin Na & Yun-Bo Zhang. (2021) Integrated metabolomics and transcriptomics reveal di(2-ethylhexyl) phthalate-induced mitochondrial dysfunction and glucose metabolism disorder through oxidative stress in rat liver. Ecotoxicology and Environmental Safety 228, pages 112988.
Crossref
Damjan Balabanič, Metka Filipič, Aleksandra Krivograd Klemenčič & Bojana Žegura. (2021) Genotoxic activity of endocrine disrupting compounds commonly present in paper mill effluents. Science of The Total Environment 794, pages 148489.
Crossref
Linling Yu, Meng Yang, Man Cheng, Lieyang Fan, Xing Wang, Tao Xu, Bin Wang & Weihong Chen. (2021) Associations between urinary phthalate metabolite concentrations and markers of liver injury in the US adult population. Environment International 155, pages 106608.
Crossref
Huan Liu, Siyu Zhu, Wenna Han, Yueqi Cai & Chunhong Liu. (2021) DMEP induces mitochondrial damage regulated by inhibiting Nrf2 and SIRT1/PGC-1α signaling pathways in HepG2 cells. Ecotoxicology and Environmental Safety 221, pages 112449.
Crossref
S. Simar-Mentières, F. Nesslany, M.-L. Sola, S. Mortier, J.-M. Raimbault, F. Gondelle, L. Chabot, P. Pandard, D. Wils & A. Chentouf. (2021) Toxicology and Biodegradability of a Phthalate-Free and Bio-Based Novel Plasticizer. Journal of Toxicology 2021, pages 1-15.
Crossref
Bukem Tanoren, Ugur Parlatan, Melita Parlak, Berzem Selcuk, Fatma Ates Alkan, Nural Pastaci Ozsobaci, Gurcan Albeniz, Leyla Turker Sener, Isil Albeniz & Mehmet Burcin Unlu. (2021) Determination of modifications in rat liver due to phthalate uptake by SAM, RS, and ICP-OES. Analytical Methods 13:26, pages 2926-2935.
Crossref
Omugha Abam Esther, Elizabeth Kuyooro Seun, Abubakar Shawai & Chineyenwa Dim Esther. (2021) Hepatotoxic and neurotoxic effects of combined lead and di-(2-ethylhexyl) phthalate exposure: Activation of total -, Ca2+- and Na+K+- ATPases in the liver of male rats. Journal of Toxicology and Environmental Health Sciences 13:1, pages 18-27.
Crossref
Arpna Kumari, Saroj Arora & Rajinder Kaur. (2020) Comparative cytotoxic and genotoxic potential of benzyl-butyl phthalate and di-n-butyl phthalate using Allium cepa assay. Energy, Ecology and Environment 6:3, pages 244-257.
Crossref
Rui-jing Liu, Yong-jian He, Huan Liu, Dong-dong Zheng, Shao-wen Huang & Chun-hong Liu. (2021) Protective effect of Lycium barbarum polysaccharide on di-(2-ethylhexyl) phthalate-induced toxicity in rat liver. Environmental Science and Pollution Research 28:18, pages 23501-23509.
Crossref
Nathalia de Assis Aguilar Duarte, Lindiane Eloisa de Lima, Flora Troina Maraslis, Michael Kundi, Emilene Arusievicz Nunes & Gustavo Rafael Mazzaron Barcelos. (2021) Acute Toxicity and DNA Instability Induced by Exposure to Low Doses of Triclosan and Phthalate DEHP, and Their Combinations, in vitro. Frontiers in Genetics 12.
Crossref
Siyu Liu, Kai Wang, Laurie K Svoboda, Christine A Rygiel, Kari Neier, Tamara R Jones, Raymond G Cavalcante, Justin A Colacino, Dana C Dolinoy & Maureen A Sartor. (2021) Perinatal DEHP exposure induces sex- and tissue-specific DNA methylation changes in both juvenile and adult mice. Environmental Epigenetics 7:1.
Crossref
Roberta Tassinari, Sabrina Tait, Luca Busani, Andrea Martinelli, Laura Narciso, Mauro Valeri, Amalia Gastaldelli, Annalisa Deodati, Cinzia La Rocca & Francesca Maranghi. (2021) Metabolic, reproductive and thyroid effects of bis(2-ethylhexyl) phthalate (DEHP) orally administered to male and female juvenile rats at dose levels derived from children biomonitoring study. Toxicology 449, pages 152653.
Crossref
Pınar Erkekoglu, Aylin ÖzyurtBalcıBalcı, Anıl Yirün & Deniz ÇakırArcaArca. (2021) Testicular dysgenesis syndrome and phthalate exposure: A review of literature. Arhiv za farmaciju 71:6, pages 508-543.
Crossref
Zhen Yu, Zhenhua Shi, Zeyu Zheng, Junyong Han, Wencong Yang, Rongmei Lu, Wei Lin, Yuanyuan Zheng, Daoshun Nie & Gang Chen. (2021) DEHP induce cholesterol imbalance via disturbing bile acid metabolism by altering the composition of gut microbiota in rats. Chemosphere 263, pages 127959.
Crossref
Xinrui Hao, Xiaoju Guan, Xingxing Zhao, Minpeng Ji, Xin Wen, Panpan Chen, Fenfen Chen, Jianying Yang, Qingquan Lian, Leping Ye & Haolin Chen. (2021) Phthalate inhibits Leydig cell differentiation and promotes adipocyte differentiation. Chemosphere 262, pages 127855.
Crossref
Natalia Quinete & Rachel Ann Hauser-Davis. (2020) Drinking water pollutants may affect the immune system: concerns regarding COVID-19 health effects. Environmental Science and Pollution Research 28:1, pages 1235-1246.
Crossref
Alberto Ferlin, Andrea Di Nisio, Luca De Toni & Carlo Foresta. 2021. Pediatric and Adolescent Andrology. Pediatric and Adolescent Andrology 29 45 .
Asuka A. Orr, Shujun He, Meichen Wang, Alicia Goodall, Sara E. Hearon, Timothy D. Phillips & Phanourios Tamamis. (2020) Insights into the interactions of bisphenol and phthalate compounds with unamended and carnitine-amended montmorillonite clays. Computers & Chemical Engineering 143, pages 107063.
Crossref
Ines Amara, Amal Salah, Rim Timoumi, Emna Annabi, Maria Scuto, Angela Trovato, Fadwa Neffati, Vittorio Calabrese & Salwa Abid-Essefi. (2020) Effect of di(2-ethylhexyl) phthalate on Nrf2-regulated glutathione homeostasis in mouse kidney. Cell Stress and Chaperones 25:6, pages 919-928.
Crossref
Luísa Camacho, John R. Latendresse, Levan Muskhelishvili, Charles D. Law & K. Barry Delclos. (2020) Effects of intravenous and oral di(2-ethylhexyl) phthalate (DEHP) and 20% Intralipid vehicle on neonatal rat testis, lung, liver, and kidney. Food and Chemical Toxicology 144, pages 111497.
Crossref
Lucie Čtveráčková, Daniel Jančula, Jan Raška, Pavel Babica & Iva Sovadinová. (2020) Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells. International Journal of Molecular Sciences 21:17, pages 6069.
Crossref
Hemily Batista-Silva, Betina Fernanda Dambrós, Keyla Rodrigues, Patrícia Acordi Cesconetto, Ariane Zamoner, Kieiv Resende Sousa de Moura, Allisson Jhonatan Gomes Castro, Glen Van Der Kraak & Fátima Regina Mena Barreto Silva. (2020) Acute exposure to bis(2-ethylhexyl)phthalate disrupts calcium homeostasis, energy metabolism and induces oxidative stress in the testis of Danio rerio. Biochimie 175, pages 23-33.
Crossref
Yongning Li, Qiannan Zhang, Jin Fang, Ning Ma, Xue Geng, Miao Xu, Hui Yang & Xudong Jia. (2020) Hepatotoxicity study of combined exposure of DEHP and ethanol: A comprehensive analysis of transcriptomics and metabolomics. Food and Chemical Toxicology 141, pages 111370.
Crossref
Gang Wang, Qian Chen, Peijun Tian, Linlin Wang, Xiu Li, Yuan-kun Lee, Jianxin Zhao, Hao Zhang & Wei Chen. (2020) Gut microbiota dysbiosis might be responsible to different toxicity caused by Di-(2-ethylhexyl) phthalate exposure in murine rodents. Environmental Pollution 261, pages 114164.
Crossref
L Shi, L Jiang, X Zhang, G Yang, C Zhang, X Yao, X Wu, M Fu, X Sun & X Liu. (2019) Pyrroloquinoline quinone protected autophagy-dependent apoptosis induced by mono(2-ethylhexyl) phthalate in INS-1 cells. Human & Experimental Toxicology 39:2, pages 194-211.
Crossref
Luciann Cuenca, Nara Shin, Laura I. Lascarez-Lagunas, Marina Martinez-Garcia, Saravanapriah Nadarajan, Rajendiran Karthikraj, Kurunthachalam Kannan & Mónica P. Colaiácovo. (2020) Environmentally-relevant exposure to diethylhexyl phthalate (DEHP) alters regulation of double-strand break formation and crossover designation leading to germline dysfunction in Caenorhabditis elegans. PLOS Genetics 16:1, pages e1008529.
Crossref
Do Jin Nam, Yeji Kim, Eun Hye Yang, Hyo Choon Lee & Jae-Hong Ryoo. (2020) Relationship between urinary phthalate metabolites and diabetes: Korean National Environmental Health Survey (KoNEHS) cycle 3 (2015–2017). Annals of Occupational and Environmental Medicine 32:1.
Crossref
Feng Liang & Biao Yan. (2020) Oxidative damage in the liver and kidney induced by dermal exposure to diisononyl phthalate in Balb/c mice. Toxicology and Industrial Health 36:1, pages 30-40.
Crossref
Frank Münch, Thomas Göen, Robert Zimmermann, Werner Adler, Ariawan Purbojo, Christine Höllerer, Robert Anton Cesnjevar & André Rüffer. (2019) Reduction of exposure to plasticizers in stored red blood cell units. Perfusion 35:1, pages 32-38.
Crossref
Ines Amara, Rim Timoumi, Emna Annabi, Gabriele Di Rosa, Maria Scuto, Mohamed F. Najjar, Vittorio Calabrese & Salwa Abid‐Essefi. (2019) Di (2‐ethylhexyl) phthalate targets the thioredoxin system and the oxidative branch of the pentose phosphate pathway in liver of Balb/c mice. Environmental Toxicology 35:1, pages 78-86.
Crossref
Andrea Di Nisio & Carlo Foresta. (2019) Water and soil pollution as determinant of water and food quality/contamination and its impact on male fertility. Reproductive Biology and Endocrinology 17:1.
Crossref
Yuki Ito, Michihiro Kamijima & Tamie Nakajima. (2019) Di(2-ethylhexyl) phthalate-induced toxicity and peroxisome proliferator-activated receptor alpha: a review. Environmental Health and Preventive Medicine 24:1.
Crossref
Yasmina M. Abd-Elhakim, Mohamed Abdo Nassan, Gamal A. Salem, Abdelkarim Sasi, Adil Aldhahrani, Khaled Ben Issa & Amany Abdel-Rahman Mohamed. (2019) Investigation of the In-Vivo Cytotoxicity and the In Silico-Prediction of MDM2-p53 Inhibitor Potential of Euphorbia peplus Methanolic Extract in Rats. Toxins 11:11, pages 642.
Crossref
Jae-Wook Lee, Seok Jong Lee, Myung Chan Gye & Eun-Yi Moon. (2019) Genotoxicity and glucose tolerance induction by acetyltriethylcitrate, substitute plasticizer compared to di(2-ethylhexyl)phthalate. Scientific Reports 9:1.
Crossref
Fei Wang, Chong Chang, Ruobi Li, Zhen Zhang, Hongmei Jiang, Ni Zeng, Daochuan Li, Liping Chen, Yongmei Xiao, Wen Chen & Qing Wang. (2019) Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells. Toxicology 424, pages 152236.
Crossref
Hyungjoo Kim, KeeSoo Nam, Sunhwa Oh, Seogho Son, Donghwan Jeon, Myung Chan Gye & Incheol Shin. (2019) Toxicological assessment of phthalates and their alternatives using human keratinocytes. Environmental Research 175, pages 316-322.
Crossref
Jianying Bai, Zhen He, Yaofu Li, Xuexia Jiang, Hongmei Yu & Qing Tan. (2019) Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells. Environmental Toxicology and Pharmacology 69, pages 104-111.
Crossref
Genoa R Warner, Zhong Li, Madeline L Houde, Cassandra E Atkinson, Daryl D Meling, Catheryne Chiang & Jodi A Flaws. (2019) Ovarian Metabolism of an Environmentally Relevant Phthalate Mixture. Toxicological Sciences 169:1, pages 246-259.
Crossref
Kim, Park, Kim & Kim. (2019) The Effects of Mono-(2-Ethylhexyl) Phthalate (MEHP) on Human Estrogen Receptor (hER) and Androgen Receptor (hAR) by YES/YAS In Vitro Assay. Molecules 24:8, pages 1558.
Crossref
Yu Wang, Hongkai Zhu & Kurunthachalam Kannan. (2019) A Review of Biomonitoring of Phthalate Exposures. Toxics 7:2, pages 21.
Crossref
Bo Zhang, Tao Zhang, Yishuang Duan, Zhen Zhao, Xiongfei Huang, Xueyuan Bai, Lei Xie, Yuan He, Jiping Ouyang, Yanduo Yang, Yili Wu & Hongwen Sun. (2019) Human exposure to phthalate esters associated with e-waste dismantling: Exposure levels, sources, and risk assessment. Environment International 124, pages 1-9.
Crossref
Nobumitsu Hanioka, Takashi Isobe, Susumu Ohkawara, Sadayuki Ochi, Toshiko Tanaka-Kagawa & Hideto Jinno. (2019) Hydrolysis of di(2-ethylhexyl) phthalate in humans, monkeys, dogs, rats, and mice: An in vitro analysis using liver and intestinal microsomes. Toxicology in Vitro 54, pages 237-242.
Crossref
Qi Zhang, Yi Zhao, Milton Talukder, Yu Han, Cong Zhang, Xue-Nan Li & Jin-Long Li. (2019) Di(2-ethylhexyl) phthalate induced hepatotoxicity in quail (Coturnix japonica) via modulating the mitochondrial unfolded protein response and NRF2 mediated antioxidant defense. Science of The Total Environment 651, pages 885-894.
Crossref
Jingsi Chen, Xiaofeng Zhou, Han Zhang, Yueming Liu, Chen Cao, Ruihua Dong, Yaqun Yuan, Min Wang, Yuanan Lu, Min Wu, Shuguang Li & Bo Chen. (2019) Association between urinary concentration of phthalate metabolites and impaired renal function in Shanghai adults. Environmental Pollution 245, pages 149-162.
Crossref
Takafumi Yamaguchi, Minoru MaedaKeiko OgataJun AbeToru UtsumiKoji Kimura. (2019) The effects on the endocrine system under hepatotoxicity induction by phenobarbital and di(2-ethylhexyl)phthalate in intact juvenile male rats. The Journal of Toxicological Sciences 44:7, pages 459-469.
Crossref
Jeong In Choi & Hyun Hee Cho. (2019) Effects of Di(2-ethylhexyl)phthalate on Bone Metabolism in Ovariectomized Mice. Journal of Bone Metabolism 26:3, pages 169.
Crossref
Rita S Strakovsky & Susan L Schantz. (2018) Using Experimental Models to Assess Effects of Bisphenol A (BPA) and Phthalates on the Placenta: Challenges and Perspectives. Toxicological Sciences 166:2, pages 250-268.
Crossref
Duygu Aydemir, Gözde Karabulut, Gülsu Şimşek, Muslum Gok, Nurhayat Barlas & Nuriye Nuray Ulusu. (2018) Impact of the Di(2-Ethylhexyl) Phthalate Administration on Trace Element and Mineral Levels in Relation of Kidney and Liver Damage in Rats. Biological Trace Element Research 186:2, pages 474-488.
Crossref
Ying-Zhi Zhang, Yu-Zhu Zuo, Zheng-Hai Du, Jun Xia, Cong Zhang, Hui Wang, Xue-Nan Li & Jin-Long Li. (2018) Di (2-ethylhexyl) phthalate (DEHP)-induced hepatotoxicity in quails (Coturnix japonica) via triggering nuclear xenobiotic receptors and modulating cytochrome P450 systems. Food and Chemical Toxicology 120, pages 287-293.
Crossref
James E. Klaunig, Xilin Li & Zemin Wang. (2018) Role of xenobiotics in the induction and progression of fatty liver disease. Toxicology Research 7:4, pages 664-680.
Crossref
Simin Liu & Qi Sun. (2018) Sex differences, endogenous sex-hormone hormones, sex-hormone binding globulin, and exogenous disruptors in diabetes and related metabolic outcomes. Journal of Diabetes 10:6, pages 428-441.
Crossref
Albino Barraza Villarreal. (2018) Exposure indices for phthalates and bisphenol A and their potential use in epidemiological studies. MOJ Toxicology 4:3.
Crossref
Sarva Mangala Praveena, Seoh Wei Teh, Ranjith Kumar Rajendran, Narayanan Kannan, Chu-Ching Lin, Rozaini Abdullah & Suresh Kumar. (2018) Recent updates on phthalate exposure and human health: a special focus on liver toxicity and stem cell regeneration. Environmental Science and Pollution Research 25:12, pages 11333-11342.
Crossref
Christine Höllerer, Günther Becker, Thomas Göen & Elisabeth Eckert. (2018) Regioselective ester cleavage of di-(2-ethylhexyl) trimellitates by porcine liver esterase. Toxicology in Vitro 47, pages 178-185.
Crossref
Emily Brehm, Saniya Rattan, Liying Gao & Jodi A Flaws. (2018) Prenatal Exposure to Di(2-Ethylhexyl) Phthalate Causes Long-Term Transgenerational Effects on Female Reproduction in Mice. Endocrinology 159:2, pages 795-809.
Crossref
Jae-Wook Lee, Sojin Park, Hae-Kyoung Han, Myung Chan Gye & Eun-Yi Moon. (2018) Di-(2-ethylhexyl) phthalate enhances melanoma tumor growth via differential effect on M1-and M2-polarized macrophages in mouse model. Environmental Pollution 233, pages 833-843.
Crossref
Eleanor C. Wilde, Katherine E. Chapman, Leanne M. Stannard, Anna L. Seager, Katja Brüsehafer, Ume-Kulsoom Shah, James A. Tonkin, M. Rowan Brown, Jatin R. Verma, Ann T. Doherty, George E. Johnson, Shareen H. Doak & Gareth J. S. Jenkins. (2017) A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells. Archives of Toxicology 92:2, pages 935-951.
Crossref
Sai Sandeep Singh Rowdhwal & Jiaxiang Chen. (2018) Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview. BioMed Research International 2018, pages 1-10.
Crossref
Gözde Karabulut & Nurhayat Barlas. (2018) Genotoxic, histologic, immunohistochemical, morphometric and hormonal effects of di-(2-ethylhexyl)-phthalate (DEHP) on reproductive systems in pre-pubertal male rats. Toxicology Research 7:5, pages 859-873.
Crossref
J. Christopher Corton, Jeffrey M. Peters & James E. Klaunig. (2017) The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions. Archives of Toxicology 92:1, pages 83-119.
Crossref
Nairong Liu, Liping Jiang, Xiance Sun, Xiaofeng Yao, Xingyue Zhai, Xiaofang Liu, Xueyan Wu, Yueran Bai, Shaopeng Wang & Guang Yang. (2017) Mono-(2-ethylhexyl) phthalate induced ROS-dependent autophagic cell death in human vascular endothelial cells. Toxicology in Vitro 44, pages 49-56.
Crossref
Sailas Benjamin, Eiji Masai, Naofumi Kamimura, Kenji Takahashi, Robin C. Anderson & Panichikkal Abdul Faisal. (2017) Phthalates impact human health: Epidemiological evidences and plausible mechanism of action. Journal of Hazardous Materials 340, pages 360-383.
Crossref
Marjory Moreau, Jeremy Leonard, Katherine A. Phillips, Jerry Campbell, Salil N. Pendse, Chantel Nicolas, Martin Phillips, Miyoung Yoon, Yu-Mei Tan, Sherrie Smith, Harish Pudukodu, Kristin Isaacs & Harvey Clewell. (2017) Using exposure prediction tools to link exposure and dosimetry for risk-based decisions: A case study with phthalates. Chemosphere 184, pages 1194-1201.
Crossref
Iman Al-Saleh, Tahreer Al-Rajudi, Ghofran Al-Qudaihi & Pulicat Manogaran. (2017) Evaluating the potential genotoxicity of phthalates esters (PAEs) in perfumes using in vitro assays. Environmental Science and Pollution Research 24:30, pages 23903-23914.
Crossref
Soohee Cho & Jeong-Yeol Yoon. (2017) Organ-on-a-chip for assessing environmental toxicants. Current Opinion in Biotechnology 45, pages 34-42.
Crossref
X Zhu, F Li, Z Z Qiu & J W Huang. (2017) Migration of DEHP from plastic to food simulants under microwave heating. IOP Conference Series: Earth and Environmental Science 64, pages 012050.
Crossref
Woong Kim & Myung Chan Gye. (2017) Maleficent Effects of Phthalates and Current States of Their Alternatives: A Review. Environmental Biology Research 35:1, pages 21-36.
Crossref
Iman Al-Saleh, Rola Elkhatib, Tahreer Al-Rajoudi & Ghofran Al-Qudaihi. (2017) Assessing the concentration of phthalate esters (PAEs) and bisphenol A (BPA) and the genotoxic potential of treated wastewater (final effluent) in Saudi Arabia. Science of The Total Environment 578, pages 440-451.
Crossref
Luca De Toni, Francesco Tisato, Roberta Seraglia, Marco Roverso, Valentina Gandin, Cristina Marzano, Roberto Padrini & Carlo Foresta. (2017) Phthalates and heavy metals as endocrine disruptors in food: A study on pre-packed coffee products. Toxicology Reports 4, pages 234-239.
Crossref
Jan Ludvig Lyche. 2017. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 829 856 .
Mahin KhatamiMahin Khatami. 2017. Inflammation, Aging and Cancer. Inflammation, Aging and Cancer 213 260 .
Jun Ling, Zenaida P. Lopez-Dee, Colby Cottell, Laura Wolfe & Derek Nye. (2016) Regulation of mRNA Translation Is a Novel Mechanism for Phthalate Toxicity. PLOS ONE 11:12, pages e0167914.
Crossref
Ida Petrovičová, Branislav Kolena, Miroslava Šidlovská, Tomáš Pilka, Soňa Wimmerová & Tomáš Trnovec. (2016) Occupational exposure to phthalates in relation to gender, consumer practices and body composition. Environmental Science and Pollution Research 23:23, pages 24125-24134.
Crossref
Lusine Yaghjyan, Gabriela L. Ghita, Marilyn Dumont-Driscoll, Richard A. Yost & Su-Hsin Chang. (2016) Maternal exposure to di-2-ethylhexylphthalate and adverse delivery outcomes: A systematic review. Reproductive Toxicology 65, pages 76-86.
Crossref
Hai-Tao Gao, Run Xu, Wei-Xin Cao, Xu Zhou, Ye-Hui-Mei Yan, Lingeng Lu, Qian Xu & Yang Shen. (2016) Food Emulsifier Glycerin Monostearate Increases Internal Exposure Levels of Six Priority Controlled Phthalate Esters and Exacerbates Their Male Reproductive Toxicities in Rats. PLOS ONE 11:8, pages e0161253.
Crossref
Kathryn Z. Guyton & Michael D. Waters. 2016. Toxicogenomics in Predictive Carcinogenicity. Toxicogenomics in Predictive Carcinogenicity 247 279 .
Nina Holland, Karen Huen, Vy Tran, Kelly Street, Brian Nguyen, Asa Bradman & Brenda Eskenazi. (2016) Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in a Mexican-American Cohort: Variability in Early and Late Pregnancy. Toxics 4:1, pages 7.
Crossref
Xiaohui Zhang, Lincong Liu, Siping Zhang, Yan Pan, Jing Li, Hongwei Pan, Shiguo Xu & Feng Luo. (2016) Biodegradation of Dimethyl Phthalate by Freshwater Unicellular Cyanobacteria. BioMed Research International 2016, pages 1-8.
Crossref
Jie Zhang, XiaoJia Xing, Yonghai Sun, Zhuolin Li, Peiyu Xue, Tuoyi Wang & Tiezhu Li. (2016) Characterization of the binding between phthalate esters and mouse PPARα for the development of a fluorescence polarization-based competitive binding assay. Analytical Methods 8:4, pages 880-885.
Crossref
Mei Ha, Li Wei, Xie Guan, Lianbing Li & Changjiang Liu. (2016) p53-dependent apoptosis contributes to di-(2-ethylhexyl) phthalate-induced hepatotoxicity. Environmental Pollution 208, pages 416-425.
Crossref
Nora Klöting, Nico Hesselbarth, Martin Gericke, Anne Kunath, Ronald Biemann, Rima Chakaroun, Joanna Kosacka, Peter Kovacs, Matthias Kern, Michael Stumvoll, Bernd Fischer, Ulrike Rolle-Kampczyk, Ralph Feltens, Wolfgang Otto, Dirk K. Wissenbach, Martin von Bergen & Matthias Blüher. (2015) Di-(2-Ethylhexyl)-Phthalate (DEHP) Causes Impaired Adipocyte Function and Alters Serum Metabolites. PLOS ONE 10:12, pages e0143190.
Crossref
Chenyu Wang, Daniel Johnson, M. Aziz Suleman, M. Adil Suleman, Wei Zhang, Dmitry Pestov, Priyanka Ramsinghani, Rennisha Wickham & Kenneth J. Wynne. (2015) Diffusion of di(2-ethylhexyl)phthalate in PVC quantified by ATR-IR spectroscopy. Polymer 76, pages 70-79.
Crossref
Guangtao Yang, Wenjuan Zhang, Qizhi Qin, Jing Wang, Hongyan Zheng, Wei Xiong & Jing Yuan. (2015) Mono(2-ethylhexyl) phthalate induces apoptosis in p53-silenced L02 cells via activation of both mitochondrial and death receptor pathways. Environmental Toxicology 30:10, pages 1178-1191.
Crossref
Patricia A. Thompson, Mahin Khatami, Carolyn J. Baglole, Jun Sun, Shelley A. Harris, Eun-Yi Moon, Fahd Al-Mulla, Rabeah Al-Temaimi, Dustin G. Brown, Anna Maria Colacci, Chiara Mondello, Jayadev Raju, Elizabeth P. Ryan, Jordan Woodrick, A.Ivana Scovassi, Neetu Singh, Monica Vaccari, Rabindra Roy, Stefano Forte, Lorenzo Memeo, Hosni K. Salem, Amedeo Amedei, Roslida A. Hamid, Leroy Lowe, Tiziana Guarnieri & William H. Bisson. (2015) Environmental immune disruptors, inflammation and cancer risk. Carcinogenesis 36:Suppl 1, pages S232-S253.
Crossref
Julia Kravchenko, Emanuela Corsini, Marc A. Williams, William Decker, Masoud H. Manjili, Takemi Otsuki, Neetu Singh, Faha Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Anna Maria Colacci, Monica Vaccari, Chiara Mondello, A.Ivana Scovassi, Jayadev Raju, Roslida A. Hamid, Lorenzo Memeo, Stefano Forte, Rabindra Roy, Jordan Woodrick, Hosni K. Salem, Elizabeth P. Ryan, Dustin G. Brown, William H. Bisson, Leroy Lowe & H. Kim Lyerly. (2015) Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions. Carcinogenesis 36:Suppl 1, pages S111-S127.
Crossref
Kannan Badri Narayanan, Manaf Ali, Barry J. Barclay, Qiang (Shawn) Cheng, Leandro D’Abronzo, Rita Dornetshuber-Fleiss, Paramita M. Ghosh, Michael J. Gonzalez Guzman, Tae-Jin Lee, Po Sing Leung, Lin Li, Suidjit Luanpitpong, Edward Ratovitski, Yon Rojanasakul, Maria Fiammetta Romano, Simona Romano, Ranjeet K. Sinha, Clement Yedjou, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Dustin G. Brown, Elizabeth P. Ryan, Anna Maria Colacci, Roslida A. Hamid, Chiara Mondello, Jayadev Raju, Hosni K. Salem, Jordan Woodrick, A.Ivana Scovassi, Neetu Singh, Monica Vaccari, Rabindra Roy, Stefano Forte, Lorenzo Memeo, Seo Yun Kim, William H. Bisson, Leroy Lowe & Hyun Ho Park. (2015) Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death. Carcinogenesis 36:Suppl 1, pages S89-S110.
Crossref
Sarah Niermann, Saniya Rattan, Emily Brehm & Jodi A. Flaws. (2015) Prenatal exposure to di-(2-ethylhexyl) phthalate (DEHP) affects reproductive outcomes in female mice. Reproductive Toxicology 53, pages 23-32.
Crossref
Virginie Rouiller-Fabre, Marie Justine Guerquin, Thierry N’Tumba-Byn, Vincent Muczynski, Delphine Moison, Sophie Tourpin, Sébastien Messiaen, René Habert & Gabriel Livera. (2015) Nuclear Receptors and Endocrine Disruptors in Fetal and Neonatal Testes: A Gapped Landscape. Frontiers in Endocrinology 6.
Crossref
Deborah Meltzer, Daniel B. Martinez–Arguelles, Enrico Campioli, Sunghoon Lee & Vassilios Papadopoulos. (2015) In utero exposure to the endocrine disruptor di(2-ethylhexyl) phthalate targets ovarian theca cells and steroidogenesis in the adult female rat. Reproductive Toxicology 51, pages 47-56.
Crossref
Peter A. Bain, Mike Williams & Anu Kumar. (2014) Assessment of multiple hormonal activities in wastewater at different stages of treatment. Environmental Toxicology and Chemistry 33:10, pages 2297-2307.
Crossref
Hanne Frederiksen, Tanja Kuiri-Hänninen, Katharina M. Main, Leo Dunkel & Ulla Sankilampi. (2014) A Longitudinal Study of Urinary Phthalate Excretion in 58 Full-Term and 67 Preterm Infants from Birth through 14 Months. Environmental Health Perspectives 122:9, pages 998-1005.
Crossref
Diana Lo, Yuh-Tai Wang & Ming-Chang Wu. (2014) Hepatoprotective effect of silymarin on di(2-ethylhexyl)phthalate (DEHP) induced injury in liver FL83B cells. Environmental Toxicology and Pharmacology 38:1, pages 112-118.
Crossref
Kathryn Z. GuytonKaren A. HoganCheryl Siegel ScottGlinda S. CooperAmbuja S. BaleLeonid KopylevStanley BaroneJr.Jr., Susan L. MakrisBarbara GlennRavi P. SubramaniamMaureen R. GwinnRebecca C. Dzubow & Weihsueh A. Chiu. (2014) Human Health Effects of Tetrachloroethylene: Key Findings and Scientific Issues. Environmental Health Perspectives 122:4, pages 325-334.
Crossref
N. Ülkü Karabay Yavaşoğlu, Çinel Köksal, Melih Dağdeviren, Hüseyin Aktuğ & Altuğ Yavaşoğlu. (2014) Induction of oxidative stress and histological changes in liver by subacute doses of butyl cyclohexyl phthalate. Environmental Toxicology 29:3, pages 345-353.
Crossref
Pınar Erkekoglu, Naciye D. Zeybek, Belma K. Giray, Walid Rachidi, Murat Kızılgün, Isabelle Hininger-Favier, Alain Favier, Esin Asan & Filiz Hincal. (2014) The effects of di(2-ethylhexyl)phthalate on rat liver in relation to selenium status. International Journal of Experimental Pathology 95:1, pages 64-77.
Crossref
Miok Kim, Na Rae Song, Jong-Ho Choi, Jeongae Lee & Heesoo Pyo. (2014) Simultaneous analysis of urinary phthalate metabolites of residents in Korea using isotope dilution gas chromatography–mass spectrometry. Science of The Total Environment 470-471, pages 1408-1413.
Crossref
M. Jiang & N. Yang. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology 815 819 .
David J. Brenner, Igor Shuryak & Rainer K. Sachs. 2014. ALERT - Adverse Late Effects of Cancer Treatment. ALERT - Adverse Late Effects of Cancer Treatment 205 226 .
Pınar Erkekoglu, Belma Giray, Walid Rachidi, Isabelle Hininger-Favier, Anne-Marie Roussel, Alain Favier & Filiz Hincal. (2014) Effects of di(2-ethylhexyl)phthalate on testicular oxidant/antioxidant status in selenium-deficient and selenium-supplemented rats. Environmental Toxicology 29:1, pages 98-107.
Crossref
Mary E. Kushman, Andrew D. Kraft, Kathryn Z. Guyton, Weihsueh A. Chiu, Susan L. Makris & Ivan Rusyn. (2013) A systematic approach for identifying and presenting mechanistic evidence in human health assessments. Regulatory Toxicology and Pharmacology 67:2, pages 266-277.
Crossref
David M.V. Saunders, Eric B. Higley, Markus Hecker, Rishikesh Mankidy & John P. Giesy. (2013) In vitro endocrine disruption and TCDD-like effects of three novel brominated flame retardants: TBPH, TBB, & TBCO. Toxicology Letters 223:2, pages 252-259.
Crossref
Leonardo TrasandeAdam J. Spanier, Sheela Sathyanarayana, Teresa M. AttinaJan Blustein. (2013) Urinary Phthalates and Increased Insulin Resistance in Adolescents. Pediatrics 132:3, pages e646-e655.
Crossref
D.B. Martinez-Arguelles, E. Campioli, M. Culty, B.R. Zirkin & V. Papadopoulos. (2013) Fetal origin of endocrine dysfunction in the adult: The phthalate model. The Journal of Steroid Biochemistry and Molecular Biology 137, pages 5-17.
Crossref
Leonardo Trasande, Sheela Sathyanarayana, Adam J. Spanier, Howard Trachtman, Teresa M. Attina & Elaine M. Urbina. (2013) Urinary Phthalates Are Associated with Higher Blood Pressure in Childhood. The Journal of Pediatrics 163:3, pages 747-753.e1.
Crossref
Xi Chen, Qizhi Qin, Wenjuan Zhang, Youjian Zhang, Hongyan Zheng, Chuanyao Liu, Yuqing Yang, Wei Xiong & Jing Yuan. (2013) Activation of the PI3K–AKT–mTOR signaling pathway promotes DEHP-induced Hep3B cell proliferation. Food and Chemical Toxicology 59, pages 325-333.
Crossref
Ryosuke Nakashima, Yumi Hayashi, Khalequzzaman Md.Xiaofang Jia, Dong Wang, Hisao Naito, Yuki Ito, Michihiro Kamijima, Frank J. Gonzalez & Tamie Nakajima. (2013) Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. Toxicology 309, pages 52-60.
Crossref
Evan S. Beach, Brian R. Weeks, Rebecca Stern & Paul T. Anastas. (2013) Plastics additives and green chemistry. Pure and Applied Chemistry 85:8, pages 1611-1624.
Crossref
Nicole C. Kleinstreuer, David J. Dix, Keith A. Houck, Robert J. Kavlock, Thomas B. Knudsen, Matthew T. Martin, Katie B. Paul, David M. Reif, Kevin M. Crofton, Kerry Hamilton, Ronald Hunter, Imran Shah & Richard S. Judson. (2013) In Vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis. Toxicological Sciences 131:1, pages 40-55.
Crossref
Chanjuan Hao, Xuejia Cheng, Hongfei Xia & Xu Ma. (2012) The endocrine disruptor mono-(2-ethylhexyl)phthalate promotes adipocyte differentiation and induces obesity in mice. Bioscience Reports 32:6, pages 619-629.
Crossref
Jane C. Caldwell. (2012) DEHP: Genotoxicity and potential carcinogenic mechanisms—A review. Mutation Research/Reviews in Mutation Research 751:2, pages 82-157.
Crossref
Yu-Chih Wang, Hung-Sheng Chen, Cheng-Yu Long, Cheng-Fang Tsai, Tsung-Hua Hsieh, Chia-Yi Hsu & Eing-Mei Tsai. (2012) Possible mechanism of phthalates-induced tumorigenesis. The Kaohsiung Journal of Medical Sciences 28:7, pages S22-S27.
Crossref
Guangtao Yang, Xue Zhou, Jing Wang, Wenjuan Zhang, Hongyan Zheng, Wenhong Lu & Jing Yuan. (2012) MEHP-induced oxidative DNA damage and apoptosis in HepG2 cells correlates with p53-mediated mitochondria-dependent signaling pathway. Food and Chemical Toxicology 50:7, pages 2424-2431.
Crossref
R. J. Rose, M. J. Priston, A. E. Rigby‐Jones & J. R. Sneyd. (2012) The effect of temperature on di(2‐ethylhexyl) phthalate leaching from PVC infusion sets exposed to lipid emulsions. Anaesthesia 67:5, pages 514-520.
Crossref
Xi Chen, Jianshu Wang, Qizhi Qin, Ying Jiang, Guangtao Yang, Kaimin Rao, Qian Wang, Wei Xiong & Jing Yuan. (2012) Mono-2-ethylhexyl phthalate induced loss of mitochondrial membrane potential and activation of Caspase3 in HepG2 cells. Environmental Toxicology and Pharmacology 33:3, pages 421-430.
Crossref
Ivan Rusyn & J. Christopher Corton. (2012) Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate. Mutation Research/Reviews in Mutation Research 750:2, pages 141-158.
Crossref
Wei Wang, Zelieann R. Craig, Mallikarjuna S. Basavarajappa, Rupesh K. Gupta & Jodi A. Flaws. (2012) Di (2-ethylhexyl) phthalate inhibits growth of mouse ovarian antral follicles through an oxidative stress pathway. Toxicology and Applied Pharmacology 258:2, pages 288-295.
Crossref
Matt Cave, Keith Cameron Falkner & Craig McClain. 2012. Zakim and Boyer's Hepatology. Zakim and Boyer's Hepatology 476 492 .
Anne-Marie Saillenfait, Alain-Claude Roudot, Frédéric Gallissot & Jean-Philippe Sabaté. (2011) Prenatal developmental toxicity studies on di-n-heptyl and di-n-octyl phthalates in Sprague-Dawley rats. Reproductive Toxicology 32:3, pages 268-276.
Crossref
M. Penza, M. Jeremic, E. Marrazzo, A. Maggi, P. Ciana, G. Rando, P.G. Grigolato & D. Di Lorenzo. (2011) The environmental chemical tributyltin chloride (TBT) shows both estrogenic and adipogenic activities in mice which might depend on the exposure dose. Toxicology and Applied Pharmacology 255:1, pages 65-75.
Crossref
Kelly K. Ferguson, Rita Loch-Caruso & John D. Meeker. (2011) Urinary phthalate metabolites in relation to biomarkers of inflammation and oxidative stress: NHANES 1999–2006. Environmental Research 111:5, pages 718-726.
Crossref
Qian Wang, Li Wang, Xi Chen, Kai Min Rao, Shao You Lu, Sheng Tao Ma, Pu Jiang, Dan Zheng, Shun Qing Xu, Hong Yan Zheng, Jian Shu Wang, Zhi Qiang Yu, Rong Zhang, Yong Tao & Jing Yuan. (2011) Increased urinary 8-hydroxy-2′-deoxyguanosine levels in workers exposed to di-(2-ethylhexyl) phthalate in a waste plastic recycling site in China. Environmental Science and Pollution Research 18:6, pages 987-996.
Crossref
Richard J. Bull, James Crook, Margaret Whittaker & Joseph A. Cotruvo. (2011) Therapeutic dose as the point of departure in assessing potential health hazards from drugs in drinking water and recycled municipal wastewater. Regulatory Toxicology and Pharmacology 60:1, pages 1-19.
Crossref
Daisuke Yamana, Takeshi Shimizu, Yang Fan, Takuya Miura, Naoki Nanashima, Toshiyuki Yamada, Kenichi Hakamada & Shigeki Tsuchida. (2011) Decrease of hepatic stellate cells in rats with enhanced sensitivity to clofibrate-induced hepatocarcinogenesis. Cancer Science 102:4, pages 735-741.
Crossref
Joshua G. DeKeyser, Elizabeth M. Laurenzana, Eric C. Peterson, Tao Chen & Curtis J. Omiecinski. (2011) Selective Phthalate Activation of Naturally Occurring Human Constitutive Androstane Receptor Splice Variants and the Pregnane X Receptor. Toxicological Sciences 120:2, pages 381-391.
Crossref
Dorien A.M. van Dartel, Jeroen L.A. Pennings, Joshua F. Robinson, Jos C.S. Kleinjans & Aldert H. Piersma. (2011) Discriminating classes of developmental toxicants using gene expression profiling in the embryonic stem cell test. Toxicology Letters 201:2, pages 143-151.
Crossref
Min-Ah ParkKyung-A HwangKyung-Chul Choi. (2011) Diverse animal models to examine potential role(s) and mechanism of endocrine disrupting chemicals on the tumor progression and prevention: Do they have tumorigenic or anti-tumorigenic property?. Laboratory Animal Research 27:4, pages 265.
Crossref
Jan L. Lyche. 2011. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 637 655 .
Bakthavachalam Babu & Jiunn-Tzong Wu. (2010) BIODEGRADATION OF PHTHALATE ESTERS BY CYANOBACTERIA1. Journal of Phycology 46:6, pages 1106-1113.
Crossref
Joshua F. Robinson, Vincent A. van Beelen, Aart Verhoef, Marc F. J. Renkens, Mirjam Luijten, Marcel H. M. van Herwijnen, Anja Westerman, Jeroen L. A. Pennings & Aldert H. Piersma. (2010) Embryotoxicant-Specific Transcriptomic Responses in Rat Postimplantation Whole-Embryo Culture. Toxicological Sciences 118:2, pages 675-685.
Crossref
Elizabeth M. Ward, Paul A. Schulte, Kurt Straif, Nancy B. Hopf, Jane C. Caldwell, Tania Carreón, David M. DeMarini, Bruce A. Fowler, Bernard D. Goldstein, Kari Hemminki, Cynthia J. Hines, Kirsti Husgafvel Pursiainen, Eileen Kuempel, Joellen Lewtas, Ruth M. Lunn, Elsebeth Lynge, Damien M. McElvenny, Hartwig Muhle, Tamie Nakajima, Larry W. Robertson, Nathaniel Rothman, Avima M. Ruder, Mary K. Schubauer-Berigan, Jack Siemiatycki, Debra Silverman, Martyn T. Smith, Tom Sorahan, Kyle Steenland, Richard G. Stevens, Paolo Vineis, Shelia Hoar Zahm, Lauren Zeise & Vincent J. Cogliano. (2010) Research Recommendations for Selected IARC-Classified Agents. Environmental Health Perspectives 118:10, pages 1355-1362.
Crossref
J. Christopher Corton. 2010. Cancer Risk Assessment. Cancer Risk Assessment 439 481 .
Jinjiang Fan, Kassim Traore, Wenping Li, Hakima Amri, Hongzhan Huang, Cathy Wu, Haolin Chen, Barry Zirkin & Vassilios Papadopoulos. (2010) Molecular Mechanisms Mediating the Effect of Mono-(2-Ethylhexyl) Phthalate on Hormone-Stimulated Steroidogenesis in MA-10 Mouse Tumor Leydig Cells. Endocrinology 151:7, pages 3348-3362.
Crossref
Francesca Maranghi, Stefano Lorenzetti, Roberta Tassinari, Gabriele Moracci, Valentina Tassinari, Daniele Marcoccia, Antonio Di Virgilio, Agostino Eusepi, Antonella Romeo, Armando Magrelli, Marco Salvatore, Fabrizio Tosto, Mara Viganotti, Antonio Antoccia, Alessandra Di Masi, Gianluca Azzalin, Caterina Tanzarella, Giuseppe Macino, Domenica Taruscio & Alberto Mantovani. (2010) In utero exposure to di-(2-ethylhexyl) phthalate affects liver morphology and metabolism in post-natal CD-1 mice. Reproductive Toxicology 29:4, pages 427-432.
Crossref
Takeshi Shimizu, Yang Fan, Daisuke Yamana, Takuya Miura, Naoki Nanashima, Toshiyuki Yamada & Shigeki Tsuchida. (2010) Glutathione S -transferase A4 is a positive marker for rat hepatic foci induced by clofibrate and genotoxic carcinogens . Cancer Science 101:5, pages 1093-1098.
Crossref
Seonyoung Choi, So‐Young Park, Ji Jeong, Eunkyung Cho, Sohee Phark, Min Lee, Dongsub Kwak, Ji‐Youn Lim, Woon‐Won Jung & Donggeun Sul. (2010) Identification of toxicological biomarkers of di(2‐ethylhexyl) phthalate in proteins secreted by HepG2 cells using proteomic analysis. PROTEOMICS 10:9, pages 1831-1846.
Crossref
Jérôme N. Feige, Alan Gerber, Cristina Casals-Casas, Qian Yang, Carine Winkler, Elodie Bedu, Manuel Bueno, Laurent Gelman, Johan Auwerx, Frank J. Gonzalez & Béatrice Desvergne. (2010) The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPARα-Dependent Mechanisms. Environmental Health Perspectives 118:2, pages 234-241.
Crossref
Shigeru Satake, Chika Nakamura, Yoshiyuki Minamide, Shinobu Kudo, Hiroshi Maeda, Yutaka Chihaya, Yasuhiro Kamimura, Hiroaki Miyajima, Jun Sasaki, Masanobu Goryo & Kosuke Okada. (2010) Effect of a Large Dose of Di (2-ethylhexyl) phthalate (DEHP) on Hepatic Peroxisome in Cynomolgus Monkeys (Macaca Fascicularis). Journal of Toxicologic Pathology 23:2, pages 75-83.
Crossref
Michael L. Cunningham, Bradley J. Collins, Milton R. Hejtmancik, Ronald A. Herbert, Gregory S. Travlos, Molly K. Vallant & Matthew D. Stout. (2010) Effects of the PPAR Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism . PPAR Research 2010, pages 1-14.
Crossref
Kathryn Z. Guyton, Weihsueh A. Chiu, Thomas F. Bateson, Jennifer Jinot, Cheryl Siegel Scott, Rebecca C. Brown & Jane C. Caldwell. (2009) A Reexamination of the PPAR-α Activation Mode of Action as a Basis for Assessing Human Cancer Risks of Environmental Contaminants. Environmental Health Perspectives 117:11, pages 1664-1672.
Crossref
Giuliana G. K. Botelho, Aedra C. Bufalo, Ana Claudia Boareto, Juliane C. Muller, Rosana N. Morais, Anderson J. Martino-Andrade, Karen R. Lemos & Paulo R. Dalsenter. (2009) Vitamin C and Resveratrol Supplementation to Rat Dams Treated with Di(2-ethylhexyl)phthalate: Impact on Reproductive and Oxidative Stress End Points in Male Offspring. Archives of Environmental Contamination and Toxicology 57:4, pages 785-793.
Crossref
Giuliana G. K. Botelho, Munisa Golin, Aedra C. Bufalo, Rosana N. Morais, Paulo R. Dalsenter & Anderson J. Martino-Andrade. (2009) Reproductive Effects of Di(2-ethylhexyl)phthalate in Immature Male Rats and Its Relation to Cholesterol, Testosterone, and Thyroxin Levels. Archives of Environmental Contamination and Toxicology 57:4, pages 777-784.
Crossref
Yuri Sano, Hiroshi Nakashima, Noriyuki Yoshioka, Norihito Etho, Tetsuo Nomiyama, Yuji Nishiwaki, Toru Takebayashi & Kazuyuki Oame. (2009) Trichloroethylene liver toxicity in mouse and rat: microarray analysis reveals species differences in gene expression. Archives of Toxicology 83:9, pages 835-849.
Crossref
Heike von Rettberg, Torsten Hannman, Ulrike Subotic, Joachim Brade, Thomas Schaible, Karl Ludwig Waag & Steffan Loff. (2009) Use of Di(2-Ethylhexyl)Phthalate–Containing Infusion Systems Increases the Risk for Cholestasis. Pediatrics 124:2, pages 710-716.
Crossref
Anne‐Marie Saillenfait, Frédéric Gallissot & Jean‐Philippe Sabaté. (2009) Differential developmental toxicities of di‐ n ‐hexyl phthalate and dicyclohexyl phthalate administered orally to rats . Journal of Applied Toxicology 29:6, pages 510-521.
Crossref
Joshua G. DeKeyser, Michael C. Stagliano, Scott S. Auerbach, K. Sandeep Prabhu, A. Daniel Jones & Curtis J. Omiecinski. (2009) Di(2-ethylhexyl) phthalate Is a Highly Potent Agonist for the Human Constitutive Androstane Receptor Splice Variant CAR2. Molecular Pharmacology 75:5, pages 1005-1013.
Crossref
Pamela K. Ross, Courtney G. Woods, Blair U. Bradford, Oksana Kosyk, Daniel M. Gatti, Michael L. Cunningham & Ivan Rusyn. (2009) Time-course comparison of xenobiotic activators of CAR and PPARα in mouse liver. Toxicology and Applied Pharmacology 235:2, pages 199-207.
Crossref
Yun-Chul Hong, Eun-Young Park, Min-Seon Park, Jeong Ah Ko, Se-Young Oh, Ho Kim, Kwan-Hee Lee, Jong-Han Leem & Eun-Hee Ha. (2009) Community level exposure to chemicals and oxidative stress in adult population. Toxicology Letters 184:2, pages 139-144.
Crossref
C Casals-Casas, J N Feige & B Desvergne. (2008) Interference of pollutants with PPARs: endocrine disruption meets metabolism. International Journal of Obesity 32:S6, pages S53-S61.
Crossref
Nadeem Rezaq Janjua, Hanne Frederiksen, Niels E. Skakkebæk, Hans Christian Wulf & Anna-Maria Andersson. (2008) Urinary excretion of phthalates and paraben after repeated whole-body topical application in humans. International Journal of Andrology 31:2, pages 118-130.
Crossref
James A. Deyo. (2008) Carcinogenicity and chronic toxicity of di-2-ethylhexyl terephthalate (DEHT) following a 2-year dietary exposure in Fischer 344 rats. Food and Chemical Toxicology 46:3, pages 990-1005.
Crossref
Jane C. Caldwell, Nagalakshmi Keshava & Marina V. Evans. (2007) Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures. Environmental and Molecular Mutagenesis 49:2, pages 142-154.
Crossref
Sheela Sathyanarayana. (2008) Phthalates and Children’s Health. Current Problems in Pediatric and Adolescent Health Care 38:2, pages 34-49.
Crossref
Yuki Ito & Tamie Nakajima. (2008) PPAR - and DEHP-Induced Cancers . PPAR Research 2008, pages 1-12.
Crossref
Igor P. Pogribny, Volodymyr P. Tryndyak, Courtney G. Woods, Sarah E. Witt & Ivan Rusyn. (2007) Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor α. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 625:1-2, pages 62-71.
Crossref
Raoul Frijters, Stefan VerhoevenWynand AlkemaRené van SchaikJan Polman. (2007) Literature-based compound profiling: application to toxicogenomics. Pharmacogenomics 8:11, pages 1521-1534.
Crossref
Hanne Frederiksen, Niels E. Skakkebaek & Anna-Maria Andersson. (2007) Metabolism of phthalates in humans. Molecular Nutrition & Food Research 51:7, pages 899-911.
Crossref
Richard W. Stahlhut, Edwin van Wijngaarden, Timothy D. Dye, Stephen Cook & Shanna H. Swan. (2007) Concentrations of Urinary Phthalate Metabolites Are Associated with Increased Waist Circumference and Insulin Resistance in Adult U.S. Males. Environmental Health Perspectives 115:6, pages 876-882.
Crossref
Jérôme N. Feige, Laurent Gelman, Daniel Rossi, Vincent Zoete, Raphaël Métivier, Cicerone Tudor, Silvia I. Anghel, Aurélien Grosdidier, Caroline Lathion, Yves Engelborghs, Olivier Michielin, Walter Wahli & Béatrice Desvergne. (2007) The Endocrine Disruptor Monoethyl-hexyl-phthalate Is a Selective Peroxisome Proliferator-activated Receptor γ Modulator That Promotes Adipogenesis. Journal of Biological Chemistry 282:26, pages 19152-19166.
Crossref
Courtney G. Woods, Amanda M. Burns, Akira Maki, Blair U. Bradford, Michael L. Cunningham, Henry D. Connor, Maria B. Kadiiska, Ronald P. Mason, Jeffrey M. Peters & Ivan Rusyn. (2007) Sustained formation of α-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-α, but not NADPH oxidase. Free Radical Biology and Medicine 42:3, pages 335-342.
Crossref

Displaying 200 of 201 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.