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Research Article

Grey Goo on the Skin? Nanotechnology, Cosmetic and Sunscreen Safety

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Pages 251-277 | Published online: 10 Oct 2008

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Patricia Brassolatti, Joice Margareth de Almeida Rodolpho, Krissia Franco de Godoy, Cynthia Aparecida de Castro, Genoveva Lourdes Flores Luna, Bruna Dias de Lima Fragelli, Matheus Pedrino, Marcelo Assis, Marcel Nani Leite, Juliana Cancino-Bernardi, Carlos Speglich, Marco Andrey Frade & Fernanda de Freitas Anibal. (2022) Functionalized Titanium Nanoparticles Induce Oxidative Stress and Cell Death in Human Skin Cells. International Journal of Nanomedicine 17, pages 1495-1509.
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S. M. Solaiman, Jennifer Algie, Shahnaz Bakand, Ronald Sluyter, Vitor Sencadas, Michael Lerch, Xu-Feng Huang, Konstantin Konstantinov & Philip J. Barker. (2019) Nano-sunscreens – a double-edged sword in protecting consumers from harm: viewing Australian regulatory policies through the lenses of the European Union. Critical Reviews in Toxicology 49:2, pages 122-139.
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Katherine A. Roach, Aleksandr B. Stefaniak & Jenny R. Roberts. (2019) Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease. Journal of Immunotoxicology 16:1, pages 87-124.
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Ying Zou, Anna Celli, Hanjiang Zhu, Akram Elmahdy, Yachao Cao, Xiaoying Hui & Howard Maibach. (2017) Confocal laser scanning microscopy to estimate nanoparticles’ human skin penetration in vitro. International Journal of Nanomedicine 12, pages 8035-8041.
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Vivek A. Miyani & Michael F. Hughes. (2017) Assessment of the in vitro dermal irritation potential of cerium, silver, and titanium nanoparticles in a human skin equivalent model. Cutaneous and Ocular Toxicology 36:2, pages 145-151.
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Chia-Chi Ho, Hui-Ling Lee, Chao-Yu Chen, Yueh-Hsia Luo, Ming-Hsien Tsai, Hui-Ti Tsai & Pinpin Lin. (2017) Involvement of the cytokine–IDO1–AhR loop in zinc oxide nanoparticle-induced acute pulmonary inflammation. Nanotoxicology 11:3, pages 360-370.
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Fei Gao, Ningjie Ma, Hong Zhou, Qing Wang, Hao Zhang, Pu Wang, Haoli Hou, Huan Wen & Lijia Li. (2016) Zinc oxide nanoparticles-induced epigenetic change and G2/M arrest are associated with apoptosis in human epidermal keratinocytes. International Journal of Nanomedicine 11, pages 3859-3874.
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Nagarjun V. Konduru, Kimberly M. Murdaugh, Archana Swami, Renato J. Jimenez, Thomas C. Donaghey, Philip Demokritou, Joseph D. Brain & Ramon M. Molina. (2016) Surface modification of zinc oxide nanoparticles with amorphous silica alters their fate in the circulation. Nanotoxicology 10:6, pages 720-727.
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Yu Gao, Khay Ming Tan, Yihan Li, Kyung Taeck Minn, Astrid Marlies Alsema & Chenjie Xu. (2015) Characterization of Titanium Dioxide Nanoparticles on Porcine Skin by Raman Microscopy. Analytical Letters 48:15, pages 2391-2399.
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Shohreh Nafisi, Monika Schäfer-Korting & Howard I. Maibach. (2015) Perspectives on percutaneous penetration: Silica nanoparticles. Nanotoxicology 9:5, pages 643-657.
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Daniel P Otto, Anja Otto & Melgardt M de Villiers. (2015) Differences in physicochemical properties to consider in the design, evaluation and choice between microparticles and nanoparticles for drug delivery. Expert Opinion on Drug Delivery 12:5, pages 763-777.
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Christian O. Dimkpa, Trevor Hansen, Jacob Stewart, Joan E. McLean, David W. Britt & Anne J. Anderson. (2015) ZnO nanoparticles and root colonization by a beneficial pseudomonad influence essential metal responses in bean (Phaseolus vulgaris). Nanotoxicology 9:3, pages 271-278.
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Jen-Kun Chen, Chia-Chi Ho, Han Chang, Jing-Fang Lin, Chung Shi Yang, Ming-Hsien Tsai, Hui-Ti Tsai & Pinpin Lin. (2015) Particulate nature of inhaled zinc oxide nanoparticles determines systemic effects and mechanisms of pulmonary inflammation in mice. Nanotoxicology 9:1, pages 43-53.
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Fiorenza Rancan, Ulrike Blume-Peytavi & Annika Vogt. (2014) Utilization of biodegradable polymeric materials as delivery agents in dermatology. Clinical, Cosmetic and Investigational Dermatology 7, pages 23-34.
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Hark-Soo Park, Seon-Ju Kim, Taek-Jin Lee, Geon-Yong Kim, EunHo Meang, Jeong-Sup Hong, Su-Hyon Kim, Sang-Bum Koh, Seung-Guk Hong, Yle-Shik Sun, Jin Seok Kang, Yu-Ri Kim, Meyoung-Kon Kim, Jayoung Jeong, Jong-Kwon Lee, Woo-Chan Son & Jae-Hak Park. (2014) A 90-day study of sub-chronic oral toxicity of 20 nm positively charged zinc oxide nanoparticles in Sprague Dawley rats. International Journal of Nanomedicine 9:sup2, pages 93-107.
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Hark-Soo Park, Sung-Sup Shin, Eun Ho Meang, Jeong-sup Hong, Jong-Il Park, Su-Hyon Kim, Sang-Bum Koh, Seung-Young Lee, Dong-Hyouk Jang, Jong-Yun Lee, Yle-Shik Sun, Jin Seok Kang, Yu-Ri Kim, Meyoung-Kon Kim, Jayoung Jeong, Jong-Kwon Lee, Woo-Chan Son & Jae-Hak Park. (2014) A 90-day study of subchronic oral toxicity of 20 nm, negatively charged zinc oxide nanoparticles in Sprague Dawley rats. International Journal of Nanomedicine 9:sup2, pages 79-92.
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Eşref Demir, Amadeu Creus & Ricard Marcos. (2014) Genotoxicity and DNA Repair Processes of Zinc Oxide Nanoparticles. Journal of Toxicology and Environmental Health, Part A 77:21, pages 1292-1303.
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Faraz Niyaghi, Karl R. Haapala, Stacey L. Harper & Michael C. Weismiller. (2014) Stability and Biological Responses of Zinc Oxide Metalworking Nanofluids (ZnO MWnF™) using Dynamic Light Scattering and Zebrafish Assays. Tribology Transactions 57:4, pages 730-739.
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Michele Shepard & Sara Brenner. (2014) Cutaneous exposure scenarios for engineered nanoparticles used in semiconductor fabrication: a preliminary investigation of workplace surface contamination. International Journal of Occupational and Environmental Health 20:3, pages 247-257.
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Shilpa Gantedi & Rama Narsimha Reddy Anreddy. (2012) Toxicological studies of zinc oxide nanomaterials in rats. Toxicological & Environmental Chemistry 94:9, pages 1768-1779.
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Christian O. Dimkpa, Joan E. Mclean, David W. Britt & Anne J. Anderson. (2012) CuO and ZnO nanoparticles differently affect the secretion of fluorescent siderophores in the beneficial root colonizer, Pseudomonas chlororaphis O6. Nanotoxicology 6:6, pages 635-642.
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Paola Pedata, Mariarosaria Boccellino, Raffaele La Porta, Maria Napolitano, Patrizia Minutolo, Lee A. Sgro, Francesca Zei, Nicola Sannolo & Lucio Quagliuolo. (2012) Interaction between combustion-generated organic nanoparticles and biological systems: In vitro study of cell toxicity and apoptosis in human keratinocytes. Nanotoxicology 6:4, pages 338-352.
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Tarl W. Prow, Nancy A. Monteiro-Riviere, Alfred O. Inman, Jeffrey E. Grice, Xianfeng Chen, Xin Zhao, Washington H. Sanchez, Audrey Gierden, Mark A. F. Kendall, Andrei V. Zvyagin, Detlev Erdmann, Jim E. Riviere & Michael S. Roberts. (2012) Quantum dot penetration into viable human skin. Nanotoxicology 6:2, pages 173-185.
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Wan-Seob Cho, Rodger Duffin, Craig A. Poland, Albert Duschl, Gertie Janneke Oostingh, William MacNee, Mark Bradley, Ian L. Megson & Ken Donaldson. (2012) Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs. Nanotoxicology 6:1, pages 22-35.
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Iman Al-Saleh, Rola Elkhatib, Reem Al-Rouqi, Sami Al-Enazi & Neptune Shinwari. (2012) The dangers of skin-lightening creams. Toxicological & Environmental Chemistry 94:1, pages 195-219.
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Threes G Smijs & Stanislav Pavel. (2011) Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness. Nanotechnology, Science and Applications 4, pages 95-112.
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Christiane Lorenz, Natalie Von Goetz, Martin Scheringer, Matthias Wormuth & Konrad Hungerbühler. (2011) Potential exposure of German consumers to engineered nanoparticles in cosmetics and personal care products. Nanotoxicology 5:1, pages 12-29.
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Rickard Arvidsson, Sverker Molander, BjörnA. Sandén & Martin Hassellöv. (2011) Challenges in Exposure Modeling of Nanoparticles in Aquatic Environments. Human and Ecological Risk Assessment: An International Journal 17:1, pages 245-262.
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Pierfrancesco Morganti. (2010) Use and potential of nanotechnology in cosmetic dermatology. Clinical, Cosmetic and Investigational Dermatology 3, pages 5-13.
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Christiane Lorenz, Karen Tiede, Steven Tear, Alistair Boxall, Natalie Von Goetz & Konrad Hungerbühler. (2010) Imaging and Characterization of Engineered Nanoparticles in Sunscreens by Electron Microscopy, Under Wet and Dry Conditions. International Journal of Occupational and Environmental Health 16:4, pages 406-428.
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Grant Gardner, Gail Jones, Amy Taylor, Jennifer Forrester & Laura Robertson. (2010) Students’ Risk Perceptions of Nanotechnology Applications: Implications for science education. International Journal of Science Education 32:14, pages 1951-1969.
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Koji Adachi, Nanako Yamada, Kazuhiro Yamamoto, Yuichi Yoshida & Osamu Yamamoto. (2010) In vivo effect of industrial titanium dioxide nanoparticles experimentally exposed to hairless rat skin. Nanotoxicology 4:3, pages 296-306.
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John W Rasmussen, Ezequiel Martinez, Panagiota Louka & Denise G Wingett. (2010) Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications. Expert Opinion on Drug Delivery 7:9, pages 1063-1077.
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Megan J. Osmond & Maxine J. Mccall. (2010) Zinc oxide nanoparticles in modern sunscreens: An analysis of potential exposure and hazard. Nanotoxicology 4:1, pages 15-41.
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Marc Schneider, Frank Stracke, Steffi Hansen & Ulrich F. Schaefer. (2009) Nanoparticles and their interactions with the dermal barrier. Dermato-Endocrinology 1:4, pages 197-206.
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Premendra D. Dwivedi, Amita Misra, Rishi Shanker & Mukul Das. (2009) Are nanomaterials a threat to the immune system?. Nanotoxicology 3:1, pages 19-26.
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Etienne Gontier, Maria-Dolores Ynsa, Tamás Bíró, Janos Hunyadi, Borbala Kiss, Krisztián Gáspár, Teresa Pinheiro, Joao-Nuno Silva, Paulo Filipe, Jerzy Stachura, Wojciech Dabros, Tilo Reinert, Tilman Butz, Philippe Moretto & Jean-Etienne Surlève-Bazeille. (2008) Is there penetration of titania nanoparticles in sunscreens through skin? A comparative electron and ion microscopy study. Nanotoxicology 2:4, pages 218-231.
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