Grey Goo on the Skin? Nanotechnology, Cosmetic and Sunscreen Safety

REFERENCES

• Afshari A., Matson. U., Ekberg. L.E. Characterisation of indoor sources of fine and ultrafine particles: A study conducted in a full-scale chamber. Indoor Air 2005; 15(2)141–150
   PubMed Web of Science ®Google Scholar
• AFSSET. Agence Francaise de Sécurité Sanitaire de l'Environnement et du Travail. Les nanomateriaux: Effets sur la santé humaine et sur l'environnement. 2006, July 2006. Available at: http://www.afsset.fr
   Google Scholar
• Alvarez-Roman R., Barre G., Guy R.H., Fessi H. Biodegradable polymer nanocapsules containing a sunscreen agent: Preparation and photoprotection. Eur. J. Pharm. Biopharm. 2001; 52: 191–195
   PubMed Web of Science ®Google Scholar
• Alvarez-Roman R., Naik A., Kalia Y. N., Guy R. H., Fessi H. Enhancement of topical delivery from biodegradable nanoparticles. Pharm. Res. 2004a; 21(10)1818–1825
   PubMed Web of Science ®Google Scholar
• Alvarez-Roman R., Naik A., Kalia Y. N., Guy R. H., Fessi H. Skin penetration and distribution of polymeric nanocapsules. J. Contr. Release 2004b; 99(1)53–62
   PubMed Web of Science ®Google Scholar
• Amstutz H. C., Campbell P., Kossowsky N., Clarke I. C. Mechanism and clinical significance of wear debris-induced osteolysis. Clin. Orthopaed. Related Res. 1992; 276: 7–18
   PubMed Web of Science ®Google Scholar
• Anonymous. Study shows nanoparticles in sun cream may affect mice brain cells. 2006, Cosmetics.design.com. 21 June 2006. Available at: http://www.cosmeticsdesign.com/news
   Google Scholar
• Ball P. Nanotechnology in the firing line. 2003, Article at: http://nanotechweb.org/articles/society/2/12/1
   Google Scholar
• Beckett W. S., Chalupa D. F., Pauly-Brown A., Speers D. M., Stewart J. C., Frampton M. W., Utell M. J., Huang L. S., Cox C., Zareba W. Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: a human inhalation study. Am. J. Respir. Crit. Care Med. 2005; 171(10)1129–1135
   PubMed Web of Science ®Google Scholar
• Bennat C., Müller-Goymann C.C. Skin penetration and stabilisation of formulations containing microfine titanium dioxide and a physical UV filter. Int. J. Cosmet. Sci. 2000; 22: 271–283
   PubMedGoogle Scholar
• Benson H. A.E. Transdermal drug delivery: Penetration enhancement techniques. Curr. Drug Deliv. 2005; 2: 23–33
   PubMedGoogle Scholar
• Bermudez E., Mangum J. B., Asgharian B., Wong B. A., Reverdy E., Janszen D. B., Hext P. M., Warheit D. B., Everitt J. I. Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary TiO2 particles. Toxicol. Sci. 2002; 70: 86–97
   PubMed Web of Science ®Google Scholar
• Bermudez E., Mangum J. B., Wong B. A., Asgharian B., Hext P. M., Warheit D. B., Everett J. J. Pulmonary responses of mice, rats and hamsters to subchronic inhalation of ultrafine TiO2 particles. Toxicol. Sci. 2004; 77: 347–357
   PubMed Web of Science ®Google Scholar
• BfR. Bundesamt für Risikobewertung. Berlin, Germany. 2006, Nanotechnologie und Lichtschutz (Nanotechnology and UV Protection), 24 February, 2006. At http://www.bfr.bund.de
   Google Scholar
• Blundell G., Henderson H. J., Price E. W. Soil particles in the tissues of the foot in endemic elephantiasis of the lower legs. Ann. Trop. Med. Parasitol. 1989; 83: 381–385
   PubMed Web of Science ®Google Scholar
• Borm P. J.A., Robbins D., Haubold S., Kuhlbusch T., Fissan H., Donaldson K., Schins R. P.F., Stone V., Kreyling W., Lademann J., Krutmann J., Warheit D., Oberdörster E. The potential risks of nanomaterials: A review conducted out for ECETOC. Particle Fibre Toxicol. 2006; 3(11), (in press). Doi: 10.1186/1743-8977-3-11.
   PubMedGoogle Scholar
• Breme H. J., Helsen J. A. Metals and Implants. Metals as Biomaterials, H.J. Breme. Wiley, Chichester 1998; 37–72
   Google Scholar
• Brown D. M., Wilson M. R., MacNee W., Stone V., Donaldson K. Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol. Appl. Pharmacol. 2001; 175: 191–199
   PubMed Web of Science ®Google Scholar
• Brown M. B., Martin G. P., Jones S. A., Akomeah F. K. Dermal and transdermal drug delivery systems: Current and future prospects. Drug Deliv. 2006; 13(3)175–187
   PubMed Web of Science ®Google Scholar
• Brunke R. A., Charlet E. Production and identification of liposomes, sphingosomes and nanoparticles. Kosmetika, Aerosole Parfümerie 1991; 64(14)514–517
   Google Scholar
• Cai R., Hashimoto K., Itoh K., Kubota Y., Fujishima A. Photo-killing of malignant cells with ultrafine TiO2 powder. Bull. Chem. Soc. Jpn. 1991; 64: 1268–1273
   Web of Science ®Google Scholar
• Castor T. P. Phospholipid nanosomes. Curr. Drug Deliv. 2005; 2(4)329–340
   PubMedGoogle Scholar
• Chen Y., Chen J., Dong J., Jin Y. X. Comparing study of the effect of nanosized silicon dioxide and microsized silicon dioxide on fibrogenensis in rats. Toxicol. Ind. Health 2004; 20: 21–27
   PubMed Web of Science ®Google Scholar
• Choi M. J., Maibach H. I. Liposomes and niosomes as topical drug delivery systems. Skin Pharmacol. Physiol. 2005; 18: 209–219
   PubMed Web of Science ®Google Scholar
• Choi M. G., Koh H. S., Kuess D., O'Connor D., Mathur A., Truskey G. A., Rubin J., Zhou D. X., Sung K. L. Effects of titanium particle size on osteoblast functions in vitro and in vivo. Proc. Natl. Acad. Sci. USA 2005; 102(12)4578–4583
   PubMed Web of Science ®Google Scholar
• Corachan M., Tura J. M., Campo E., Soley M., Traveria A. Podoconiosis in Aequatorial Guinea. Report of two cases from different geological environments. Top. Geogr. Med. 1988; 40: 359–364
   PubMedGoogle Scholar
• Cormier M., Trautman J., Kim H. L. 2001, Skin treatment apparatus for sustained transdermal drug delivery. USP WO 01/41864 A1.
   Google Scholar
• Crichton M. Prey. Harper Collins, New York 2001
   Google Scholar
• Cross S. E., Innes B., Roberts M. S., Tsuzuki T., Robertson T. A., McCormick P. Human skin penetration of sunscreen nanoparticles: In vitro assessment of a novel micronised zinc oxide formulation. Skin Pharmacol. Physiol. 2007, (in press)
   PubMed Web of Science ®Google Scholar
• CSTEE. EU Scientific Committee on Toxicity, Ecotoxicity and the Environment. 2003, Opinion on the risk assessment of zinc metal, zinc chloride, sulphate, distearate, phosphate and zinc oxide. Adopted by the CSTEE during the 39th plenary meeting, 10 September 2003. Available at: http://europa.eu.int/comm/health
   Google Scholar
• Diembeck W., Beck H., Benech-Kieffer F., Courtellement P., Dupuis J., Lovell W., Paye M., Spengler J., Steiling W. Test guidelines for in vitro assessment of dermal absorption and percutaneous penetration of cosmetic ingredients. Food Chem. Toxicol. 1999; 37: 191–205
   PubMed Web of Science ®Google Scholar
• Drexler E. Engines of Abundance, Engines of Creation 1986, Details of the Grey Goo Theory at: http://www.greenlibdems.org.uk/articles/8.html
   Google Scholar
• Dufour E. K., Kumaravel T, Nohynek G. J., Kirkland D., Toutain H. Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity? Genotoxic effects of ZnO in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cells. Mutat. Res. 2006; 607: 215–224
   PubMed Web of Science ®Google Scholar
• Du Plessis J., Ramachandran C., Weiner N., Müller D. G. The influence of particle size of liposomes on the deposition of drug into skin. Int. J. Pharm. 1994; 103: 277–282
   Web of Science ®Google Scholar
• Dussert A. S., Gooris E. Characterisation of the mineral content of a physical sunscreen emulsion and its distribution onto human stratum corneum. Int. J. Cosmet. Sci. 1997; 19: 119–129
   PubMedGoogle Scholar
• ECETOC. Contact sensitisation: classification according to potency. 2003, Technical Report No. 87, ECETOC, Brussels, Belgium, April 2003. Available at: http://www.ecetoc.org
   Google Scholar
• ECETOC. Workshop on the testing strategies to establish the safety of nanomaterials. 2005, Barcelona, Spain. 7–8 November, 2005. Workshop Report No. 7. Available at: http://www.ecetoc.org
   Google Scholar
• El Maghraby G.M., Williams A. C., Barry B. W. Can drug-bearing liposomes penetrate intact skin?. J. Pharm. Pharmacol. 2006; 58(4)415–429
   PubMed Web of Science ®Google Scholar
• FOE. Friends of the Earth. Nanomaterials, sunscreens and cosmetics: Small Ingredients, Big Risks. 2006a, May. Available at: http://www.foe.org
   Google Scholar
• FOE. Nanoparticles in sunscreens stress brain cells. 2006b, Available at: http://www.foe.org
   Google Scholar
• Gamer A., Leibold E., van Ravenzwaay B. The in vitroabsorption of microfine ZnO and TiO2 through porcine skin. Toxicol. In Vitro 2006; 20(3)301–307
   PubMed Web of Science ®Google Scholar
• Ganesan M., Weiner N. Influence of liposomal drug entrapment on percutaneous absorption. Int. J. Pharm. 1984; 20: 134–154
   Google Scholar
• Garnett M. C., Kallinteri P. Nanomedicines and nanotoxicology: some physiological principles. Occup. Med. 2006; 56(5)307–311
   Google Scholar
• Geiser M., Rothen-Rutishauser B., Kapp N., Schürch S., Kreyling W., Schulz H., Semmler M., Imhof V., Gehr P. Ultrafine particles cross cellular membranes by non-phagocytotic mechanisms in lungs and in cultured cells. Environ. Health Perspect. 2005; 113(11)1555–1560
   PubMed Web of Science ®Google Scholar
• Gontier E., Habchi C., Pouthier T., Aguer P., Barberet P., Barbotteau Y., Incerti S., Ynsa M. D., Surleve-Bazeille J.E., Moretto P. Nuclear microscopy and electron microscopy studies of percutaneous penetration of nanoparticles in mammalian skin. 34th EDSR Meeting 2004, Abstract 64.
   Google Scholar
• Gopee N. V., Roberts D. W., Webb P., Cozart C., Siitonen P., Warbritton A. R., Walker N. J., Yu W. W., Colvin V. L., Howard P. C. Penetration of nanoscale quantum dots in dermabraded mouse skin. 2006, 2006 FDA Science Forum, Abstract B-38, 27 March. At: http://www.cfsan.fda.gov
   Google Scholar
• Görög P., Pearson J. D., Kakkar V. V. Generation of reactive oxygen metabolites by phagocytosing endothelial cells. Artherosclerosis 1988; 72(1)19–27
   PubMed Web of Science ®Google Scholar
• Gottbrath S., Mueller-Goymann C.C. Penetration and visualisation of titanium dioxide microparticles in human stratum corneum—Effect of different formulations on the penetration of titanium dioxide. SOFW J 2004; 129: 11–14, 16–17. Abstract No 64, 34th European Dermatological research Meeting, Vienna, Austria, 9–11, September, 2004
   Google Scholar
• Greenpeace. Future Technologies, Today's Choices. 2003, July 2003. At http://www.greenpeace.org.uk
   Google Scholar
• Gunther C., Kecskes S., Staks T., Tauber U. Percutaneous absorption of methylprednisolone aceponate following topical application of Avantan lotion on intact, inflamed and stripped skin of male volunteers. Skin Pharmacol. Appl. Skin Physiol. 1998; 11(1)35–42
   PubMedGoogle Scholar
• Gurr J. R., Wang A. S.S., Chen C. H., Jan K. Y. Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchila epithelial cells. Toxicology 2005; 213: 66–73
   PubMed Web of Science ®Google Scholar
• Hardman R. A toxicologic review of quantum dots: Toxicity depends on physicochemical and environmental factors. Environ. Health Perspect. 2006; 114: 165–172
   PubMed Web of Science ®Google Scholar
• Hexte P. M., Tomenson J. A., Thompson P. A. Titanium dioxide: Inhalation toxicity and epidemiology. Ann. Occup. Hyg. 2005; 49(6)461–472
   PubMedGoogle Scholar
• Hirakawa K., Bauer T. W., Stulberg B. N., Wilde A. H. Comparison and quantification of wear debris of failed total hip and knee arthroplasty. J. Biomed. Mater. Res. 1996; 31: 257–263
   PubMed Web of Science ®Google Scholar
• Hoet P. H.M., Brüske-Hohlfeld I., Sata O. V. Nanoparticles—Known and unknown health risks. J. Nanotechnol. 2004; 2(12)1–15
   Google Scholar
• Honeywell-Nguyen P. L., Gooris G. S., Bouwstra J. A. Quantitative assessment of the transport of elastic and rigid vesicle components and a model drug from these vesicle formulations into human skin in vivo. J. Invest. Dermatol. 2004; 123(5)902–910
   PubMed Web of Science ®Google Scholar
• Hostynek J. J. Factors determining percutaneous metal absorption. Food Chem. Toxicol. 2003; 41: 327–345
   PubMed Web of Science ®Google Scholar
• Hussain S. M., Hess K. L., Gearhart J. M., Geiss K. T., Schlager J. J. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol. In Vitro 2005; 19(7)975–983
   PubMed Web of Science ®Google Scholar
• ICH. International Conference on Harmonisation. 1996, ICH Topic S2A. Genotoxicity: Guidance on specific aspects of regulatory genotoxicity tests for pharmaceuticals. 1 April, 1996. At: http://www.emea.eu.int
   Google Scholar
• ICH. Notes for Guidance on Repeated Dose Toxicity. 2000, CPMP (Committee for Proprietary Medicinal Products). EMEA, London, 27 July. At http://www.emea.eu.int
   Google Scholar
• ICTA. International Center of Technology Assessment. 2006, Legal Petition on FDA's Regulation of Nanoparticles and Nanomaterials Production. FDA Docket No. 2006P-0210/CP 1, 2006. At: http://www.icta.org/nanotech
   Google Scholar
• ILSI. The relevance of the rat lung response to particle overload for human risk assessment: A workshop consensus report. Inhal. Toxicol. 2000; 12: 1–17
   Web of Science ®Google Scholar
• IRSST. Institute de recherche Robert-Sauvé en santé et sécurité du travail. 2006, Health Effects of Nanoparticles. Report R-451. Montréal, Quebec, Canada. Available at http://www.irsst.qc.ca
   Google Scholar
• Jani P. U., McCarthy D.E., Florence A. T. Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administrations. Int. J. Pharm. 1994; 105: 157–168
   Web of Science ®Google Scholar
• Jowsey I. R., Basketter D. A., Westmoreland C., Kimber I. A future approach to measuring relative skin sensitising potential: A proposal. J. Appl. Toxicol. 2006; 26(4)341–350
   PubMed Web of Science ®Google Scholar
• Junginger H. E., Hofland H. E.J., Bouwstra J. A. Liposomes and niosomes: Interactions with human skin. Cosm. Toiletries 1991; 106: 45–50
   Google Scholar
• Kim. S., Lim Y. T., Soltesz E. G., De Grand A.M., Lee J., Nakayama A., Parker J. A., Mihaljevic T., Laurence R. G., Dor D. M., Cohn L. H., Bawendi M. G., Frangioni J. V. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat. Biotechnol. 2004; 22: 93–97
   PubMed Web of Science ®Google Scholar
• Kimber I., Basketter D. A., Butler M., Garrigue J. L., Gerberick G. F., Newsome C., Steiling W., Vohr H. W. Classification of contact allergens according to potency: Proposals. Food Chem. Toxicol. 2003; 41(12)1799–1809
   PubMed Web of Science ®Google Scholar
• Kogan A., Garti N. Microemulsions as transdermal drug delivery vehicles. Adv. Coll. Interface Sci. 2006, in press. Advance electronic copy at: http://www.sciencedirect.com/science/journals/ (doi: 10.1016/j.cis.2006.05.014).
   PubMed Web of Science ®Google Scholar
• Kohli A. K., Alpar. H.O. Potential use of nanoparticles for transcutaneous vaccine delivery: Effect of particle size and charge. Int. J. Pharm 2004; 275: 13–17
   PubMed Web of Science ®Google Scholar
• Korting H. C., Zienecke H., Schäfer-Korting M., Braun-Falco O. Liposome encapsulation improves efficacy of betamethasone dipropionate in atopic eczema but not in psoriasis vulgaris. Eur. J. Clin. Pharmacol. 1990; 39(4)349–351
   PubMed Web of Science ®Google Scholar
• Korting H. C., Schmid M. H., Hartinger A., Maierhofer G., Stolz W., Braun-Falco O. Evidence for the phagocytosis of intact oligomellar liposomes by human keratinocytes in vitro and consecutive intracellular disintegration. J. Microencapsul. 1993; 10: 223–228
   PubMed Web of Science ®Google Scholar
• Kreilgard M. Influence of microemulsions on cutaneous drug delivery. Adv. Drug Deliv. Rev. 2002; 54(Suppl. 1)s77–s98
   Google Scholar
• Kurath M., Maasen S. Toxicology as a nanoscience?—Disciplinary identities reconsidered. Particle Fibre Toxicol. 2006; 3: 6, 2006. Available at: http://www.particleandfibretoxicology.com
   PubMed Web of Science ®Google Scholar
• Lademann J., Weigmann H. J., Rickmeier C. H., Barthelmes H., Schaefer H., Mueller G., Sterry W. Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol. Appl. Skin Physiol. 1999; 2: 247–256
   Google Scholar
• Lademann J., Otberg N., Richter H., Weigmann H. J., Lindemann U., Schaefer H., Sterry W. Investigation of folllicular penetration of topically applied substances. Skin Pharmacol. Appl. Skin Physiol. 2001; 14(Suppl. 1)17–22
   PubMedGoogle Scholar
• Lademann J., Richter H., Otberg N., Lawrenz F., Blume-Peytavi U., Sterry W. Application of a dermatological laser scanning confocal microscope for investigation in skin physiology. J. Laser Phys. 2003; 3: 46–51
   Google Scholar
• Lademann J., Richter H., Schaefer U. F., Blume-Peytavi U., Teichmann A., Otberg N., Sterry W. Hair follicles—a long term reservoir for drug delivery. Skin Pharmacol. Physiol. 2007, 2006, in press
   Web of Science ®Google Scholar
• Lam C. W., James J. T., McCluskey R., Arepalli S., Hunter R. L. A review of carbon nanotubes toxicity and assessment of potential occupational and environmental health risks. Crit. Rev. Toxicol. 2006; 36: 189–217
   PubMed Web of Science ®Google Scholar
• Landsdown A.B.G., Taylor A. Zinc and titanium oxides: Promising UV-absorbers, but what influence do they have on the intact skin?. Int. J. Cosm. Sci. 1997; 19: 167–172
   PubMedGoogle Scholar
• Lee K. P., Trochimowicz H. J., Reinhardt C. F. Pulmonary response of rats exposed for to titanium dioxide by inhalation for two years. Toxicol. Appl. Pharmacol. 1985; 79: 179–192
   PubMed Web of Science ®Google Scholar
• Limbach L.K., Li Y., Grass R. N., Brunner T. J., Hintermann M. A., Müller M., Gunther D., Stark W. J. Oxide nanoparticle uptake in human lung fibroblasts: Effects of particle size, agglomeration, and diffusion at low concentrations. Environ. Sci. Technol. 2005; 39: 9370–9376
   PubMed Web of Science ®Google Scholar
• Lipinski C.A., Lombardo F., Dominy B. W., Feeney P. J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev 2001; 46((1–3))3–26
   PubMed Web of Science ®Google Scholar
• Long T. C., Saleh N., Tilton R. D., Lowry G. V., Veronesi B. Titanium dioxide (P25) produces reactive oxygen species in immortalize microglia (BV2): implications for nanoparticles neurotoxicity. Environ. Sci. Technol. 2007, in press
   Web of Science ®Google Scholar
• Lopez C. Focus on the supramolecular structure of milk fat in dairy products. Reprod. Nutr. Develop. 2005; 45: 497–511
   PubMedGoogle Scholar
• Luengo J., Weiss B., Schneider M., Ehlers A, Stracke F., Konig K., Kostka K. H., Lehr C. M., Schaefer U. F. Influence of nanoencapsulation on human skin transport of flufenamic acid. Skin Pharmacol. Physiol. 2006; 19(4)190–197
   PubMed Web of Science ®Google Scholar
• Magnusson B. M., Walters K. A., Roberts M. S. Veterinary drug delivery: Potential for skin penetration enhancement. Adv. Drug. Deliv. Rev. 2001; 50(3)205–27
   PubMed Web of Science ®Google Scholar
• Magnusson B. M., Anissimov Y. G., Cross S. E., Roberts M. S. Molecular size as the main determinant of solute maximum flux across the skin. J. Invest. Dermatol. 2004; 122(4)993–999
   PubMed Web of Science ®Google Scholar
• Maita K., Hirano M., Mitsumori K., Takahashi K., Shirasu Y. Subacute toxicity studies with zinc sulfate in mice and rats. J. Pestic. Sci. 1981; 6: 327–336
   Web of Science ®Google Scholar
• Mavon A., Miquel C., Lejeune O., Payre B., Moretto P. In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen. Skin. Pharmacol. Physiol 2007; 20: 10–20
   PubMed Web of Science ®Google Scholar
• Maynard A. D. Nanotechnology: a Research Strategy for Addressing Risk. Project on Emerging Nanotechnologies. 2006, Woodrow Wilson International Center for Scholars, June 2006. At: http://www.nanotechproject.org/file_download/77
   Google Scholar
• Menzel F., Reinet T., Vogt J., Butz T. Investigations of percutaneous uptake of ultrafine TiO2 particles at the high energy ion nanoprobe LIPSION. Nucl. Instr. Meth. Phys. Res. B. 2004; 219–220: 82–86
   Web of Science ®Google Scholar
• Moghimi S. M., Hunter A. C., Murray J. C. Long-circulating and target-specific nanoparticles: Theory to practice. Pharmacol. Rev. 2001; 53(2)283–318
   PubMed Web of Science ®Google Scholar
• Monteiro-Riviere N.A., Nemanich R. J., Inman A. O., Wang Y., Riviere J. E. Multi-wall carbon nanotube interactions with human epidermal keratinocytes. Toxicol. Lett. 2005a; 155: 377–384
   PubMed Web of Science ®Google Scholar
• Monteiro-Riviere N. A., Inman A. O., Wang Y. Y., Nemanich R. J. Surfactant effects on carbon nanotube interactions with human keratinocytes. Nanomed. Nanotech. Biol. Med. 2005b; 1: 2993–2999
   Web of Science ®Google Scholar
• Monteiro-Riviere N. A., Inman A. O. Challenges for assessing carbon nanomaterial toxicity to the skin. Carbon 2006; 44: 1070–1078
   Web of Science ®Google Scholar
• Mudway I. S., Duggan S. T., Vekataraman C., Habib G., Kelly F. J., Grigg J. Combustion of dried animal dung as biofuel results in the generation of highly redox-active particulates. Particul. Fibre Toxicol. 2005; 2(6)1–11
   PubMedGoogle Scholar
• Nakagawa Y., Wakuri S., Sakamoto K., Tanaka N. The photogenotoxicity of titanium dioxide particles. Mut. Res. 1997; 394: 125–132
   PubMed Web of Science ®Google Scholar
• NCI. US National Cancer Institute Bioassay on titanium dioxide for possible carcinogenicity. Natl. Cancer Inst. Tech. Rep. Ser. 1979; 97: 1–117
   Google Scholar
• Nel A., Xia T., Mädler L., Ning L. Toxic potential of materials at the nanolevel. Science 2006; 311: 622–627
   PubMed Web of Science ®Google Scholar
• Niki E., Yoshida Y., Saito Y., Noguchi N. Lipid peroxidation: mechanisms, inhibition and biological effects. Biochem. Biophys. Res. Commun. 2005; 338: 668–676
   PubMed Web of Science ®Google Scholar
• Nohynek G. J., Schaefer H. Benefit and risk of organic ultraviolet filters. Regul. Toxicol. Pharmacol. 2001; 33: 285–291
   PubMed Web of Science ®Google Scholar
• NTP/NIEHS. Developing Experimental Approaches for the Evaluation of Toxicological Interactions of Nanoscale Materials. 2004, Gainesville, FL, November 3–4, 2004. At: http://www.nanotoxicology.ufl.edu/workshop/images/NanoToxWorkshop.pdf
   Google Scholar
• Oberdörster G., Oberdörster E., Oberdörster J. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 2005a; 113: 823–839
   PubMed Web of Science ®Google Scholar
• Oberdörster G., Maynard A., Donaldson K., Castranova V., Fitzpatrick J., Ausman K., Carter J., Karn B., Kreyling W., Lai D., Olin S., Monteiro-Riviere N., Warheit D., Yang H. Principles for characterisation the potential human health effects from exposure to nanomaterials: Elements of a screening strategy. Particul. Fibre Toxicol. 2005b; 2(8)1–35
   PubMed Web of Science ®Google Scholar
• Olivier V., Duval J. L., Hindie M., Poukletaut P., Nagel M. D. Comparative particle-induced cytotoxicity towards macrophages and fibroblasts. Cell Biol. Toxicol. 2003; 19: 145–159
   PubMed Web of Science ®Google Scholar
• Olson D. A., Burke J. M. Distributions of PM2.5 source strengths for cooking from the Research Triangle Park particulate matter panel study. Environ. Sci. Technol. 2006; 40(1)163–169
   PubMed Web of Science ®Google Scholar
• Otberg N., Richter H., Knuttel A., Schaefer H., Sterry W, Lademann J. Laser spectroscopic methods for the characterization of open and closed follicles. J. Laser Phys. 2004; 1(1)46–49
   Web of Science ®Google Scholar
• Padamwar M. N., Pokharkar V. B. Development of vitamin loaded liposomal formulations using factorial design approach: Drug deposition and stability. Int. J. Pharm. 2006; 320: 37–44
   PubMed Web of Science ®Google Scholar
• Paliwal. S., Menon G. K., Mitragotri S. Low-frequency sonophoresis: Ultrastructural basis for stratum corneum permeability assessed using quantum dots. J. Invest. Dermatol. 2006; 126: 1095–1101
   PubMed Web of Science ®Google Scholar
• Pflücker F., Wendel V., Hohenberg H., Gärtner E., Witt T., Pfeiffer S., Wepf R., Gers-Berlag H. The human stratum corneum layer: An effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide. Skin Pharm. Appl. Skin Physiol. 2001; 14(Suppl.1)92–97
   PubMedGoogle Scholar
• Pirot F., Millet J., Kalia Y. N., Humbert P. In vitro study of percutaneous absorption, cutaneous bioavailability and bioequivalence of zinc and copper from five topical formulations. Skin Pharmacol. 1996; 9(4)259–269
   PubMedGoogle Scholar
• Pogoda J., Preston-Martin S. Solar radiation, lip protection, and lip cancer risk in Los Angeles County women (California, United States). Cancer Causes Control 1996; 7(4)458–463
   PubMed Web of Science ®Google Scholar
• Popov A. P., Lademann J., Priezzhev A. V., Myllylä R. Effect of size of TiO2 nanoparticles embedded into stratum corneum on ultraviolet-A and ultraviolet-B sun-blocking properties of the skin. J. Biomed. Optics 2005; 10(6)1–9
   Web of Science ®Google Scholar
• Potts R. O., Guy R. H. Predicting skin permeability. Pharm. Res. 1992; 9(5)663–669
   PubMed Web of Science ®Google Scholar
• Roberts M. S. The latest science (including safety) on nanotechnology and skin penetration. CTFA/FDA Nanotechnology Public Meeting. 2006, Washington, D.C., September 2006. Available at: http://www.ctfa.org
   Google Scholar
• Royal Society and Royal Academy of Engineering. Nanoscience and nanotechnologies, opportunities and uncertainties. 2004, Available at: http://www.royalsoc.ac.uk/policy/
   Google Scholar
• Ryman-Rasmussen J. P., Riviere J. E., Monteiro-Riviere N.A. Surface coatings determine cytotoxicity and irritation potential of quantum dot nanoparticles in epidermal keratinocytes. J. Invest. Dermatol. 2007; 127(1)143–153
   PubMed Web of Science ®Google Scholar
• Ryman-Rasmussen J. P., Riviere J. E., Monteiro-Riviere N.A. Penetration of intact skin by quantum dots with diverse physicochemical properties. Toxicol. Sci. 2006; 91(1)159–165
   PubMed Web of Science ®Google Scholar
• Santos M. C., Mehnert W., Schaller M., Korting M. C., Gysier A., Haberland A., Schäfer-Korting M. Drug targeting by solid lipid nanoparticles for dermal use. J. Drug Target. 2002; 10(6)489–495
   PubMed Web of Science ®Google Scholar
• Sayes C. M., Warheit D. B., Austman K. D., Colvin V. I. Nano-TiO2 anatase vs. rutile particles: a cytotoxicity and inflammatory response study with human dermal fibroblasts and lung epithelial cells. Toxicologist 2006; 90(1)318
   Google Scholar
• SCCNFP. Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers Concerning Titanium Dioxide. 2000, 24 October, 2000, European Commission, Brussels, Belgium. At: http://ec.europa.eu/health/ph_risk/committees/04_sccp/04_sccp_en.htm
   Google Scholar
• SCCNFP. 2003a, Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers concerning Zinc Oxide COLIPA No. S 76. 24–25 June, 2003. European Commission, Brussels, Belgium. At: http://ec.europa.eu/health/ph_risk/committees/04_sccp/04_sccp_en.htm
   Google Scholar
• SCCNFP. 2003b, Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. Notes of Guidance for the testing of cosmetic ingredients and their safety evaluation. 5th revision. 20 October, 2003. European Commission, Brussels, Belgium. At: http://ec.europa.eu/health/ph_risk/committees/04_sccp/04_sccp_en.htm
   Google Scholar
• Schäfer-Korting M., Korting H. C., Ponce-Paschal E. Liposomal tretinoin for uncomplicated acne vulgaris. Clin. Invest. 1994; 72(12)1086–1091
   PubMedGoogle Scholar
• Schaefer H., Redelmeier T. E. In vivo measurements of percutaneous absorption. Skin Barrier—Principles of Percutaneous Absorption, H. Schaefer, T.E. Redelmeier. S. Karger AG, BaselSwitzerland 1996; 120–129
   Google Scholar
• Schaefer H., Redelmaier T., Nohynek G. J. Pharmacokinetics and topical application of drugs. Fitzpatrick's Dermatology in General Medicine, I.M. Freedberg, A.Z. Eisen, K. Wolff, F.K. Austen, L.A. Goldsmith, S.I. Katz. MacGraw-Hill, New York 2003; 2313–2318
   Google Scholar
• SCENIHR. 2005, EU Scientific Committee on Emerging and Newly Identified Health Risks. Opinion on the appropriateness of existing methodologies to assess the potential risks associated with engineered and adventitious products of nanotechnologies. European Commission, Health and Consumer Protection, Directorate General, 28–29 September, 2005. At: http://ec.europa.eu/health/ph_risk/committees/04_scenihr/
   Google Scholar
• Schilling M., Besselmann M., Müller M., Strecker M., Ringelstein E. B., Kiefer R. Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: An investigation using green fluorescent protein transgenic bone marrow chimeric mice. Experim. Neurol. 2005; 196(2)209–297
   Web of Science ®Google Scholar
• Shim. J., Seok Kang H., Park W. S., Han S. H., Kim J., Chang I. S. Transdermal delivery of minoxidil with block copolymer nanoparticles. J. Controlled Release 2004; 97(3)477–484
   PubMed Web of Science ®Google Scholar
• Schins R. P. Mechanism of genotoxicity of particles and fibres. Inhal. Toxicol. 2002; 14(1)57–78
   PubMed Web of Science ®Google Scholar
• Schreier H., Bouwstra J. A. Liposomes and niosomes as topical drug carriers: Dermal and transdermal drug delivery. Int. J. Pharm. 1994; 30: 1–15
   Google Scholar
• Schulz J., Hohenberg F., Pflücker F., Gärtner B., Will T., Pfeiffer S., Wepf R., Wendel V., Gers-Berlag H., Wittern K. P. Distribution of sunscreens on skin. Adv. Drug Deliv. Rev. 2002; 54(Suppl. 1)S157–S163
   PubMed Web of Science ®Google Scholar
• Serpone N., Salinaro A., Emeline A. V. Deleterious effects of sunscreen titanium dioxide nanoparticles on DNA: Efforts to limit DNA damage by particle surface modification. Proc. SPIE 2001; 4258: 86–98
   Google Scholar
• Shvedova A.A., Castranova V., Kisin E. R., Schwegler-Berry D., Murray A. R., Gandelsmann V. Z., Maynard A., Baron P. Z. Exposure to carbon nanotube material: Assessment of nanotube cytotoxicity using human keratinocyte cells. J. Toxicol Environ. Health A 2003; 66(20)1909–1926
   PubMed Web of Science ®Google Scholar
• Sinico C., Manconi M., Peppi M., Lai F., Valenti D., Fadda A. M. Liposomes as carriers for dermal delivery of tretinoin: In vitro evaluation of drug permeation and vesicle–skin interaction. J. Controlled Release 2005; 103: 123–136
   PubMed Web of Science ®Google Scholar
• Sonneville-Aubrun O., Simonnet J. T., L'Alloret F. Nanoemulsions: A new vehicle for skincare products. Adv. Colloid. Interface Sci. 2004; 108/109: 145–149
   Web of Science ®Google Scholar
• Stefanidou M., Maravelias C., Dona A. Zinc: A multi-purpose trace element. Arch. Toxicol. 2006; 80: 1–9
   PubMed Web of Science ®Google Scholar
• Stracke F., Weiss B., Lehr C. M., Konig K., Schaefer U. F., Schneider M. Multiphoton microscopy for the investigation of dermal penetration of nanoparticle-borne drugs. J. Invest. Dermatol. 2006; 126(10)2224–2233
   PubMed Web of Science ®Google Scholar
• Surber C., Wilhelm K. P., Hori M., Maibach H. I., Guy R. H. Optimization of topical therapy; Partitioning of drugs into stratum corneum. Pharm. Res. 1990; 7(12)1320–1324
   PubMed Web of Science ®Google Scholar
• Tan M. H., Commens C. A., Burnett L., Snitch P. A pilot study on the percutaneous absorption of microfine titanium dioxide from sunscreens. Austr. J. Dermatol. 1996; 37: 185–187
   PubMedGoogle Scholar
• Teichmann A., Ossadnik M., Richter H., Sterry W., Lademann J. Semiquantitative determination of the penetration of a fluorescent hydrogel formulation into the hair follicle with and without follicular closure by microparticles by means of differential stripping. Skin Pharmacol. Physiol. 2006; 9(2)101–105
   Google Scholar
• Telegraph. 2003, Spare us all from royal nanoangest—Roger Highfield reports on the Prince's distaste for Grey Goo 30 April, 2003. At: http://www.telegraph.co.uk/
   Google Scholar
• TGA. 2006, Therapeutics Goods Administration, Australia. A review of the scientific literature on the safety of nanoparticles titanium dioxide or zinc oxide in sunscreens. 2nd February 2006. At: http://www.tga.gov.au
   Google Scholar
• Thomas B. J., Finnin B. C. The transdermal revolution. Drug Discovery Today 2004; 9(14)697–703
   PubMedGoogle Scholar
• Tinkle S.S, Antonini J. M., Rich B. A., Roberts J. R., Salmen R., DePree K., Adkins E. J. Skin as a route of exposure and sensitisation in chronic beryllium disease. Environ. Health Perspect. 2003; 111(9)1202–1208
   PubMed Web of Science ®Google Scholar
• Toll R., Jacobi U., Richter H., Lademann J., Schaefer H., Blume-Peytavi U. Penetration profile of microspheres in follicular targeting of terminal hair follicles. J. Invest. Dermatol. 2004; 123: 168–176
   PubMed Web of Science ®Google Scholar
• Tsuji J. S., Maynard A. D., Howard P. C., James J. T., Lam C. W., Warheit D. B., Santamaria A. B. Research strategies for safety evaluation of nanomaterials, Part IV: Risk assessment of nanoparticles. Toxicol. Sci. 2006; 89: 42–50
   PubMed Web of Science ®Google Scholar
• Upadhyay P. Enhanced transdermal-immunization with diptheria-toxoid using local hyperthermia. Vaccine 2006; 24: 5593–5598
   PubMed Web of Science ®Google Scholar
• U.S. Environmental Prrotection Agency. Nanotechnology Workgroup / EPA's Science Policy Council. 2005a, Nanotechnology White Paper, 68–70, December 2, 2005. At: http://www.epa.gov/OSA/pdfs/EPA_nanotechnology_white_paper_external_review_draft_12-02-2005.pdf
   Google Scholar
• U.S. Environmental Protection Agency. Toxicological review of zinc and compounds. 2005b, EPA/635/R-05/002. Available at: http://www.epa.gov/iris/toxreviews/
   Google Scholar
• Van d en Bergh B.A.I., Vroom J., Gerritsen H., Junginger H. E., Bouwstra J. A. Interactions of elastic and rigid vesicles with human skin in vitro: Electron microscopy and two-photon excitation microscopy. Biochim. Biophys. Acta 1999; 1461: 155–173
   PubMed Web of Science ®Google Scholar
• Verma D. D., Verma S., Blume G., Fahr A. Particle size of liposomes influences dermal delivery of substances into the skin. Int. J. Pharm. 2003; 258: 141–151
   PubMed Web of Science ®Google Scholar
• Walker S. L., Hawk J.L.M, Young A. R. Acute and chronic effects of ultraviolet radiation on the skin. Fitzpatrick's Dermatology in General Medicine 6th, I.M. Freedberg, A.Z. Eisen, K. Wolff, F.K. Austen, L.A. Goldsmith, S.I. Katz. McGraw-Hill, New York 2003; 1275–1282
   Google Scholar
• Wallace L., Howard-Reed C. Continuous monitoring of ultrafine, fine and coarse particles in a residence for 18 months in 1999–2000. J. Air Waste Manage. Assoc. 2002; 52: 828–844
   Web of Science ®Google Scholar
• Walter P., Welcomme E., Hallegot P., Zaluzec N., Deeb C., Castaing J., Veyssière P., Breniaux R., Leveque J. L., Tsoucaris G. Early use of nanotechnology for an ancient hair dyeing formula. Nano Lett. 2006, Electronic pre-publication, DOI: 10.1021/nl6149u
   Web of Science ®Google Scholar
• Walters K.A., Roberts M. S. Veterinary applications of skin penetration enhancers. Skin Penetration Enhancement., K.A. Walters, J. Hadgraft. Marcel Dekker, New York 1993; 331–350
   Google Scholar
• Warheit D. B., Laurence B. R., Reed K. L., Roach D. H., Reynolds G. A.M., Webb T. R. Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol. Sci. 2004; 77(1)117–125
   PubMed Web of Science ®Google Scholar
• Warheit D. B., Webbs T. R., Sayes C. M., Colvin V. L., Reed K. L. Pulmonary instillation studies with nanoscale TiO2, rods and dots in rats: Toxicity is not dependent upon particle size and surface area. Toxicol. Sci. 2006; 91(1)227–236
   PubMed Web of Science ®Google Scholar
• Wei A. L., Meng Z. Q. Induction of chromosome aberrations in cultured human lymphocytes treated with sand dust storm fine particles (PM2.5). Toxicol. Lett. 2006; 166(1)37–43, Pre-publication at: http://www.sciencedirect.com/science/journals/
   PubMed Web of Science ®Google Scholar
• Weigmann H. J., Lademann J., Meffert H., Schaefer H., Sterry W. Determination of the horny layer profile by tape stripping in combination with optical spectroscopy in the visible range as a prerequisite to quantify percutaneous absorption. Skin Pharmacol. Appl. Skin Physiol. 1999; 12: 34–45
   PubMedGoogle Scholar
• WHO 1998, INTERSUN, The Global UV Project, Protection Against Exposure to Ultraviolet Radiation, World Health Organisation, Geneva, Switzerland. At: http://www.who.org
   Google Scholar
• Wiebert P., Sanchez-Crespo A., Seitz J., Falk R., Philipson K., Kreyling W. G., Moeller W., Sommerer K., Larsson S., Svartengren M. Negligible clearance of ultrafine particles retained in healthy and affected human lungs. Eur. Respir. J. 2006a; 28(2)286–290
   PubMed Web of Science ®Google Scholar
• Wiebert P., Sanchez-Crespo A., Falk R., Philipson K., Lundlin A., Larsson S., Moeller W., Kreyling W. G., Svartengren M. No significant translocation of inhaled 35-nm carbon particles to the circulation in humans. Inhal. Toxicol. 2006b; 18(10)741–747
   PubMed Web of Science ®Google Scholar
• Wissing S. A., Müller R. H. Cosmetic applications for solid lipid nanoparticles (SLN). Int. J. Pharm. 2003; 254(1)65–68
   PubMed Web of Science ®Google Scholar
• Yamamoto A., Honma R., Sumita M., Hanawa K. Cytotoxicity evaluation of ceramic particles of different sizes and shapes. J. Biomed. Mater. Res. 2004; 68A: 244–256
   Web of Science ®Google Scholar
• Yoshikawa S. Biological response to a foreign body. J. Jpn. Soc. Biomater. 1991; 9: 94–103
   Google Scholar
• Yu H. Y., Liao H. M. Triamcinolone permeation from different liposome formulations through rat skin in vitro. Int. J. Pharm. 1996; 127: 1–7
   Web of Science ®Google Scholar
• Zhai H., Maibach H. I. Effects of occlusion on percutaneous absorption. Skin Pharmacol. Appl. Skin Physiol. 2001; 14: 1–10
   PubMedGoogle Scholar
• Zhang Y., So M. K., Rao J. Protease-modulated cellular uptake of quantum dots. Nano. Lett. 2006; 6: 1988–1992
   PubMed Web of Science ®Google Scholar