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Research Article

The Debate on Carcinogenicity of Permanent Hair Dyes: New Insights

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Pages 521-536 | Published online: 10 Oct 2008

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Nazeer Hussain Khan, Faiz Ullah, Taskin Aman Khan, Ujala Zafar, Muhammad Farhan Ali Khan, Muhammad Mustaqeem, Syed Sakhawat Shah, Dong-Dong Wu & Xin-Ying Ji. (2021) Personal-Care Cosmetic Practices in Pakistan: Current Perspectives and Management. Clinical, Cosmetic and Investigational Dermatology 14, pages 9-21.
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Kevin M. Towle, Ruth Y. Hwang, Ernest S. Fung, Dana M. Hollins & Andrew D. Monnot. (2020) Hair dye and risk of skin sensitization induction: a product survey and quantitative risk assessment for para-phenylenediamine (PPD). Cutaneous and Ocular Toxicology 39:4, pages 311-316.
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Sunil Kumar, Veena Vishwakarma, Bharti Yadav, Ranjan Gupta, Neeraj Aggarwal & Anita Yadav. (2020) Antigenotoxic Effects of Epigallocatechin Gallate against Hair Dye Induced Genotoxicity in Cultured Human Peripheral Blood Lymphocytes. Journal of Biologically Active Products from Nature 10:2, pages 141-152.
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Kishor Hadkhale, Jan Ivar Martinsen, Elisabete Weiderpass, Kristina Kjærheim, Pär Sparén, Laufey Tryggvadóttir, Elsebeth Lynge & Eero Pukkala. (2019) Occupational variation in bladder cancer in Nordic males adjusted with approximated smoking prevalence. Acta Oncologica 58:1, pages 29-37.
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Eugen Krech, Silvia Selinski, Meinolf Blaszkewicz, Hannah Bürger, Thura Kadhum, Jan G. Hengstler, Michael C. Truss & Klaus Golka. (2017) Urinary bladder cancer risk factors in an area of former coal, iron, and steel industries in Germany. Journal of Toxicology and Environmental Health, Part A 80:7-8, pages 430-438.
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King-Thom Chung. (2016) Azo dyes and human health: A review. Journal of Environmental Science and Health, Part C 34:4, pages 233-261.
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Wolfram Föllmann, Meinolf Blaszkewicz, Claudia Behm, Gisela H. Degen & Klaus Golka. (2012) N-Acetylation of p-Aminobenzoic Acid and p-Phenylenediamine in Primary Porcine Urinary Bladder Epithelial Cells and in the Human Urothelial Cell Line 5637. Journal of Toxicology and Environmental Health, Part A 75:19-20, pages 1206-1215.
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Klaus Golka, Peter Heitmann, Frank Gieseler, Jasmin Hodzic, Nicolas Masche, HermannM. Bolt & Frank Geller. (2008) Elevated Bladder Cancer Risk Due to Colorants—A Statewide Case-Control Study in North Rhine-Westphalia, Germany. Journal of Toxicology and Environmental Health, Part A 71:13-14, pages 851-855.
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Articles from other publishers (69)

Jung-eun Lim, Jiaqi Huang, Stephanie J. Weinstein, Dominick Parisi, Satu Mӓnnistö & Demetrius Albanes. (2023) Serum metabolomic profile of hair dye use. Scientific Reports 13:1.
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Y. Tafurt-Cardona, P. Suares-Rocha, B.O. Silva, K.C.M. Moraes & M.A. Marin-Morales. (2023) Toxic effects of Arianor Ebony hair dye on human cells. Brazilian Journal of Medical and Biological Research 56.
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Asif Ali, Moinuddin, Shaziya Allarakha, Shamila Fatima, Syed Amaan Ali & Safia Habib. (2022) Risk of Carcinogenicity Associated with Synthetic Hair Dyeing Formulations: A Biochemical View on Action Mechanisms, Genetic Variation and Prevention. Indian Journal of Clinical Biochemistry 37:4, pages 399-409.
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Lin He, Freideriki Michailidou, Hailey L. Gahlon & Weibin Zeng. (2022) Hair Dye Ingredients and Potential Health Risks from Exposure to Hair Dyeing. Chemical Research in Toxicology 35:6, pages 901-915.
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Yang Wang, Kunna Li, Ying Zou, Mengyue Zhou, Jing Li, Chutian Wu, Rong Tan, Yufen Liao, Weiwei Li & Jiang Zheng. (2022) Metabolic activation of 3-aminodibenzofuran mediated by P450 enzymes and sulfotransferases. Toxicology Letters 360, pages 44-52.
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Horst Hartmann & Dominic M. Pratt. (2022) Kosmetikindustrie: Henna und Heteroaromatisches. Nachrichten aus der Chemie 70:2, pages 26-28.
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Xue ZUO, Zheng DI, Yong DU, Ling YANG, Rong ZHANG & Guoqing WU. (2022) Determination of 40 dyes in oxidative hair dye products by high performance liquid chromatography. Chinese Journal of Chromatography 39:11, pages 1222-1229.
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Su Zhou, Rui Li, Zhichao Zhang, Minyang Gu, Hongyan Zhu, Jing Fang, Zhiwen Ji, Xiaodong Xu & Liming Tang. (2021) Analysis of mutagenic components of oxidative hair dyes with the Ames test. Human & Experimental Toxicology 40:11, pages 1921-1937.
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Haiyan Gao, Yue Zhou, Jianguo Wang & Hujun Xu. (2021) Weakening of the Transdermal Effect of p -Phenylenediamine Pigments by the Temperature-Sensitive Poloxamer Sodium Alginate Gel . Tenside Surfactants Detergents 58:5, pages 342-352.
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Surulivel Gokul Eswaran, Himanshu Narayan & N. Vasimalai. (2021) Reductive photocatalytic degradation of toxic aniline blue dye using green synthesized banyan aerial root extract derived silver nanoparticles. Biocatalysis and Agricultural Biotechnology 36, pages 102140.
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Andrew Towns. (2021) A review of developments in industrial hair colorant actives for oxidative dyes. Coloration Technology 137:4, pages 301-335.
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Klaus Golka, Ralf Böthig, Olaf Jungmann, Martin Forchert, Michael Zellner & Wolfgang Schöps. (2021) Berufsbedingte Krebserkrankungen in der UrologieOccupational cancers in urology. Der Urologe 60:8, pages 1061-1072.
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Syed Faiz Mujtaba, Agha Parvez Masih, Ibrahim Alqasmi, Ahmad Alsulimani, Faizan Haider Khan & Shafiul Haque. (2021) Oxidative-Stress-Induced Cellular Toxicity and Glycoxidation of Biomolecules by Cosmetic Products under Sunlight Exposure. Antioxidants 10:7, pages 1008.
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Varsha MishraGanesh Balasubramaniam. (2020) Urinary bladder cancer and its associated factors – An epidemiological overview. Indian Journal of Medical Sciences 73, pages 239-248.
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Wenqian Yu, Shijin Wang, Dongling Cao, Hongyue Rui, Chengcheng Liu, Yongjie Sheng, Yanhong Sun, Jin Zhang, Jiacui Xu & Dazhi Jiang. (2020) Insight into an Oxidative DNA-Cleaving DNAzyme: Multiple Cofactors, the Catalytic Core Map and a Highly Efficient Variant. iScience 23:10, pages 101555.
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Hazrina Hadi, Nur’ain Ai, Mazlina Zamli, Ammar Ihsan Awadh, Muhammad Zeeshan Zafar & Shazia Jamshed. (2020) Cosmetic Use-Related Adverse Events: Findings from Lay Public in Malaysia. Cosmetics 7:2, pages 41.
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Simona Funar-Timofei & Gheorghe Ilia. 2020. Ecotoxicological QSARs. Ecotoxicological QSARs 405 436 .
Lin Wang, Ling Zhao, Xiaomeng Jia, Lina Jiang, Yeqiong Song, Qinong Ye & Zhaohui Lyu. (2019) Aminophenols increase proliferation of thyroid tumor cells by inducing the transcription factor activity of estrogen receptor α. Biomedicine & Pharmacotherapy 109, pages 621-628.
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Vivian Silva Kahl, Mónica Cappetta & Juliana Da Silva. 2019. The DNA, RNA, and Histone Methylomes. The DNA, RNA, and Histone Methylomes 265 293 .
Yuan Ma, Zi-man Jia, Feng-yang Bai, Xiu-mei Pan & Liang Zhao. (2018) Theoretical study on the formation mechanisms, dynamics and the effective catalysis of the nitrophenols. ChemistrySelect 3:36, pages 10188-10197.
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Paul M. Rose, Victoria Cantrill, Meryem Benohoud, Alenka Tidder, Christopher M. Rayner & Richard S. Blackburn. (2018) Application of Anthocyanins from Blackcurrant ( Ribes nigrum L.) Fruit Waste as Renewable Hair Dyes . Journal of Agricultural and Food Chemistry 66:26, pages 6790-6798.
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Saya L Jacob, Erika Cornell, Michael Kwa, William E Funk & Shuai Xu. (2018) Cosmetics and Cancer: Adverse Event Reports Submitted to the Food and Drug Administration. JNCI Cancer Spectrum 2:2.
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Syed Faiz Mujtaba, Ajeet K. Srivastav, Shikha Agnihotry, Sandeep Negi, Jaya Upadhayay & Ratan S. Ray. 2018. Photocarcinogenesis & Photoprotection. Photocarcinogenesis & Photoprotection 109 128 .
Kevin M. Towle, Matthew E. Grespin & Andrew D. Monnot. (2017) Personal use of hair dyes and risk of leukemia: a systematic literature review and meta-analysis. Cancer Medicine 6:10, pages 2471-2486.
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Ivan G. Shterev & Vassil B. Delchev. (2017) Phototransformations in m-aminophenol: A theoretical and experimental study. Journal of Molecular Structure 1141, pages 6-11.
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Özlem Sultan Aslantürk & Tülay Aşkin Çelik. (2017) Genotoxic risk assessment in professionals working hairdressers area using buccal micronucleus assay, in Aydın City, Turkey. Environmental Science and Pollution Research 24:17, pages 14700-14705.
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Bryan C. Huayhuas-Chipana, Marcos Vinicius Foguel, Luís Moreira Gonçalves & Maria D.P.T. Sotomayor. (2017) Modified screen-printed electrode for the FIA-amperometric determination of 2-nitro-p-phenylenediamine. Microchemical Journal 131, pages 92-97.
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Shu-Yu Tai, Hui-Min Hsieh, Shu-Pin Huang & Ming-Tsang Wu. (2016) Hair dye use, regular exercise, and the risk and prognosis of prostate cancer: multicenter case–control and case-only studies. BMC Cancer 16:1.
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Lucia D’Ulivo & Yong-Lai Feng. (2016) A Novel Open Tubular Capillary Electrochromatographic Method for Differentiating the DNA Interaction Affinity of Environmental Contaminants. PLOS ONE 11:4, pages e0153081.
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Waranya Boonchai, Monthathip Bunyavaree, Waranaree Winayanuwattikun & Pranee Kasemsarn. (2016) Contact sensitizers in commercial hair dye products sold in Thailand. Contact Dermatitis 74:4, pages 222-229.
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Ki-Hyun Kim, Ehsanul Kabir & Shamin Ara Jahan. (2016) The use of personal hair dye and its implications for human health. Environment International 89-90, pages 222-227.
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Signe Vedel-Krogh, Sune F. Nielsen, Peter Schnohr & Børge G. Nordestgaard. (2016) Morbidity and Mortality in 7,684 Women According to Personal Hair Dye Use: The Copenhagen City Heart Study followed for 37 Years. PLOS ONE 11:3, pages e0151636.
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