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Critical Reviews in Toxicology Volume 47, 2017 - Issue 8
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Review Articles

Metabolomic approaches in the discovery of potential urinary biomarkers of drug-induced liver injury (DILI)

Ana Margarida AraújoUCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal; Correspondence[email protected]
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Márcia CarvalhoUCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal; ;UFP Energy, Environment and Health Research Unit (FP-ENAS), University Fernando Pessoa, Porto, Portugal
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Félix CarvalhoUCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal;
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Maria de Lourdes BastosUCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal;
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Paula Guedes de PinhoUCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal; Correspondence[email protected]
Pages 638-654 | Received 04 Oct 2016, Accepted 19 Mar 2017, Published online: 24 Apr 2017

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Yvonne Gloor, Domitille Schvartz & Caroline F.Samer. (2019) Old problem, new solutions: biomarker discovery for acetaminophen liver toxicity. Expert Opinion on Drug Metabolism & Toxicology 15:8, pages 659-669.
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Michele S. Barnhill, Mark Real & James H. Lewis. (2018) Latest advances in diagnosing and predicting DILI: what was new in 2017?. Expert Review of Gastroenterology & Hepatology 12:10, pages 1033-1043.
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Baisong Chang, Jie Chen, Jiasheng Bao, Taolei Sun & Zhen Cheng. (2023) Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window. Chemical Reviews.
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Francisco Andújar-Vera, María Luisa Alés-Palmer, Paloma Muñoz-de-Rueda, Iván Iglesias-Baena & Esther Ocete-Hita. (2023) Metabolomic Analysis of Pediatric Patients with Idiosyncratic Drug-Induced Liver Injury According to the Updated RUCAM. International Journal of Molecular Sciences 24:17, pages 13562.
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Limei Li, Qingce Zang, Xinzhu Li, Ying Zhu, Shanjing Wen, Jiuming He, Ruiping Zhang & Zeper Abliz. (2023) Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids. Journal of Pharmaceutical Analysis 13:5, pages 483-493.
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Xuan Qin, John M. Hakenjos & Feng Li. 2023. Biomarkers in Toxicology. Biomarkers in Toxicology 539 563 .
Ming-Gui Wang, Shou-Quan Wu, Meng-Meng Zhang & Jian-Qing He. (2022) Urine metabolomics and microbiome analyses reveal the mechanism of anti-tuberculosis drug-induced liver injury, as assessed for causality using the updated RUCAM: A prospective study. Frontiers in Immunology 13.
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Hyun-A Oh, Ye-Ji Kim, Kyoung-Sik Moon, Joung-Wook Seo, Byung Hwa Jung & Dong Ho Woo. (2022) Identification of integrative hepatotoxicity induced by lysosomal phospholipase A2 inhibition of cationic amphiphilic drugs via metabolomics. Biochemical and Biophysical Research Communications 607, pages 1-8.
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Cong Hu, Hong-Wei Li, Jia-Qun Ke, Xue-Chun Yu, Mei-Yu Zhao, Xin-Yue Shi, Lin-Jing Wu, Xi-Lan Tang & Yin-Hua Xiong. (2022) Metabolic profiling of lysophosphatidylcholines in chlorpromazine hydrochloride- and N -acetyl- p -amino-phenoltriptolide-induced liver injured rats based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry . Human & Experimental Toxicology 41, pages 096032712211083.
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Xuan Qin, John M. Hakenjos & Feng Li. 2022. Biomarkers in Toxicology. Biomarkers in Toxicology 1 25 .
Guillermo Quintás, Teresa Martínez-Sena, Isabel Conde, Eugenia Pareja Ibars, Jos Kleinjans & José V. Castell. (2021) Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes. Archives of Toxicology 95:9, pages 3049-3062.
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Matthew J. Sorensen & Robert T. Kennedy. (2021) Capillary ultrahigh-pressure liquid chromatography-mass spectrometry for fast and high resolution metabolomics separations. Journal of Chromatography A 1635, pages 461706.
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Cátia F. Marques & M. Matilde Marques. 2021. Systems Medicine. Systems Medicine 480 500 .
Venkat R Pannala, Kalyan C Vinnakota, Shanea K Estes, Irina Trenary, Tracy P OˈBrien, Richard L Printz, Jason A Papin, Jaques Reifman, Tatsuya Oyama, Masakazu Shiota, Jamey D Young & Anders Wallqvist. (2020) Genome-Scale Model-Based Identification of Metabolite Indicators for Early Detection of Kidney Toxicity. Toxicological Sciences 173:2, pages 293-312.
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Kaushik Mitra. 2020. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters 487 506 .
Lucy Meunier & Dominique Larrey. (2019) Drug-Induced Liver Injury: Biomarkers, Requirements, Candidates, and Validation. Frontiers in Pharmacology 10.
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Mark Real, Michele S. Barnhill, Cory Higley, Jessica Rosenberg & James H. Lewis. (2018) Drug-Induced Liver Injury: Highlights of the Recent Literature. Drug Safety 42:3, pages 365-387.
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Yuanfu Lu, Xue-Mei Zhao, Zhaoyong Hu, Li Wang & Feng Li. (2018) LC–MS-Based Metabolomics in the Study of Drug-Induced Liver Injury. Current Pharmacology Reports 5:1, pages 56-67.
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David J. Borts. 2019. Biomarkers in Toxicology. Biomarkers in Toxicology 1111 1124 .
Ana Margarida Araújo, Maria de Lourdes Bastos, Eduarda Fernandes, Félix Carvalho, Márcia Carvalho & Paula Guedes de Pinho. (2018) GC–MS metabolomics reveals disturbed metabolic pathways in primary mouse hepatocytes exposed to subtoxic levels of 3,4-methylenedioxymethamphetamine (MDMA). Archives of Toxicology 92:11, pages 3307-3323.
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Aleksandar Gavrić, Marija Ribnikar, Lojze Šmid, Boštjan Luzar & Borut Štabuc. (2018) Fat burner–induced acute liver injury: Case series of four patients. Nutrition 47, pages 110-114.
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K.S. Ramos, T. Camenisch & Q. He. 2018. Comprehensive Toxicology. Comprehensive Toxicology 664 679 .

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