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Review Article

Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity

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Pages 201-222 | Received 06 May 2009, Accepted 22 May 2009, Published online: 28 Jul 2009

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Read on this site (9)

Kaat Leroy, Alanah Pieters, Andrés Tabernilla, Axelle Cooreman, Raf Van Campenhout, Bruno Cogliati & Mathieu Vinken. (2020) Targeting gap junctional intercellular communication by hepatocarcinogenic compounds. Journal of Toxicology and Environmental Health, Part B 23:6, pages 255-275.
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Pavel Babica, Lucie Čtveráčková, Zuzana Lenčešová, James E. Trosko & Brad L. Upham. (2016) Chemopreventive Agents Attenuate Rapid Inhibition of Gap Junctional Intercellular Communication Induced by Environmental Toxicants. Nutrition and Cancer 68:5, pages 827-837.
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Michaël Maes, Mitchell R. McGill, Tereza Cristina da Silva, Margitta Lebofsky, Cintia Maria Monteiro de Araújo, Taynã Tiburcio, Isabel Veloso Alves Pereira, Joost Willebrords, Sara Crespo Yanguas, Anwar Farhood, Maria Lucia Zaidan Dagli, Hartmut Jaeschke, Bruno Cogliati & Mathieu Vinken. (2016) Connexin32: a mediator of acetaminophen-induced liver injury?. Toxicology Mechanisms and Methods 26:2, pages 88-96.
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Patricia Bizarro-Nevares, Marcela Rojas-Lemus, Laura Colin-Barenque, Adriana Gonzalez-Villalva & Teresa I. Fortoul. (2016) Inhalation of vanadium modifies gap junctions in mouse seminiferous tubules. Toxicological & Environmental Chemistry 98:2, pages 266-278.
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Joost Willebrords, Sara Crespo Yanguas, Michaël Maes, Elke Decrock, Nan Wang, Luc Leybaert, Tereza Cristina da Silva, Isabel Veloso Alves Pereira, Hartmut Jaeschke, Bruno Cogliati & Mathieu Vinken. (2015) Structure, Regulation and Function of Gap Junctions in Liver. Cell Communication & Adhesion 22:2-6, pages 29-37.
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Jérôme Gilleron, Diane Carette, Daniel Chevallier, Dominique Segretain & Georges Pointis. (2012) Molecular connexin partner remodeling orchestrates connexin traffic: From physiology to pathophysiology. Critical Reviews in Biochemistry and Molecular Biology 47:5, pages 407-423.
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Mathieu Vinken, Joery de Kock, André G. Oliveira, Gustavo B. Menezes, Bruno Cogliati, Maria Lúcia Zaidan Dagli, Tamara Vanhaecke & Vera Rogiers. (2012) Modifications in Connexin Expression in Liver Development and Cancer. Cell Communication & Adhesion 19:3-4, pages 55-62.
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Tatyana Y. Doktorova, Marleen Pauwels, Mathieu Vinken, Tamara Vanhaecke & Vera Rogiers. (2012) Opportunities for an alternative integrating testing strategy for carcinogen hazard assessment?. Critical Reviews in Toxicology 42:2, pages 91-106.
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Georges Pointis, Jérome Gilleron, Diane Carette & Dominique Segretain. (2011) Testicular connexin 43, a precocious molecular target for the effect of environmental toxicants on male fertility. Spermatogenesis 1:4, pages 303-317.
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Lingyu Hu, Ting Xu, Xiaofang Wang, Mingrong Qian & Yuanxiang Jin. (2023) Exposure to the fungicide prothioconazole and its metabolite prothioconazole-desthio induced hepatic metabolism disorder and oxidative stress in mice. Pesticide Biochemistry and Physiology 193, pages 105452.
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Chao Li, Liang Shi, Cheng Peng, Gongchang Yu, Yanshu Zhang & Zhongjun Du. (2021) Lead-induced cardiomyocytes apoptosis by inhibiting gap junction intercellular communication via autophagy activation. Chemico-Biological Interactions 337, pages 109331.
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Jeremy Gingrich, Yong Pu, Brad L. Upham, Madeline Hulse, Sarah Pearl, Denny Martin, Anita Avery & Almudena Veiga-Lopez. (2021) Bisphenol S enhances gap junction intercellular communication in ovarian theca cells. Chemosphere 263, pages 128304.
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Hui Zou, Junzhao Yuan, Yi Zhang, Tao Wang, Yan Chen, Yan Yuan, Jianchun Bian & Zongping Liu. (2020) Gap Junction Intercellular Communication Negatively Regulates Cadmium-Induced Autophagy and Inhibition of Autophagic Flux in Buffalo Rat Liver 3A Cells. Frontiers in Pharmacology 11.
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Lucie Čtveráčková, Daniel Jančula, Jan Raška, Pavel Babica & Iva Sovadinová. (2020) Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells. International Journal of Molecular Sciences 21:17, pages 6069.
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Yang, Dong, Tian, Ji, Yang & Li. (2019) Gadolinium Chloride Restores the Function of the Gap Junctional Intercellular Communication between Hepatocytes in a Liver Injury. International Journal of Molecular Sciences 20:15, pages 3748.
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Tirthadipa Pradhan-Sundd & Satdarshan Pal Monga. (2019) Blood‐Bile Barrier: Morphology, Regulation, and Pathophysiology. Gene Expression 19:2, pages 69-87.
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Axelle Cooreman, Raf Van Campenhout, Steven Ballet, Pieter Annaert, Bert Van Den Bossche, Isabelle Colle, Bruno Cogliati & Mathieu Vinken. (2019) Connexin and Pannexin (Hemi)Channels: Emerging Targets in the Treatment of Liver Disease. Hepatology 69:3, pages 1317-1323.
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F. Pierucci, A. Frati, R. Squecco, E. Lenci, C. Vicenti, J. Slavik, F. Francini, M. Machala & E. Meacci. (2016) Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment. Archives of Toxicology 91:2, pages 749-760.
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Pavel Babica, Rimma Zurabian, Esha R. Kumar, Rajus Chopra, Maxwell J. Mianecki, Joon-Suk Park, Libor Jaša, James E. Trosko & Brad L. Upham. (2016) Methoxychlor and Vinclozolin Induce Rapid Changes in Intercellular and Intracellular Signaling in Liver Progenitor Cells. Toxicological Sciences 153:1, pages 174-185.
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Ji-Sun Kim, Woo-Moon Lee, Han Cheol Rhee & Suna Kim. (2016) Red paprika (Capsicum annuum L.) and its main carotenoids, capsanthin and β-carotene, prevent hydrogen peroxide-induced inhibition of gap-junction intercellular communication. Chemico-Biological Interactions 254, pages 146-155.
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Mathieu Vinken. (2016) Regulation of connexin signaling by the epigenetic machinery. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1859:2, pages 262-268.
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Di HuHui ZouTao HanJunze XieNannan DaiLiling ZhuoJianhong GuJianchun BianYan YuanXuezhong LiuZongping Liu. (2016) Gap junction blockage promotes cadmium-induced apoptosis in BRL 3A derived from Buffalo rat liver cells. Journal of Veterinary Science 17:1, pages 63.
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Pavel Babica, Iva Sovadinová & Brad L. Upham. 2016. Gap Junction Protocols. Gap Junction Protocols 133 144 .
Michaël Maes, Sara Crespo Yanguas, Joost Willebrords & Mathieu Vinken. (2015) Models and methods for in vitro testing of hepatic gap junctional communication. Toxicology in Vitro 30:1, pages 569-577.
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Michaël Maes, Sara Crespo Yanguas, Joost Willebrords, Bruno Cogliati & Mathieu Vinken. (2015) Connexin and pannexin signaling in gastrointestinal and liver disease. Translational Research 166:4, pages 332-343.
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