Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity

References

• Abbaci M, Barberi-Heyob M, Stines JR, Blondel W, Dumas D, Guillemin F and Didelon J. 2007. Gap junctional intercellular communication capacity by gap-FRAP technique: a comparative study. Biotechnol J 2:50–61.
   PubMed Web of Science ®Google Scholar
• Abbaci M, Barberi-Heyob M, Blondel W, Guillemin F and Didelon J. 2008. Advantages and limitations of commonly used methods to assay the molecular permeability of gap junctional intercellular communication. Biotechniques 45:33–52, 56–62.
   PubMed Web of Science ®Google Scholar
• Abou Hashieh I, Mathieu S, Besson F and Gerolami A. 1996. Inhibition of gap junction intercellular communications of cultured rat hepatocytes by ethanol: role of ethanol metabolism. J Hepatol 24:360–367.
   PubMed Web of Science ®Google Scholar
• Albright CD, Kuo J and Jeong S. 2001. cAMP enhances Cx43 gap junction formation and function and reverses choline deficiency apoptosis. Exp Mol Pathol 71:34–39.
   Google Scholar
• Alexander DB and Goldberg GS. 2003. Transfer of biologically important molecules between cells through gap junction channels. Curr Med Chem 10:2045–2058.
   PubMed Web of Science ®Google Scholar
• Asamoto M, Oyamada M, el Aoumari A, Gros D and Yamasaki H. 1991. Molecular mechanisms of TPA-mediated inhibition of gap-junctional intercellular communication: evidence for action on the assembly or function but not the expression of connexin 43 in rat liver epithelial cells. Mol Carcinog 4:322–327.
   PubMed Web of Science ®Google Scholar
• Asamoto M, Hokaiwado N, Murasaki T and Shirai T. 2004. Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals. Hepatology 40:205–210.
   PubMed Web of Science ®Google Scholar
• Auman JT, Chou J, Gerrish K, Huang Q, Jayadev S, Blanchard K and Paules RS. 2007. Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue. Environ Health Perspect 115:572–578.
   Google Scholar
• Bager Y, Kenne K, Krutovskikh V, Mesnil M, Traub O and Warngard L. 1994. Alteration in expression of gap junction proteins in rat liver after treatment with the tumour promoter 3,4,5,3’,4’-pentachlorobiphenyl. Carcinogenesis 15:2439–2443.
   PubMed Web of Science ®Google Scholar
• Bager Y, Kato Y, Kenne K and Warngard L. 1997. The ability to alter the gap junction protein expression outside GST-P positive foci in liver of rats was associated to the tumour promotion potency of different polychlorinated biphenyls. Chem Biol Interact 103:199–212.
   Google Scholar
• Baker TK, Kwiatkowski AP, Madhukar BV and Klaunig JE. 1995. Inhibition of gap junctional intercellular communication by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rat hepatocytes. Carcinogenesis 16:2321–2326.
   PubMed Web of Science ®Google Scholar
• Barhoumi R and Burghardt RC. 1996. Kinetic analysis of the chronology of patulin- and gossypol-induced cytotoxicity in vitro. Fundam Appl Toxicol 30:290–297.
   PubMedGoogle Scholar
• Beard J. 2006. DDT and human health. Sci Total Environ 355:78–89.
   PubMed Web of Science ®Google Scholar
• Beekman JM, Boess F, Hildebrand H, Kalkuhl A and Suter L. 2006. Gene expression analysis of the hepatotoxicant methapyrilene in primary rat hepatocytes: an interlaboratory study. Environ Health Perspect 114:92–99.
   PubMed Web of Science ®Google Scholar
• Beer DG, Neveu MJ, Paul DL, Rapp UR and Pitot HC. 1988. Expression of the c-raf protooncogene, gamma-glutamyltranspeptidase, and gap junction protein in rat liver neoplasms. Cancer Res 48:1610–1617.
   PubMed Web of Science ®Google Scholar
• Berthoud VM, Iwanij V, Garcia AM and Saez JC. 1992. Connexins and glucagon receptors during development of rat hepatic acinus. Am J Physiol 263:G650–658.
   PubMed Web of Science ®Google Scholar
• Berthoud VM, Rook MB, Traub O, Hertzberg EL and Saez JC. 1993. On the mechanisms of cell uncoupling induced by a tumor promoter phorbol ester in clone 9 cells, a rat liver epithelial cell line. Eur J Cell Biol 62:384–396.
   PubMed Web of Science ®Google Scholar
• Blaha L, Kapplova P, Vondracek J, Upham B and Machala M. 2002. Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbons. Toxicol Sci 65:43–51.
   PubMed Web of Science ®Google Scholar
• Bode HP, Wang L, Cassio D, Leite MF, St-Pierre MV, Hirata K, Okazaki K, Sears ML, Meda P, Nathanson MH and Dufour JF. 2002. Expression and regulation of gap junctions in rat cholangiocytes. Hepatology 36:631–640.
   PubMed Web of Science ®Google Scholar
• Bokkala S, Reis HM, Rubin E and Joseph SK. 2001. Effect of angiotensin II and ethanol on the expression of connexin 43 in WB rat liver epithelial cells. Biochem J 357:769–777.
   PubMed Web of Science ®Google Scholar
• Brautbar N and Williams 2nd J. 2002. Industrial solvents and liver toxicity: risk assessment, risk factors and mechanisms. Int J Hyg Environ Health 205:479–491.
   PubMed Web of Science ®Google Scholar
• Budunova IV and Williams GM. 1994. Cell culture assays for chemicals with tumor-promoting or tumor-inhibiting activity based on the modulation of intercellular communication. Cell Biol Toxicol 10:71–116.
   PubMed Web of Science ®Google Scholar
• Budunova IV, Williams GM and Spray DC. 1993. Effect of tumor promoting stimuli on gap junction permeability and connexin43 expression in ARL18 rat liver cell line. Arch Toxicol 67:565–572.
   Google Scholar
• Bukauskas FF, Elfgang C, Willecke K and Weingart R. 1995. Heterotypic gap junction channels (connexin26-connexin32) violate the paradigm of unitary conductance. Pflugers Arch 429:870–872.
   Google Scholar
• Cascio M, Kumar NM, Safarik R and Gilula NB. 1995. Physical characterization of gap junction membrane connexons ( hemi-channels) isolated from rat liver. J Biol Chem 270:18643–18648.
   PubMed Web of Science ®Google Scholar
• Chaumontet C, Droumaguet C, Bex V, Heberden C, Gaillard-Sanchez I and Martel P. 1997. Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells. Cancer Lett 114:207–210.
   PubMed Web of Science ®Google Scholar
• Chipman JK, Mally A and Edwards GO. 2003. Disruption of gap junctions in toxicity and carcinogenicity. Toxicol Sci 71:146–153.
   PubMed Web of Science ®Google Scholar
• Cho JH, Cho SD, Hu H, Kim SH, Lee SK, Lee YS and Kang KS. 2002. The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide. Carcinogenesis 23:1163–1169.
   PubMed Web of Science ®Google Scholar
• Cillo F, de Eguileor M, Gandolfi F and Brevini TA. 2007. Aroclor-1254 affects mRNA polyadenylation, translational activation, cell morphology, and DNA integrity of rat primary prostate cells. Endocr Relat Cancer 14:257–266.
   Google Scholar
• Combes RD. 2000. The use of structure-activity relationships and markers of cell toxicity to detect non-genotoxic carcinogens. Toxicol In Vitro 14:387–399.
   PubMed Web of Science ®Google Scholar
• Contreras JE, Sanchez HA, Veliz LP, Bukauskas FF, Bennett MV and Saez JC. 2004. Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue. Brain Res Brain Res Rev 47:290–303.
   PubMed Web of Science ®Google Scholar
• Cooper CD, Solan JL, Dolejsi MK and Lampe PD. 2000. Analysis of connexin phosphorylation sites. Methods 20:196–204.
   PubMed Web of Science ®Google Scholar
• Cooper RG and Magwere T. 2008. Nitric oxide-mediated pathogenesis during nicotine and alcohol consumption. Indian J Physiol Pharmacol 52:11–18.
   PubMedGoogle Scholar
• Correa PR, Guerra MT, Leite MF, Spray DC and Nathanson MH. 2004. Endotoxin unmasks the role of gap junctions in the liver. Biochem Biophys Res Commun 322:718–726.
   PubMed Web of Science ®Google Scholar
• Corton JC and Lapinskas PJ. 2005. Peroxisome proliferator-activated receptors: mediators of phthalate ester-induced effects in the male reproductive tract? Toxicol Sci 83:4–17.
   PubMed Web of Science ®Google Scholar
• Cottrell GT and Burt JM. 2005. Functional consequences of heterogeneous gap junction channel formation and its influence in health and disease. Biochim Biophys Acta 1711:126–141.
   PubMed Web of Science ®Google Scholar
• Cowles C, Mally A and Chipman JK. 2007. Different mechanisms of modulation of gap junction communication by non-genotoxic carcinogens in rat liver in vivo. Toxicology 238:49–59.
   PubMed Web of Science ®Google Scholar
• Craig A, Sidaway J, Holmes E, Orton T, Jackson D, Rowlinson R, Nickson J, Tonge R, Wilson I and Nicholson J. 2006. Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat. J Proteome Res 5:1586–1601.
   PubMed Web of Science ®Google Scholar
• Dagli ML, Yamasaki H, Krutovskikh V and Omori Y. 2004. Delayed liver regeneration and increased susceptibility to chemical hepatocarcinogenesis in transgenic mice expressing a dominant-negative mutant of connexin32 only in the liver. Carcinogenesis 25:483–492.
   PubMed Web of Science ®Google Scholar
• Dakin K, Zhao Y and Li WH. 2005. LAMP, a new imaging assay of gap junctional communication unveils that Ca2+ influx inhibits cell coupling. Nat Methods 2:55–62.
   PubMed Web of Science ®Google Scholar
• David RM. 2006. Proposed mode of action for in utero effects of some phthalate esters on the developing male reproductive tract. Toxicol Pathol 34:209–219.
   PubMed Web of Science ®Google Scholar
• Dbouk HA, Mroue RM, El-Sabban ME and Talhouk RS. 2009. Connexins: a myriad of functions extending beyond assembly of gap junction channels. Cell Commun Signal 7:4.
   PubMed Web of Science ®Google Scholar
• De Maio A, Gingalewski C, Theodorakis NG and Clemens MG. 2000. Interruption of hepatic gap junctional communication in the rat during inflammation induced by bacterial lipopolysaccharide. Shock 14:53–59.
   PubMed Web of Science ®Google Scholar
• De Vuyst E, De Bock M, Decrock E, Van Moorhem M, Naus C, Mabilde C and Leybaert L. 2008. In situ bipolar electroporation for localized cell loading with reporter dyes and investigating gap junctional coupling. Biophys J 94:469–479.
   PubMed Web of Science ®Google Scholar
• Decrock E, Vinken M, De Vuyst E, Krysko DV, D’Herde K, Vanhaecke T, Vandenabeele P, Rogiers V and Leybaert L. 2009. Connexin-related signaling in cell death: to live or let die? Cell Death Differ 16:524–536.
   PubMed Web of Science ®Google Scholar
• Dermietzel R, Yancey SB, Traub O, Willecke K and Revel JP. 1987. Major loss of the 28-kD protein of gap junction in proliferating hepatocytes. J Cell Biol 105:1925–1934.
   PubMed Web of Science ®Google Scholar
• Duffy HS, Iacobas I, Hotchkiss K, Hirst-Jensen BJ, Bosco A, Dandachi N, Dermietzel R, Sorgen PL and Spray DC. 2007. The gap junction protein connexin32 interacts with the Src homology 3/hook domain of discs large homolog 1. J Biol Chem 282:9789–9796.
   PubMed Web of Science ®Google Scholar
• Duga S, Asselta R, Del Giacco L, Malcovati M, Ronchi S, Tenchini ML and Simonic T. 1999. A new exon in the 5’ untranslated region of the connexin32 gene. Eur J Biochem 259:188–196.
   PubMedGoogle Scholar
• Eastmond DA. 2008. Evaluating genotoxicity data to identify a mode of action and its application in estimating cancer risk at low doses: A case study involving carbon tetrachloride. Environ Mol Mutagen 49:132–141.
   PubMed Web of Science ®Google Scholar
• el-Fouly MH, Trosko JE and Chang CC. 1987. Scrape-loading and dye transfer. A rapid and simple technique to study gap junctional intercellular communication. Exp Cell Res 168:422–430.
   PubMed Web of Science ®Google Scholar
• Elaut G, Henkens T, Papeleu P, Snykers S, Vinken M, Vanhaecke T and Rogiers V. 2006. Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures. Curr Drug Metab 7:629–660.
   PubMed Web of Science ®Google Scholar
• Elcock FJ, Chipman JK and Roberts RA. 1998. The rodent nongenotoxic hepatocarcinogen and peroxisome proliferator nafenopin inhibits intercellular communication in rat but not guinea-pig hepatocytes, perturbing S-phase but not apoptosis. Arch Toxicol 72:439–444.
   PubMed Web of Science ®Google Scholar
• Ellinger-Ziegelbauer H, Aubrecht J, Kleinjans JC and Ahr HJ. 2009. Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity. Toxicol Lett 186:36–44.
   PubMed Web of Science ®Google Scholar
• Elvira M, Diez JA, Wang KK and Villalobo A. 1993. Phosphorylation of connexin-32 by protein kinase C prevents its proteolysis by mu-calpain and m-calpain. J Biol Chem 268:14294–14300.
   PubMed Web of Science ®Google Scholar
• Eugenin EA, Gonzalez HE, Sanchez HA, Branes MC and Saez JC. 2007. Inflammatory conditions induce gap junctional communication between rat Kupffer cells both in vivo and in vitro. Cell Immunol 247:103–110.
   PubMed Web of Science ®Google Scholar
• Fidaleo M. 2009. Human health risk assessment for peroxisome proliferators: More than 30 years of research. Exp Toxicol Pathol 61:215-221.
   Google Scholar
• Field JM, Tate LA, Chipman JK and Minchin SD. 2003. Identification of functional regulatory regions of the connexin32 gene promoter. Biochim Biophys Acta 1628:22–29.
   PubMed Web of Science ®Google Scholar
• Fischer R, Reinehr R, Lu TP, Schonicke A, Warskulat U, Dienes HP and Haussinger D. 2005. Intercellular communication via gap junctions in activated rat hepatic stellate cells. Gastroenterology 128:433–448.
   PubMed Web of Science ®Google Scholar
• Fladmark KE, Gjertsen BT, Molven A, Mellgren G, Vintermyr OK and Doskeland SO. 1997. Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. Hepatology 25:847–855.
   PubMed Web of Science ®Google Scholar
• Fujimoto K, Nagafuchi A, Tsukita S, Kuraoka A, Ohokuma A and Shibata Y. 1997. Dynamics of connexins, E-cadherin and alpha-catenin on cell membranes during gap junction formation. J Cell Sci 110:311–322.
   PubMed Web of Science ®Google Scholar
• Fukumoto M, Kujiraoka T, Hara M, Shibasaki T, Hosoya T and Yoshida M. 2001. Effect of cadmium on gap junctional intercellular communication in primary cultures of rat renal proximal tubular cells. Life Sci 69:247–254.
   PubMed Web of Science ®Google Scholar
• Gagliano N, Donne ID, Torri C, Migliori M, Grizzi F, Milzani A, Filippi C, Annoni G, Colombo P, Costa F, Ceva-Grimaldi G, Bertelli AA, Giovannini L and Gioia M. 2006. Early cytotoxic effects of ochratoxin A in rat liver: a morphological, biochemical and molecular study. Toxicology 225:214–224.
   PubMed Web of Science ®Google Scholar
• Gaspers LD and Thomas AP. 2005. Calcium signaling in liver. Cell Calcium 38:329–342.
   PubMed Web of Science ®Google Scholar
• Gingalewski C, Wang K, Clemens MG and De Maio A. 1996. Posttranscriptional regulation of connexin 32 expression in liver during acute inflammation. J Cell Physiol 166:461–467.
   PubMed Web of Science ®Google Scholar
• Goel G, Makkar HP, Francis G and Becker K. 2007. Phorbol esters: structure, biological activity, and toxicity in animals. Int J Toxicol 26:279–288.
   PubMed Web of Science ®Google Scholar
• Goldberg GS, Bechberger JF and Naus CC. 1995. A pre-loading method of evaluating gap junctional communication by fluorescent dye transfer. Biotechniques 18:490–497.
   PubMed Web of Science ®Google Scholar
• Goldberg GS, Lampe PD, Sheedy D, Stewart CC, Nicholson BJ and Naus CC. 1998. Direct isolation and analysis of endogenous transjunctional ADP from Cx43 transfected C6 glioma cells. Exp Cell Res 239:82–92.
   PubMed Web of Science ®Google Scholar
• Goldberg GS, Lampe PD and Nicholson BJ. 1999. Selective transfer of endogenous metabolites through gap junctions composed of different connexins. Nat Cell Biol 1:457–459.
   PubMed Web of Science ®Google Scholar
• Goldberg GS, Moreno AP and Lampe PD. 2002. Gap junctions between cells expressing connexin 43 or 32 show inverse permselectivity to adenosine and ATP. J Biol Chem 277:36725–36730.
   PubMed Web of Science ®Google Scholar
• Gonzalez FJ and Shah YM. 2008. PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators. Toxicology 246:2–8.
   PubMed Web of Science ®Google Scholar
• Gonzalez HE, Eugenin EA, Garces G, Solis N, Pizarro M, Accatino L and Saez JC. 2002. Regulation of hepatic connexins in cholestasis: possible involvement of Kupffer cells and inflammatory mediators. Am J Physiol Gastrointest Liver Physiol 282:G991–G1001.
   PubMed Web of Science ®Google Scholar
• Gotow T, Shiozaki M, Higashi T, Yoshimura K, Shibata M, Kominami E and Uchiyama Y. 2008. Hepatic gap junctions in the hepatocarcinogen-resistant DRH rat. Histochem Cell Biol 130:583–594.
   Google Scholar
• Greenwel P, Rubin J, Schwartz M, Hertzberg EL and Rojkind M. 1993. Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, and connexin 43. Lab Invest 69:210–216.
   PubMed Web of Science ®Google Scholar
• Griner EM and Kazanietz MG. 2007. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 7:281–294.
   PubMed Web of Science ®Google Scholar
• Guan X and Ruch RJ. 1996. Gap junction endocytosis and lysosomal degradation of connexin43-P2 in WB-F344 rat liver epithelial cells treated with DDT and lindane. Carcinogenesis 17:1791–1798.
   PubMedGoogle Scholar
• Guan X, Bonney WJ and Ruch RJ. 1995. Changes in gap junction permeability, gap junction number, and connexin43 expression in lindane-treated rat liver epithelial cells. Toxicol Appl Pharmacol 130:79–86.
   PubMed Web of Science ®Google Scholar
• Guo X, Ohno Y and Takanaka A. 1993. Inhibition of hepatocyte gap junctional communication by 25-hydroxycholesterol may be mediated through free radicals. Eur J Pharmacol 248:337–340.
   Google Scholar
• Hakulinen P, Rintala E, Maki-Paakkanen J and Komulainen H. 2006. Altered expression of connexin43 in the inhibition of gap junctional intercellular communication by chlorohydroxyfuranones in WB-F344 rat liver epithelial cells. Toxicol Appl Pharmacol 212:146–155.
   Google Scholar
• Hamadeh HK, Knight BL, Haugen AC, Sieber S, Amin RP, Bushel PR, Stoll R, Blanchard K, Jayadev S, Tennant RW, Cunningham ML, Afshari CA and Paules RS. 2002. Methapyrilene toxicity: anchorage of pathologic observations to gene expression alterations. Toxicol Pathol 30:470–482.
   PubMed Web of Science ®Google Scholar
• Hamill OP, Marty A, Neher E, Sakmann B and Sigworth FJ. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391:85–100.
   PubMed Web of Science ®Google Scholar
• Hamilton GA, Jolley SL, Gilbert D, Coon DJ, Barros S and LeCluyse EL. 2001. Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell–cell interactions. Cell Tissue Res 306:85–99.
   PubMed Web of Science ®Google Scholar
• Harada T, Yamaguchi S, Ohtsuka R, Takeda M, Fujisawa H, Yoshida T, Enomoto A, Chiba Y, Fukumori J, Kojima S, Tomiyama N, Saka M, Ozaki M and Maita K. 2003. Mechanisms of promotion and progression of preneoplastic lesions in hepatocarcinogenesis by DDT in F344 rats. Toxicol Pathol 31:87–98.
   PubMed Web of Science ®Google Scholar
• Herrmann S, Seidelin M, Bisgaard HC and Vang O. 2002. Indolo[3,2-b]carbazole inhibits gap junctional intercellular communication in rat primary hepatocytes and acts as a potential tumor promoter. Carcinogenesis 23:1861–1868.
   PubMed Web of Science ®Google Scholar
• Herve JC, Pluciennik F, Bastide B, Cronier L, Verrecchia F, Malassine A, Joffre M and Deleze J. 1996. Contraceptive gossypol blocks cell-to-cell communication in human and rat cells. Eur J Pharmacol 313:243–255.
   PubMed Web of Science ®Google Scholar
• Herve JC, Bourmeyster N and Sarrouilhe D. 2004. Diversity in protein–protein interactions of connexins: emerging roles. Biochim Biophys Acta 1662:22–41.
   PubMed Web of Science ®Google Scholar
• Herve JC, Bourmeyster N, Sarrouilhe D and Duffy HS. 2007. Gap junctional complexes: from partners to functions. Prog Biophys Mol Biol 94:29–65.
   Google Scholar
• Heudorf U, Mersch-Sundermann V and Angerer J. 2007. Phthalates: toxicology and exposure. Int J Hyg Environ Health 210: 623–634.
   PubMed Web of Science ®Google Scholar
• Hill CS, Oh SY, Schmidt SA, Clark KJ and Murray AW. 1994. Lysophosphatidic acid inhibits gap-junctional communication and stimulates phosphorylation of connexin-43 in WB cells: possible involvement of the mitogen-activated protein kinase cascade. Biochem J 303:475–479.
   PubMed Web of Science ®Google Scholar
• Hokaiwado N, Asamoto M, Ogawa K and Shirai T. 2005. Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat. Toxicol Pathol 33:695–701.
   PubMedGoogle Scholar
• Hokaiwado N, Asamoto M, Futakuchi M, Ogawa K, Takahashi S and Shirai T. 2007. Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication. J Membr Biol 218:101–106.
   PubMed Web of Science ®Google Scholar
• Horvath A, Upham BL, Ganev V and Trosko JE. 2002. Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line. Toxicon 40:273–282.
   PubMedGoogle Scholar
• Hu GX, Lian QQ, Ge RS, Hardy DO and Li XK. 2009. Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence. Trends Endocrinol Metab 20:139–145.
   PubMed Web of Science ®Google Scholar
• Hu J and Cotgreave IA. 1995. Glutathione depletion potentiates 12-O-tetradecanoyl phorbol-13-acetate(TPA)-induced inhibition of gap junctional intercellular communication in WB-F344 rat liver epithelial cells: relationship to intracellular oxidative stress. Chem Biol Interact 95:291–307.
   Google Scholar
• Hu J, Engman L and Cotgreave IA. 1995a. Redox-active chalcogen-containing glutathione peroxidase mimetics and antioxidants inhibit tumour promoter-induced downregulation of gap junctional intercellular communication between WB-F344 liver epithelial cells. Carcinogenesis 16:1815–1824.
   PubMedGoogle Scholar
• Hu J, Speisky H and Cotgreave IA. 1995b. The inhibitory effects of boldine, glaucine, and probucol on TPA-induced down regulation of gap junction function. Relationships to intracellular peroxides, protein kinase C translocation, and connexin 43 phosphorylation. Biochem Pharmacol 50:1635–1643.
   PubMed Web of Science ®Google Scholar
• Huang RP, Peng A, Hossain MZ, Fan Y, Jagdale A and Boynton AL. 1999. Tumor promotion by hydrogen peroxide in rat liver epithelial cells. Carcinogenesis 20:485–492.
   PubMedGoogle Scholar
• Huang RP, Peng A, Golard A, Hossain MZ, Huang R, Liu YG and Boynton AL. 2001. Hydrogen peroxide promotes transformation of rat liver non-neoplastic epithelial cells through activation of epidermal growth factor receptor. Mol Carcinog 30:209–217.
   PubMed Web of Science ®Google Scholar
• Hutchinson RW, Barhoumi R, Miles JM and Burghardt RC. 1998. Attenuation of gossypol cytotoxicity by cyclic AMP in a rat liver cell line. Toxicol Appl Pharmacol 151:311–318.
   PubMed Web of Science ®Google Scholar
• Hwang JW, Park JS, Jo EH, Kim SJ, Yoon BS, Kim SH, Lee YS and Kang KS. 2005. Chinese cabbage extracts and sulforaphane can protect H2O2-induced inhibition of gap junctional intercellular communication through the inactivation of ERK1/2 and p38 MAP kinases. J Agric Food Chem 53:8205–8210.
   PubMed Web of Science ®Google Scholar
• Hwang JW, Jung JW, Lee YS and Kang KS. 2008. Indole-3-carbinol prevents H(2)O(2)-induced inhibition of gap junctional intercellular communication by inactivation of PKB/Akt. J Vet Med Sci 70:1057–1063.
   PubMed Web of Science ®Google Scholar
• Imlay JA. 2008. Cellular defenses against superoxide and hydrogen peroxide. Annu Rev Biochem 77:755–776.
   PubMed Web of Science ®Google Scholar
• Isenberg JS, Kamendulis LM, Smith JH, Ackley DC, Pugh G, Jr., Lington AW and Klaunig JE. 2000. Effects of Di-2-ethylhexyl phthalate (DEHP) on gap-junctional intercellular communication (GJIC), DNA synthesis, and peroxisomal beta oxidation (PBOX) in rat, mouse, and hamster liver. Toxicol Sci 56:73–85.
   PubMed Web of Science ®Google Scholar
• Isenberg JS, Kamendulis LM, Ackley DC, Smith JH, Pugh G, Jr., Lington AW, McKee RH and Klaunig JE. 2001. Reversibility and persistence of di-2-ethylhexyl phthalate (DEHP)- and phenobarbital-induced hepatocellular changes in rodents. Toxicol Sci 64:192–199.
   PubMed Web of Science ®Google Scholar
• Ito S, Tateno C, Tanaka M and Yoshitake A. 1993. Effects of fenvalerate and esfenvalerate on hepatic gap junctional intercellular communication in rats. Cell Biol Toxicol 9:189–196.
   Google Scholar
• Ito S, Tsuda M, Yoshitake A, Yanai T and Masegi T. 1998. Effect of phenobarbital on hepatic gap junctional intercellular communication in rats. Toxicol Pathol 26:253–259.
   PubMed Web of Science ®Google Scholar
• Iwai M, Harada Y, Muramatsu A, Tanaka S, Mori T, Okanoue T, Katoh F, Ohkusa T and Kashima K. 2000. Development of gap junctional channels and intercellular communication in rat liver during ontogenesis. J Hepatol 32:11–18.
   PubMed Web of Science ®Google Scholar
• Jaeschke H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D and Lemasters JJ. 2002. Mechanisms of hepatotoxicity. Toxicol Sci 65:166–176.
   PubMed Web of Science ®Google Scholar
• Jeon SH, Cho MH and Cho JH. 2001. Effects of cadmium on gap junctional intercellular communication in WB-F344 rat liver epithelial cells. Hum Exp Toxicol 20:577–583.
   PubMed Web of Science ®Google Scholar
• Jeong SH, Habeebu SS and Klaassen CD. 2000. Cadmium decreases gap junctional intercellular communication in mouse liver. Toxicol Sci 57:156–166.
   PubMed Web of Science ®Google Scholar
• Jones DP. 2008. Radical-free biology of oxidative stress. Am J Physiol Cell Physiol 295:C849–868.
   PubMed Web of Science ®Google Scholar
• Jung JW, Cho SD, Ahn NS, Yang SR, Park JS, Jo EH, Hwang JW, Aruoma OI, Lee YS and Kang KS. 2006. Effects of the histone deacetylases inhibitors sodium butyrate and trichostatin A on the inhibition of gap junctional intercellular communication by H2O2- and 12-O-tetradecanoylphorbol-13-acetate in rat liver epithelial cells. Cancer Lett 241:301–308.
   PubMed Web of Science ®Google Scholar
• Kabak B, Dobson AD and Var I. 2006. Strategies to prevent mycotoxin contamination of food and animal feed: a review. Crit Rev Food Sci Nutr 46:593–619.
   PubMed Web of Science ®Google Scholar
• Kamendulis LM, Isenberg JS, Smith JH, Pugh G, Jr., Lington AW and Klaunig JE. 2002. Comparative effects of phthalate monoesters on gap junctional intercellular communication and peroxisome proliferation in rodent and primate hepatocytes. J Toxicol Environ Health A 65:569–588.
   PubMed Web of Science ®Google Scholar
• Kanemitsu MY and Lau AF. 1993. Epidermal growth factor stimulates the disruption of gap junctional communication and connexin43 phosphorylation independent of 12-0-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: the possible involvement of mitogen-activated protein kinase. Mol Biol Cell 4:837–848.
   PubMed Web of Science ®Google Scholar
• Kanemitsu MY, Jiang W and Eckhart W. 1998. Cdc2-mediated phosphorylation of the gap junction protein, connexin43, during mitosis. Cell Growth Differ 9:13–21.
   PubMedGoogle Scholar
• Kang KS, Kang BC, Lee BJ, Che JH, Li GX, Trosko JE and Lee YS. 2000. Preventive effect of epicatechin and ginsenoside Rb(2) on the inhibition of gap junctional intercellular communication by TPA and H(2)O(2). Cancer Lett 152:97–106.
   PubMed Web of Science ®Google Scholar
• Kang KS, Yun JW, Yoon B, Lim YK and Lee YS. 2001. Preventive effect of germanium dioxide on the inhibition of gap junctional intercellular communication by TPA. Cancer Lett 166:147–153.
   Google Scholar
• Kang NJ, Lee KM, Kim JH, Lee BK, Kwon JY, Lee KW and Lee HJ. 2008. Inhibition of gap junctional intercellular communication by the green tea polyphenol (-)-epigallocatechin gallate in normal rat liver epithelial cells. J Agric Food Chem 56:10422–10427.
   PubMed Web of Science ®Google Scholar
• Kanno Y and Loewenstein WR. 1964. Intercellular Diffusion. Science 143:959–960.
   PubMed Web of Science ®Google Scholar
• Kato Y and Kenne K. 1996. Inhibition of cell–cell communication by commercial chlorinated paraffins in rat liver epithelial IAR 20 cells. Pharmacol Toxicol 79:23–28.
   Google Scholar
• Kato Y, Kenne K, Haraguchi K, Masuda Y, Kimura R and Warngard L. 1998. Inhibition of cell–cell communication by methylsulfonyl metabolites of polychlorinated biphenyl congeners in rat liver epithelial IAR 20 cells. Arch Toxicol 72:178–182.
   PubMed Web of Science ®Google Scholar
• Kenne K, Fransson-Steen R, Honkasalo S and Warngard L. 1994. Two inhibitors of gap junctional intercellular communication, TPA and endosulfan: different effects on phosphorylation of connexin 43 in the rat liver epithelial cell line, IAR 20. Carcinogenesis 15:1161–1165.
   PubMed Web of Science ®Google Scholar
• Kim JH, Lee BK, Lee KW and Lee HJ. 2009a. Resveratrol counteracts gallic acid-induced down-regulation of gap-junction intercellular communication. J Nutr Biochem 20:149–154.
   PubMed Web of Science ®Google Scholar
• Kim JS, Ha TY, Ahn J, Kim HK and Kim S. 2009b. Pterostilbene from Vitis coignetiae protect H2O2-induced inhibition of gap junctional intercellular communication in rat liver cell line. Food Chem Toxicol 47:404–409.
   PubMed Web of Science ®Google Scholar
• King TJ and Lampe PD. 2004. Mice deficient for the gap junction protein Connexin32 exhibit increased radiation-induced tumorigenesis associated with elevated mitogen-activated protein kinase (p44/Erk1, p42/Erk2) activation. Carcinogenesis 25:669–680.
   PubMed Web of Science ®Google Scholar
• King TJ, Gurley KE, Prunty J, Shin JL, Kemp CJ and Lampe PD. 2005. Deficiency in the gap junction protein connexin32 alters p27Kip1 tumor suppression and MAPK activation in a tissue-specific manner. Oncogene 24:1718–1726.
   PubMed Web of Science ®Google Scholar
• Klaunig JE and Ruch RJ. 1987. Strain and species effects on the inhibition of hepatocyte intercellular communication by liver tumor promoters. Cancer Lett 36:161–168.
   PubMed Web of Science ®Google Scholar
• Klaunig JE, Ruch RJ and Lin EL. 1989. Effects of trichloroethylene and its metabolites on rodent hepatocyte intercellular communication. Toxicol Appl Pharmacol 99:454–465.
   PubMed Web of Science ®Google Scholar
• Klaunig JE, Ruch RJ and Weghorst CM. 1990. Comparative effects of phenobarbital, DDT, and lindane on mouse hepatocyte gap junctional intercellular communication. Toxicol Appl Pharmacol 102:553–563.
   PubMed Web of Science ®Google Scholar
• Klotz LO, Patak P, Ale-Agha N, Buchczyk DP, Abdelmohsen K, Gerber PA, von Montfort C and Sies H. 2002. 2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade. Cancer Res 62:4922–4928.
   PubMed Web of Science ®Google Scholar
• Knerr S and Schrenk D. 2006a. Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in experimental models. Mol Nutr Food Res 50:897–907.
   PubMedGoogle Scholar
• Knerr S and Schrenk D. 2006b. Carcinogenicity of “non-dioxinlike” polychlorinated biphenyls. Crit Rev Toxicol 36:663–694.
   PubMed Web of Science ®Google Scholar
• Koffler L, Roshong S, Kyu Park I, Cesen-Cummings K, Thompson DC, Dwyer-Nield LD, Rice P, Mamay C, Malkinson AM and Ruch RJ. 2000. Growth inhibition in G(1) and altered expression of cyclin D1 and p27(kip-1 )after forced connexin expression in lung and liver carcinoma cells. J Cell Biochem 79:347–354.
   PubMed Web of Science ®Google Scholar
• Koffler LD, Fernstrom MJ, Akiyama TE, Gonzalez FJ and Ruch RJ. 2002. Positive regulation of connexin32 transcription by hepatocyte nuclear factor-1alpha. Arch Biochem Biophys 407:160–167.
   PubMed Web of Science ®Google Scholar
• Kojima T, Mitaka T, Shibata Y and Mochizuki Y. 1995. Induction and regulation of connexin26 by glucagon in primary cultures of adult rat hepatocytes. J Cell Sci 108:2771–2780.
   PubMed Web of Science ®Google Scholar
• Kojima T, Yamamoto M, Mochizuki C, Mitaka T, Sawada N and Mochizuki Y. 1997. Different changes in expression and function of connexin 26 and connexin 32 during DNA synthesis and redifferentiation in primary rat hepatocytes using a DMSO culture system. Hepatology 26:585–597.
   PubMed Web of Science ®Google Scholar
• Kojima T, Sawada N, Chiba H, Kokai Y, Yamamoto M, Urban M, Lee GH, Hertzberg EL, Mochizuki Y and Spray DC. 1999. Induction of tight junctions in human connexin 32 (hCx32)-transfected mouse hepatocytes: connexin 32 interacts with occludin. Biochem Biophys Res Commun 266:222–229.
   PubMed Web of Science ®Google Scholar
• Kojima T, Fort A, Tao M, Yamamoto M and Spray DC. 2001a. Gap junction expression and cell proliferation in differentiating cultures of Cx43 KO mouse hepatocytes. Am J Physiol Gastrointest Liver Physiol 281:G1004–1013.
   Web of Science ®Google Scholar
• Kojima T, Kokai Y, Chiba H, Yamamoto M, Mochizuki Y and Sawada N. 2001b. Cx32 but not Cx26 is associated with tight junctions in primary cultures of rat hepatocytes. Exp Cell Res 263:193–201.
   PubMed Web of Science ®Google Scholar
• Kojima T, Spray DC, Kokai Y, Chiba H, Mochizuki Y and Sawada N. 2002. Cx32 formation and/or Cx32-mediated intercellular communication induces expression and function of tight junctions in hepatocytic cell line. Exp Cell Res 276:40–51.
   PubMed Web of Science ®Google Scholar
• Kojima T, Yamamoto T, Murata M, Lan M, Takano K, Go M, Ichimiya S, Chiba H and Sawada N. 2003. Role of the p38 MAP-kinase signaling pathway for Cx32 and claudin-1 in the rat liver. Cell Commun Adhes 10:437–443.
   PubMed Web of Science ®Google Scholar
• Kojima T, Yamamoto T, Lan M, Murata M, Takano K, Go M, Ichimiya S, Chiba H and Sawada N. 2004. Inhibition of MAP kinase activity moderates changes in expression and function of Cx32 but not claudin-1 during DNA synthesis in primary cultures of rat hepatocytes. Med Electron Microsc 37:101–113.
   PubMedGoogle Scholar
• Koo SK, Kim DY, Park SD, Kang KW and Joe CO. 1997. PKC phosphorylation disrupts gap junctional communication at G0/S phase in clone 9 cells. Mol Cell Biochem 167:41–49.
   PubMed Web of Science ®Google Scholar
• Kren BT, Kumar NM, Wang SQ, Gilula NB and Steer CJ. 1993. Differential regulation of multiple gap junction transcripts and proteins during rat liver regeneration. J Cell Biol 123:707–718.
   PubMed Web of Science ®Google Scholar
• Krutovskikh VA, Mesnil M, Mazzoleni G and Yamasaki H. 1995. Inhibition of rat liver gap junction intercellular communication by tumor-promoting agents in vivo. Association with aberrant localization of connexin proteins. Lab Invest 72:571–577.
   PubMed Web of Science ®Google Scholar
• Krutovskikh VA, Piccoli C and Yamasaki H. 2002. Gap junction intercellular communication propagates cell death in cancerous cells. Oncogene 21:1989–1999.
   PubMed Web of Science ®Google Scholar
• Laird DW. 2005. Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation. Biochim Biophys Acta 1711:172–182.
   PubMed Web of Science ®Google Scholar
• Lampe PD. 1994. Analyzing phorbol ester effects on gap junctional communication: a dramatic inhibition of assembly. J Cell Biol 127:1895–1905.
   PubMed Web of Science ®Google Scholar
• Lampe PD and Lau AF. 2004. The effects of connexin phosphorylation on gap junctional communication. Int J Biochem Cell Biol 36:1171–1186.
   PubMed Web of Science ®Google Scholar
• Lampe PD, Kurata WE, Warn-Cramer BJ and Lau AF. 1998. Formation of a distinct connexin43 phosphoisoform in mitotic cells is dependent upon p34cdc2 kinase. J Cell Sci 111:833–841.
   PubMed Web of Science ®Google Scholar
• Lee KW, Jung JW, Kang KS and Lee HJ. 2004. p38 is a key signaling molecule for H-ras-induced inhibition of gap junction intercellular communication in rat liver epithelial cells. Ann NY Acad Sci 1030:258–263.
   Google Scholar
• Lee KW, Hur HJ, Lee HJ and Lee CY. 2005a. Antiproliferative effects of dietary phenolic substances and hydrogen peroxide. J Agric Food Chem 53:1990–1995.
   PubMed Web of Science ®Google Scholar
• Lee KW, Hwang ES, Kang NJ, Kim KH and Lee HJ. 2005b. Extraction and chromatographic separation of anticarcinogenic fractions from cacao bean husk. Biofactors 23:141–150.
   Google Scholar
• Lee SJ, Lee KW and Lee HJ. 2004. Abies nephrolepis leaf phenolics prevent the inhibition of gap junction intercellular communication by hydrogen peroxide in rat liver epithelial cells. Biofactors 21:357–360.
   Google Scholar
• Leibold E and Schwarz LR. 1993. Inhibition of intercellular communication in rat hepatocytes by phenobarbital, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and gamma-hexachlorocyclohexane (lindane): modification by antioxidants and inhibitors of cyclo-oxygenase. Carcinogenesis 14:2377–2382.
   Google Scholar
• Leithe E and Rivedal E. 2004. Ubiquitination and down-regulation of gap junction protein connexin-43 in response to 12-O-tetradecanoylphorbol 13-acetate treatment. J Biol Chem 279:50089–50096.
   PubMed Web of Science ®Google Scholar
• Leithe E, Cruciani V, Sanner T, Mikalsen SO and Rivedal E. 2003. Recovery of gap junctional intercellular communication after phorbol ester treatment requires proteasomal degradation of protein kinase C. Carcinogenesis 24:1239–1245.
   PubMedGoogle Scholar
• Leybaert L and Sanderson MJ. 2001. Intercellular calcium signaling and flash photolysis of caged compounds. A sensitive method to evaluate gap junctional coupling. Methods Mol Biol 154:407–430.
   PubMedGoogle Scholar
• Loch-Caruso R, Galvez MM, Brant K and Chung D. 2004. Cell and toxicant specific phosphorylation of conexin43: effects of lindane and TPA on rat myometrial and WB-F344 liver cell gap junctions. Cell Biol Toxicol 20:147–169.
   PubMed Web of Science ®Google Scholar
• Lu Y and Cederbaum AI. 2008. CYP2E1 and oxidative liver injury by alcohol. Free Radic Biol Med 44:723–738.
   PubMed Web of Science ®Google Scholar
• Luebeck EG, Buchmann A, Schneider D, Moolgavkar SH and Schwarz M. 2005. Modulation of liver tumorigenesis in Connexin32-deficient mouse. Mutat Res 570:33–47.
   PubMedGoogle Scholar
• Luster-Teasley SL, Ganey PE, DiOrio M, Ward JS, 3rd, Maleczka RE, Jr., Trosko JE and Masten SJ. 2005. Effect of byproducts from the ozonation of pyrene: biphenyl-2,2’,6,6’-tetracarbaldehyde and biphenyl-2,2’,6,6’-tetracarboxylic acid on gap junction intercellular communication and neutrophil function. Environ Toxicol Chem 24:733–740.
   PubMed Web of Science ®Google Scholar
• Machala M, Blaha L, Vondracek J, Trosko JE, Scott J and Upham BL. 2003. Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action. Toxicol Sci 76:102–111.
   PubMed Web of Science ®Google Scholar
• Machala M, Blaha L, Lehmler HJ, Pliskova M, Majkova Z, Kapplova P, Sovadinova I, Vondracek J, Malmberg T and Robertson LW. 2004. Toxicity of hydroxylated and quinoid PCB metabolites: inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells. Chem Res Toxicol 17:340–347.
   PubMed Web of Science ®Google Scholar
• Machala M, Svihalkova-Sindlerova L, Pencikova K, Krcmar P, Topinka J, Milcova A, Novakova Z, Kozubik A and Vondracek J. 2008. Effects of methylated chrysenes on AhR-dependent and –independent toxic events in rat liver epithelial cells. Toxicology 247:93–101.
   Google Scholar
• Mally A and Chipman JK. 2002. Non-genotoxic carcinogens: early effects on gap junctions, cell proliferation and apoptosis in the rat. Toxicology 180:233–248.
   PubMed Web of Science ®Google Scholar
• Manclus JJ, Abad A, Lebedev MY, Mojarrad F, Mickova B, Mercader JV, Primo J, Miranda MA and Montoya A. 2004. Development of a monoclonal immunoassay selective for chlorinated cyclodiene insecticides. J Agric Food Chem 52:2776–2784.
   PubMed Web of Science ®Google Scholar
• Maroni M, Colosio C, Ferioli A and Fait A. 2000. Biological monitoring of pesticide exposure: a review. Introduction. Toxicology 143:1–118.
   PubMed Web of Science ®Google Scholar
• Marvanova S, Vondracek J, Penccikova K, Trilecova L, Krcmarr P, Topinka J, Novakova Z, Milcova A and Machala M. 2008. Toxic effects of methylated benz[a]anthracenes in liver cells. Chem Res Toxicol 21:503–512.
   Google Scholar
• Marx-Stoelting P, Mahr J, Knorpp T, Schreiber S, Templin MF, Ott T, Buchmann A and Schwarz M. 2008. Tumor promotion in liver of mice with a conditional Cx26 knockout. Toxicol Sci 103:260–267.
   PubMed Web of Science ®Google Scholar
• Masten SJ, Tian M, Upham BL and Trosko JE. 2001. Effect of selected pesticides and their ozonation by-products on gap junctional intercellular communication using rat liver epithelial cell lines. Chemosphere 44:457–465.
   PubMed Web of Science ®Google Scholar
• Matesic DF, Rupp HL, Bonney WJ, Ruch RJ and Trosko JE. 1994. Changes in gap-junction permeability, phosphorylation, and number mediated by phorbol ester and non-phorbol-ester tumor promoters in rat liver epithelial cells. Mol Carcinog 10:226–236.
   PubMed Web of Science ®Google Scholar
• McKarns SC, Bombick DW, Morton MJ and Doolittle DJ. 2000. Gap junction intercellular communication and cytotoxicity in normal human cells after exposure to smoke condensates from cigarettes that burn or primarily heat tobacco. Toxicol In Vitro 14:41–51.
   PubMed Web of Science ®Google Scholar
• McKee RH. 2000. The role of inhibition of gap junctional intercellular communication in rodent liver tumor induction by phthalates: review of data on selected phthalates and the potential relevance to man. Regul Toxicol Pharmacol 32:51–55.
   Google Scholar
• McVicker BL, Tuma DJ and Casey CA. 2007. Effect of ethanol on pro-apoptotic mechanisms in polarized hepatic cells. World J Gastroenterol 13:4960–4966.
   PubMed Web of Science ®Google Scholar
• Meda P. 2000. Probing the function of connexin channels in primary tissues. Methods 20:232–244.
   PubMed Web of Science ®Google Scholar
• Mehendale HM, Roth RA, Gandolfi AJ, Klaunig JE, Lemasters JJ and Curtis LR. 1994. Novel mechanisms in chemically induced hepatotoxicity. Faseb J 8:1285–1295.
   PubMed Web of Science ®Google Scholar
• Mesnil M, Fitzgerald DJ and Yamasaki H. 1988. Phenobarbital specifically reduces gap junction protein mRNA level in rat liver. Mol Carcinog 1:79–81.
   Google Scholar
• Mesnil M, Krutovskikh V, Omori Y and Yamasaki H. 1995. Role of blocked gap junctional intercellular communication in non-genotoxic carcinogenesis. Toxicol Lett 82–83:701–706.
   PubMed Web of Science ®Google Scholar
• Meyer DJ, Yancey SB and Revel JP. 1981. Intercellular communication in normal and regenerating rat liver: a quantitative analysis. J Cell Biol 91:505–523.
   PubMed Web of Science ®Google Scholar
• Miyashita T, Takeda A, Iwai M and Shimazu T. 1991. Single administration of hepatotoxic chemicals transiently decreases the gap-junction-protein levels of connexin 32 in rat liver. Eur J Biochem 196:37–42.
   PubMedGoogle Scholar
• Moennikes O, Buchmann A, Romualdi A, Ott T, Werringloer J, Willecke K and Schwarz M. 2000. Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice. Cancer Res 60:5087–5091.
   PubMed Web of Science ®Google Scholar
• Moennikes O, Stahl S, Bannasch P, Buchmann A and Schwarz M. 2003. WY-14,643-mediated promotion of hepatocarcinogenesis in connexin32-wild-type and connexin32-null mice. Carcinogenesis 24:1561–1565.
   PubMedGoogle Scholar
• Muramatsu A, Iwai M, Morikawa T, Tanaka S, Mori T, Harada Y and Okanoue T. 2002. Influence of transfection with connexin 26 gene on malignant potential of human hepatoma cells. Carcinogenesis 23:351–358.
   PubMedGoogle Scholar
• Musil LS, Le AC, VanSlyke JK and Roberts LM. 2000. Regulation of connexin degradation as a mechanism to increase gap junction assembly and function. J Biol Chem 275:25207–25215.
   PubMed Web of Science ®Google Scholar
• Nakata Y, Iwai M, Kimura S and Shimazu T. 1996. Prolonged decrease in hepatic connexin32 in chronic liver injury induced by carbon tetrachloride in rats. J Hepatol 25:529–537.
   PubMed Web of Science ®Google Scholar
• Nathanson MH, Rios-Velez L, Burgstahler AD and Mennone A. 1999. Communication via gap junctions modulates bile secretion in the isolated perfused rat liver. Gastroenterology 116:1176–1183.
   PubMed Web of Science ®Google Scholar
• Nelles E, Butzler C, Jung D, Temme A, Gabriel HD, Dahl U, Traub O, Stumpel F, Jungermann K, Zielasek J, Toyka KV, Dermietzel R and Willecke K. 1996. Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice. Proc Natl Acad Sci USA 93:9565–9570.
   PubMed Web of Science ®Google Scholar
• Neuhaus IM, Bone L, Wang S, Ionasescu V and Werner R. 1996. The human connexin32 gene is transcribed from two tissue-specific promoters. Biosci Rep 16:239–248.
   PubMed Web of Science ®Google Scholar
• Neveu MJ, Hully JR, Paul DL and Pitot HC. 1990. Reversible alteration in the expression of the gap junctional protein connexin 32 during tumor promotion in rat liver and its role during cell proliferation. Cancer Commun 2:21–31.
   PubMed Web of Science ®Google Scholar
• Neveu MJ, Babcock KL, Hertzberg EL, Paul DL, Nicholson BJ and Pitot HC. 1994a. Colocalized alterations in connexin32 and cytochrome P450IIB1/2 by phenobarbital and related liver tumor promoters. Cancer Res 54:3145–3152.
   PubMed Web of Science ®Google Scholar
• Neveu MJ, Hully JR, Babcock KL, Hertzberg EL, Nicholson BJ, Paul DL and Pitot HC. 1994b. Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver. J Cell Sci 107:83–95.
   PubMed Web of Science ®Google Scholar
• Neveu MJ, Sattler CA, Sattler GL, Hully JR, Hertzberg EL, Paul DL, Nicholson BJ and Pitot HC. 1994c. Differences in the expression of connexin genes in rat hepatomas in vivo and in vitro. Mol Carcinog 11:145–154.
   PubMed Web of Science ®Google Scholar
• Neveu MJ, Hully JR, Babcock KL, Vaughan J, Hertzberg EL, Nicholson BJ, Paul DL and Pitot HC. 1995. Proliferation-associated differences in the spatial and temporal expression of gap junction genes in rat liver. Hepatology 22:202–212.
   PubMed Web of Science ®Google Scholar
• Neyton J and Trautmann A. 1985. Single-channel currents of an intercellular junction. Nature 317:331–335.
   PubMed Web of Science ®Google Scholar
• Nielsen M, Ruch RJ and Vang O. 2000. Resveratrol reverses tumor-promoter-induced inhibition of gap-junctional intercellular communication. Biochem Biophys Res Commun 275:804–809.
   PubMed Web of Science ®Google Scholar
• Ogawa T, Hayashi T, Tokunou M, Nakachi K, Trosko JE, Chang CC and Yorioka N. 2005. Suberoylanilide hydroxamic acid enhances gap junctional intercellular communication via acetylation of histone containing connexin 43 gene locus. Cancer Res 65:9771–9778.
   PubMedGoogle Scholar
• Oh SY, Madhukar BV and Trosko JE. 1988. Inhibition of gap junctional blockage by palmitoyl carnitine and TMB-8 in a rat liver epithelial cell line. Carcinogenesis 9:135–139.
   PubMed Web of Science ®Google Scholar
• Okamiya H, Mitsumori K, Onodera H, Ito S, Imazawa T, Yasuhara K and Takahashi M. 1998. Mechanistic study on liver tumor promoting effects of piperonyl butoxide in rats. Arch Toxicol 72:744–750.
   Google Scholar
• Okamura A, Kamijima M, Shibata E, Ohtani K, Takagi K, Ueyama J, Watanabe Y, Omura M, Wang H, Ichihara G, Kondo T and Nakajima T. 2005. A comprehensive evaluation of the testicular toxicity of dichlorvos in Wistar rats. Toxicology 213:129–137.
   PubMed Web of Science ®Google Scholar
• Ott T, Jokwitz M, Lenhard D, Romualdi A, Dombrowski F, Ittrich C, Schwarz M and Willecke K. 2006. Ablation of gap junctional communication in hepatocytes of transgenic mice does not lead to disrupted cellular homeostasis or increased spontaneous tumourigenesis. Eur J Cell Biol 85:717–728.
   PubMed Web of Science ®Google Scholar
• Ottinger S, Barhoumi R, McKenzie KS, McDonald T, Burghardt R, Huebner HJ and Phillips TD. 2005. FIA/MS analysis of temporally ozonated benzo[a]pyrene and pyrene and their reaction products: inhibition of gap junction-mediated intercellular communication. Chemosphere 60:1025–1033.
   Google Scholar
• Oyamada M, Oyamada Y and Takamatsu T. 2005. Regulation of connexin expression. Biochim Biophys Acta 1719:6–23.
   PubMed Web of Science ®Google Scholar
• Paku S, Nagy P, Kopper L and Thorgeirsson SS. 2004. 2-acetylaminofluorene dose-dependent differentiation of rat oval cells into hepatocytes: confocal and electron microscopic studies. Hepatology 39:1353–1361.
   PubMed Web of Science ®Google Scholar
• Papeleu P, vanhaecke T and Rogiers V. 2006. Histone deacetylase inhibition: a differentiation therapy for cultured primary hepatocytes. Current Enzyme Inhibition 2:91–104.
   Google Scholar
• Park JR, Park JS, Jo EH, Hwang JW, Kim SJ, Ra JC, Aruoma OI, Lee YS and Kang KS. 2006. Reversal of the TPA-induced inhibition of gap junctional intercellular communication by Chaga mushroom (Inonotus obliquus) extracts: effects on MAP kinases. Biofactors 27:147–155.
   Google Scholar
• Pelclova D, Urban P, Preiss J, Lukas E, Fenclova Z, Navratil T, Dubska Z and Senholdova Z. 2006. Adverse health effects in humans exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Rev Environ Health 21:119–138.
   PubMedGoogle Scholar
• Plante I, Charbonneau M and Cyr DG. 2002. Decreased gap junctional intercellular communication in hexachlorobenzene-induced gender-specific hepatic tumor formation in the rat. Carcinogenesis 23:1243–1249.
   PubMed Web of Science ®Google Scholar
• Plante I, Charbonneau M and Cyr DG. 2006. Activation of the integrin-linked kinase pathway downregulates hepatic connexin32 via nuclear Akt. Carcinogenesis 27:1923–1929.
   PubMed Web of Science ®Google Scholar
• Plante I, Cyr DG and Charbonneau M. 2007. Sexual dimorphism in the regulation of liver connexin32 transcription in hexachlorobenzene-treated rats. Toxicol Sci 96:47–57.
   PubMed Web of Science ®Google Scholar
• Prochazka L, Turanek J, Tesarik R, Knotigova P, Polaskova P, Andrysik Z, Kozubik A, Zak F, Sova P, Neuzil J and Machala M. 2007. Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complex. Arch Biochem Biophys 462:54–61.
   Google Scholar
• Puga A, Ma C and Marlowe JL. 2009. The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways. Biochem Pharmacol 77:713–722.
   PubMed Web of Science ®Google Scholar
• Rae RS, Mehta PP, Chang CC, Trosko JE and Ruch RJ. 1998. Neoplastic phenotype of gap-junctional intercellular communication-deficient WB rat liver epithelial cells and its reversal by forced expression of connexin 32. Mol Carcinog 22:120–127.
   PubMed Web of Science ®Google Scholar
• Rahman MF, Mahboob M, Danadevi K, Saleha Banu B and Grover P. 2002. Assessment of genotoxic effects of chloropyriphos and acephate by the comet assay in mice leucocytes. Mutat Res 516:139–147.
   PubMed Web of Science ®Google Scholar
• Raptis LH, Brownell HL, Firth KL and Mackenzie LW. 1994. A novel technique for the study of intercellular, junctional communication: electroporation of adherent cells on a partly conductive slide. DNA Cell Biol 13:963–975.
   PubMed Web of Science ®Google Scholar
• Reeves WR, Barhoumi R, Burghardt RC, Lemke SL, Mayura K, McDonald TJ, Phillips TD and Donnelly KC. 2001. Evaluation of methods for predicting the toxicity of polycyclic aromatic hydrocarbon mixtures. Environ Sci Technol 35:1630–1636.
   PubMed Web of Science ®Google Scholar
• Ren P, Mehta PP and Ruch RJ. 1998. Inhibition of gap junctional intercellular communication by tumor promoters in connexin43 and connexin32-expressing liver cells: cell specificity and role of protein kinase C. Carcinogenesis 19:169–175.
   PubMed Web of Science ®Google Scholar
• Rivedal E and Leithe E. 2005. Connexin43 synthesis, phosphorylation, and degradation in regulation of transient inhibition of gap junction intercellular communication by the phorbol ester TPA in rat liver epithelial cells. Exp Cell Res 302:143–152.
   PubMed Web of Science ®Google Scholar
• Rivedal E and Opsahl H. 2001. Role of PKC and MAP kinase in EGF- and TPA-induced connexin43 phosphorylation and inhibition of gap junction intercellular communication in rat liver epithelial cells. Carcinogenesis 22:1543–1550.
   PubMed Web of Science ®Google Scholar
• Rivedal E and Witz G. 2005. Metabolites of benzene are potent inhibitors of gap-junction intercellular communication. Arch Toxicol 79:303–311.
   PubMedGoogle Scholar
• Rivedal E, Yamasaki H and Sanner T. 1994. Inhibition of gap junctional intercellular communication in Syrian hamster embryo cells by TPA, retinoic acid and DDT. Carcinogenesis 15:689–694.
   PubMed Web of Science ®Google Scholar
• Rivedal E, Myhre O, Sanner T and Eide I. 2003. Supplemental role of the Ames mutation assay and gap junction intercellular communication in studies of possible carcinogenic compounds from diesel exhaust particles. Arch Toxicol 77:533–542.
   Google Scholar
• Roberts RA, Chevalier S, Hasmall SC, James NH, Cosulich SC and Macdonald N. 2002. PPAR alpha and the regulation of cell division and apoptosis. Toxicology 181–182:167–170.
   PubMed Web of Science ®Google Scholar
• Romualdi A, Niessen H, Dombrowski F, Willecke K and Ott T. 2002. Quantitative analysis of gap-junctional intercellular communication in precision-cut mouse liver slices. Cell Tissue Res 307:315–320.
   PubMed Web of Science ®Google Scholar
• Rosenberg E, Faris RA, Spray DC, Monfils B, Abreu S, Danishefsky I and Reid LM. 1996. Correlation of expression of connexin mRNA isoforms with degree of cellular differentiation. Cell Adhes Commun 4:223–235.
   PubMed Web of Science ®Google Scholar
• Ruch RJ and Klaunig JE. 1986. Effects of tumor promoters, genotoxic carcinogens and hepatocytotoxins on mouse hepatocyte intercellular communication. Cell Biol Toxicol 2:469–483.
   PubMed Web of Science ®Google Scholar
• Ruch RJ and Klaunig JE. 1988. Inhibition of mouse hepatocyte intercellular communication by paraquat-generated oxygen free radicals. Toxicol Appl Pharmacol 94:427–436.
   PubMed Web of Science ®Google Scholar
• Ruch RJ, Fransson R, Flodstrom S, Warngard L and Klaunig JE. 1990. Inhibition of hepatocyte gap junctional intercellular communication by endosulfan, chlordane and heptachlor. Carcinogenesis 11:1097–1101.
   PubMed Web of Science ®Google Scholar
• Ruch RJ, Bonney WJ, Sigler K, Guan X, Matesic D, Schafer LD, Dupont E and Trosko JE. 1994. Loss of gap junctions from DDT-treated rat liver epithelial cells. Carcinogenesis 15:301–306.
   PubMed Web of Science ®Google Scholar
• Ruch RJ, Trosko JE and Madhukar BV. 2001. Inhibition of connexin43 gap junctional intercellular communication by TPA requires ERK activation. J Cell Biochem 83:163–169.
   PubMed Web of Science ®Google Scholar
• Rummel AM, Trosko JE, Wilson MR and Upham BL. 1999. Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity. Toxicol Sci 49:232–240.
   PubMed Web of Science ®Google Scholar
• Rusyn I, Peters JM and Cunningham ML. 2006. Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver. Crit Rev Toxicol 36:459–479.
   PubMed Web of Science ®Google Scholar
• Saez JC. 1997. Intercellular gap junctional communication is required for an optimal metabolic response of the functional units of liver. Hepatology 25:775–776.
   PubMed Web of Science ®Google Scholar
• Saez JC, Spray DC, Nairn AC, Hertzberg E, Greengard P and Bennett MV. 1986. cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide. Proc Natl Acad Sci U S A 83:2473–2477.
   PubMed Web of Science ®Google Scholar
• Saez JC, Bennett MV and Spray DC. 1987. Carbon tetrachloride at hepatotoxic levels blocks reversibly gap junctions between rat hepatocytes. Science 236:967–969.
   PubMed Web of Science ®Google Scholar
• Saez JC, Nairn AC, Czernik AJ, Spray DC, Hertzberg EL, Greengard P and Bennett MV. 1990. Phosphorylation of connexin 32, a hepatocyte gap-junction protein, by cAMP-dependent protein kinase, protein kinase C and Ca2+/calmodulin-dependent protein kinase II. Eur J Biochem 192:263–273.
   PubMedGoogle Scholar
• Saez JC, Berthoud VM, Branes MC, Martinez AD and Beyer EC. 2003. Plasma membrane channels formed by connexins: their regulation and functions. Physiol Rev 83:1359–1400.
   PubMed Web of Science ®Google Scholar
• Sai K, Upham BL, Kang KS, Hasegawa R, Inoue T and Trosko JE. 1998. Inhibitory effect of pentachlorophenol on gap junctional intercellular communication in rat liver epithelial cells in vitro. Cancer Lett 130:9–17.
   PubMed Web of Science ®Google Scholar
• Sai K, Kanno J, Hasegawa R, Trosko JE and Inoue T. 2000. Prevention of the down-regulation of gap junctional intercellular communication by green tea in the liver of mice fed pentachlorophenol. Carcinogenesis 21:1671–1676.
   PubMed Web of Science ®Google Scholar
• Sai K, Kang KS, Hirose A, Hasegawa R, Trosko JE and Inoue T. 2001. Inhibition of apoptosis by pentachlorophenol in v-myc-transfected rat liver epithelial cells: relation to down-regulation of gap junctional intercellular communication. Cancer Lett 173:163–174.
   PubMed Web of Science ®Google Scholar
• Sharovskaya J, Kobliakova I, Solomatina N and Kobliakov V. 2006. Effect of some carcinogenic and non-carcinogenic polycyclic aromatic hydrocarbons on gap junction intercellular communication in hepatoma cell cultures. Eur J Cell Biol 85:387–397.
   Google Scholar
• Shiao YH. 2009. Genetic signature for human risk assessment: lessons from trichloroethylene. Environ Mol Mutagen 50:68–77.
   Google Scholar
• Shiojiri N, Niwa T, Sugiyama Y and Koike T. 2006. Preferential expression of connexin37 and connexin40 in the endothelium of the portal veins during mouse liver development. Cell Tissue Res 324:547–552.
   PubMed Web of Science ®Google Scholar
• Shoda T, Mitsumori K, Onodera H, Toyoda K, Uneyama C, Imazawa T and Hirose M. 1999. The relationship between decrease in Cx32 and induction of P450 isozymes in the early phase of clofibrate hepatocarcinogenesis in the rat. Arch Toxicol 73:373–380.
   PubMed Web of Science ®Google Scholar
• Shoda T, Mitsumori K, Onodera H, Toyoda K, Uneyama C, Takada K and Hirose M. 2000. Liver tumor-promoting effect of beta-naphthoflavone, a strong CYP 1A1/2 inducer, and the relationship between CYP 1A1/2 induction and Cx32 decrease in its hepatocarcinogenesis in the rat. Toxicol Pathol 28:540–547.
   PubMed Web of Science ®Google Scholar
• Simeckova P, Vondracek J, Andrysik Z, Zatloukalova J, Krcmar P, Kozubik A and Machala M. 2009. The 2,2’,4,4’,5,5’-hexachlorobiphenyl-enhanced degradation of connexin 43 involves both proteasomal and lysosomal activities. Toxicol Sci 107:9–18.
   PubMed Web of Science ®Google Scholar
• Sirnes S, Kjenseth A, Leithe E and Rivedal E. 2009. Interplay between PKC and the MAP kinase pathway in Connexin43 phosphorylation and inhibition of gap junction intercellular communication. Biochem Biophys Res Commun.
   Google Scholar
• Siu ER, Wong EW, Mruk DD, Sze KL, Porto CS and Cheng CY. 2009. An occludin-focal adhesion kinase (FAK) protein complex at the blood-testis barrier: a study using the cadmium model. Endocrinology.
   Google Scholar
• Smith JH, Isenberg JS, Pugh G, Jr., Kamendulis LM, Ackley D, Lington AW and Klaunig JE. 2000. Comparative in vivo hepatic effects of Di-isononyl phthalate (DINP) and related C7-C11 dialkyl phthalates on gap junctional intercellular communication (GJIC), peroxisomal beta-oxidation (PBOX), and DNA synthesis in rat and mouse liver. Toxicol Sci 54:312–321.
   PubMed Web of Science ®Google Scholar
• Sohl G and Willecke K. 2004. Gap junctions and the connexin protein family. Cardiovasc Res 62:228–232.
   PubMed Web of Science ®Google Scholar
• Sohl G, Theis M, Hallas G, Brambach S, Dahl E, Kidder G and Willecke K. 2001. A new alternatively spliced transcript of the mouse connexin32 gene is expressed in embryonic stem cells, oocytes, and liver. Exp Cell Res 266:177–186.
   PubMed Web of Science ®Google Scholar
• Solan JL and Lampe PD. 2005. Connexin phosphorylation as a regulatory event linked to gap junction channel assembly. Biochim Biophys Acta 1711:154–163.
   PubMed Web of Science ®Google Scholar
• Solan JL and Lampe PD. 2009. Connexin43 phosphorylation: structural changes and biological effects. Biochem J 419:261–272.
   PubMed Web of Science ®Google Scholar
• Soto AM, Sonnenschein C, Chung KL, Fernandez MF, Olea N and Serrano FO. 1995. The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ Health Perspect 103 Suppl 7:113–122.
   PubMed Web of Science ®Google Scholar
• Spray DC, Harris AL and Bennett MV. 1979. Voltage dependence of junctional conductance in early amphibian embryos. Science 204:432–434.
   Google Scholar
• Spray DC, Harris AL and Bennett MV. 1981. Equilibrium properties of a voltage-dependent junctional conductance. J Gen Physiol 77:77–93.
   PubMed Web of Science ®Google Scholar
• Spray DC, Bai S, Burk RD and Saez JC. 1994. Regulation and function of liver gap junctions and their genes. Prog Liver Dis 12:1–18.
   PubMedGoogle Scholar
• Stahl S, Ittrich C, Marx-Stoelting P, Kohle C, Ott T, Buchmann A and Schwarz M. 2005. Effect of the tumor promoter phenobarbital on the pattern of global gene expression in liver of connexin32-wild-type and connexin32-deficient mice. Int J Cancer 115:861–869.
   PubMed Web of Science ®Google Scholar
• Stumpel F, Ott T, Willecke K and Jungermann K. 1998. Connexin 32 gap junctions enhance stimulation of glucose output by glucagon and noradrenaline in mouse liver. Hepatology 28:1616–1620.
   PubMed Web of Science ®Google Scholar
• Sugie S, Mori H and Takahashi M. 1987. Effect of in vivo exposure to the liver tumor promoters phenobarbital or DDT on the gap junctions of rat hepatocytes: a quantitative freeze-fracture analysis. Carcinogenesis 8:45–51.
   PubMed Web of Science ®Google Scholar
• Sugiyama Y and Ohta H. 1990. Changes in density and distribution of gap junctions after partial hepatectomy: immunohistochemical and morphometric studies. Arch Histol Cytol 53:71–80.
   PubMedGoogle Scholar
• Svihalkova-Sindlerova L, Machala M, Pencikova K, Marvanova S, Neca J, Topinka J, Sevastyanova O, Kozubik A and Vondracek J. 2007. Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver ‘stem-like’ cells. Toxicology 232:147–159.
   PubMed Web of Science ®Google Scholar
• Tateno C, Ito S, Tanaka M, Oyamada M and Yoshitake A. 1994. Effect of DDT on hepatic gap junctional intercellular communication in rats. Carcinogenesis 15:517–521.
   Google Scholar
• Temme A, Buchmann A, Gabriel HD, Nelles E, Schwarz M and Willecke K. 1997. High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32. Curr Biol 7:713–716.
   PubMed Web of Science ®Google Scholar
• Temme A, Ott T, Dombrowski F and Willecke K. 2000a. The extent of synchronous initiation and termination of DNA synthesis in regenerating mouse liver is dependent on connexin32 expressing gap junctions. J Hepatol 32:627–635.
   PubMed Web of Science ®Google Scholar
• Temme A, Ott T, Haberberger T, Traub O and Willecke K. 2000b. Acute-phase response and circadian expression of connexin26 are not altered in connexin32-deficient mouse liver. Cell Tissue Res 300:111–117.
   PubMed Web of Science ®Google Scholar
• Temme A, Stumpel F, Sohl G, Rieber EP, Jungermann K, Willecke K and Ott T. 2001. Dilated bile canaliculi and attenuated decrease of nerve-dependent bile secretion in connexin32-deficient mouse liver. Pflugers Arch 442:961–966.
   PubMed Web of Science ®Google Scholar
• Theiss C and Meller K. 2002. Aluminum impairs gap junctional intercellular communication between astroglial cells in vitro. Cell Tissue Res 310:143–154.
   PubMedGoogle Scholar
• Theodorakis NG and De Maio A. 1999. Cx32 mRNA in rat liver: effects of inflammation on poly(A) tail distribution and mRNA degradation. Am J Physiol 276:R1249–1257.
   PubMed Web of Science ®Google Scholar
• Tiemann U. 2008. In vivo and in vitro effects of the organochlorine pesticides DDT, TCPM, methoxychlor, and lindane on the female reproductive tract of mammals: a review. Reprod Toxicol 25:316–326.
   PubMed Web of Science ®Google Scholar
• Traub O, Druge PM and Willecke K. 1983. Degradation and resynthesis of gap junction protein in plasma membranes of regenerating liver after partial hepatectomy or cholestasis. Proc Natl Acad Sci USA 80:755–759.
   PubMed Web of Science ®Google Scholar
• Tsuda H, Asamoto M, Baba-Toriyama H, Iwahori Y, Hori T, Kim DJ, Tsuchiya T, Mutai M and Yamasaki H. 1995. Clofibrate-induced neoplastic development in the rat liver is associated with decreased connexin 32 expression but not with a co-ordinated shift in expression of marker enzymes. Toxicol Lett 82–83:693–699.
   Google Scholar
• Uehara T, Kiyosawa N, Hirode M, Omura K, Shimizu T, Ono A, Mizukawa Y, Miyagishima T, Nagao T and Urushidani T. 2008. Gene expression profiling of methapyrilene-induced hepatotoxicity in rat. J Toxicol Sci 33:37–50.
   Google Scholar
• Upham BL, Kang KS, Cho HY and Trosko JE. 1997. Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells. Carcinogenesis 18:37–42.
   PubMed Web of Science ®Google Scholar
• Upham BL, Weis LM and Trosko JE. 1998. Modulated gap junctional intercellular communication as a biomarker of PAH epigenetic toxicity: structure-function relationship. Environ Health Perspect 106 Suppl 4:975–981.
   Google Scholar
• Upham BL, Guzvic M, Scott J, Carbone JM, Blaha L, Coe C, Li LL, Rummel AM and Trosko JE. 2007. Inhibition of gap junctional intercellular communication and activation of mitogen-activated protein kinase by tumor-promoting organic peroxides and protection by resveratrol. Nutr Cancer 57:38–47.
   PubMed Web of Science ®Google Scholar
• Upham BL, Blaha L, Babica P, Park JS, Sovadinova I, Pudrith C, Rummel AM, Weis LM, Sai K, Tithof PK, Guzvic M, Vondracek J, Machala M and Trosko JE. 2008. Tumor promoting properties of a cigarette smoke prevalent polycyclic aromatic hydrocarbon as indicated by the inhibition of gap junctional intercellular communication via phosphatidylcholine-specific phospholipase C. Cancer Sci 99:696–705.
   PubMed Web of Science ®Google Scholar
• van der Zandt PT, de Feijter AW, Homan EC, Spaaij C, de Haan LH, van Aelst AC and Jongen WM. 1990. Effects of cigarette smoke condensate and 12-O-tetradecanoylphorbol-13-acetate on gap junction structure and function in cultured cells. Carcinogenesis 11:883–888.
   Google Scholar
• Vinken M, Papeleu P, Snykers S, De Rop E, Henkens T, Chipman JK, Rogiers V and Vanhaecke T. 2006a. Involvement of cell junctions in hepatocyte culture functionality. Crit Rev Toxicol 36:299–318.
   PubMed Web of Science ®Google Scholar
• Vinken M, Vanhaecke T, Papeleu P, Snykers S, Henkens T and Rogiers V. 2006b. Connexins and their channels in cell growth and cell death. Cell Signal 18:592–600.
   PubMed Web of Science ®Google Scholar
• Vinken M, Henkens T, De Rop E, Fraczek J, Vanhaecke T and Rogiers V. 2008. Biology and pathobiology of gap junctional channels in hepatocytes. Hepatology 47:1077–1088.
   PubMed Web of Science ®Google Scholar
• Vinken M, De Rop E, Decrock E, De Vuyst E, Leybaert L, Vanhaecke T and Rogiers V. 2009. Epigenetic regulation of gap junctional intercellular communication: more than a way to keep cells quiet? Biochim Biophys Acta 1795:53–61.
   PubMed Web of Science ®Google Scholar
• Waalkes MP. 2000. Cadmium carcinogenesis in review. J Inorg Biochem 79:241–244.
   PubMed Web of Science ®Google Scholar
• Wade MH, Trosko JE and Schindler M. 1986. A fluorescence photobleaching assay of gap junction-mediated communication between human cells. Science 232:525–528.
   PubMed Web of Science ®Google Scholar
• Wagner ED, McMillan SM and Plewa MJ. 2005. Cytotoxicity of organophosphorus ester (OP) insecticides and cytotoxic synergism of 2-acetoxyacetylaminofluorene (2AAAF) in Chinese hamster ovary (CHO) cells. Bull Environ Contam Toxicol 75:329–334.
   PubMed Web of Science ®Google Scholar
• Waring JF, Ulrich RG, Flint N, Morfitt D, Kalkuhl A, Staedtler F, Lawton M, Beekman JM and Suter L. 2004. Interlaboratory evaluation of rat hepatic gene expression changes induced by methapyrilene. Environ Health Perspect 112:439–448.
   PubMed Web of Science ®Google Scholar
• Warner KA, Fernstrom MJ and Ruch RJ. 2003. Inhibition of mouse hepatocyte gap junctional intercellular communication by phenobarbital correlates with strain-specific hepatocarcinogenesis. Toxicol Sci 71:190–197.
   PubMed Web of Science ®Google Scholar
• Warngard L, Bager Y, Kato Y, Kenne K and Ahlborg UG. 1996. Mechanistical studies of the inhibition of intercellular communication by organochlorine compounds. Arch Toxicol Suppl 18:149–159.
   Google Scholar
• Wasser S and Tan CE. 1999. Experimental models of hepatic fibrosis in the rat. Ann Acad Med Singapore 28:109–111.
   PubMedGoogle Scholar
• Weis LM, Rummel AM, Masten SJ, Trosko JE and Upham BL. 1998. Bay or baylike regions of polycyclic aromatic hydrocarbons were potent inhibitors of Gap junctional intercellular communication. Environ Health Perspect 106:17–22.
   PubMed Web of Science ®Google Scholar
• Wilson MR, Close TW and Trosko JE. 2000. Cell population dynamics (apoptosis, mitosis, and cell–cell communication) during disruption of homeostasis. Exp Cell Res 254:257–268.
   PubMed Web of Science ®Google Scholar
• Wu J, Lin L, Luan T, Chan Gilbert YS and Lan C. 2007. Effects of organophosphorus pesticides and their ozonation byproducts on gap junctional intercellular communication in rat liver cell line. Food Chem Toxicol 45:2057–2063.
   PubMed Web of Science ®Google Scholar
• Xie H, Laird DW, Chang TH and Hu VW. 1997. A mitosis-specific phosphorylation of the gap junction protein connexin43 in human vascular cells: biochemical characterization and localization. J Cell Biol 137:203–210.
   PubMed Web of Science ®Google Scholar
• Yamasaki H. 1997. Cellular and molecular methods to study the role of gap junctional intercellular communication in toxicology. Toxicol In Vitro 11:535–542.
   Google Scholar
• Yang J, Ichikawa A and Tsuchiya T. 2003. A novel function of connexin 32: marked enhancement of liver function in a hepatoma cell line. Biochem Biophys Res Commun 307:80–85.
   PubMed Web of Science ®Google Scholar
• Yang S and Li WH. 2009. Assaying dynamic cell–cell junctional communication using noninvasive and quantitative fluorescence imaging techniques: LAMP and infrared-LAMP. Nat Protoc 4:94–101.
   Google Scholar
• Yano T, Hernandez-Blazquez FJ, Omori Y and Yamasaki H. 2001. Reduction of malignant phenotype of HEPG2 cell is associated with the expression of connexin 26 but not connexin 32. Carcinogenesis 22:1593–1600.
   PubMed Web of Science ®Google Scholar
• Yee AG and Revel JP. 1978. Loss and reappearance of gap junctions in regenerating liver. J Cell Biol 78:554–564.
   PubMed Web of Science ®Google Scholar
• Yoshida M, Kujiraoka T, Hara M, Nakazawa H and Sumi Y. 1998. Methylmercury inhibits gap junctional intercellular communication in primary cultures of rat proximal tubular cells. Arch Toxicol 72:192–196.
   Google Scholar
• Zhang M and Thorgeirsson SS. 1994. Modulation of connexins during differentiation of oval cells into hepatocytes. Exp Cell Res 213:37–42.
   PubMed Web of Science ®Google Scholar
• Ziambaras K, Lecanda F, Steinberg TH and Civitelli R. 1998. Cyclic stretch enhances gap junctional communication between osteoblastic cells. J Bone Miner Res 13:218–228.
   PubMed Web of Science ®Google Scholar