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Original Article: Clinical

Prophylactic low-dose aspirin is effective antithrombotic therapy for combination treatments of thalidomide or lenalidomide in myeloma

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Pages 2330-2337 | Received 11 Jul 2007, Accepted 23 Aug 2007, Published online: 01 Jul 2009

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Read on this site (9)

Sylvain Garciaz, Diane Coso, Jean-Marc Schiano de Colella & Réda Bouabdallah. (2016) Lenalidomide for the treatment of B-cell lymphoma. Expert Opinion on Investigational Drugs 25:9, pages 1103-1116.
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Peter H Wiernik. (2013) Lenalidomide in lymphomas and chronic lymphocytic leukemia. Expert Opinion on Pharmacotherapy 14:4, pages 475-488.
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Eileen M Boyle, Guillemette Fouquet, Salomon Manier, Jordan Gauthier, Marie Pierre Noel, Claire Borie, Thierry Facon, Ismail Elalamy & Xavier Leleu. (2012) Immunomodulator drug-based therapy in myeloma and the occurrence of thrombosis. Expert Review of Hematology 5:6, pages 619-629.
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Gabriela Cesarman-Maus, Esteban Braggio & Rafael Fonseca. (2012) Thrombosis in multiple myeloma (MM). Hematology 17:sup1, pages s177-s180.
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Patrizia Falco, Federica Cavallo, Alessandra Larocca, Anna Marina Liberati, Pellegrino Musto, Mario Boccadoro & Antonio Palumbo. (2008) Lenalidomide and its role in the management of multiple myeloma. Expert Review of Anticancer Therapy 8:6, pages 865-874.
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Ruben Niesvizky & Déborah M. Martínez-Baños. (2008) Aspirin as thromboprophylaxis in myeloma. Leukemia & Lymphoma 49:8, pages 1646-1647.
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Semra Paydas. (2008) Tailored thromboprophylaxis for patients with multiple myeloma treated by IMIDs. Leukemia & Lymphoma 49:8, pages 1644-1645.
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Donna E. Reece, Heather A. Leitch, Harold Atkins, Michael Voralia, Leah A. Canning, Richard LeBlanc, Andrew R. Belch, Darrell White & Michael J. Kovacs. (2008) Treatment of relapsed and refractory myeloma. Leukemia & Lymphoma 49:8, pages 1470-1485.
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Efstathios Kastritis & Meletios Dimopoulos. (2007) How to prevent deep vein thrombosis in myeloma patients receiving thalidomide or lenalidomide. Leukemia & Lymphoma 48:12, pages 2295-2297.
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Articles from other publishers (44)

Vignesh Narayan R & Tarun Narang. (2022) Comment on: ‘The role of thalidomide in dermatology’. Clinical and Experimental Dermatology 47:5, pages 982-983.
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Marco SANTORO, Alessandra ROMANO, Salvatrice MANCUSO, Sergio SIRAGUSA, Francesco DI RAIMONDO, Giovanni MARTINELLI & Claudio CERCHIONE. (2021) Prevention of venous thromboembolic events occurring in myeloma patients treated with second-generation novel agents. Panminerva Medica 63:1.
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Anne WS Rutjes, Ettore Porreca, Matteo Candeloro, Emanuele Valeriani & Marcello Di Nisio. (2020) Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy. Cochrane Database of Systematic Reviews 2020:12.
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Valeria Calafiore, Silvia Giamporcaro, Concetta Conticello, Alessandra Romano, Marina Parisi, Gaetano Giuffrida, Daniele Tibullo, Francesco Di Raimondo & Salvatore Santo Signorelli. (2020) A Real-Life Survey of Venous Thromboembolic Events Occurring in Myeloma Patients Treated in Third Line with Second-Generation Novel Agents. Journal of Clinical Medicine 9:9, pages 2876.
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Fehaid Alanazi, Faith A.A. Kwa, Genia Burchall & Denise E. Jackson. (2020) New generation drugs for treatment of multiple myeloma. Drug Discovery Today 25:2, pages 367-379.
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Ranjit Nair & Krina Patel. 2020. Oncologic Critical Care. Oncologic Critical Care 1513 1530 .
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Giacomo Zoppellaro, Nicola Veronese, Serena Granziera, Laura Gobbi, Brendon Stubbs & Alexander T. Cohen. (2018) Primary thromboembolic prevention in multiple myeloma patients: An exploratory meta-analysis on aspirin use. Seminars in Hematology 55:4, pages 182-184.
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Pashtoon Murtaza Kasi & Grzegorsz S. Nowakowski. 2018. Resistance of Targeted Therapies Excluding Antibodies for Lymphomas. Resistance of Targeted Therapies Excluding Antibodies for Lymphomas 73 83 .
Aurore Palmaro, Marie-Eve Rougé-Bugat, Martin Gauthier, Fabien Despas, Guillaume Moulis & Maryse Lapeyre-Mestre. (2017) Real-life practices for preventing venous thromboembolism in multiple myeloma patients: a cohort study from the French health insurance database. Pharmacoepidemiology and Drug Safety 26:5, pages 578-586.
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Maria T. De Sancho & Jacob H. Rand. 2016. Holland‐Frei Cancer Medicine. Holland‐Frei Cancer Medicine 1 11 .
Jiang-Hua Ding, Li-Ya Yuan & Guo-An Chen. (2017) Aspirin enhances the cytotoxic activity of bortezomib against myeloma cells via suppression of Bcl-2, survivin and phosphorylation of AKT. Oncology Letters 13:2, pages 647-654.
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Marcello Di Nisio, Ettore Porreca, Matteo Candeloro, Michele De Tursi, Ilaria Russi & Anne WS Rutjes. (2016) Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy. Cochrane Database of Systematic Reviews.
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José Ramiro Espinoza-Zamora, César Miguel Portilla-Espinosa, Juan Rafael Labardini-Méndez, Eduardo Cervera, Ruben Niesvisky & Luis F. Oñate-Ocaña. (2015) Quality of life in multiple myeloma: clinical validation of the Mexican-Spanish version of the QLQ-MY20 instrument. Annals of Hematology 94:6, pages 1017-1024.
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Jiang-hua Ding, Li-ya Yuan, Rui-Bin Huang & Guo-an Chen. (2014) Aspirin inhibits proliferation and induces apoptosis of multiple myeloma cells through regulation of Bcl-2 and Bax and suppression of VEGF. European Journal of Haematology 93:4, pages 329-339.
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Marcello Di Nisio, Ettore Porreca, Hans-Martin Otten & Anne WS Rutjes. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Jacek Treliński, Małgorzata Misiewicz, Marta Robak, Piotr Smolewski & Krzysztof Chojnowski. (2014) Assessment of rotation thromboelastometry (ROTEM) parameters in patients with multiple myeloma at diagnosis. Thrombosis Research 133:4, pages 667-670.
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Kihyun Kim, Seok Jin Kim, Verena Voelter, Cheolwon Suh, Sung-Soo Yoon, Je-Jung Lee, Jae-Yong Kwak, Hun-Mo Ryoo, Yang Soo Kim, Joon Ho Moon, Seong Kyu Park, Sung-Hyun Kim, Yeung-Chul Mun, Jin Seok Kim, Hyeon-Seok Eom, Deog-Yeon Jo, Hyun Jung Jun, Ki-Hwan Kim, Jeong-Ok Lee, Jae Hoon Lee & Chang-Ki Min. (2013) Lenalidomide with dexamethasone treatment for relapsed/refractory myeloma patients in Korea—experience from 110 patients. Annals of Hematology 93:1, pages 113-121.
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Garrett B Aikens, Michael P Rivey & Carly J Hansen. (2013) Primary Venous Thromboembolism Prophylaxis in Ambulatory Cancer Patients. Annals of Pharmacotherapy 47:2, pages 198-209.
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P. Casassus. (2013) Traitement du myélome multiple. EMC - Hématologie 8:1, pages 1-16.
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Xavier Leleu, Philippe Rodon, Cyrille Hulin, Laurent Daley, Charles Dauriac, Maya Hacini, Olivier Decaux, Jean-Claude Eisemann, Olivier Fitoussi, Bruno Lioure, Laurent Voillat, Borhane Slama, Ahmad Al Jijakli, Riad Benramdane, Carinne Chaleteix, Régis Costello, Antoine Thyss, Claire Mathiot, Boyle Eileen, Frédéric Maloisel, Anne-Marie Stoppa, Brigitte Kolb, Mauricette Michallet, Anne Lamblin, Patrick Natta, Thierry Facon, Ismail Elalamy, Jean-Paul Fermand & Philippe Moreau. (2017) MELISSE, a large multicentric observational study to determine risk factors of venous thromboembolism in patients with multiple myeloma treated with immunomodulatory drugs. Thrombosis and Haemostasis 110:10, pages 844-851.
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Marliese ALEXANDER, Sue KIRSA & James D MELLOR. (2012) Thalidomide thromboprophylaxis in multiple myeloma: A review of current evidence. Asia-Pacific Journal of Clinical Oncology 8:4, pages 319-324.
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Marta Robak, Jacek Treliński & Krzysztof Chojnowski. (2012) Hemostatic changes after 1 month of thalidomide and dexamethasone therapy in patients with multiple myeloma. Medical Oncology 29:5, pages 3574-3580.
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Antonio Palumbo & Carmela Palladino. (2012) Venous and arterial thrombotic risks with thalidomide: evidence and practical guidance. Therapeutic Advances in Drug Safety 3:5, pages 255-266.
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Xavier Leleu. (2012) Thrombosis in Myeloma treated with IMiDs. Thrombosis Research 130, pages S63-S65.
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Andrzej Jakubowiak. (2012) Management Strategies for Relapsed/Refractory Multiple Myeloma: Current Clinical Perspectives. Seminars in Hematology 49, pages S16-S32.
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G Cesarman-Maus, E Braggio, H Maldonado & R Fonseca. (2012) Absence of tissue factor expression by neoplastic plasma cells in multiple myeloma. Leukemia 26:7, pages 1671-1674.
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Gordon F. Rushworth, Stephen J. Leslie, Peter Forsyth & Claire Vincent. (2012) Evidence-based case report: multiple thrombotic episodes associated with lenalidomide and dexamethasone therapy for multiple myeloma. Therapeutic Advances in Drug Safety 3:3, pages 115-122.
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Cristina João, Alfredo Figueiredo & Helena Figueira Martins. (2012) Advantageous use of lenalidomide in multiple myeloma. Current Opinion in Oncology 24:Supplement 2, pages S13-S20.
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Alessandra LaroccaFederica CavalloSara BringhenFrancesco Di RaimondoAnna FalangaAndrea EvangelistaMaide CavalliAnfisa StanevskyPaolo CorradiniSara PezzattiFrancesca PatriarcaMichele CavoJacopo PeccatoriLucio CatalanoAngelo Michele CarellaAnna Maria CafroAgostina SiniscalchiClaudia CrippaMaria Teresa PetrucciDina Ben Yehuda, Eloise Beggiato, Tommaso Caravita Di TorittoMario BoccadoroArnon NaglerAntonio Palumbo. (2012) Aspirin or enoxaparin thromboprophylaxis for patients with newly diagnosed multiple myeloma treated with lenalidomide. Blood 119:4, pages 933-939.
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