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Original Article: Clinical

Chromosomal aberrations in 17p predict in vitro drug resistance and short overall survival in acute myeloid leukemia

, MD, , , , , & show all
Pages 508-516 | Received 08 Jul 2007, Accepted 10 Dec 2007, Published online: 01 Jul 2009

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A Quintás-Cardama, C Hu, A Qutub, Y H Qiu, X Zhang, S M Post, N Zhang, K Coombes & S M Kornblau. (2016) p53 pathway dysfunction is highly prevalent in acute myeloid leukemia independent of TP53 mutational status. Leukemia 31:6, pages 1296-1305.
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Zhen Zhao, Johannes Zuber, Ernesto Diaz-Flores, Laura Lintault, Scott C. Kogan, Kevin Shannon & Scott W. Lowe. (2010) p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. Genes & Development 24:13, pages 1389-1402.
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Anissa M. JabbourCarmel P. DauntBenjamin D. GreenSandra VogelLavinia GordonRachel S. Lee, Natasha SilkeRichard B. Pearson, Cassandra J. Vandenberg, Priscilla N. Kelly, Stephen L. Nutt, Andreas Strasser, Christoph BornerPaul G. Ekert. (2010) Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation. Blood 115:2, pages 344-352.
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H Seifert, B Mohr, C Thiede, U Oelschlägel, U Schäkel, T Illmer, S Soucek, G Ehninger & M Schaich. (2009) The prognostic impact of 17p (p53) deletion in 2272 adults with acute myeloid leukemia. Leukemia 23:4, pages 656-663.
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Jasmine C. Wong, Michelle M. Le Beau & Kevin Shannon. (2008) Tumor suppressor gene inactivation in myeloid malignancies. Best Practice & Research Clinical Haematology 21:4, pages 601-614.
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