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Original Article: Clinical

Chromosomal aberrations in 17p predict in vitro drug resistance and short overall survival in acute myeloid leukemia

, MD, , , , , & show all
Pages 508-516 | Received 08 Jul 2007, Accepted 10 Dec 2007, Published online: 01 Jul 2009

References

  • Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G, Rees J, Hann I, Stevens R, Burnett A, Goldstone A. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood 1998; 92: 2322–2333
  • Fenaux P, Preudhomme C, Lai J L, Quiquandon I, Jonveaux P, Vanrumbeke M, Sartiaux C, Morel P, Loucheux-Lefebvre M H, Bauters F. Mutations of the p53 gene in B-cell chronic lymphocytic leukemia: a report on 39 cases with cytogenetic analysis. Leukemia 1992; 6: 246–250
  • Stirewalt D L, Kopecky K J, Meshinchi S, Appelbaum F R, Slovak M L, Willman C L, Radich J P. FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia. Blood 2001; 97: 3589–3595
  • Lamb P, Crawford L. Characterization of the human p53 gene. Mol Cell Biol 1986; 6: 1379–1385
  • Evan G I, Vousden K H. Proliferation, cell cycle and apoptosis in cancer. Nature 2001; 411: 342–348
  • Ko L J, Prives C. p53: puzzle and paradigm. Genes Dev 1996; 10: 1054–1072
  • Chin K V, Ueda K, Pastan I, Gottesman M M. Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. Science 1992; 255: 459–462
  • Eischen C M, Weber J D, Roussel M F, Sherr C J, Cleveland J L. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev 1999; 13: 2658–2669
  • Chene P. Inhibiting the p53-MDM2 interaction: an important target for cancer therapy. Nat Rev Cancer 2003; 3: 102–109
  • Prives C. Signaling to p53: breaking the MDM2-p53 circuit. Cell 1998; 95: 5–8
  • Tidefelt U, Elmhorn-Rosenborg A, Paul C, Hao X Y, Mannervik B, Eriksson L C. Expression of glutathione transferase pi as a predictor for treatment results at different stages of acute nonlymphoblastic leukemia. Cancer Res 1992; 52: 3281–3285
  • Sundman-Engberg B, Tidefelt U, Gruber A, Paul C. Intracellular concentrations of mitoxantrone in leukemic cells in vitro vs. in vivo. Leuk Res 1993; 17: 347–352
  • Rhedin A S, Tidefelt U, Jonsson K, Lundin A, Paul C. Comparison of a bioluminescence assay with differential staining cytotoxicity for cytostatic drug testing in vitro in human leukemic cells. Leuk Res 1993; 17: 271–276
  • Andreotti P E, Cree I A, Kurbacher C M, Hartmann D M, Linder D, Harel G, Gleiberman I, Caruso P A, Ricks S H, Untch M, et al. Chemosensitivity testing of human tumors using a microplate adenosine triphosphate luminescence assay: clinical correlation for cisplatin resistance of ovarian carcinoma. Cancer Res 1995; 55: 5276–5282
  • Cree I A, Neale M H, Myatt N E, de Takats P G, Hall P, Grant J, Kurbacher C M, Reinhold U, Neuber K, MacKie R M, Chana J, Weaver P C, Khoury G G, Sartori C, Andreotti P E. Heterogeneity of chemosensitivity of metastatic cutaneous melanoma. Anticancer Drugs 1999; 10: 437–444
  • Kangas L, Gronroos M, Nieminen A L. Bioluminescence of cellular ATP: a new method for evaluating cytotoxic agents in vitro. Med Biol 1984; 62: 338–343
  • Pinzani P, Carotti S, Gerli A, Pazzagli M, Mazzei T, Mini E. Evaluation of methotrexate sensitivity in human leukemia cell lines by an adenosine triphosphate bioluminescence assay. Anticancer Drugs 1997; 8: 767–777
  • Tidefelt U, Prenkert M, Paul C. Comparison of idarubicin and daunorubicin and their main metabolites regarding intracellular uptake and effect on sensitive and multidrug-resistant HL60 cells. Cancer Chemother Pharmacol 1996; 38: 476–480
  • Squatrito R C, Connor J P, Buller R E. Comparison of a novel redox dye cell growth assay to the ATP bioluminescence assay. Gynecol Oncol 1995; 58: 101–105
  • Soenen V, Preudhomme C, Roumier C, Daudignon A, Lai J L, Fenaux P. 17p Deletion in acute myeloid leukemia and myelodysplastic syndrome. Analysis of breakpoints and deleted segments by fluorescence in situ. Blood 1998; 91: 1008–1015
  • Yin B, Kogan S C, Dickins R A, Lowe S W, Largaespada D A. Trp53 loss during in vitro selection contributes to acquired Ara-C resistance in acute myeloid leukemia. Exp Hematol 2006; 34: 631–641
  • Nakai H, Misawa S, Toguchida J, Yandell D W, Ishizaki K. Frequent p53 gene mutations in blast crisis of chronic myelogenous leukemia, especially in myeloid crisis harboring loss of a chromosome 17p. Cancer Res 1992; 52: 6588–6593
  • Harris C C, Hollstein M. Clinical implications of the p53 tumor-suppressor gene. N Engl J Med 1993; 329: 1318–1327
  • Kowalczyk J, Sandberg A A. A possible subgroup of ALL with 9p. Cancer Genet Cytogenet 1983; 9: 383–385
  • Diaz M O, Rubin C M, Harden A, Ziemin S, Larson R A, Le Beau M M, Rowley J D. Deletions of interferon genes in acute lymphoblastic leukemia. N Engl J Med 1990; 322: 77–82
  • Siebert R, Willers C P, Schramm A, Fossa A, Dresen I M, Uppenkamp M, Nowrousian M R, Seeber S, Opalka B. Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines. Br J Haematol 1995; 91: 350–354
  • Momand J, Zambetti G P, Olson D C, George D, Levine A J. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992; 69: 1237–1245
  • Bates S, Phillips A C, Clark P A, Stott F, Peters G, Ludwig R L, Vousden K H. p14ARF links the tumour suppressors RB and p53. Nature 1998; 395: 124–125
  • Ito A, Lai C H, Zhao X, Saito S, Hamilton M H, Appella E, Yao T P. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J 2001; 20: 1331–1340
  • Nahi H, Merup M, Lehmann S, Bengtzen S, Mollgard L, Selivanova G, Wiman K G, Paul C. PRIMA-1 induces apoptosis in acute myeloid leukaemia cells with p53 gene deletion. Br J Haematol 2006; 132: 230–236
  • Nahi H, Lehmann S, Mollgard L, Bengtzen S, Selivanova G, Wiman K G, Paul C, Merup M. Effects of PRIMA-1 on chronic lymphocytic leukaemia cells with and without hemizygous p53 deletion. Br J Haematol 2004; 127: 285–291
  • Kojima K, Konopleva M, Samudio I J, Shikami M, Cabreira-Hansen M, McQueen T, Ruvolo V, Tsao T, Zeng Z, Vassilev L T, Andreeff M. MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy. Blood 2005; 106: 3150–3159

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