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Incorporating FLT3 inhibitors into acute myeloid leukemia treatment regimens

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Pages 852-863 | Received 05 Dec 2007, Accepted 05 Jan 2008, Published online: 01 Jul 2009

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Angela Y.-C. Tan, Stephen Q. Wong, Charlotte Guldborg Nyvold, Dennis A. Carney, Andrew Wei, John F. Seymour, Peter Hokland, Westerman & Alexander Dobrovic. (2012) Rapid detection of FLT3 exon 20 tyrosine kinase domain mutations in patients with acute myeloid leukemia by high-resolution melting analysis. Leukemia & Lymphoma 53:6, pages 1225-1229.
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Sun-Young Han & Young-Won Chin. (2011) A FLT3-inhibitory constituent from the rhizomes of Anemarrhena asphodeloides. Journal of Enzyme Inhibition and Medicinal Chemistry 26:3, pages 445-448.
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Hye Jin Chung, Majid Rasool Kamli, Hyo Jeong Lee, Jae Du Ha, Sung Yun Cho, Jongkook Lee, Jae Yang Kong & Sun-Young Han. (2014) Discovery of quinolinone derivatives as potent FLT3 inhibitors. Biochemical and Biophysical Research Communications 445:3, pages 561-565.
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Xiaochuan Yang, Amy Sexauer & Mark Levis. (2014) Bone marrow stroma-mediated resistance to FLT3 inhibitors in FLT3-ITD AML is mediated by persistent activation of extracellular regulated kinase. British Journal of Haematology 164:1, pages 61-72.
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Young-Won Chin, Jae Yang Kong & Sun-Young Han. (2013) Flavonoids as receptor tyrosine kinase FLT3 inhibitors. Bioorganic & Medicinal Chemistry Letters 23:6, pages 1768-1770.
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Ho-June Lee, Gabriele Schaefer, Timothy P. Heffron, Lily Shao, Xiaofen Ye, Steve Sideris, Shiva Malek, Emily Chan, Mark Merchant, Hank La, Savita Ubhayakar, Robert L. Yauch, Valentina Pirazzoli, Katerina Politi & Jeff Settleman. (2013) Noncovalent Wild-type–Sparing Inhibitors of EGFR T790M. Cancer Discovery 3:2, pages 168-181.
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Hugo F Fernandez. (2012) Targeted therapy in acute myeloid leukemia: aim with caution. International Journal of Hematologic Oncology 1:2, pages 99-101.
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R Swords, C Freeman & F Giles. (2012) Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia. Leukemia 26:10, pages 2176-2185.
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Babu P. Mohan, Gee‐fung How, Yvonne Loh & Yeh‐ching Linn. (2011) Sorafenib monotherapy gives sustainable suppression of FLT3 clone in untreated patients with FLT3‐internal tandem duplication positive acute myeloid Leukaemia. British Journal of Haematology 157:1, pages 131-132.
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Shinichiro Takahashi. (2011) Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications. Journal of Hematology & Oncology 4:1.
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Jenna VanLiere Canzoniero, Bhavana Bhatnagar, Maria R. Baer & Ivana Gojo. (2011) Upfront Therapy of Acute Myeloid Leukemia. Current Oncology Reports 13:5, pages 361-370.
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Takashi Sato, Xiaochuan Yang, Steven Knapper, Paul White, B. Douglas Smith, Steven Galkin, Donald Small, Alan Burnett & Mark Levis. (2011) FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo. Blood 117:12, pages 3286-3293.
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E Weisberg, M Sattler, A Ray & J D Griffin. (2010) Drug resistance in mutant FLT3-positive AML. Oncogene 29:37, pages 5120-5134.
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Sun‐Young Han, Jin Hee Ahn, Chan Young Shin & Sang‐Un Choi. (2010) Effects of indirubin derivatives on the FLT3 activity and growth of acute myeloid leukemia cell lines. Drug Development Research 71:4, pages 221-227.
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Muneyoshi Futami & Seth J. Corey. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 2821 2829 .
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Miguel Sanz, Alan Burnett, Francesco Lo-Coco & Bob Löwenberg. (2009) FLT3 inhibition as a targeted therapy for acute myeloid leukemia. Current Opinion in Oncology 21:6, pages 594-600.
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W Korver, X Zhao, S Singh, C Pardoux, J Zhao, M L Guzman, S Sen, S Yonkovich, S Liu, X Zhan, N Tomasevic, C Zhou, D Gros, C T Jordan, J Gotlib, E D Hsi & A Abo. (2009) Monoclonal antibodies against IREM-1: potential for targeted therapy of AML. Leukemia 23:9, pages 1587-1597.
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Ellen Weisberg, Rosemary Barrett, Qingsong Liu, Richard Stone, Nathanael Gray & James D. Griffin. (2009) FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML. Drug Resistance Updates 12:3, pages 81-89.
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Wen-Chung ShiehJoe McKennaJoseph A. SclafaniSong XueMichael GirgisJames ViveloBranko RadetichKapa Prasad. (2008) Syntheses of a Triad of Flt3 Kinase Inhibitors: From Bench to Pilot Plant. Organic Process Research & Development 12:6, pages 1146-1155.
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