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Original Article: Research

Leukemic cells with increased telomerase activity exhibit resistance to imatinib

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Pages 1168-1177 | Received 26 Dec 2007, Accepted 07 Mar 2008, Published online: 01 Jul 2009

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Read on this site (2)

Neelam Varma, Maninder Singh Anand, Subhash Varma & Sominder Singh Juneja. (2011) Role of hTERT and WT1 gene expression in disease progression and imatinib responsiveness of patients with BCR–ABL positive chronic myeloid leukemia. Leukemia & Lymphoma 52:4, pages 687-693.
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Articles from other publishers (13)

Alessandro Allegra, Vanessa Innao, Giuseppa Penna, Demetrio Gerace, Andrea G. Allegra & Caterina Musolino. (2017) Telomerase and telomere biology in hematological diseases: A new therapeutic target. Leukemia Research 56, pages 60-74.
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Wei W. Chien, Régine Catallo, Amel Chebel, Laurence Baranger, Xavier Thomas, Marie-Christine Béné, Luc M. Gerland, Aline Schmidt, Kheira Beldjord, Nathalie Klein, Martine Escoffre-Barbe, Thibaut Leguay, Françoise Huguet, Fabrice Larosa, Sandrine Hayette, Adriana Plesa, Norbert Ifrah, Hervé Dombret, Gilles Salles, Agnès Chassevent & Martine Ffrench. (2015) The p16INK4A/pRb pathway and telomerase activity define a subgroup of Ph+ adult Acute Lymphoblastic Leukemia associated with inferior outcome. Leukemia Research 39:4, pages 453-461.
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Ali Amini, Seyed Hamidollah Ghaffari, Yousef Mortazai, Karim Daliri, Shahrouz Taranejoo, Kamran Alimoghadam & Ardeshir Ghavamzadeh. (2014) Expression pattern of hTERT telomerase subunit gene in different stages of chronic myeloid leukemia. Molecular Biology Reports 41:9, pages 5557-5561.
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Zaidatul Shakila Mohamad Ashari, Sarina Sulong, Rosline Hassan, Azlan Husin, Goh Ai Sim & S. Fadilah Abdul Wahid. (2014) Low Level of TERC Gene Amplification between Chronic Myeloid Leukaemia Patients Resistant and Respond to Imatinib Mesylate Treatment. Asian Pacific Journal of Cancer Prevention 15:4, pages 1863-1869.
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Oumar Samassekou. (2013) Dynamic Length Changes of Telomeres and Their Nuclear Organization in Chronic Myeloid Leukemia. Cancers 5:4, pages 1086-1102.
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Haloom Rafehi, Andrea J. Smith, Aneta Balcerczyk, Mark Ziemann, Jenny Ooi, Shanon J. Loveridge, Emma K. Baker, Assam El-Osta & Tom C. Karagiannis. (2011) Investigation into the biological properties of the olive polyphenol, hydroxytyrosol: mechanistic insights by genome-wide mRNA-Seq analysis. Genes & Nutrition 7:2, pages 343-355.
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Riccardo Dolcetti & Anita De Rossi. (2010) Telomere/telomerase interplay in virus‐driven and virus‐independent lymphomagenesis: pathogenic and clinical implications. Medicinal Research Reviews 32:2, pages 233-253.
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Shahinaz M. Gadalla & Sharon A. Savage. (2011) Telomere biology in hematopoiesis and stem cell transplantation. Blood Reviews 25:6, pages 261-269.
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Osamu Yamada, Kohji Ozaki, Thoru Furukawa, Mitsuyo Machida, Yan-Hua Wang, Toshiko Motoji, Tsuyoshi Mitsuishi, Masaharu Akiyama, Hisashi Yamada, Kiyotaka Kawauchi & Rumiko Matsuoka. (2011) Activation of STAT5 confers imatinib resistance on leukemic cells through the transcription of TERT and MDR1. Cellular Signalling 23:7, pages 1119-1127.
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Leo Kretzner, Anna Scuto, Pamela M. Dino, Claudia M. Kowolik, Jun Wu, Patrick Ventura, Richard Jove, Stephen J. Forman, Yun Yen & Mark H. Kirschbaum. (2011) Combining Histone Deacetylase Inhibitor Vorinostat with Aurora Kinase Inhibitors Enhances Lymphoma Cell Killing with Repression of c-Myc, hTERT, and microRNA Levels. Cancer Research 71:11, pages 3912-3920.
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Laure Deville, Josette Hillion, Frédéric Pendino, Mona Samy, Eric Nguyen & Evelyne Ségal-Bendirdjian. (2011) hTERT Promotes Imatinib Resistance in Chronic Myeloid Leukemia Cells: Therapeutic Implications. Molecular Cancer Therapeutics 10:5, pages 711-719.
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Oumar Samassekou, Aimé Ntwari, Josée Hébert & Ju Yan. (2009) Individual Telomere Lengths in Chronic Myeloid Leukemia. Neoplasia 11:11, pages 1146-IN6.
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Laure Deville, Josette Hillion & Evelyne Ségal-Bendirdjian. (2009) Telomerase regulation in hematological cancers: A matter of stemness?. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1792:4, pages 229-239.
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