Citations (51)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (9)
Abdel-Hameed I. M. Ebid, Ahmed Hossam, Mosaad M. El Gammal, Sameh Soror, Nadia O.M Mangoud & Mohamed Adel Mahmoud. (2022) High dose methotrexate in adult Egyptian patients with hematological malignancies: impact of ABCB1 3435C > T rs1045642 and MTHFR 677C > T rs1801133 polymorphisms on toxicities and delayed elimination. Journal of Chemotherapy 34:6, pages 381-390.
Read now
Read now
Dimitri Maamari, Habib El-Khoury, Omran Saifi, Samar A Muwakkit & Nathalie K Zgheib. (2020) Implementation of Pharmacogenetics to Individualize Treatment Regimens for Children with Acute Lymphoblastic Leukemia. Pharmacogenomics and Personalized Medicine 13, pages 295-317.
Read now
Read now
Maitane Umerez, Ángela Gutierrez-Camino, Carmen Muñoz-Maldonado, Idoia Martin-Guerrero & Africa Garcia-Orad. (2017) MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy. Pharmacogenomics and Personalized Medicine 10, pages 69-78.
Read now
Read now
Nirmalya Roy Moulik, Archana Kumar, Suraksha Agrawal, Shally Awasthi, Abbas Ali Mahdi & Ashutosh Kumar. (2015) Role of folate status and methylenetetrahydrofolate reductase genotype on the toxicity and outcome of induction chemotherapy in children with acute lymphoblastic leukemia. Leukemia & Lymphoma 56:5, pages 1379-1384.
Read now
Read now
Velia D’Angelo, Maria Ramaglia, Adriana Iannotta & Raffaele Addeo. (2014) Pharmacogenetics of methotrexate in pediatric hematological neoplasm treatment: does it need a personalized regimen based on MTHFR polymorphisms?. Expert Review of Hematology 7:5, pages 517-519.
Read now
Read now
Masaru Kubota, Rieko Nakata, Souichi Adachi, Ken-Ichiro Watanabe, Toshio Heike, Yasufumi Takeshita & Midori Shima. (2014) Plasma homocysteine, methionine and S-adenosylhomocysteine levels following high-dose methotrexate treatment in pediatric patients with acute lymphoblastic leukemia or Burkitt lymphoma: association with hepatotoxicity. Leukemia & Lymphoma 55:7, pages 1591-1595.
Read now
Read now
Irit Avivi, Tsila Zuckerman, Norberto Krivoy & Edna Efrati. (2014) Genetic polymorphisms predicting methotrexate blood levels and toxicity in adult non-Hodgkin lymphoma. Leukemia & Lymphoma 55:3, pages 565-570.
Read now
Read now
Velia D’Angelo, Maria Ramaglia, Adriana Iannotta, Matteo Francese, Elvira Pota, Maria Carmen Affinita, Giulia Pecoraro, Cristiana Indolfi, Martina Di Martino, Daniela Di Pinto, Salvatore Buffardi, Vincenzo Poggi, Paolo Indolfi & Fiorina Casale. (2013) Influence of methylenetetrahydrofolate reductase gene polymorphisms on the outcome of pediatric patients with non-Hodgkin lymphoma treated with high-dose methotrexate. Leukemia & Lymphoma 54:12, pages 2639-2644.
Read now
Read now
Shu-Guang Liu, Zhi-Gang Li, Lei Cui, Chao Gao, Wei-Jing Li & Xiao-Xi Zhao. (2011) Effects of methylenetetrahydrofolate reductase gene polymorphisms on toxicities during consolidation therapy in pediatric acute lymphoblastic leukemia in a Chinese population. Leukemia & Lymphoma 52:6, pages 1030-1040.
Read now
Read now
Articles from other publishers (42)
Qishan Hao, Yang Song, Qiuyun Fang, Yani LinLong ChenXiaodan Wang, Ping Zhang, Zhe Wang, Xiaoyuan Gong, Kaiqi Liu, Qinghua Li, Zheng Tian, Min Wang, Jianxiang Wang & Yingchang Mi. (2023) Effects of genetic polymorphisms on methotrexate levels and toxicity in Chinese patients with acute lymphoblastic leukemia. Blood Science 5:1, pages 32-38.
Crossref
Crossref
Evelien G. E. Hurkmans, Annouk C. A. M. Brand, Job A. J. Verdonschot, D. Maroeska W. M. te Loo & Marieke J. H. Coenen. (2022) Pharmacogenetics of chemotherapy treatment response and -toxicities in patients with osteosarcoma: a systematic review. BMC Cancer 22:1.
Crossref
Crossref
Rim Frikha, Moez Elloumi, Tarek Rebai & Hassen Kamoun. (2021) MTHFR 677T-1298C haplotype in acute lymphoblastic leukemia: Impact on methotrexate therapy. Journal of Oncology Pharmacy Practice 28:5, pages 1031-1034.
Crossref
Crossref
Amit K. Maiti. 2022. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects
3345
3361
.
Yaqing Shen, Zhujun Wang, Fen Zhou & Runming Jin. (2021) The influence of MTHFR genetic polymorphisms on methotrexate therapy in pediatric acute lymphoblastic leukemia. Open Life Sciences 16:1, pages 1203-1212.
Crossref
Crossref
Xia He, Pingli Yao, Mengting Li, Hong Liang, Yilong Liu, Shan Du, Min Zhang, Wenzhuo Sun, Zeyuan Wang, Xin Hao, Ze Yu, Fei Gao, Xinxia Liu & Rongsheng Tong. (2021) A Risk Scoring Model for High-Dose Methotrexate-Induced Liver Injury in Children With Acute Lymphoblastic Leukemia Based on Gene Polymorphism Study. Frontiers in Pharmacology 12.
Crossref
Crossref
Rim Frikha, Maha Ben Jemaa, Fakher Frikha, Ines Turki, Moez Elloumi, Leila Keskes, Hassen Kamoun & Tarek Rebai. (2020) Involvement of C677T MTHFR variant but not A1298C in methotrexate-induced toxicity in acute lymphoblastic leukemia. Journal of Oncology Pharmacy Practice 27:6, pages 1382-1387.
Crossref
Crossref
Rim Frikha, Fatma Turki, Fakher Frikha, Moez Elloumi & Tarek Rebai. (2021) Involvement of MTHFR rs1801133 in the Susceptibility of Acute Lymphoblastic Leukemia: A Preliminary Study. Journal of Pediatric Hematology/Oncology 43:6, pages e816-e818.
Crossref
Crossref
Xiaoli Chang, Yixian Guo, Li Su, Yunxiu Zhang, Wuhan Hui, Hong Zhao, Ronghua Hu & Wanling Sun. (2021) Influence of MTHFR C677T Polymorphism on High-Dose Methotrexate-Related Toxicity in Patients With Primary Central Nervous System Diffuse Large B-Cell Lymphoma. Clinical Lymphoma Myeloma and Leukemia 21:2, pages 91-96.
Crossref
Crossref
Amit K. Maiti. 2021. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects
1
17
.
Rim Frikha. (2020) Assessment of the relationship between methylenetetrahydrofolate reductase polymorphism and acute lymphoblastic leukemia: Evidence from an updated meta-analysis. Journal of Oncology Pharmacy Practice 26:7, pages 1598-1610.
Crossref
Crossref
Magdalena Cwiklinska, Malgorzata Czogala, Kinga Kwiecinska, Anna Madetko-Talowska, Malgorzata Szafarz, Katarzyna Pawinska, Aleksandra Wieczorek, Tomasz Klekawka, Magdalena Rej, Konrad Stepien, Przemyslaw Halubiec, Agnieszka Lazarczyk, Karol Miklusiak, Miroslaw Bik-Multanowski, Walentyna Balwierz & Szymon Skoczen. (2020) Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate. Frontiers in Pediatrics 8.
Crossref
Crossref
Amna Riaz, Maliha Ghaffar & Hina Salahuddin. 2020. 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine. 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine
401
412
.
Guillermo Gervasini & Sonia Mota-Zamorano. (2019) Clinical Implications of Methotrexate Pharmacogenetics in Childhood Acute Lymphoblastic Leukaemia. Current Drug Metabolism 20:4, pages 313-330.
Crossref
Crossref
Jennifer H. Foster, Patrick A. Thompson, M. Brooke Bernhardt, Judith F. Margolin, Susan G. Hilsenbeck, Eunji Jo, Deborah A. Marquez-Do, Michael E. Scheurer & Eric S. Schafer. (2018) A prospective study of a simple algorithm to individually dose high-dose methotrexate for children with leukemia at risk for methotrexate toxicities. Cancer Chemotherapy and Pharmacology 83:2, pages 349-360.
Crossref
Crossref
Rachel Conyers, Subalatha Devaraja & David Elliott. (2018) Systematic review of pharmacogenomics and adverse drug reactions in paediatric oncology patients. Pediatric Blood & Cancer 65:4, pages e26937.
Crossref
Crossref
Shu-mei Wang, Wei-xin Zeng, Wan-shui Wu, Lu-lu Sun & Dan Yan. (2018) Association between a microRNA binding site polymorphism in SLCO1A2 and the risk of delayed methotrexate elimination in Chinese children with acute lymphoblastic leukemia. Leukemia Research 65, pages 61-66.
Crossref
Crossref
Noor Ahmed Nahid, Mohd Nazmul Hasan Apu, Md. Reazul Islam, Samia Shabnaz, Surid Mohammad Chowdhury, Maizbha Uddin Ahmed, Zabun Nahar, Md. Siddiqul Islam, Mohammad Safiqul Islam & Abul Hasnat. (2017) DPYD*2A and MTHFR C677T predict toxicity and efficacy, respectively, in patients on chemotherapy with 5-fluorouracil for colorectal cancer. Cancer Chemotherapy and Pharmacology 81:1, pages 119-129.
Crossref
Crossref
Shu-Mei Wang, Wei-Xin Zeng, Wan-Shui Wu, Lu-Lu Sun & Dan Yan. (2017)
Association between
MTHFR
microRNA binding site polymorphisms and methotrexate concentrations in Chinese pediatric patients with acute lymphoblastic leukemia
. The Journal of Gene Medicine 19:11, pages e2990.
Crossref
Crossref
Daphne Bertholee, Jan Gerard Maring & André B. P. van Kuilenburg. (2016) Genotypes Affecting the Pharmacokinetics of Anticancer Drugs. Clinical Pharmacokinetics 56:4, pages 317-337.
Crossref
Crossref
Beibei Zhang, Weiming Zhang, Liang Yan & Daogang Wang. (2017) The association between MTHFR gene C677T polymorphism and ALL risk based on a meta-analysis involving 17,469 subjects. Clinica Chimica Acta 466, pages 85-92.
Crossref
Crossref
Andrea Scheuern, Nadine Fischer, Joseph McDonald, Hermine I. Brunner, Johannes-Peter Haas & Boris Hügle. (2016) Mutations in the MTHFR gene are not associated with Methotrexate intolerance in patients with juvenile idiopathic arthritis. Pediatric Rheumatology 14:1.
Crossref
Crossref
Lin Mei, Evelena P. Ontiveros, Elizabeth A. Griffiths, James E. Thompson, Eunice S. Wang & Meir Wetzler. (2015) Pharmacogenetics predictive of response and toxicity in acute lymphoblastic leukemia therapy. Blood Reviews 29:4, pages 243-249.
Crossref
Crossref
Sujatha Suthandiram, Gin-Gin Gan, Shamsul Mohd Zain, Ping-Chong Bee, Lay-Hoong Lian, Kian-Meng Chang, Tee-Chuan Ong & Zahurin Mohamed. (2014) Effect of polymorphisms within methotrexate pathway genes on methotrexate toxicity and plasma levels in adults with hematological malignancies. Pharmacogenomics 15:11, pages 1479-1494.
Crossref
Crossref
Elixabet Lopez-Lopez, Angela Gutierrez-Camino, Nerea Bilbao-Aldaiturriaga, Maria Pombar-Gomez, Idoia Martin-Guerrero & Africa Garcia-Orad. (2014) Pharmacogenetics of childhood acute lymphoblastic leukemia. Pharmacogenomics 15:10, pages 1383-1398.
Crossref
Crossref
Yan Liu, You Yin, Qi Sheng, Xiaotong Lu, Fang Wang, Zhiyan Lin, Huaiping Tian, Ajing Xu & Jian Zhang. (2014) Association of ABCC2 −24C>T Polymorphism with High-Dose Methotrexate Plasma Concentrations and Toxicities in Childhood Acute Lymphoblastic Leukemia. PLoS ONE 9:1, pages e82681.
Crossref
Crossref
E Lopez-Lopez, I Martin-Guerrero, J Ballesteros & A Garcia-Orad. (2012) A systematic review and meta-analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia. The Pharmacogenomics Journal 13:6, pages 498-506.
Crossref
Crossref
Yuan Jiang, Jing Hou, Qiang Zhang, Shu-Ting Jia, Bo-Yuan Wang, Ji-Hong Zhang, Wen-Ru Tang & Ying Luo. (2013) The MTHFR C677T Polymorphism and Risk of Acute Lymphoblastic Leukemia: an Updated Meta-analysis Based on 37 Case-control Studies. Asian Pacific Journal of Cancer Prevention 14:11, pages 6357-6362.
Crossref
Crossref
Susanne RadtkeOliver ZolkBertold RennerMarios PaulidesMartin Zimmermann, Anja Möricke, Martin Stanulla, Martin Schrappe & Thorsten Langer. (2013) Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia. Blood 121:26, pages 5145-5153.
Crossref
Crossref
Deena Samir Eissa & Tamer Mohamed Ahmed. (2013) C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene. Blood Coagulation & Fibrinolysis 24:2, pages 181-188.
Crossref
Crossref
Elixabet Lopez-Lopez, Javier Ballesteros, Maria A. Piñan, José Sanchez de Toledo, Nagore Garcia de Andoin, Purificacion Garcia-Miguel, Aurora Navajas & Africa Garcia-Orad. (2013) Polymorphisms in the methotrexate transport pathway. Pharmacogenetics and Genomics 23:2, pages 53-61.
Crossref
Crossref
J Salazar, A Altés, E del Río, J Estella, S Rives, M Tasso, A Navajas, J Molina, M Villa, J L Vivanco, M Torrent, M Baiget & I Badell. (2011) Methotrexate consolidation treatment according to pharmacogenetics of MTHFR ameliorates event-free survival in childhood acute lymphoblastic leukaemia. The Pharmacogenomics Journal 12:5, pages 379-385.
Crossref
Crossref
Lin Yang, Xin Hu & Luhang Xu. (2012) Impact of methylenetetrahydrofolate reductase (MTHFR) polymorphisms on methotrexate-induced toxicities in acute lymphoblastic leukemia: a meta-analysis. Tumor Biology 33:5, pages 1445-1454.
Crossref
Crossref
Mutlu Dogan, Halil G. Karabulut, Ajlan Tukun, Ahmet Demirkazik, Gungor Utkan, Bulent Yalcin, Dilek Dincol, Hakan Akbulut & Fikri Icli. (2012) Relationship Between Antimetabolite Toxicity and Pharmacogenetics in Turkish Cancer Patients. Asian Pacific Journal of Cancer Prevention 13:4, pages 1553-1556.
Crossref
Crossref
Patrizia Chiusolo, Sabrina Giammarco, Silvia Bellesi, Elisabetta Metafuni, Nicola Piccirillo, Daniela De Ritis, Sara Marietti, Sorà Federica, Luca Laurenti, Luana Fianchi, Stefan Hohaus, Leone Giuseppe & Simona Sica. (2011) The role of MTHFR and RFC1 polymorphisms on toxicity and outcome of adult patients with hematological malignancies treated with high-dose methotrexate followed by leucovorin rescue. Cancer Chemotherapy and Pharmacology 69:3, pages 691-696.
Crossref
Crossref
Kelong Ma, Yinghua He, Hongyu Zhang, Qi Fei, Dandan Niu, Dongmei Wang, Xia Ding, Hua Xu, Xiaoping Chen & Jingde Zhu. (2012) DNA Methylation-regulated miR-193a-3p Dictates Resistance of Hepatocellular Carcinoma to 5-Fluorouracil via Repression of SRSF2 Expression. Journal of Biological Chemistry 287:8, pages 5639-5649.
Crossref
Crossref
Elixabet Lopez–Lopez, Javier Ballesteros & Africa Garcia-Orad. (2011) MTHFR 677TT genotype and toxicity of methotrexate: controversial results. Cancer Chemotherapy and Pharmacology 68:5, pages 1369-1370.
Crossref
Crossref
Velia D’Angelo, Maria Ramaglia, Adriana Iannotta, Stefania Crisci, Paolo Indolfi, Matteo Francese, Maria Carmen Affinita, Giulia Pecoraro, Addolorata Napolitano, Claudia Fusco, Matilde Oreste, Cristiana Indolfi & Fiorina Casale. (2011) Methotrexate toxicity and efficacy during the consolidation phase in paediatric acute lymphoblastic leukaemia and MTHFR polymorphisms as pharmacogenetic determinants. Cancer Chemotherapy and Pharmacology 68:5, pages 1339-1346.
Crossref
Crossref
Barbara Faganel Kotnik, Iztok Grabnar, Petra Bohanec Grabar, Vita Dolžan & Janez Jazbec. (2011) Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma. European Journal of Clinical Pharmacology 67:10, pages 993-1006.
Crossref
Crossref
Elixabet Lopez‐Lopez, Idoia Martin‐Guerrero, Javier Ballesteros, M. Angeles Piñan, Purificacion Garcia‐Miguel, Aurora Navajas & Africa Garcia‐Orad. (2011) Polymorphisms of the SLCO1B1 gene predict methotrexate‐related toxicity in childhood acute lymphoblastic leukemia. Pediatric Blood & Cancer 57:4, pages 612-619.
Crossref
Crossref
Nikolaos V. KarathanasisEftichia StiakakiGeorge N. GoulielmosMaria Kalmanti. (2011) The Role of the Methylenetetrahydrofolate Reductase 677 and 1298 Polymorphisms in Cretan Children with Acute Lymphoblastic Leukemia. Genetic Testing and Molecular Biomarkers 15:1-2, pages 5-10.
Crossref
Crossref
Luis Alberto Henríquez-Hernández, Adolfo Murias-Rosales, Ana González-Hernández, Antonio Cabrera de León, Nicolás Díaz-Chico & Leandro Fernández-Pérez. (2010) Distribution of TYMS, MTHFR, p53 and MDR1 gene polymorphisms in patients with breast cancer treated with neoadjuvant chemotherapy. Cancer Epidemiology 34:5, pages 634-638.
Crossref
Crossref