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Original

The protective effect of alpha lipoic acid against traumatic brain injury in rats

, , , , & , PhD
Pages 658-667 | Received 18 Feb 2009, Published online: 21 Jul 2009

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Crossref
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Crossref
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Crossref
Edward D. Hall, Radhika A. Vaishnav & Ayman G. Mustafa. (2010) Antioxidant therapies for traumatic brain injury. Neurotherapeutics 7:1, pages 51-61.
Crossref

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