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Research Article

Respirable controlled release polymeric colloid (RCRPC) of bosentan for the management of pulmonary hypertension: in vitro aerosolization, histological examination and in vivo pulmonary absorption

Lydia A. HannaDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Emad B. BasaliousDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptCorrespondence[email protected] [email protected]

Omaima N. ELGazayerlyDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Pages 188-198 | Received 08 Jul 2016, Accepted 19 Sep 2016, Published online: 03 Feb 2017

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https://doi.org/10.1080/10717544.2016.1239661
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Hamza Boucetta, Lei Zhang, Alejandro Sosnik & Wei He. (2024) Pulmonary arterial hypertension nanotherapeutics: New pharmacological targets and drug delivery strategies. Journal of Controlled Release 365, pages 236-258.
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Duygu YILMAZ USTA, Seval OLGAC, Burcu TIMUR & Zeynep Safak TEKSIN. (2023) Development and pharmacokinetic evaluation of Neusilin® US2-based S-SNEDDS tablets for bosentan: Fasted and fed states bioavailability, IVIS® real-time biodistribution, and ex-vivo imaging. International Journal of Pharmaceutics 643, pages 123219.
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Shamsun Nahar, Srishti Kanda, Uzair Chatha, Victor A Odoma, Aakanksha Pitliya, Esraa M AlEdani, Japneet K Bhangu, Khalid Javed, Prabhleen Kaur Manshahia & Ann Kashmer Yu. (2023) Current Status of Endothelin Receptor Antagonists in Pulmonary Arterial Hypertension: A Combined Study Results and Pharmacology-Based Review. Cureus.
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Shuya Wang, Qiaohui Chen, Tianjiao Zhao, Kelong Ai & Changping Hu. (2023) Nanomedicine-based treatment: An emerging therapeutical strategy for pulmonary hypertension. Nano Research 16:5, pages 7007-7029.
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Riya Mahar, Arpita Chakraborty, Nidhi Nainwal, Richa Bahuguna, Meenakshi Sajwan & Vikash Jakhmola. (2023) Application of PLGA as a Biodegradable and Biocompatible Polymer for Pulmonary Delivery of Drugs. AAPS PharmSciTech 24:1.
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Alam Zeb, Maleeha Gul, Thi-Thao-Linh Nguyen & Han-Joo Maeng. (2022) Controlled release and targeted drug delivery with poly(lactic-co-glycolic acid) nanoparticles: reviewing two decades of research. Journal of Pharmaceutical Investigation 52:6, pages 683-724.
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Sagar Dhoble, Vandana Patravale, Edward Weaver, Dimitrios A. Lamprou & Tanmay Patravale. (2022) Comprehensive review on novel targets and emerging therapeutic modalities for pulmonary arterial Hypertension. International Journal of Pharmaceutics 621, pages 121792.
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Qun Zhao, Cuilan Hou, Yi Lu, Qingzhu Qiu, Lijian Xie, Shan Xu, Tingting Xiao & Mingkang Zhong. (2022) Characterization and protective effects of a novel Bosentan nano-particle. Journal of Drug Delivery Science and Technology 68, pages 102970.
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Yi Guo, Hriday Bera, Changzhi Shi, Li Zhang, Dongmei Cun & Mingshi Yang. (2021) Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines. Acta Pharmaceutica Sinica B 11:8, pages 2565-2584.
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Guravtar Singh Mann, Lakhwinder Pal Singh, Parmod Kumar, Sunpreet Singh & Chander Prakash. (2019) On briefing the surface modifications of polylactic acid: A scope for betterment of biomedical structures. Journal of Thermoplastic Composite Materials 34:7, pages 977-1005.
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Nermeen A. ElKasabgy, Islam M. Adel & Mohamed F. Elmeligy. (2020) Respiratory Tract: Structure and Attractions for Drug Delivery Using Dry Powder Inhalers. AAPS PharmSciTech 21:7.
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Andrew M. Shen & Tamara Minko. (2020) Pharmacokinetics of inhaled nanotherapeutics for pulmonary delivery. Journal of Controlled Release 326, pages 222-244.
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Mennatullah M. Ibrahim, Emad B. Basalious & Mohamed A. El-Nabarawi. (2020) Consolidated bile-based vesicles/self-nanoemulsifying system (CBBVs/SNES) as a solution for limitations of oral delivery of vesicular dispersions: In-vitro optimization and elucidation of ex-vivo intestinal transport mechanisms. Journal of Drug Delivery Science and Technology 56, pages 101489.
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Bibek Laha, Sanjib Das, Sabyasachi Maiti & Kalyan Kumar Sen. (2019) Novel propyl karaya gum nanogels for bosentan: In vitro and in vivo drug delivery performance. Colloids and Surfaces B: Biointerfaces 180, pages 263-272.
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Amira A. Boseila, Amal Y. Abdel-Reheem & Emad B. Basalious. (2019) Design of bile-based vesicles (BBVs) for hepatocytes specific delivery of Daclatasvir: Comparison of ex-vivo transenterocytic transport, in-vitro protein adsorption resistance and HepG2 cellular uptake of charged and β-sitosterol decorated vesicles. PLOS ONE 14:7, pages e0219752.
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Enas M. Elmowafy, Mattia Tiboni & Mahmoud E. Soliman. (2019) Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic-co-glycolic acid) micro and nanoparticles. Journal of Pharmaceutical Investigation 49:4, pages 347-380.
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Virna M. Giménez, Norma Sperandeo, Sonia Faudone, Sandra Noriega, Walter Manucha & Diego Kassuha. (2018) Preparation and characterization of bosentan monohydrate/ε‐polycaprolactone nanoparticles obtained by electrospraying. Biotechnology Progress 35:2, pages e2748.
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Christopher Howell, James R. Smith & Janis K. Shute. (2018) Targeting matrix metalloproteinase-13 in bronchial epithelial repair. Clinical & Experimental Allergy 48:9, pages 1214-1221.
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Mustafa M. Abo Elela, Nermeen A. ElKasabgy & Emad B. Basalious. (2017) Bio-shielding In Situ Forming Gels (BSIFG) Loaded With Lipospheres for Depot Injection of Quetiapine Fumarate: In Vitro and In Vivo Evaluation. AAPS PharmSciTech 18:8, pages 2999-3010.
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Respirable controlled release polymeric colloid (RCRPC) of bosentan for the management of pulmonary hypertension: in vitro aerosolization, histological examination and in vivo pulmonary absorption

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Respirable controlled release polymeric colloid (RCRPC) of bosentan for the management of pulmonary hypertension: in vitro aerosolization, histological examination and in vivo pulmonary absorption

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