2,198
Views
39
CrossRef citations to date
0
Altmetric
Research Article

Fabrication of novel elastosomes for boosting the transdermal delivery of diacerein: statistical optimization, ex-vivo permeation, in-vivo skin deposition and pharmacokinetic assessment compared to oral formulation

, &
Pages 815-826 | Received 08 Feb 2018, Accepted 08 Mar 2018, Published online: 20 Mar 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Rofida Albash, Maha H. Ragaie, Mahmoud A. El Hassab, Radwan El-Haggar, Wagdy M. Eldehna, Sara T. Al-Rashood & Shaimaa Mosallam. (2022) Fenticonazole nitrate loaded trans-novasomes for effective management of tinea corporis: design characterization, in silico study, and exploratory clinical appraisal. Drug Delivery 29:1, pages 1100-1111.
Read now
Yan Liang, Manzhen Duan, Wei Yi, Teng Zhang, Yonggang Wang, Zhiming Wu & Huaibo Tang. (2022) Ion-pair compounds of diacerein for enhancing skin permeability in vitro: the compatibility–permeability relationship of counter ion and diacerein. Drug Delivery 29:1, pages 499-505.
Read now
Heba F Salem, Mohammed M Nafady, Adel A Ali, Nermeen M Khalil & Amani A Elsisi. (2022) Evaluation of Metformin Hydrochloride Tailoring Bilosomes as an Effective Transdermal Nanocarrier. International Journal of Nanomedicine 17, pages 1185-1201.
Read now
Shaimaa Mosallam, Maha H Ragaie, Noha H Moftah, Ahmed Hassen Elshafeey & Aly Ahmed Abdelbary. (2021) Use of Novasomes as a Vesicular Carrier for Improving the Topical Delivery of Terconazole: In Vitro Characterization, In Vivo Assessment and Exploratory Clinical Experimentation. International Journal of Nanomedicine 16, pages 119-132.
Read now
Mohamed Ahmed Naseef Soliman, Howida Kamal Ibrahim & Samia Abd El-Kader Nour. (2021) Diacerein solid dispersion loaded tablets for minimization of drug adverse effects: statistical design, formulation, in vitro, and in vivo evaluation. Pharmaceutical Development and Technology 26:3, pages 302-315.
Read now
Liwei Mao, Wei Wu, Miao Wang, Jianmin Guo, Hui Li, Shihua Zhang, Jiake Xu & Jun Zou. (2021) Targeted treatment for osteoarthritis: drugs and delivery system. Drug Delivery 28:1, pages 1861-1876.
Read now
Mona Elhabak, Samar Ibrahim & Samar M. Abouelatta. (2021) Topical delivery of l-ascorbic acid spanlastics for stability enhancement and treatment of UVB induced damaged skin. Drug Delivery 28:1, pages 445-453.
Read now
Amira Yousry Farrah, Abdulaziz M Al-mahallawi, Emad B Basalious & Demiana I Nesseem. (2020) Investigating the Potential of Phosphatidylcholine-Based Nano-Sized Carriers in Boosting the Oto-Topical Delivery of Caroverine: in vitro Characterization, Stability Assessment and ex vivo Transport Studies. International Journal of Nanomedicine 15, pages 8921-8931.
Read now
Rawia M. Khalil, Ahmed Abdelbary, Silvia Kocova El-Arini, Mona Basha & Hadeer A. El-Hashemy. (2019) Evaluation of bilosomes as nanocarriers for transdermal delivery of tizanidine hydrochloride: in vitro and ex vivo optimization. Journal of Liposome Research 29:2, pages 171-182.
Read now

Articles from other publishers (27)

Radwa M.A. Abd-Elal, Aya M. Essawy, Maha A. Salem, Mahitab Elsayed, Mona G. Khalil, Eman Abdelhakeem, Nouran A. Ali & Mai Ahmed Tawfik. (2023) Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for antidepressant effect after intranasal and transdermal delivery. International Journal of Pharmaceutics: X 6, pages 100194.
Crossref
Mai Ahmed Tawfik, Mai M. Eltaweel, Ahmed M. Fatouh, Hesham A. Shamsel-Din & Ahmed B. Ibrahim. (2023) Brain targeting of zolmitriptan via transdermal terpesomes: statistical optimization and in vivo biodistribution study by 99mTc radiolabeling technique. Drug Delivery and Translational Research 13:12, pages 3059-3076.
Crossref
Maryam Shabbir, Kashif Barkat, Muhammad Umer Ashraf & Uzair Nagra. (2023) Development of a Novel Self-Dissolving Microneedle-Assisted Percutaneous Delivery System of Diacerein through Solid Dispersion Gel: Solubility Enhancement, Proof of Anti-inflammatory Activity and Safety. Current Drug Delivery 20:9, pages 1351-1367.
Crossref
Diana Aziz, Sally Mohamed, Saadia Tayel & Amal Makhlouf. (2023) Flexosomes as a promising nanoplatform for enhancing tolnaftate ocular delivery: Formulation, in vitro characterization, statistical optimization, ex vivo and microbial in vivo studies. International Journal of Pharmaceutics 646, pages 123471.
Crossref
Nermin E Eleraky, Mahmoud El-Badry, Mahmoud Omar, Wesam El-Koussi, Noha Mohamed, Mohamed Abdel-Lateef & Abeer Hassan. (2023) Curcumin Transferosome-Loaded Thermosensitive Intranasal in situ Gel as Prospective Antiviral Therapy for SARS-Cov-2. International Journal of Nanomedicine Volume 18, pages 5831-5869.
Crossref
Taufik M Kazi & Panchaxari M Dandagi. (2023) A New Stability-Indicating RP-HPLC Method for Simultaneous Quantification of Diacerein and Aceclofenac in Novel Nanoemulgel Formulation and Commercial Tablet Dosage Form in the Presence of their Major Degradation Products Using DoE Approach. Journal of Chromatographic Science.
Crossref
AJENG I. ROSALINA, ISKANDARSYAH & ERNY SAGITA. (2023) PLACENTA EXTRACT-LOADED NOVASOME SIGNIFICANTLY IMPROVED HAIR GROWTH IN A RAT IN VIVO MODEL. International Journal of Applied Pharmaceutics, pages 138-145.
Crossref
Eva Rahman Kabir, Nausheen Syeara & Tanisha Tabassum Sayka Khan. (2023) Formulation design and optimization of sustained release tablet dosage form of Diacerein. European Polymer Journal 189, pages 111982.
Crossref
Ajeng illastria Rosalina, Erny Sagita & Iskandarsyah Iskandarsyah. (2023) Novasome: Combining Ufasome and Niosome for Excellent Vesicular Drug Delivery System. Sciences of Pharmacy 2:1, pages 35-49.
Crossref
Susanne M. Brunner, Andrea Ramspacher, Caroline Rieser, Julia Leitner, Hannah Heil, Michael Ablinger, Julia Tevini, Monika Wimmer, Andreas Koller, Josefina Piñón Hofbauer, Thomas K. Felder, Johann W. Bauer, Barbara Kofler, Roland Lang & Verena Wally. (2023) Topical Diacerein Decreases Skin and Splenic CD11c+ Dendritic Cells in Psoriasis. International Journal of Molecular Sciences 24:5, pages 4324.
Crossref
Diana Aziz, Sally A. Mohamed, Saadia Tayel & Amal Makhlouf. (2022) Enhanced Ocular Anti-Aspergillus Activity of Tolnaftate Employing Novel Cosolvent-Modified Spanlastics: Formulation, Statistical Optimization, Kill Kinetics, Ex Vivo Trans-Corneal Permeation, In Vivo Histopathological and Susceptibility Study. Pharmaceutics 14:8, pages 1746.
Crossref
Lobna M. Khalil, Ossama Y. Abdallah, Yosra S.R. Elnaggar & Wessam M. El-Refaie. (2022) Novel dermal nanobilosomes with promising browning effect of adipose tissue for management of obesity. Journal of Drug Delivery Science and Technology 74, pages 103522.
Crossref
Ameeduzzafar Zafar, Omar Awad Alsaidan, Syed Sarim Imam, Mohd Yasir, Khalid Saad Alharbi & Mohammad Khalid. (2022) Formulation and Evaluation of Moxifloxacin Loaded Bilosomes In-Situ Gel: Optimization to Antibacterial Evaluation. Gels 8:7, pages 418.
Crossref
Hongtao Shang, Ayesha Younas & Nan Zhang. (2022) Recent advances on transdermal delivery systems for the treatment of arthritic injuries: From classical treatment to nanomedicines. WIREs Nanomedicine and Nanobiotechnology 14:3.
Crossref
Yongyue Han, Juanli Pan, Yanhong Ma, Dongfang Zhou & Wei Xu. (2022) Protein-based biomaterials for combating viral infections: Current status and future prospects for development. Biosafety and Health 4:2, pages 87-94.
Crossref
Sandra Pacios-Michelena, José Daniel García-García, Rodolfo Ramos-González, Mónica Chávez-González, Elan Iñaky Laredo-Alcalá, Mayela Govea-Salas, Leticia A. Menchaca-Castro, Patricia Segura-Ceniseros, Alejandra Vargas-Segura, Roberto Arredondo-Valdes, José Luis Martínez-Hernández, Erika Nava-Reyna & Anna Ilyina. 2022. Bio-Based Nanoemulsions for Agri-Food Applications. Bio-Based Nanoemulsions for Agri-Food Applications 413 439 .
Bhupinder Singh, Teenu Sharma, Ranjot Kaur, Sumant Saini, Ripandeep Kaur & Sarwar Beg. 2022. Biomedical Translational Research. Biomedical Translational Research 315 350 .
Heba M.K. Ebada, Maha M.A. Nasra, Yosra S.R. Elnaggar, Rasha A. Nassra, Amany A. Solaiman & Ossama Y. Abdallah. (2021) Novel rhein integrate transphytosomes as non-invasive local therapy for osteoarthritis to ameliorate cartilage deterioration in MIA-arthritic rats. Colloids and Surfaces B: Biointerfaces 202, pages 111713.
Crossref
Nouran O. Eladawy, Nadia M. Morsi & Rehab N. Shamma. (2021) Diacerein-Loaded Hyaluosomes as a Dual-Function Platform for Osteoarthritis Management via Intra-Articular Injection: In Vitro Characterization and In Vivo Assessment in a Rat Model. Pharmaceutics 13:6, pages 765.
Crossref
Shaimaa Mosallam, Nermin M. Sheta, Ahmed Hassen Elshafeey & Aly Ahmed Abdelbary. (2021) Fabrication of Highly Deformable Bilosomes for Enhancing the Topical Delivery of Terconazole: In Vitro Characterization, Microbiological Evaluation, and In Vivo Skin Deposition Study. AAPS PharmSciTech 22:2.
Crossref
Nishtha Chaurawal & Kaisar Raza. 2021. Design of Experiments for Pharmaceutical Product Development. Design of Experiments for Pharmaceutical Product Development 27 56 .
Helen Chattopadhyay, Biswajit Auddy, Tapas Sur, Mradu Gupta & Sriparna Datta. (2020) Transdermal co-delivery of glucosamine sulfate and diacerein for the induction of chondroprotection in experimental osteoarthritis. Drug Delivery and Translational Research 10:5, pages 1327-1340.
Crossref
Nair, Shah, Aljaeid, Al-Dhubiab & Jacob. (2019) Gellan Gum-Based Hydrogel for the Transdermal Delivery of Nebivolol: Optimization and Evaluation. Polymers 11:10, pages 1699.
Crossref
Alaa Emad Eldeeb, Salwa Salah & Mahmoud Ghorab. (2019) Formulation and evaluation of cubosomes drug delivery system for treatment of glaucoma: Ex-vivo permeation and in-vivo pharmacodynamic study. Journal of Drug Delivery Science and Technology 52, pages 236-247.
Crossref
Aleksandra Kurowska, Vivek Ghate, Arun Kodoth, Aarti Shah, Abhishek Shah, Badalamoole Vishalakshi, Bharathi Prakash & Shaila A. Lewis. (2019) Non-Propellant Foams of Green Nano-Silver and Sulfadiazine: Development and In Vivo Evaluation for Burn Wounds. Pharmaceutical Research 36:8.
Crossref
Hongmin Zhang, Susu Liu, Juan Yue, Shengtao Sun, Qixue Lv, Shoujun Jian, Yanting Xie, Lei Han, Fenfen Zhang, Yanfang Dai & Liya Wang. (2019) In Vitro Antimicrobial Activity of Diacerein on 76 Isolates of Gram-Positive Cocci from Bacterial Keratitis Patients and In Vivo Study of Diacerein Eye Drops on Staphylococcus aureus Keratitis in Mice . Antimicrobial Agents and Chemotherapy 63:4.
Crossref
Mohamed Ahmed Naseef, Howida Kamal Ibrahim & Samia Abd El-Kader Nour. (2018) Solid Form of Lipid-Based Self-Nanoemulsifying Drug Delivery Systems for Minimization of Diacerein Adverse Effects: Development and Bioequivalence Evaluation in Albino Rabbits. AAPS PharmSciTech 19:7, pages 3097-3109.
Crossref