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Drug Delivery Volume 29, 2022 - Issue 1
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Review Article

Nanocrystals based pulmonary inhalation delivery system: advance and challenge

Pengfei Yuea Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of ChinaView further author information
,
Weicheng Zhoua Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of ChinaView further author information
,
Guiting Huanga Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of ChinaView further author information
,
Fangfang Leia Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of ChinaView further author information
,
Yingchong Chena Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of ChinaCorrespondence[email protected]
View further author information
,
Zhilin Mab Langka Biotechnology (Shanghai) Co., Ltd, Shanghai, People's Republic of ChinaCorrespondence[email protected]
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,
Liru Chenc Beijing Hospital, Beijing, People's Republic of ChinaView further author information
&
Ming Yanga Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of ChinaView further author information
 show all
Pages 637-651 | Received 03 Jan 2022, Accepted 01 Feb 2022, Published online: 21 Feb 2022

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Xujun Feng, Yuan Shi, Ye Zhang, Fei Lei, Rong Ren & Xiangdong Tang. (2024) Opportunities and Challenges for Inhalable Nanomedicine Formulations in Respiratory Diseases: A Review. International Journal of Nanomedicine 19, pages 1509-1538.
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Shuiying Zhang, Rui Li, Tong Jiang, Yihan Gao, Kai Zhong, Hong Cheng, Xin Chen & Shiying Li. (2024) Inhalable nanomedicine for lung cancer treatment. Smart Materials in Medicine 5:2, pages 261-280.
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Manish Kumar, Abhishek Jha, Kanchan Bharti, Manjit Manjit, Pradnya Kumbhar, Vividha Dhapte-Pawar & Brahmeshwar Mishra. (2024) Lipid-coated nanocrystals of paclitaxel as dry powder for inhalation: Characterization, in-vitro performance, and pharmacokinetic assessment. Colloids and Surfaces B: Biointerfaces 237, pages 113865.
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Liuhan Dong & Xiaomei Zhuang. (2024) Insights into Inhalation Drug Disposition: The Roles of Pulmonary Drug-Metabolizing Enzymes and Transporters. International Journal of Molecular Sciences 25:9, pages 4671.
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Mayank Sharma, Rahul Shah, Apeksha Saraf, Rohit Kumar, Rahul Maheshwari, Kalpana Balakrishnan, Abhinav Nair, Ranvijay Kumar & Piyush Kumar Gupta. (2024) Current advances in the therapeutic potential of nanomedicines for pulmonary disorders. Emergent Materials.
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Jianqing Peng, Xiaobo Zhang, Ke Zhang, Qin Wang, Runbin Sun, Yan Chen, Yi Chen & Zipeng Gong. (2024) Polysaccharides screening for pulmonary mucus penetration by molecular dynamics simulation and in vitro verification. International Journal of Biological Macromolecules 265, pages 130839.
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Benjamin Rossier, Olivier Jordan, Eric Allémann & Carlos Rodríguez-Nogales. (2024) Nanocrystals and nanosuspensions: an exploration from classic formulations to advanced drug delivery systems. Drug Delivery and Translational Research.
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Chan Hee Gil, Chanhee Oh, Jeongsoo Lee, Mincheol Jang, Junhee Han, Sung-Dong Cho, Su-Hyung Park, Ji-Ho Park & Hyun Jik Kim. (2024) Inhalation Delivery of Interferon-λ-Loaded Pulmonary Surfactant Nanoparticles Induces Rapid Antiviral Immune Responses in the Lung. ACS Applied Materials & Interfaces 16:9, pages 11147-11158.
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Yidan Ding, Tongyi Zhao, Jianing Fang, Jiexin Song, Haobo Dong, Jiarui Liu, Sijin Li & Min Zhao. (2024) Recent developments in the use of nanocrystals to improve bioavailability of APIs . WIREs Nanomedicine and Nanobiotechnology 16:2.
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Akanksha Chaturvedi, Swapnil Sharma & Rahul Shukla. (2024) Drug Nanocrystals: A Delivery Channel for Antiviral Therapies. AAPS PharmSciTech 25:3.
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Aditi Negi, Shubham Nimbkar & Jeyan Arthur Moses. (2023) Engineering Inhalable Therapeutic Particles: Conventional and Emerging Approaches. Pharmaceutics 15:12, pages 2706.
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Heba Banat, Rita Ambrus & Ildikó Csóka. (2023) Drug combinations for inhalation: Current products and future development addressing disease control and patient compliance. International Journal of Pharmaceutics 643, pages 123070.
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Yu Tang, Lanfang Zhang, Rui Sun, Baiyi Luo, Yu Zhou, Yan Zhang, Yuqi Liang, Bo Xiao & Chenhui Wang. (2023) Pulmonary delivery of mucus-traversing PF127-modified silk fibroin nanoparticles loading with quercetin for lung cancer therapy. Asian Journal of Pharmaceutical Sciences 18:4, pages 100833.
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Mengqin Guo, Tingting Peng, Chuanbin Wu, Xin Pan & Zhengwei Huang. (2023) Engineering Ferroptosis Inhibitors as Inhalable Nanomedicines for the Highly Efficient Treatment of Idiopathic Pulmonary Fibrosis. Bioengineering 10:6, pages 727.
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David Rudolph, Natalja Redinger, Katharina Schwarz, Feng Li, Gabriela Hädrich, Michaela Cohrs, Lea Ann Dailey, Ulrich E. Schaible & Claus Feldmann. (2023) Amorphous Drug Nanoparticles for Inhalation Therapy of Multidrug-Resistant Tuberculosis. ACS Nano 17:10, pages 9478-9486.
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Sıla Gülbağ Pınar, Ayşe Nur Oktay, Alptuğ Eren Karaküçük & Nevin Çelebi. (2023) Formulation Strategies of Nanosuspensions for Various Administration Routes. Pharmaceutics 15:5, pages 1520.
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Riya Mahar, Arpita Chakraborty, Nidhi Nainwal, Richa Bahuguna, Meenakshi Sajwan & Vikash Jakhmola. (2023) Application of PLGA as a Biodegradable and Biocompatible Polymer for Pulmonary Delivery of Drugs. AAPS PharmSciTech 24:1.
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Yuan-Yuan Liu, Jie Liu, Hao Wu, Qiangqiang Zhang, Xue-Rui Tang, Dan Li, Chen-Si Li, Yuanfang Liu, Aoneng Cao & Haifang Wang. (2022) Endocytosis, Distribution, and Exocytosis of Polystyrene Nanoparticles in Human Lung Cells. Nanomaterials 13:1, pages 84.
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Ying Wang, Deng-Guang Yu, Yang Liu & Ya-Nan Liu. (2022) Progress of Electrospun Nanofibrous Carriers for Modifications to Drug Release Profiles. Journal of Functional Biomaterials 13:4, pages 289.
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Abeer S. Hassan & Ghareb M. Soliman. (2022) Rutin Nanocrystals with Enhanced Anti-Inflammatory Activity: Preparation and Ex Vivo/In Vivo Evaluation in an Inflammatory Rat Model. Pharmaceutics 14:12, pages 2727.
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Vinith Kotian, Marina Koland & Srinivas Mutalik. (2022) Nanocrystal-Based Topical Gels for Improving Wound Healing Efficacy of Curcumin. Crystals 12:11, pages 1565.
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Jimin Lee & Hongkee Sah. (2022) Preparation of PLGA Nanoparticles by Milling Spongelike PLGA Microspheres. Pharmaceutics 14:8, pages 1540.
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Nidhi Nainwal, Yuwanshi Sharma & Vikash Jakhmola. (2022) Dry powder inhalers of antitubercular drugs. Tuberculosis 135, pages 102228.
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