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Original Articles

The Future of Toxicity Testing

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Pages 163-196 | Published online: 21 Jun 2010

Keep up to date with the latest research on this topic with citation updates for this article.

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Daniel Krewski, Michael Bird, Mustafa Al-Zoughool, Nicholas Birkett, Mélissa Billard, Brittany Milton, Jerry M. Rice, Yann Grosse, Vincent J. Cogliano, Mark A. Hill, Robert. A. Baan, Julian Little & Jan M. Zielinski. (2019) Key characteristics of 86 agents known to cause cancer in humans. Journal of Toxicology and Environmental Health, Part B 22:7-8, pages 244-263.
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Filipa Esteves, Eduardo Teixeira, Tânia Amorim, Carla Costa, Cristiana Pereira, Sónia Fraga, Vanessa Moraes De Andrade, João Paulo Teixeira & Solange Costa. (2017) Assessment of DNA damage in a group of professional dancers during a 10-month dancing season. Journal of Toxicology and Environmental Health, Part A 80:13-15, pages 797-804.
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Joachim D. Pleil & Jon R. Sobus. (2013) Estimating Lifetime Risk from Spot Biomarker Data and Intraclass Correlation Coefficients (ICC). Journal of Toxicology and Environmental Health, Part A 76:12, pages 747-766.
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Brooke T. Mossman$suffix/text()$suffix/text(), Morton Lippmann, Thomas W. Hesterberg, Karl T. Kelsey, Aaron Barchowsky & James C. Bonner. (2011) Pulmonary Endpoints (Lung Carcinomas and Asbestosis) Following Inhalation Exposure to Asbestos. Journal of Toxicology and Environmental Health, Part B 14:1-4, pages 76-121.
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Articles from other publishers (40)

Susan A. Elmore & Gary A. Boorman. 2023. Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 3. Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 3 3 32 .
Maria Walczak. 2023. Handbook of Animal Models and its Uses in Cancer Research. Handbook of Animal Models and its Uses in Cancer Research 715 726 .
Donald Wlodkowic & Marcus Jansen. (2022) High-throughput screening paradigms in ecotoxicity testing: Emerging prospects and ongoing challenges. Chemosphere 307, pages 135929.
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Donald Wlodkowic, Aleksandra Czerw, Beata Karakiewicz & Andrzej Deptała. (2021) Recent progress in cytometric technologies and their applications in ecotoxicology and environmental risk assessment. Cytometry Part A 101:3, pages 203-219.
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Maria Walczak. 2022. Handbook of Animal Models and its Uses in Cancer Research. Handbook of Animal Models and its Uses in Cancer Research 1 13 .
Kyung-Taek Rim. (2020) Adverse outcome pathways for chemical toxicity and their applications to workers’ health: a literature review. Toxicology and Environmental Health Sciences 12:2, pages 99-108.
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Julie Vrana Miller, Nicole Prince, Julia A. Mouch & Jonathan W. Boyd. 2019. Cellular Signal Transduction in Toxicology and Pharmacology. Cellular Signal Transduction in Toxicology and Pharmacology 239 266 .
Deepti Mittal & Gautam Kaul. 2019. Comprehensive Nanoscience and Nanotechnology. Comprehensive Nanoscience and Nanotechnology 343 360 .
Adi Baumgartner, Veronika Hartleb & Jim D. Taylor. 2019. Genotoxicity Assessment. Genotoxicity Assessment 209 234 .
Boris V. Krivoshiev, Gerrit T.S. Beemster, Katrien Sprangers, Ronny Blust & Steven J. Husson. (2018) A toxicogenomics approach to screen chlorinated flame retardants tris(2-chloroethyl) phosphate and tris(2-chloroisopropyl) phosphate for potential health effects. Journal of Applied Toxicology 38:4, pages 459-470.
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Boris V. Krivoshiev, Gerrit T. S. Beemster, Katrien Sprangers, Bart Cuypers, Kris Laukens, Ronny Blust & Steven J. Husson. (2018) Transcriptome profiling of HepG2 cells exposed to the flame retardant 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide (DOPO). Toxicology Research 7:3, pages 492-502.
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E.L. LeCluyse, L.M. Norona, J.A. Akingbasote, L.S. Howell, J.L. Woodhead, M.J. Cross, A.B. Roth & C.E. Goldring. 2018. Comprehensive Toxicology. Comprehensive Toxicology 651 712 .
E. Hodgson & S.A. Meyer. 2018. Comprehensive Toxicology. Comprehensive Toxicology 538 574 .
Alexander Gosslau. 2016. Food Toxicology. Food Toxicology 11 34 .
Alexander Gosslau. (2016) Assessment of food toxicology. Food Science and Human Wellness 5:3, pages 103-115.
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Joachim D Pleil & Kristin K Isaacs. (2016) High-resolution mass spectrometry: basic principles for using exact mass and mass defect for discovery analysis of organic molecules in blood, breath, urine and environmental media. Journal of Breath Research 10:1, pages 012001.
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Mabrouk Hamadache, Othmane Benkortbi, Salah Hanini, Abdeltif Amrane, Latifa Khaouane & Cherif Si Moussa. (2016) A Quantitative Structure Activity Relationship for acute oral toxicity of pesticides on rats: Validation, domain of application and prediction. Journal of Hazardous Materials 303, pages 28-40.
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Yuanming Xu, Francesca E. Duncan, Min Xu & Teresa K. Woodruff. (2016) Use of an organotypic mammalian in vitro follicle growth assay to facilitate female reproductive toxicity screening. Reproduction, Fertility and Development 28:9, pages 1295.
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Sebastian Hoffmann, Thomas Hartung & Martin Stephens. 2016. Validation of Alternative Methods for Toxicity Testing. Validation of Alternative Methods for Toxicity Testing 231 241 .
Margarethe Hofmann-Amtenbrink, David W. Grainger & Heinrich Hofmann. (2015) Nanoparticles in medicine: Current challenges facing inorganic nanoparticle toxicity assessments and standardizations. Nanomedicine: Nanotechnology, Biology and Medicine 11:7, pages 1689-1694.
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Michelle M. Angrish, Michael C. Madden & Joachim D. Pleil. (2015) Probe Molecule (PrM) Approach in Adverse Outcome Pathway (AOP) Based High-Throughput Screening (HTS): In Vivo Discovery for Developing in Vitro Target Methods . Chemical Research in Toxicology 28:4, pages 551-559.
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Daniel Krewski, Margit Westphal, Melvin E. Andersen, Gregory M. Paoli, Weihsueh A. Chiu, Mustafa Al-Zoughool, Maxine C. Croteau, Lyle D. Burgoon & Ila Cote. (2014) A Framework for the Next Generation of Risk Science. Environmental Health Perspectives 122:8, pages 796-805.
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Steven Wink, Steven Hiemstra, Suzanna Huppelschoten, Erik Danen, Marije Niemeijer, Giel Hendriks, Harry Vrieling, Bram Herpers & Bob van de Water. (2014) Quantitative High Content Imaging of Cellular Adaptive Stress Response Pathways in Toxicity for Chemical Safety Assessment. Chemical Research in Toxicology 27:3, pages 338-355.
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Yu-Mei Tan, Daniel T. Chang, Martin Phillips, Stephen Edwards, Christopher M. Grulke, Michael-Rock Goldsmith, Jon Sobus, Rory Conolly, Rogelio Tornero-Velez & Curtis C. Dary. 2014. Biomarkers in Toxicology. Biomarkers in Toxicology 1039 1055 .
Damien Breheny. 2014. Systems Biology of Free Radicals and Antioxidants. Systems Biology of Free Radicals and Antioxidants 2853 2872 .
Ernest Hodgson, Andrew D. Wallace, Ruchir R. Shah, Kyoungju Choi & Hyun Joo. (2014) Human Variation and Risk Assessment: Microarray and Other Studies Utilizing Human Hepatocytes and Human Liver Subcellular Preparations. Journal of Biochemical and Molecular Toxicology 28:1, pages 1-10.
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Monika Nendza, Silke Gabbert, Ralph Kühne, Anna Lombardo, Alessandra Roncaglioni, Emilio Benfenati, Romualdo Benigni, Cecilia Bossa, Sebastian Strempel, Martin Scheringer, Alberto Fernández, Robert Rallo, Francesc Giralt, Sabcho Dimitrov, Ovanes Mekenyan, Frank Bringezu & Gerrit Schüürmann. (2013) A comparative survey of chemistry-driven in silico methods to identify hazardous substances under REACH. Regulatory Toxicology and Pharmacology 66:3, pages 301-314.
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Robert A. Ettlin. (2012) Toxicologic Pathology in the 21st Century. Toxicologic Pathology 41:5, pages 689-708.
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Dale M. Walker, Janice A. Nicklas & Vernon E. Walker. (2013) The stress response resolution assay. II. Quantitative assessment of environmental agent/condition effects on cellular stress resolution outcomes in epithelium. Environmental and Molecular Mutagenesis 54:4, pages 281-293.
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Susan A. Elmore & Gary A. Boorman. 2013. Haschek and Rousseaux's Handbook of Toxicologic Pathology. Haschek and Rousseaux's Handbook of Toxicologic Pathology 1029 1049 .
Adolf Baumgartner. 2013. Genotoxicity Assessment. Genotoxicity Assessment 245 268 .
Raghuraman Venkatapathy & Nina Ching Y. Wang. 2013. Computational Toxicology. Computational Toxicology 305 340 .
Silvia Lapenna, Silke Gabbert & Andrew Worth. (2012) Training Needs for Toxicity Testing in the 21st Century: A Survey-informed Analysis. Alternatives to Laboratory Animals 40:6, pages 313-320.
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Joachim D. Pleil, Marc A. Williams & Jon R. Sobus. (2012) Chemical Safety for Sustainability (CSS): Human in vivo biomonitoring data for complementing results from in vitro toxicology—A commentary. Toxicology Letters 215:3, pages 201-207.
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Albert R. Cunningham, C. Alex Carrasquer, Shahid Qamar, Jon M. Maguire, Suzanne L. Cunningham & John O. Trent. (2012) Global structure–activity relationship model for nonmutagenic carcinogens using virtual ligand-protein interactions as model descriptors. Carcinogenesis 33:10, pages 1940-1945.
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Klaus-Peter Wilhelm, Hongbo Zhai & Howard I. MaibachSebastian Hoffmann, Thomas Hartung & David Basketter. 2012. Dermatotoxicology. Dermatotoxicology 21 27 .
Jens-Uwe Peters, Jérôme Hert, Caterina Bissantz, Alexander Hillebrecht, Grégori Gerebtzoff, Stefanie Bendels, Fabien Tillier, Jacques Migeon, Holger Fischer, Wolfgang Guba & Manfred Kansy. (2012) Can we discover pharmacological promiscuity early in the drug discovery process?. Drug Discovery Today 17:7-8, pages 325-335.
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Zhiwu Lin & Yvonne Will. (2012) Evaluation of Drugs With Specific Organ Toxicities in Organ-Specific Cell Lines. Toxicological Sciences 126:1, pages 114-127.
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Sudin Bhattacharya, Qiang Zhang, Paul L. Carmichael, Kim Boekelheide & Melvin E. Andersen. (2011) Toxicity Testing in the 21st Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways. PLoS ONE 6:6, pages e20887.
Crossref
Daniel KrewskiMargit WestphalMustafa Al-ZoughoolMaxine C. CroteauMelvin E. Andersen. (2011) New Directions in Toxicity Testing. Annual Review of Public Health 32:1, pages 161-178.
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