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Original Articles

Dose-Response Relationships For Blood Cobalt Concentrations and Health Effects: A Review of the Literature and Application of a Biokinetic Model

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Pages 493-523 | Published online: 30 Nov 2012

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Read on this site (9)

Noora Honkasaari, Olli Lainiala, Outi Laine, Aleksi Reito & Antti Eskelinen. (2020) No association between blood count levels and whole-blood cobalt and chromium levels in 1,900 patients with metal-on-metal hip arthroplasty. Acta Orthopaedica 91:6, pages 711-716.
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Michael Kovochich, Brent L. Finley, Rachel Novick, Andrew D. Monnot, Ellen Donovan, Kenneth M. Unice, Ernest S. Fung, David Fung & Dennis J. Paustenbach. (2018) Understanding outcomes and toxicological aspects of second generation metal-on-metal hip implants: a state-of-the-art review. Critical Reviews in Toxicology 48:10, pages 839-887.
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Brooke E. Tvermoes, Dennis J. Paustenbach, Brent D. Kerger, Brent L. Finley & Kenneth M. Unice. (2015) Review of cobalt toxicokinetics following oral dosing: Implications for health risk assessments and metal-on-metal hip implant patients. Critical Reviews in Toxicology 45:5, pages 367-387.
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Marieke A. Dijkman, Irma de Vries & Jan Meulenbelt. (2014) Interpreting cobalt blood concentrations in hip implant patients – let us not, yet, skip the uncertainty factor. Clinical Toxicology 52:5, pages 568-568.
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Dennis J. Paustenbach, David A. Galbraith & Brent L. Finley. (2014) Interpreting cobalt blood concentrations in hip implant patients. Clinical Toxicology 52:2, pages 98-112.
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Brent L. Finley, Kenneth M. Unice, Brent D. Kerger, Joanne M. Otani, Dennis J. Paustenbach, David A. Galbraith & Brooke E. Tvermoes. (2013) 31-Day Study of Cobalt(II) Chloride Ingestion in Humans: Pharmacokinetics and Clinical Effects. Journal of Toxicology and Environmental Health, Part A 76:21, pages 1210-1224.
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Dennis J. Paustenbach, Brooke E. Tvermoes, Kenneth M. Unice, Brent L. Finley & Brent D. Kerger. (2013) A review of the health hazards posed by cobalt. Critical Reviews in Toxicology 43:4, pages 316-362.
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Brent D. Kerger, Russell Gerads, Hakan Gurleyuk, Kerry A. Thuett, Brent L. Finley & Dennis J. Paustenbach. (2013) Cobalt speciation assay for human serum, Part I. Method for measuring large and small molecular cobalt and protein-binding capacity using size exclusion chromatography with inductively coupled plasma-mass spectroscopy detection. Toxicological & Environmental Chemistry 95:4, pages 687-708.
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