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Biomarkers Volume 9, 2004 - Issue 4-5
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Research Article

Development of a multivariate statistical model to predict peroxisome proliferation in the rat, based on urinary 1H-NMR spectral patterns

Susan C. Connor Safety Assessment, GlaxoSmithKline, Park Road, Hertfordshire, SG12 0DP, Ware, UKCorrespondence[email protected]
,
Mark P. Hodson Safety Assessment, GlaxoSmithKline, Park Road, Hertfordshire, SG12 0DP, Ware, UK
,
Stephanie Ringeissen Safety Assessment, GlaxoSmithKline, Park Road, Hertfordshire, SG12 0DP, Ware, UK
,
Brian C. Sweatman Safety Assessment, GlaxoSmithKline, Park Road, Hertfordshire, SG12 0DP, Ware, UK
,
Paul J. Mcgill Safety Assessment, GlaxoSmithKline, Park Road, Hertfordshire, SG12 0DP, Ware, UK
,
Catherine J. Waterfield Safety Assessment, GlaxoSmithKline, Park Road, Hertfordshire, SG12 0DP, Ware, UK
&
John N. Haselden Safety Assessment, GlaxoSmithKline, Park Road, Hertfordshire, SG12 0DP, Ware, UK
 show all
Pages 364-385 | Received 11 Dec 2003, Accepted 21 Jul 2004, Published online: 04 Oct 2008

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Donald G Robertson, Michael D Reily & J David Baker. (2005) Metabonomics in preclinical drug development. Expert Opinion on Drug Metabolism & Toxicology 1:3, pages 363-376.
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Elina Ioannou, Stavros Oikonomou, Nikolaos Efthymiou, Andria Constantinou, Thibaut Delplancke, Pantelis Charisiadis & Konstantinos C. Makris. (2023) A time differentiated dietary intervention effect on the biomarkers of exposure to pyrethroids and neonicotinoids pesticides. iScience 26:2, pages 105847.
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Xinming Yun, Shu Dong, Qiaoqiao Hu, Yue Dai & Yufeng Xia. (2018) 1H NMR-based metabolomics approach to investigate the urine samples of collagen-induced arthritis rats and the intervention of tetrandrine. Journal of Pharmaceutical and Biomedical Analysis 154, pages 302-311.
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Tingting Wei, Liangcai Zhao, Jianmin Jia, Huanhuan Xia, Yao Du, Qiuting Lin, Xiaodong Lin, Xinjian Ye, Zhihan Yan & Hongchang Gao. (2015) Metabonomic analysis of potential biomarkers and drug targets involved in diabetic nephropathy mice. Scientific Reports 5:1.
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Baldeep Kumar, Ajay Prakash, Rakesh Kumar Ruhela & Bikash Medhi. (2014) Potential of metabolomics in preclinical and clinical drug development. Pharmacological Reports 66:6, pages 956-963.
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Katharine CunninghamSandrine P. ClausJohn C. LindonElaine HolmesJeremy R. EverettJeremy K. NicholsonMuireann Coen. (2012) Pharmacometabonomic Characterization of Xenobiotic and Endogenous Metabolic Phenotypes That Account for Inter-individual Variation in Isoniazid-Induced Toxicological Response. Journal of Proteome Research 11:9, pages 4630-4642.
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Alexander V. LyubimovBo Wen. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 29 .
Zsuzsanna Ament, Mojgan Masoodi & Julian L Griffin. (2012) Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer. Genome Medicine 4:4, pages 32.
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Seok-Min Kang, Jong-Chul Park, Min-Jeong Shin, Hyeran Lee, Jaewon Oh, Do Hyun Ryu, Geum-Sook Hwang & Ji Hyung Chung. (2011) 1H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure. Clinical Biochemistry 44:4, pages 293-299.
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Warwick B. Dunn, David I. Broadhurst, Helen J. Atherton, Royston Goodacre & Julian L. Griffin. (2011) Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy. Chem. Soc. Rev. 40:1, pages 387-426.
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Muireann Coen. (2010) A metabonomic approach for mechanistic exploration of pre-clinical toxicology. Toxicology 278:3, pages 326-340.
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B. van Ravenzwaay, G. C. Cunha, E. Fabian, M. Herold, H. Kamp, G. Krennrich, A. Krotzky, E. Leibold, R. Looser, W. Mellert, A. Prokoudine, V. Strauss, R. Trethewey, T. Walk & J. Wiemer. 2010. An Omics Perspective on Cancer Research. An Omics Perspective on Cancer Research 141 166 .
Wei Xie, Qian Wu, Izabela Kania-Korwel, Job C. Tharappel, Sanjay Telu, Mitchell C. Coleman, Howard P. Glauert, Kurunthachalam Kannan, S. V. S. Mariappan, Douglas R. Spitz, Jamie Weydert & Hans-Joachim Lehmler. (2009) Subacute exposure to N-ethyl perfluorooctanesulfonamidoethanol results in the formation of perfluorooctanesulfonate and alters superoxide dismutase activity in female rats. Archives of Toxicology 83:10, pages 909-924.
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Andrew D. Patterson, Ondřej Slanař, Kristopher W. Krausz, Fei Li, Constance C. Höfer, František Perlík, Frank J. Gonzalez & Jeffrey R. Idle. (2009) Human Urinary Metabolomic Profile of PPARα Induced Fatty Acid β-Oxidation. Journal of Proteome Research 8:9, pages 4293-4300.
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Muireann Coen, Elaine Holmes, John C. Lindon & Jeremy K. Nicholson. (2008) NMR-Based Metabolic Profiling and Metabonomic Approaches to Problems in Molecular Toxicology. Chemical Research in Toxicology 21:1, pages 9-27.
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H. C. Keun. 2008. Oncogenes Meet Metabolism. Oncogenes Meet Metabolism 79 98 .
Yueying ZhenKristopher W. KrauszChi ChenJeffrey R. Idle & Frank J. Gonzalez. (2007) Metabolomic and Genetic Analysis of Biomarkers for Peroxisome Proliferator-Activated Receptor α Expression and Activation. Molecular Endocrinology 21:9, pages 2136-2151.
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Laura K. Schnackenberg, Yvonne P. Dragan, Michael D. Reily, Donald G. Robertson & Richard D. Beger. (2007) Evaluation of NMR spectral data of urine in conjunction with measured clinical chemistry and histopathology parameters to assess the effects of liver and kidney toxicants. Metabolomics 3:2, pages 87-100.
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R. M. Salek, M. L. Maguire, E. Bentley, D. V. Rubtsov, T. Hough, M. Cheeseman, D. Nunez, B. C. Sweatman, J. N. Haselden, R. D. Cox, S. C. Connor & J. L. Griffin. (2007) A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human. Physiological Genomics 29:2, pages 99-108.
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Mark P. Hodson, Gordon J. Dear, Andy D. Roberts, Claire L. Haylock, Rachel J. Ball, Robert S. Plumb, Chris L. Stumpf, Julian L. Griffin & John N. Haselden. (2007) A gender-specific discriminator in Sprague–Dawley rat urine: The deployment of a metabolic profiling strategy for biomarker discovery and identification. Analytical Biochemistry 362:2, pages 182-192.
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Donald G. Robertson, Michael D. Reily & Glenn H. Cantor. 2007. The Handbook of Metabonomics and Metabolomics. The Handbook of Metabonomics and Metabolomics 241 277 .
I.D. Wilson & J.K. Nicholson. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 989 1007 .
Kenji Ishihara, Naruo Katsutani & Toyohiko Aoki. (2006) A Metabonomics Study of the Hepatotoxicants Galactosamine, Methylene Dianiline and Clofibrate in Rats. Basic & Clinical Pharmacology & Toxicology 99:3, pages 251-260.
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Julian L Griffin. (2005) The Cinderella story of metabolic profiling: does metabolomics get to go to the functional genomics ball?. Philosophical Transactions of the Royal Society B: Biological Sciences 361:1465, pages 147-161.
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Jane Delaney, Mark P. Hodson, Hansa Thakkar, Susan C. Connor, Brian C. Sweatman, Steve P. Kenny, Paul J. McGill, Julie C. Holder, Kathryn A. Hutton, John N. Haselden & Catherine J. Waterfield. (2004) Tryptophan?NAD+ pathway metabolites as putative biomarkers and predictors of peroxisome proliferation. Archives of Toxicology 79:4, pages 208-223.
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Marielle Delnomdedieu & Richard P. Schneider. 2005. Annual Reports in Medicinal Chemistry Volume 40. Annual Reports in Medicinal Chemistry Volume 40 387 402 .
Konstantinos Makris, Elina Ioannou, Stavros Oikonomou, Nikolaos Efthymiou, Andria Constantinou, Thibault Delplancke & Pantelis Charisiadis. (2022) An Iso-Pesticide and Time-Restricted Dietary Intervention on the Biomarkers of Exposure to Pyrethroids and Neonicotonoid Pesticides: The Circa-Chem Cross-Over Randomized Trial. SSRN Electronic Journal.
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