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Original

Effect of pure genistein on bone markers and hot flushes

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Pages 371-379 | Received 13 Jun 2005, Accepted 17 Aug 2005, Published online: 03 Jul 2009

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Masoumeh Akhlaghi, Maryam Ghasemi Nasab, Maryam Riasatian & Fatemeh Sadeghi. (2020) Soy isoflavones prevent bone resorption and loss, a systematic review and meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition 60:14, pages 2327-2341.
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David W. Sturdee & Alastair H. MacLennan. (2006) Not all placebos are equally pleasing. Climacteric 9:6, pages 401-403.
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Annalidia Sammartino, Giovanni Antonio Tommaselli, Virginia Gargano, Costantino di Carlo, Wanda Attianese & Carmine Nappi. (2006) Short-term effects of a combination of isoflavones, lignans and Cimicifuga racemosa on climacteric-related symptoms in postmenopausal women: A double-blind, randomized, placebo-controlled trial. Gynecological Endocrinology 22:11, pages 646-650.
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Articles from other publishers (32)

Priyanka Ramesh, Rahul Jagadeesan, Saravanan Sekaran, Anuradha Dhanasekaran & Selvaraj Vimalraj. (2021) Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling. Frontiers in Endocrinology 12.
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Yan-Bin Ye, Kai-Yin He, Wan-Lin Li, Shu-Yu Zhuo, Yu-Ming Chen, Wei Lu, Shang-Ling Wu, Juan Liu, Yan-Bing Li & Fang-Fang Zeng. (2021) Effects of daidzein and genistein on markers of cardiovascular disease risk among women with impaired glucose regulation: a double-blind, randomized, placebo-controlled trial. Food & Function 12:17, pages 7997-8006.
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Gonzalo R. Malca-Garcia, Yang Liu, Huali Dong, Dejan Nikolić, J. Brent Friesen, David C. Lankin, James McAlpine, Shao-Nong Chen, Birgit M. Dietz & Guido F. Pauli. (2021) Auto-hydrolysis of red clover as “green” approach to (iso)flavonoid enriched products. Fitoterapia 152, pages 104878.
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Wiesław Kanadys, Agnieszka Barańska, Agata Błaszczuk, Małgorzata Polz-Dacewicz, Bartłomiej Drop, Maria Malm & Krzysztof Kanecki. (2021) Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Environmental Research and Public Health 18:10, pages 5346.
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Hansongyi LeeRyowon ChoueHyunjung Lim. (2017) Effect of soy isoflavones supplement on climacteric symptoms, bone biomarkers, and quality of life in Korean postmenopausal women: a randomized clinical trial. Nutrition Research and Practice 11:3, pages 223.
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Supanimit Teekachunhatean, Natnita Mattawanon & Surapan Khunamornpong. (2015) Short-Term Isoflavone Intervention in the Treatment of Severe Vasomotor Symptoms after Surgical Menopause: A Case Report and Literature Review. Case Reports in Obstetrics and Gynecology 2015, pages 1-7.
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Wirin Limopasmanee, Sunee Chansakaow, Noppamas Rojanasthien, Maleeya Manorot, Chaichan Sangdee & Supanimit Teekachunhatean. (2015) Effects of the Chinese Herbal Formulation ( Liu Wei Di Huang Wan ) on the Pharmacokinetics of Isoflavones in Postmenopausal Women . BioMed Research International 2015, pages 1-8.
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Annette J. Thomas, Rita Ismail, Lisa Taylor-Swanson, Lori Cray, Janet G. Schnall, Ellen Sullivan Mitchell & Nancy Fugate Woods. (2014) Effects of isoflavones and amino acid therapies for hot flashes and co-occurring symptoms during the menopausal transition and early postmenopause: A systematic review. Maturitas 78:4, pages 263-276.
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Violet S. Lagari & Silvina Levis. (2014) Phytoestrogens for menopausal bone loss and climacteric symptoms. The Journal of Steroid Biochemistry and Molecular Biology 139, pages 294-301.
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Anne Lethaby, Jane Marjoribanks, Fredi Kronenberg, Helen Roberts, John Eden & Julie Brown. (2013) Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database of Systematic Reviews 2013:12.
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Yu Qin, Kai Niu, Yuan Zeng, Peng Liu, Long Yi, Ting Zhang, Qian Yong Zhang, Jun Dong Zhu & Man Tian Mi. (2013) Isoflavones for hypercholesterolaemia in adults. Cochrane Database of Systematic Reviews 2013:6.
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. (2012) Scientific Opinion on the substantiation of health claims related to soy isoflavones and maintenance of bone mineral density (ID 1655) and reduction of vasomotor symptoms associated with menopause (ID 1654, 1704, 2140, 3093, 3154, 3590) (further assessmen. EFSA Journal 10:8, pages 2847.
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Kyoko Taku, Melissa K. Melby, Fredi Kronenberg, Mindy S. Kurzer & Mark Messina. (2012) Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity. Menopause 19:7, pages 776-790.
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Yu Qin, Kai Niu & Man Tian Mi. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Pooneh Salari Sharif, Shekoufeh Nikfar & Mohammad Abdollahi. (2010) Prevention of bone resorption by intake of phytoestrogens in postmenopausal women: a meta-analysis. AGE 33:3, pages 421-431.
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Okechukwu Ibeanu, Susan C. Modesitt, Jennifer Ducie, Vivian von Gruenigen, Modupe Agueh & Amanda Nickles Fader. (2011) Hormone replacement therapy in gynecologic cancer survivors: Why not?. Gynecologic Oncology 122:2, pages 447-454.
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. (2011) Scientific Opinion on the substantiation of health claims related to soy isoflavones and protection of DNA, proteins and lipids from oxidative damage (ID 1286, 4245), maintenance of normal blood LDL cholesterol concentrations (ID 1135, 1704a, 3093a), reduction of vasomotor symptoms associated with menopause (ID 1654, 1704b, 2140, 3093b, 3154, 3590), maintenance of normal skin tonicity (ID 1704a), contribution to normal hair growth (ID 1704a, 4254), “cardiovascular health” (ID 3587), treatment of prostate cancer (ID 3588) and “upper respiratory tract” (ID 3589) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 9:7.
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Malkanthi Evans, James G. Elliott, Prachi Sharma, Robert Berman & Najla Guthrie. (2011) The effect of synthetic genistein on menopause symptom management in healthy postmenopausal women: A multi-center, randomized, placebo-controlled study. Maturitas 68:2, pages 189-196.
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Y. Zhang, Q. Li, H.-Y. Wan, H.-H. Xiao, W.-P. Lai, X.-S. Yao & M.-S. Wong. (2010) Study of the mechanisms by which Sambucus williamsii HANCE extract exert protective effects against ovariectomy-induced osteoporosis in vivo. Osteoporosis International 22:2, pages 703-709.
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Violet S Lagari & Silvina Levis. (2010) Phytoestrogens and bone health. Current Opinion in Endocrinology, Diabetes & Obesity 17:6, pages 546-553.
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Kyoko Taku, Melissa K. Melby, Mindy S. Kurzer, Shoichi Mizuno, Shaw Watanabe & Yoshiko Ishimi. (2010) Effects of soy isoflavone supplements on bone turnover markers in menopausal women: Systematic review and meta-analysis of randomized controlled trials. Bone 47:2, pages 413-423.
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Rafael Bolaños, Angélica Del Castillo & José Francia. (2010) Soy isoflavones versus placebo in the treatment of climacteric vasomotor symptoms. Menopause 17:3, pages 660-666.
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Augusto Ferrari. (2009) Soy extract phytoestrogens with high dose of isoflavones for menopausal symptoms. Journal of Obstetrics and Gynaecology Research 35:6, pages 1083-1090.
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Clemens B. Tempfer, Georg Froese, Georg Heinze, Eva-Katrin Bentz, Lukas A. Hefler & Johannes C. Huber. (2009) Side Effects of Phytoestrogens: A Meta-analysis of Randomized Trials. The American Journal of Medicine 122:10, pages 939-946.e9.
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Raewyn C Poulsen & Marlena C Kruger. (2008) Soy phytoestrogens: impact on postmenopausal bone loss and mechanisms of action. Nutrition Reviews 66:7, pages 359-374.
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Gary Deng, Andrew J. Vickers, K. Simon Yeung, Gabriella M. D'Andrea, Han Xiao, Alexandra S. Heerdt, Steven Sugarman, Tiffany Troso-Sandoval, Andrew D. Seidman, Clifford A. Hudis & Barrie R. Cassileth. (2007) Randomized, Controlled Trial of Acupuncture for the Treatment of Hot Flashes in Breast Cancer Patients. Journal of Clinical Oncology 25:35, pages 5584-5590.
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Anne Lethaby, Jane Marjoribanks, Fredi Kronenberg, Helen Roberts, John Eden & Julie Brown. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Jittima Manonai, Apichart Chittacharoen, Urusa Theppisai & Hathai Theppisai. (2007) Effect of Pueraria mirifica on vaginal health. Menopause 14:5, pages 919-924.
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Wolfgang Wuttke, Hubertus Jarry & Dana Seidlová-Wuttke. (2007) Isoflavones—Safe food additives or dangerous drugs?. Ageing Research Reviews 6:2, pages 150-188.
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Hassanali Vatanparast & Philip D. Chilibeck. (2008) Does the Effect of Soy Phytoestrogens on Bone in Postmenopausal Women Depend on the Equol-Producing Phenotype?. Nutrition Reviews 65:6, pages 294-299.
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Mhairi CL West. (2007) The impact of dietary oestrogens on male and female fertility. Current Opinion in Obstetrics & Gynecology 19:3, pages 215-221.
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