Effect of pure genistein on bone markers and hot flushes

References

• Albertazzi P. Purified phytoestrogens in postmenopausal bone health. Is there a role for genistein?. Climacteric 2002; 5: 190–196
   PubMed Web of Science ®Google Scholar
• Albertazzi P, Purdie D W. The nature and utility of phytoestrogens: a critical review of the evidence? An unconventional approach to postmenopausal health. Maturitas 2002; 42: 173–186
   PubMed Web of Science ®Google Scholar
• Morito K, Hirose T, Kinjo J, et al. Interaction of phytoestrogens with estrogen receptor α and β. Biol Pharm Bull 2001; 24: 351–356
   PubMed Web of Science ®Google Scholar
• Turner N J, Thomson B M, Shaw I C. Bioactive isoflavones in functional foods: the importance of gut micro flora on bioavailability. Nutr Rev 2003; 6: 204–213
   Web of Science ®Google Scholar
• Richelle M, Pridmore-Merten S, Bodenstab S, Enslen M, Offord E A. Hydrolysis of isoflavone glycosides to aglycones by beta-glycosidase does not alter plasma and urine isoflavone pharmacokinetics in postmenopausal women. J Nutr 2002; 132: 2587–2592
   PubMed Web of Science ®Google Scholar
• Messina M, Hughes C. Efficacy of soyfoods and soybean isoflavone supplements for alleviating menopausal symptoms is positively related to initial hot flush frequency. J Med Food 2003; 6: 1–11
   PubMedGoogle Scholar
• Shulman L P, Yankov V, Uhl K. Safety and efficacy of a continuous once-a-week 17beta-estradiol/levonorgestrel transdermal system and its effects on vasomotor symptoms and endometrial safety in postmenopausal women: the results of two multicenter, double-blind, randomized, controlled trials. Menopause 2002; 9: 195–207
   PubMed Web of Science ®Google Scholar
• Lock M. Encounters with Ageing. Mythology of Menopause in Japan and North America. University of California Press Ltd. 1993
   Google Scholar
• Morabito N, Crisafulli A, Vergara C, et al. Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study. J Bone Miner Res 2002; 17: 1904–1912
   PubMed Web of Science ®Google Scholar
• Squadrito F, Altavilla D, Morabito N, et al. The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women. Atherosclerosis 2002; 163: 339–347
   PubMed Web of Science ®Google Scholar
• Setchell K D, Brown N M, Desai P, et al. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J Nutr 2001; 131(Suppl 4)1362–1375S
   Google Scholar
• Greene J. Constructing a standard climacteric scale. Maturitas 1998; 29: 25–31
   PubMed Web of Science ®Google Scholar
• Wang G J, Lapcik O, Hampl R, et al. Time-resolved fluoroimmunoassay of plasma daidzein and genistein. Steroids 2000; 65: 339–348
   PubMed Web of Science ®Google Scholar
• Brouwers E, L'Homme R, Al-Maharik N, et al. Time-resolved fluoroimmunoassay for equol in plasma and urine. J Steroid Biochem Molec Biol 2003; 84: 577–588
   PubMed Web of Science ®Google Scholar
• Quella S K, Loprinzi C L, Barton D L, et al. Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: A North Central Cancer Treatment Group Trial. J Clin Oncol 2000; 18: 1068–1074
   PubMed Web of Science ®Google Scholar
• Crisafulli A, Marini H, Bitto A, et al. Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study. Menopause 2004; 11: 400–444
   PubMed Web of Science ®Google Scholar
• Sammartino A, Di Carlo C, Mandato V D, Bifulco G, Di Stefano M, Nappi C. Effects of genistein on the endometrium: ultrasonographic evaluation. Gynecol Endocrinol 2003; 17: 45–49
   PubMed Web of Science ®Google Scholar
• Albertazzi P, Pansini F, Bonaccorsi G, Zanotti L, Forini E, De Aloysio D. The effect of dietary soy supplementation on hot flushes. Obstet Gynecol 1998; 91: 6–11
   PubMed Web of Science ®Google Scholar
• Muthyala R S, Ju Y H, Sheng S, et al. Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg Med Chem 2004; 12: 1559–1567
   PubMed Web of Science ®Google Scholar
• Setchell K D, Brown N M, Lydeking-Olsen E. The clinical importance of the metabolite equol – a clue to the effectiveness of soy and its isoflavones. J Nutr 2002; 132: 3577–3584
   PubMed Web of Science ®Google Scholar
• Morton M S, Arisaka O, Miyake N, Morgan L D, Evans B A. Phytoestrogen concentrations in serum from Japanese men and women over forty years of age. J Nutr 2002; 132: 3168–3171
   PubMed Web of Science ®Google Scholar
• Nikander E, Kilkkinen A, Metsä-Heikkilä M, et al. A randomized placebo-controlled crossover trial with phytoestrogens in treatment of menopause in breast cancer patients. Obstet Gynecol 2003; 10: 1213–1220
   Web of Science ®Google Scholar
• Adlercreutz H, Mazur W. Phyto-oestrogens and Western diseases. Ann Med 1997; 29: 95–120
   PubMed Web of Science ®Google Scholar
• Cumming R S, Menton L J, III. Epidemiology and outcome of osteoporosis fractures. Lancet 2002; 359: 1761–1767
   PubMed Web of Science ®Google Scholar
• Ishimi Y, Yoshida M, Wakimoto S, et al. Genistein, a soybean isoflavone, affects bone marrow lymphopoiesis and prevents bone loss in castrated male mice. Bone 2002; 31: 180–185
   PubMed Web of Science ®Google Scholar
• Unfer V, Casini M L, Costabile L, Mignosa M, Gerli S, Di Renzo G C. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study. Fertil Steril 2004; 82: 145–148
   PubMed Web of Science ®Google Scholar