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Review

The role of insulin receptors and IGF-I receptors in cancer and other diseases

, M.D., Ph.D., , , , , & show all
Pages 23-37 | Received 18 Dec 2007, Accepted 06 Feb 2008, Published online: 10 Oct 2008

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Mariusz Dąbrowski. (2021) Diabetes, Antidiabetic Medications and Cancer Risk in Type 2 Diabetes: Focus on SGLT-2 Inhibitors. International Journal of Molecular Sciences 22:4, pages 1680.
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Sanjay Kumar Dey & Sabyasachi Senapati. 2021. Obesity and Cancer. Obesity and Cancer 25 48 .
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Crossref
Benjamin Rahmani, Jason Gandhi, Gunjan Joshi, Noel L. Smith, Inefta Reid & Sardar Ali Khan. (2020) The Role of Diabetes Mellitus in Diseases of the Gallbladder and Biliary Tract. Current Diabetes Reviews 16:9, pages 931-948.
Crossref
Jacek Rysz, Beata Franczyk, Janusz Ławiński, Robert Olszewski & Anna Gluba-Brzózka. (2020) The Role of Metabolic Factors in Renal Cancers. International Journal of Molecular Sciences 21:19, pages 7246.
Crossref
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Crossref
Valentina Guaitoli, Yoanna María Alvarez-Ginarte, Luis Alberto Montero-Cabrera, Alberto Bencomo-Martínez, Yoana Pérez Badel, Alejandro Giorgetti & Eda Suku. (2020) A computational strategy to understand structure-activity relationship of 1,3-disubstituted imidazole [1,5-α] pyrazine derivatives described as ATP competitive inhibitors of the IGF-1 receptor related to Ewing sarcoma. Journal of Molecular Modeling 26:8.
Crossref
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Crossref
Y. Wang, X. Liu, P. Yan, Y. Bi, Y. Liu & Z.-J. Zhang. (2020) Association between type 1 and type 2 diabetes and risk of non-Hodgkin's lymphoma: A meta-analysis of cohort studies. Diabetes & Metabolism 46:1, pages 8-19.
Crossref
Lise Alschuler. 2020. Textbook of Natural Medicine. Textbook of Natural Medicine 972 976.e2 .
Riccardo Vigneri & Laura Sciacca. 2020. Diabetes Complications, Comorbidities and Related Disorders. Diabetes Complications, Comorbidities and Related Disorders 377 410 .
Siddarth Agrawal, Marta Woźniak, Mateusz Łuc, Sebastian Makuch, Ewa Pielka, Anil Kumar Agrawal, Joanna Wietrzyk, Joanna Banach, Andrzej Gamian, Monika Pizon & Piotr Ziółkowski. (2019) Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulating PIK3CA and GRB2. Scientific Reports 9:1.
Crossref
Angela S Kelley, Yolanda R Smith & Vasantha Padmanabhan. (2019) A Narrative Review of Placental Contribution to Adverse Pregnancy Outcomes in Women With Polycystic Ovary Syndrome. The Journal of Clinical Endocrinology & Metabolism 104:11, pages 5299-5315.
Crossref
Hong Yu, Xi Zhong, Peng Gao, Jinxin Shi, Zhonghua Wu, Zhexu Guo, Zhenning Wang & Yongxi Song. (2019) The Potential Effect of Metformin on Cancer: An Umbrella Review. Frontiers in Endocrinology 10.
Crossref
Vella, Nicolosi, Giuliano, Morrione, Malaguarnera & Belfiore. (2019) Insulin Receptor Isoform A Modulates Metabolic Reprogramming of Breast Cancer Cells in Response to IGF2 and Insulin Stimulation. Cells 8:9, pages 1017.
Crossref
Wojciech Solarek, Michal Koper, Slawomir Lewicki, Cezary Szczylik & Anna M. Czarnecka. (2019) Insulin and insulin-like growth factors act as renal cell cancer intratumoral regulators. Journal of Cell Communication and Signaling 13:3, pages 381-394.
Crossref
Agnieszka Baranowska-Bik & Wojciech Bik. (2019) Vascular Dysfunction and Insulin Resistance in Aging. Current Vascular Pharmacology 17:5, pages 465-475.
Crossref
Alfonso Mate, Antonio J. Blanca, Rocío Salsoso, Fernando Toledo, Pablo Stiefel, Luis Sobrevia & Carmen M. Vázquez. (2019) Insulin Therapy in Pregnancy Hypertensive Diseases and its Effect on the Offspring and Mother Later in Life. Current Vascular Pharmacology 17:5, pages 455-464.
Crossref
Oleg I. Kit, Elena M. Franciyants, Aleksey N. Shevchenko, Anna A. Breus, Irina V. Neskubina, Yuliya A. Pogorelova, Elena V. Shalashnaya & E. A. Jankova. (2019) Gender differences in components of insulin-like signaling pathway in kidney tissues in local and advanced clear cell renal cell carcinoma. Medical Herald of the South of Russia 10:1, pages 35-41.
Crossref
James Y. Dai, Bo Wang, Xiaoyu Wang, Anqi Cheng, Suzanne Kolb, Janet L. Stanford & Jonathan L. Wright. (2019) Vigorous Physical Activity Is Associated with Lower Risk of Metastatic–Lethal Progression in Prostate Cancer and Hypomethylation in the CRACR2A Gene . Cancer Epidemiology, Biomarkers & Prevention 28:2, pages 258-264.
Crossref
Mattias Johansson, Robert Carreras-Torres, Ghislaine Scelo, Mark P. Purdue, Daniela Mariosa, David C. Muller, Nicolas J. Timpson, Philip C. Haycock, Kevin M. Brown, Zhaoming Wang, Yuanqing Ye, Jonathan N. Hofmann, Matthieu Foll, Valerie Gaborieau, Mitchell J. Machiela, Leandro M. Colli, Peng Li, Jean-Guillaume Garnier, Helene Blanche, Anne Boland, Laurie Burdette, Egor Prokhortchouk, Konstantin G. Skryabin, Meredith Yeager, Sanja Radojevic-Skodric, Simona Ognjanovic, Lenka Foretova, Ivana Holcatova, Vladimir Janout, Dana Mates, Anush Mukeriya, Stefan Rascu, David Zaridze, Vladimir Bencko, Cezary Cybulski, Eleonora Fabianova, Viorel Jinga, Jolanta Lissowska, Jan Lubinski, Marie Navratilova, Peter Rudnai, Simone Benhamou, Geraldine Cancel-Tassin, Olivier Cussenot, Elisabete Weiderpass, Börje Ljungberg, Raviprakash Tumkur Sitaram, Christel Häggström, Fiona Bruinsma, Susan J. Jordan, Gianluca Severi, Ingrid Winship, Kristian Hveem, Lars J. Vatten, Tony Fletcher, Susanna C. Larsson, Alicja Wolk, Rosamonde E. Banks, Peter J. Selby, Douglas F. Easton, Gabriella Andreotti, Laura E. Beane Freeman, Stella Koutros, Satu Männistö, Stephanie Weinstein, Peter E. Clark, Todd L. Edwards, Loren Lipworth, Susan M. Gapstur, Victoria L. Stevens, Hallie Carol, Matthew L. Freedman, Mark M. Pomerantz, Eunyoung Cho, Kathryn M. Wilson, J. Michael Gaziano, Howard D. Sesso, Neal D. Freedman, Alexander S. Parker, Jeanette E. Eckel-Passow, Wen-Yi Huang, Richard J. Kahnoski, Brian R. Lane, Sabrina L. Noyes, David Petillo, Bin Tean Teh, Ulrike Peters, Emily White, Garnet L. Anderson, Lisa Johnson, Juhua Luo, Julie Buring, I-Min Lee, Wong-Ho Chow, Lee E. Moore, Timothy Eisen, Marc Henrion, James Larkin, Poulami Barman, Bradley C. Leibovich, Toni K. Choueiri, G. Mark Lathrop, Jean-Francois Deleuze, Marc Gunter, James D. McKay, Xifeng Wu, Richard S. Houlston, Stephen J. Chanock, Caroline Relton, J. Brent Richards, Richard M. Martin, George Davey Smith & Paul Brennan. (2019) The influence of obesity-related factors in the etiology of renal cell carcinoma—A mendelian randomization study. PLOS Medicine 16:1, pages e1002724.
Crossref
Patrycja Nowak-Sliwinska, Judy R. van Beijnum, Elisabeth J. M. Huijbers, Paula C. Gasull, Laurie Mans, Axel Bex & Arjan W. Griffioen. (2018) Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment. British Journal of Cancer 120:2, pages 218-228.
Crossref
Erine H. Budi, Ons Mamai, Steven Hoffman, Rosemary J. Akhurst & Rik Derynck. (2019) Enhanced TGF-β Signaling Contributes to the Insulin-Induced Angiogenic Responses of Endothelial Cells. iScience 11, pages 474-491.
Crossref
Riccardo Vigneri & Laura Sciacca. 2019. Diabetes Complications, Comorbidities and Related Disorders. Diabetes Complications, Comorbidities and Related Disorders 1 34 .
Stephania Casco, Jose Carlos Arroyo-Kuribreña & Elena Soto-Vega. 2019. The Diabetes Textbook. The Diabetes Textbook 863 871 .
Barbara Altieri, Annamaria Colao & Antongiulio Faggiano. (2018) The role of insulin-like growth factor system in the adrenocortical tumors. Minerva Endocrinologica 44:1.
Crossref
Kinga Kwiecinska, Wojciech Strojny, Danuta Pietrys, Miroslaw Bik-Multanowski, Maciej Siedlar, Walentyna Balwierz & Szymon Skoczen. (2018) Late effects in survivors of childhood acute lymphoblastic leukemia in the context of selected gene polymorphisms. Italian Journal of Pediatrics 44:1.
Crossref
Zahra Nozhat, Samira Mohammadi-Yeganeh, Feridoun Azizi, Maryam Zarkesh & Mehdi Hedayati. (2018) Effects of metformin on the PI3K/AKT/FOXO1 pathway in anaplastic thyroid Cancer cell lines. DARU Journal of Pharmaceutical Sciences 26:2, pages 93-103.
Crossref
Veronica Vella, Agostino Milluzzo, Nunzio Scalisi, Paolo Vigneri & Laura Sciacca. (2018) Insulin Receptor Isoforms in Cancer. International Journal of Molecular Sciences 19:11, pages 3615.
Crossref
Naresh M. Punjabi & Jonathan M. Samet. (2018) Sleeping, eating, and cancer risk. International Journal of Cancer 143:10, pages 2367-2368.
Crossref
Grace Y. Kiyabu, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Taichi Shimazu, Shizuka Sasazuki, Manami Inoue & Shoichiro Tsugane. (2018) The association between plasma C-peptide concentration and the risk of prostate cancer: a nested case–control study within a Japanese population-based prospective study. European Journal of Cancer Prevention 27:5, pages 461-467.
Crossref
Mabel Yau, Lu Xu, Chien-Ling Huang & Chi-Ming Wong. (2018) Long Non-Coding RNAs in Obesity-Induced Cancer. Non-Coding RNA 4:3, pages 19.
Crossref
Giulia Biondani & Jean-François Peyron. (2018) Metformin, an Anti-diabetic Drug to Target Leukemia. Frontiers in Endocrinology 9.
Crossref
Caroline W Cohen, Kevin R Fontaine, Rebecca C Arend, Ronald D Alvarez, Charles A LeathIIIIII, Warner K Huh, Kerri S Bevis, Kenneth H Kim, John M StraughnJrJr & Barbara A Gower. (2018) A Ketogenic Diet Reduces Central Obesity and Serum Insulin in Women with Ovarian or Endometrial Cancer. The Journal of Nutrition 148:8, pages 1253-1260.
Crossref
Mani Ghanipoor-Samami, Ali Javadmanesh, Brian M. Burns, Dana A. Thomsen, Greg S. Nattrass, Consuelo Amor S. Estrella, Karen L. Kind & Stefan Hiendleder. (2018) Atlas of tissue- and developmental stage specific gene expression for the bovine insulin-like growth factor (IGF) system. PLOS ONE 13:7, pages e0200466.
Crossref
Caterina Mancarella & Katia Scotlandi. (2018) 40 YEARS OF IGF1: IGF system in sarcomas: a crucial pathway with many unknowns to exploit for therapy. Journal of Molecular Endocrinology 61:1, pages T45-T60.
Crossref
Ajay N. Sharma, Marilyn Tan, Ezra A. Amsterdam & Gagan D. Singh. (2018) Acromegalic cardiomyopathy: Epidemiology, diagnosis, and management. Clinical Cardiology 41:3, pages 419-425.
Crossref
Giovanna Scapin, Venkata P. Dandey, Zhening Zhang, Winifred Prosise, Alan Hruza, Theresa Kelly, Todd Mayhood, Corey Strickland, Clinton S. Potter & Bridget Carragher. (2018) Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis. Nature 556:7699, pages 122-125.
Crossref
Hae Jin Kim, SooJin Lee, Ki Hong Chun, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Young Seol Kim, Jeong-Taek Woo, Moon-Suk Nam, Sei Hyun Baik, Kyu Jeung Ahn & Kwan Woo Lee. (2018) Metformin reduces the risk of cancer in patients with type 2 diabetes. Medicine 97:8, pages e0036.
Crossref
Luisa Maria Seoane, Sulay Tovar & Carlos Dieguez. 2018. Hypothalamic-Pituitary Diseases. Hypothalamic-Pituitary Diseases 1 33 .
Riccardo Vigneri & Laura Sciacca. 2018. Diabetes Complications, Comorbidities and Related Disorders. Diabetes Complications, Comorbidities and Related Disorders 377 410 .
L. M. Seoane, S. Tovar & C. Dieguez. 2017. Thyroid Diseases. Thyroid Diseases 1 33 .
Riccardo Vigneri & Laura Sciacca. 2018. Diabetes. Epidemiology, Genetics, Pathogenesis, Diagnosis, Prevention, and Treatment. Diabetes. Epidemiology, Genetics, Pathogenesis, Diagnosis, Prevention, and Treatment 1 34 .
Ilona Argirion, Stephanie J. Weinstein, Satu Männistö, Demetrius Albanes & Alison M. Mondul. (2017) Serum Insulin, Glucose, Indices of Insulin Resistance, and Risk of Lung Cancer. Cancer Epidemiology, Biomarkers & Prevention 26:10, pages 1519-1524.
Crossref
Zhihua Du & Vladimir Uversky. (2017) A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes. International Journal of Molecular Sciences 18:10, pages 2010.
Crossref
Bo Xu, Xiufang Zhou, Xiaohong Li, Chaoyang Liu & Caizhe Yang. (2017) Diabetes mellitus carries a risk of esophageal cancer. Medicine 96:35, pages e7944.
Crossref
Rafael Calais Gaspar, José Diego Botezelli, Gabriel Keine Kuga, Vitor Rosetto Muñoz, Andressa Coope, Rodrigo Martins Pereira, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Leandro Pereira de Moura, Eduardo Rochete Ropelle & José Rodrigo Pauli. (2017) High Dosage of Vitamin D Regulates the Energy Metabolism and Increases Insulin Sensitivity, but are Associated with High Levels of Kidney Damage. Drug Development Research 78:5, pages 203-209.
Crossref
Marta Schirripa, Wu Zhang, Volker Heinemann, Shu Cao, Satoshi Okazaki, Dongyun Yang, Fotios Loupakis, Martin D. Berger, Yan Ning, Yuji Miyamoto, Mitsukuni Suenaga, Roel F. Gopez, Jordan D. West, Diana Hanna, Afsaneh Barzi, Alfredo Falcone, Sebastian Stintzing & Heinz‐Josef Lenz. (2017) Single nucleotide polymorphisms in the IGF‐IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE‐3 trial. International Journal of Cancer 141:2, pages 383-392.
Crossref
Giovanna Scapin, Venkata Dandey, Zhening Zhang, Winifred Prosise, Alan Hruza, Corey Strickland, Clinton S. Potter & Bridget Carragher. (2017) Structure of the Insulin Receptor in Complex with Insulin using Single Particle CryoEM Analysis. Microscopy and Microanalysis 23:S1, pages 1186-1187.
Crossref
Alex Farr, Myriam Stolz, Lukas Baumann, Zsuzsanna Bago-Horvath, Elisabeth Oppolzer, Georg Pfeiler, Michael Seifert & Christian F. Singer. (2017) The effect of obesity on pathological complete response and survival in breast cancer patients receiving uncapped doses of neoadjuvant anthracycline-taxane-based chemotherapy. The Breast 33, pages 153-158.
Crossref
Claudia Becker, Susan S. Jick, Christoph R. Meier & Michael Bodmer. (2017) Metformin and the risk of renal cell carcinoma: a case–control analysis. European Journal of Cancer Prevention 26:3, pages 257-262.
Crossref
Margarita S Florova, Mariya I Yarmolinskaya & Vladimir V Potin. (2017) Prospects of metformin in the treatment of endometriosis. Journal of obstetrics and women's diseases 66:2, pages 67-76.
Crossref
Harrison M. Penrose, Sandra Heller, Chloe Cable, Hani Nakhoul, Melody Baddoo, Erik Flemington, Susan E. Crawford & Suzana D. Savkovic. (2017) High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors. Carcinogenesis 38:3, pages 302-311.
Crossref
Yingying Sun, Xilin Sun & Baozhong Shen. (2017) Molecular Imaging of IGF-1R in Cancer. Molecular Imaging 16, pages 153601211773664.
Crossref
Pushpendra Singh, Shashank Kumar & Felix Bast. 2017. Translational Bioinformatics and Its Application. Translational Bioinformatics and Its Application 177 202 .
S. Elizabeth Franks, Robert A. Jones, Ritesh Briah, Payton Murray & Roger A. Moorehead. (2016) BMS-754807 is cytotoxic to non-small cell lung cancer cells and enhances the effects of platinum chemotherapeutics in the human lung cancer cell line A549. BMC Research Notes 9:1.
Crossref
Vanessa C. Miranda, Maria Ignez Braghiroli, Luiza Dib Faria, Giovanni Bariani, Alexandra Alex, João Evangelista Bezerra Neto, Fernanda C. Capareli, Jorge Sabbaga, Juliana Ferreira Lobo dos Santos, Paulo M. Hoff & Rachel P. Riechelmann. (2016) Phase 2 Trial of Metformin Combined With 5-Fluorouracil in Patients With Refractory Metastatic Colorectal Cancer. Clinical Colorectal Cancer 15:4, pages 321-328.e1.
Crossref
Thurkaa Shanmugalingam, Cecilia Bosco, Anne J. Ridley & Mieke Van Hemelrijck. (2016) Is there a role for IGF ‐1 in the development of second primary cancers? . Cancer Medicine 5:11, pages 3353-3367.
Crossref
Qiuyan Chen, Siyuan Qin, Yang Liu, Minghuang Hong, Chao-Nan Qian, Evan T. Keller, Jian Zhang & Yi Lu. (2016) IGFBP6 is a novel nasopharyngeal carcinoma prognostic biomarker. Oncotarget 7:42, pages 68140-68150.
Crossref
J. L. Dixon, L. A. Copeland, J. E. Zeber, A. A. MacCarthy, S. I. Reznik, W. R. Smythe & P. A. Rascoe. (2016) Association between diabetes and esophageal cancer, independent of obesity, in the United States Veterans Affairs population. Diseases of the Esophagus 29:7, pages 747-751.
Crossref
. 2016. The Glycemic Index. The Glycemic Index 127 155 .
Anastasios Papaioannou, Serdar Kuyucak & Zdenka Kuncic. (2016) Elucidating the Activation Mechanism of the Insulin-Family Proteins with Molecular Dynamics Simulations. PLOS ONE 11:8, pages e0161459.
Crossref
Adel M.A. Assiri & Hala F.M. Kamel. (2016) Evaluation of diagnostic and predictive value of serum adipokines: Leptin, resistin and visfatin in postmenopausal breast cancer. Obesity Research & Clinical Practice 10:4, pages 442-453.
Crossref
Seema Patel, Neeta Singh & Lalit Kumar. (2016) Anticancer role of antidiabetic drug Metformin in ovarian cancer cells. International Journal of Cancer Therapy and Oncology 4:2, pages 427.
Crossref
Atsushi Nakayama, Shigehisa Aoki, Kazuyoshi Uchihashi, Aki Nishijima-Matsunobu, Mihoko Yamamoto, Nahoko Kakihara, Ryuichi Iwakiri, Kazuma Fujimoto & Shuji Toda. (2016) Interaction between Esophageal Squamous Cell Carcinoma and Adipose Tissue in Vitro. The American Journal of Pathology 186:5, pages 1180-1194.
Crossref
Hao Cai, Yunhui Zhang, Tianxiang Kevin Han, Ruth S. Everett & Dhiren R. Thakker. (2016) Cation-selective transporters are critical to the AMPK-mediated antiproliferative effects of metformin in human breast cancer cells. International Journal of Cancer 138:9, pages 2281-2292.
Crossref
F. Westermeier, T. Sáez, P. Arroyo, F. Toledo, J. Gutiérrez, C. Sanhueza, F. Pardo, A. Leiva & L. Sobrevia. (2016) Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus. Diabetes/Metabolism Research and Reviews 32:4, pages 350-365.
Crossref
Valeria Simone, Morena D’Avenia, Antonella Argentiero, Claudia Felici, Francesca Maria Rizzo, Giovanni De Pergola & Franco Silvestris. (2016) Obesity and Breast Cancer: Molecular Interconnections and Potential Clinical Applications. The Oncologist 21:4, pages 404-417.
Crossref
Tristan I. Croll, Brian J. Smith, Mai B. Margetts, Jonathan Whittaker, Michael A. Weiss, Colin W. Ward & Michael C. Lawrence. (2016) Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain. Structure 24:3, pages 469-476.
Crossref
Krista C.J. Wink, José S.A. Belderbos, Edith M.T. Dieleman, Maddalena Rossi, Coen R.N. Rasch, Ronald A.M. Damhuis, Ruud M.A. Houben & Esther G.C. Troost. (2016) Improved progression free survival for patients with diabetes and locally advanced non-small cell lung cancer (NSCLC) using metformin during concurrent chemoradiotherapy. Radiotherapy and Oncology 118:3, pages 453-459.
Crossref
G. Capon, R. Caremel, M. de Sèze, A. Even, S. Fontaine, C.-M. Loche, S. Bart, E. Castel-Lacanal, F. Duchêne, G. Karsenty, P. Mouracade, M.-A. Perrouin-Verbe, V. Phé, D. Rey, M.-C. Scheiber-Nogueira & X. Gamé. (2016) Le retentissement du diabète sur le bas appareil urinaire : une revue du comité de neuro-urologie de l’Association française d’urologie. Progrès en Urologie 26:4, pages 245-253.
Crossref
Andre De Souza, Khadija Irfan Khawaja, Faisal Masud & Muhammad Wasif Saif. (2016) Metformin and pancreatic cancer: Is there a role?. Cancer Chemotherapy and Pharmacology 77:2, pages 235-242.
Crossref
J. M. Cottam Jones, P. W. R. Harris, D. B. Scanlon, B. E. Forbes, M. A. Brimble & A. D. Abell. (2016) Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R. Organic & Biomolecular Chemistry 14:9, pages 2698-2705.
Crossref
Suzanne L. Doyle, Claire L. Donohoe & John V. Reynolds. 2016. Critical Dietary Factors in Cancer Chemoprevention. Critical Dietary Factors in Cancer Chemoprevention 321 337 .
Günter Müller. 2016. Drug Discovery and Evaluation: Pharmacological Assays. Drug Discovery and Evaluation: Pharmacological Assays 3119 3166 .
Robert W. O’Rourke. 2016. Metabolic Syndrome and Diabetes. Metabolic Syndrome and Diabetes 111 123 .
Min Jung Bae, Sang Soo Kim, Won Jin Kim, Yang Seon Yi, Yun Kyung Jeon, Bo Hyun Kim, Byung Joo Lee, Jin Choon Lee, In Joo Kim, Soo Geun Wang & Yong Ki Kim. (2016) High prevalence of papillary thyroid cancer in Korean women with insulin resistance. Head & Neck 38:1, pages 66-71.
Crossref
Jieyan Li, Dongmei Li & Weiyuan Zhang. (2015) Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R. Oncology Reports.
Crossref
Ryan JO Dowling, Saroj Niraula, Martin C Chang, Susan J Done, Marguerite Ennis, David R McCready, Wey L Leong, Jaime M Escallon, Michael Reedijk, Pamela J Goodwin & Vuk Stambolic. (2015) Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study. Breast Cancer Research 17:1.
Crossref
H J Choi, J Y Kim, S-C Lim, G Kim, H J Yun & H S Choi. (2015) Dipeptidyl peptidase 4 promotes epithelial cell transformation and breast tumourigenesis via induction of PIN1 gene expression. British Journal of Pharmacology 172:21, pages 5096-5109.
Crossref
Paolo Giovanni Vigneri, Elena Tirrò, Maria Stella Pennisi, Michele Massimino, Stefania Stella, Chiara Romano & Livia Manzella. (2015) The Insulin/IGF System in Colorectal Cancer Development and Resistance to Therapy. Frontiers in Oncology 5.
Crossref
W Solarek, A M Czarnecka, B Escudier, Z F Bielecka, F Lian & C Szczylik. (2015) Insulin and IGFs in renal cancer risk and progression. Endocrine-Related Cancer 22:5, pages R253-R264.
Crossref
M. Agostina Santoro, R. Eric Blue, Sarah F. Andres, Amanda T. Mah, Laurianne Van Landeghem & P. Kay Lund. (2015) Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon. American Journal of Physiology-Gastrointestinal and Liver Physiology 309:7, pages G578-G589.
Crossref
Erine H. BudiBaby-Periyanayaki MuthusamyRik Derynck. (2015) The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors. Science Signaling 8:396.
Crossref
Carolin Maria Frisch, Katrin Zimmermann, Pia Zilleßen, Alexander Pfeifer, Kurt Racké & Peter Mayer. (2015) Non-small cell lung cancer cell survival crucially depends on functional insulin receptors. Endocrine-Related Cancer 22:4, pages 609-621.
Crossref
Elena Gershtein & Nikolay Kushlinskii. (2015) Clinical prospects of IGF-signaling system components study in ovarian cancer patients. Drug Metabolism and Personalized Therapy 30:2, pages 75-85.
Crossref
Ashfaque A. Memon, Louise Bennet, Bengt Zöller, Xiao Wang, Karolina Palmer, Kristina Sundquist & Jan Sundquist. (2014) Circulating human epidermal growth factor receptor 2 ( HER2 ) is associated with hyperglycaemia and insulin resistance循环中的人类表皮生长因子受体2(HER2)与高血糖以及胰岛素抵抗有关 . Journal of Diabetes 7:3, pages 369-377.
Crossref
ARTUR MATYSZEWSKI, ANNA M. CZARNECKA, WOJCIECH SOLAREK, PIOTR KORZEŃ, ILAN J. SAFIR, WOJCIECH KUKWA & CEZARY SZCZYLIK. (2015) Molecular basis of carcinogenesis in diabetic patients (Review). International Journal of Oncology 46:4, pages 1435-1443.
Crossref
Chang Dong Yeo, Ki Hoon Park, Chan Kwon Park, Sang Haak Lee, Seung Joon Kim, Hyung Kyu Yoon, Youn Soo Lee, Eun Jung Lee, Kyo Young Lee & Tae-Jung Kim. (2015) Expression of insulin-like growth factor 1 receptor (IGF-1R) predicts poor responses to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in non-small cell lung cancer patients harboring activating EGFR mutations. Lung Cancer 87:3, pages 311-317.
Crossref
Ross C. McLean & Jennifer Logue. (2014) The Individual and Combined Effects of Obesity and Type 2 Diabetes on Cancer Predisposition and Survival. Current Nutrition Reports 4:1, pages 22-32.
Crossref
Kaori Austin, Nuvair A. Imam, John E. Pintar & Patricia L. Brubaker. (2015) IGF Binding Protein-4 is Required for the Growth Effects of Glucagon-Like Peptide-2 in Murine Intestine. Endocrinology 156:2, pages 429-436.
Crossref
Fei Huang, Han Chang, Ann Greer, Stephen Hillerman, Karen A. Reeves, Warren Hurlburt, John Cogswell, Dharmesh Patel, Zhenhao Qi, Craig Fairchild, Rolf-Peter Ryseck, Tai W. Wong, Friedrich G. Finckenstein, Jeffrey Jackson & Joan M. Carboni. (2015) IRS2 Copy Number Gain, KRAS and BRAF Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines . Molecular Cancer Therapeutics 14:2, pages 620-630.
Crossref
Geoff S. Higgins, Sean M. O’Cathail, Ruth J. Muschel & W. Gillies McKenna. (2015) Drug radiotherapy combinations: Review of previous failures and reasons for future optimism. Cancer Treatment Reviews 41:2, pages 105-113.
Crossref
Sarah F. Andres, M. Agostina Santoro, Amanda T. Mah, J. Adeola Keku, Amy E. Bortvedt, R. Eric Blue & P. Kay Lund. (2015) Deletion of intestinal epithelial insulin receptor attenuates high-fat diet-induced elevations in cholesterol and stem, enteroendocrine, and Paneth cell mRNAs. American Journal of Physiology-Gastrointestinal and Liver Physiology 308:2, pages G100-G111.
Crossref
Daniel R. Morales & Andrew D. Morris. (2015) Metformin in Cancer Treatment and Prevention. Annual Review of Medicine 66:1, pages 17-29.
Crossref
Jin KimYoon Hee LeeJung Han Yoon ParkMi-Kyung Sung. (2015) Estrogen deprivation and excess energy supply accelerate 7,12-dimethylbenz(a)anthracene-induced mammary tumor growth in C3H/HeN mice. Nutrition Research and Practice 9:6, pages 628.
Crossref
Hendrik Ungefroren, Frank Gieseler, Stephanie Fliedner & Hendrik Lehnert. (2015) Obesity and cancer. Hormone Molecular Biology and Clinical Investigation 21:1.
Crossref
Michael Cerezo, Tijana Tomic, Robert Ballotti & Stéphane Rocchi. (2014) Is it time to test biguanide metformin in the treatment of melanoma?. Pigment Cell & Melanoma Research 28:1, pages 8-20.
Crossref
Francisco Westermeier, Carlos Salomón, Marcelo Farías, Pablo Arroyo, Bárbara Fuenzalida, Tamara Sáez, Rocío Salsoso, Carlos Sanhueza, Enrique Guzmán‐Gutiérrez, Fabián Pardo, Andrea Leiva & Luis Sobrevia. (2014) Insulin requires normal expression and signaling of insulin receptor A to reverse gestational diabetes‐reduced adenosine transport in human umbilical vein endothelium. The FASEB Journal 29:1, pages 37-49.
Crossref
Günter Müller. 2014. Drug Discovery and Evaluation: Pharmacological Assays. Drug Discovery and Evaluation: Pharmacological Assays 1 54 .
Sebastian Stahl, Fabian Mueller, Ira Pastan & Ulrich Brinkmann. 2015. Resistance to Immunotoxins in Cancer Therapy. Resistance to Immunotoxins in Cancer Therapy 57 73 .
Jiaojiao Su, Hongwei Liang, Weiyan Yao, Nan Wang, Suyang Zhang, Xin Yan, Hui Feng, Wenjing Pang, Yanbo Wang, Xueliang Wang, Zhen Fu, Yanqing Liu, Chihao Zhao, Junfeng Zhang, Chen-Yu Zhang, Ke Zen, Xi Chen & Yalei Wang. (2014) MiR-143 and MiR-145 Regulate IGF1R to Suppress Cell Proliferation in Colorectal Cancer. PLoS ONE 9:12, pages e114420.
Crossref
Barbara Salani, Alberto Del Rio, Cecilia Marini, Gianmario Sambuceti, Renzo Cordera & Davide Maggi. (2014) Metformin, cancer and glucose metabolism. Endocrine-Related Cancer 21:6, pages R461-R471.
Crossref
Fernando Arrellano-Valdez, Marta Urrutia-Osorio, Carlos Arroyo & Elena Soto-Vega. (2014) A comprehensive review of urologic complications in patients with diabetes. SpringerPlus 3:1.
Crossref
Claudia Pivonello, Maria Cristina De Martino, Mariarosaria Negri, Gaia Cuomo, Federica Cariati, Francesco Izzo, Annamaria Colao & Rosario Pivonello. (2014) The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets. Infectious Agents and Cancer 9:1.
Crossref
Ahmad Aljada, Ayman M Saleh & Salem Al Suwaidan. (2014) Modulation of insulin/IGFs pathways by sirtuin-7 inhibition in drug-induced chemoreistance. Diagnostic Pathology 9:1.
Crossref
Yun-Ji Kim, Jong-Sang Kim, Young Rok Seo, Jung Han Yoon Park, Myung-Sook Choi & Mi-Kyung Sung. (2014) Carnosic acid suppresses colon tumor formation in association with antiadipogenic activity. Molecular Nutrition & Food Research 58:12, pages 2274-2285.
Crossref
Maria A. Burza, Rocco Spagnuolo, Tiziana Montalcini, Patrizia Doldo, Arturo Pujia & Stefano Romeo. (2014) Effect of Excess Body Weight on the Genetic Susceptibility to Cancer. Journal of Clinical Gastroenterology 48:Supplement 1, pages S78-S79.
Crossref
Robert W. O’Rourke. (2014) Obesity and cancer: at the crossroads of cellular metabolism and proliferation. Surgery for Obesity and Related Diseases 10:6, pages 1208-1219.
Crossref
Na-Young Song, Hye-Kyung Na, Jeong-Heum Baek & Young-Joon Surh. (2014) Docosahexaenoic acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon epithelial cells. Biochemical Pharmacology 92:1, pages 142-148.
Crossref
M. Agostina Santoro, Sarah F. Andres, Joseph A. Galanko, Robert S. Sandler, Temitope O. Keku & P. Kay Lund. (2014) Reduced Insulin-like Growth Factor I Receptor and Altered Insulin Receptor Isoform mRNAs in Normal Mucosa Predict Colorectal Adenoma Risk. Cancer Epidemiology, Biomarkers & Prevention 23:10, pages 2093-2100.
Crossref
Han Kiat Ho, Boon Tin Chua, Winnie Wong, Kah Suan Lim, Vivian Teo, Hooi-Tin Ong, Xiao Chen, Wei Zhang, Kam M. Hui, Mei Lin Go & Axel Ullrich. (2014) Benzylidene‐indolinones are effective as multi‐targeted kinase inhibitor therapeutics against hepatocellular carcinoma. Molecular Oncology 8:7, pages 1266-1277.
Crossref
Hyun Sook Lee, Han Jin Cho, Gyoo Taik Kwon & Jung Han Yoon Park. (2014) Kaempferol Downregulates Insulin-like Growth Factor-I Receptor and ErbB3 Signaling in HT-29 Human Colon Cancer Cells. Journal of Cancer Prevention 19:3, pages 161-169.
Crossref
Sun Wook Cho, Ka Hee Yi, Sun Kyoung Han, Hyun Jin Sun, Ye An Kim, Byung-Chul Oh, Young Joo Park & Do Joon Park. (2014) Therapeutic potential of metformin in papillary thyroid cancer in vitro and in vivo. Molecular and Cellular Endocrinology 393:1-2, pages 24-29.
Crossref
Utku Donem Dilli, Mustafa Yildırim, Dinc Suren, Arsenal Alikanoglu, Vildan Kaya, Sevil Goktas, Mustafa Yildiz, Cem Sezer & Seyda Gunduz. (2014) Lack of any Prognostic Role of Insulin-Like Growth Factor-1 Receptor in Non-Small Cell Lung Cancer. Asian Pacific Journal of Cancer Prevention 15:14, pages 5753-5757.
Crossref
Ashok Kumar Pandurangan & Norhaizan Mohd Esa. (2014) Luteolin, a Bioflavonoid Inhibits Colorectal Cancer through Modulation of Multiple Signaling Pathways: A Review. Asian Pacific Journal of Cancer Prevention 15:14, pages 5501-5508.
Crossref
Sanjay Rampal, Moon Hee Yang, Jidong Sung, Hee Jung Son, Yoon–Ho Choi, Jun Haeng Lee, Young–Ho Kim, Dong Kyung Chang, Poong–Lyul Rhee, Jong Chul Rhee, Eliseo Guallar & Juhee Cho. (2014) Association Between Markers of Glucose Metabolism and Risk of Colorectal Adenoma. Gastroenterology 147:1, pages 78-87.e3.
Crossref
C-L Soh, K McNeil, C M Owczarek, M P Hardy, L J Fabri, M Pearse, C A Delaine & B E Forbes. (2014) Exogenous administration of protease-resistant, non-matrix-binding IGFBP-2 inhibits tumour growth in a murine model of breast cancer. British Journal of Cancer 110:12, pages 2855-2864.
Crossref
Célia Rosilio, Issam Ben-Sahra, Frédéric Bost & Jean-François Peyron. (2014) Metformin: A metabolic disruptor and anti-diabetic drug to target human leukemia. Cancer Letters 346:2, pages 188-196.
Crossref
Igor Adamovich Tyuzikov. (2014) Insulin resistance as a systemic player in renal pathology: a review. Diabetes mellitus 17:1, pages 47-56.
Crossref
Michael Orth, Kirsten Lauber, Maximilian Niyazi, Anna A. Friedl, Minglun Li, Cornelius Maihöfer, Lars Schüttrumpf, Anne Ernst, Olivier M. Niemöller & Claus Belka. (2013) Current concepts in clinical radiation oncology. Radiation and Environmental Biophysics 53:1, pages 1-29.
Crossref
John A. Corbin, Vinay Bhaskar, Ira D. Goldfine, Daniel H. Bedinger, Angela Lau, Kristen Michelson, Lisa M. Gross, Betty A. Maddux, Hua F. Kuan, Catarina Tran, Llewelyn Lao, Masahisa Handa, Susan R. Watson, Ajay J. Narasimha, Shirley Zhu, Raphael Levy, Lynn Webster, Sujeewa D. Wijesuriya, Naichi Liu, Xiaorong Wu, David Chemla-Vogel, Steve R. Lee, Steve Wong, Diane Wilcock & Mark L. White. (2014) Improved Glucose Metabolism In Vitro and In Vivo by an Allosteric Monoclonal Antibody That Increases Insulin Receptor Binding Affinity. PLoS ONE 9:2, pages e88684.
Crossref
S. K. Garg, H. Maurer, K. Reed & R. Selagamsetty. (2013) Diabetes and cancer: two diseases with obesity as a common risk factor. Diabetes, Obesity and Metabolism 16:2, pages 97-110.
Crossref
V. R. Praveen Kumar, Priyanka Sehgal, Balram Thota, Shilpa Patil, Vani Santosh & Paturu Kondaiah. (2014) Insulin like growth factor binding protein 4 promotes GBM progression and regulates key factors involved in EMT and invasion. Journal of Neuro-Oncology 116:3, pages 455-464.
Crossref
Pushpendra Singh, Jimi Marin Alex & Felix Bast. (2013) Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer. Medical Oncology 31:1.
Crossref
Chunjing Chen, Ying Xu & Yanfeng Song. (2013) IGF-1 gene-modified muscle-derived stem cells are resistant to oxidative stress via enhanced activation of IGF-1R/PI3K/AKT signaling and secretion of VEGF. Molecular and Cellular Biochemistry 386:1-2, pages 167-175.
Crossref
Tiange Wang, Guang Ning & Zachary Bloomgarden. (2013) Diabetes and cancer relationships (糖尿病与肿瘤的关联性). Journal of Diabetes 5:4, pages 378-390.
Crossref
Rikke Hjortebjerg & Jan Frystyk. (2013) Determination of IGFs and their binding proteins. Best Practice & Research Clinical Endocrinology & Metabolism 27:6, pages 771-781.
Crossref
Yan-bo Chen, Qi Chen, Zhong Wang & Juan Zhou. (2013) Insulin Therapy and Risk of Prostate Cancer: a Systematic Review and Meta-Analysis of Observational Studies. PLoS ONE 8:11, pages e81594.
Crossref
Iliana C. Lega, Peter C. Austin, Andrea Gruneir, Pamela J. GoodwinPaula A. Rochon & Lorraine L. Lipscombe. (2013) Association Between Metformin Therapy and Mortality After Breast Cancer. Diabetes Care 36:10, pages 3018-3026.
Crossref
YAO LIU, LI JIANG & YI MU. (2013) Somatostatin receptor subtypes 2 and 5 are associated with better survival in operable hepatitis B-related hepatocellular carcinoma following octreotide long-acting release treatment. Oncology Letters 6:3, pages 821-828.
Crossref
K Takahara, N Ibuki, M Ghaffari, H Tearle, C J Ong, H Azuma, M E Gleave, M Pollak & M E Cox. (2013) The influence of growth hormone/insulin-like growth factor deficiency on prostatic dysplasia in pbARR2-Cre, PTEN knockout mice. Prostate Cancer and Prostatic Diseases 16:3, pages 239-247.
Crossref
Amanda N. Sferruzzi-Perri, Owen R. Vaughan, Alison J. Forhead & Abigail L. Fowden. (2013) Hormonal and nutritional drivers of intrauterine growth. Current Opinion in Clinical Nutrition and Metabolic Care 16:3, pages 298-309.
Crossref
Cristina Maglio, Ulrika Ericson, Maria Antonella Burza, Rosellina Margherita Mancina, Carlo Pirazzi, Johanna Andersson Assarsson, Kajsa Sjöholm, Marco Giorgio Baroni, Per-Arne Svensson, Tiziana Montalcini, Arturo Pujia, Lars Sjöström, Olov Wiklund, Lena M. S. Carlsson, Jan Borén, Marju Orho-Melander & Stefano Romeo. (2013) The IRS1 rs2943641 Variant and Risk of Future Cancer Among Morbidly Obese Individuals . The Journal of Clinical Endocrinology & Metabolism 98:4, pages E785-E789.
Crossref
Xiu Fen Liu, David J. FitzGerald & Ira Pastan. (2013) The Insulin Receptor Negatively Regulates the Action of Pseudomonas Toxin-Based Immunotoxins and Native Pseudomonas Toxin . Cancer Research 73:7, pages 2281-2288.
Crossref
Christos V. Rizos & Moses S. Elisaf. (2013) Metformin and cancer. European Journal of Pharmacology 705:1-3, pages 96-108.
Crossref
Zhi-Hua Zhang, Pu-Yu Su, Jia-Hu Hao & Ye-Huan Sun. (2013) The Role of Preexisting Diabetes Mellitus on Incidence and Mortality of Endometrial Cancer. International Journal of Gynecological Cancer 23:2, pages 294-303.
Crossref
Jemma AhnJong Kyun Lee. (2013) New-onset Diabetes as an Early Sign of Pancreatic Cancer. The Korean Journal of Gastroenterology 62:5, pages 263.
Crossref
Giovanni De Pergola & Franco Silvestris. (2013) Obesity as a Major Risk Factor for Cancer. Journal of Obesity 2013, pages 1-11.
Crossref
Valentina EvdokimovaCristina E. TognonTania BenatarWenyi YangKonstantin KrutikovMichael PollakPoul H. B. SorensenArun Seth. (2012) IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors. Science Signaling 5:255.
Crossref
Nicola M Tomas, Kai Masur, Jonas C Piecha, Bernd Niggemann & Kurt S Zänker. (2012) Akt and phospholipase Cγ are involved in the regulation of growth and migration of MDA-MB-468 breast cancer and SW480 colon cancer cells when cultured with diabetogenic levels of glucose and insulin. BMC Research Notes 5:1.
Crossref
Do Young Lim, Han Jin Cho, Jongdai Kim, Chu Won Nho, Ki Won Lee & Jung Han Yoon Park. (2012) Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells. BMC Gastroenterology 12:1.
Crossref
E. Yehuda-Shnaidman & B. Schwartz. (2012) Mechanisms linking obesity, inflammation and altered metabolism to colon carcinogenesis. Obesity Reviews 13:12, pages 1083-1095.
Crossref
JIAO JIAN TONG, HUANG TAO, OUYANG TAO HUI & CHEN JIAN. (2012) Diabetes mellitus and risk of brain tumors: A meta-analysis. Experimental and Therapeutic Medicine 4:5, pages 877-882.
Crossref
YunFeng Cui & Dana K Andersen. (2012) Diabetes and pancreatic cancer. Endocrine-Related Cancer 19:5, pages F9-F26.
Crossref
Dara Hope Cohen & Derek LeRoith. (2012) Obesity, type 2 diabetes, and cancer: the insulin and IGF connection. Endocrine-Related Cancer 19:5, pages F27-F45.
Crossref
A. J. Varewijck & J. A. M. J. L. Janssen. (2012) Insulin and its analogues and their affinities for the IGF1 receptor. Endocrine Related Cancer 19:5, pages F63-F75.
Crossref
Meghan M. Mensack, John N. McGinley & Henry J. Thompson. (2012) Metabolomic analysis of the effects of edible dry beans ( Phaseolus vulgaris L.) on tissue lipid metabolism and carcinogenesis in rats . British Journal of Nutrition 108:S1, pages S155-S165.
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