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Research Article

Antioxidant activity and in vitro inhibition of tumor cell growth by leaf extracts from the carob tree (Ceratonia siliqua)

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Pages 721-728 | Received 29 Jul 2008, Accepted 15 Sep 2008, Published online: 24 Jun 2009

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Mohammadine Moumou, Imane Mokhtari, Dragan Milenkovic, Souliman Amrani & Hicham Harnafi. (2023) Carob (Ceratonia siliqua L.): A Comprehensive Review on Traditional Uses, Chemical Composition, Pharmacological Effects and Toxicology (2002-2022). Journal of Biologically Active Products from Nature 13:3, pages 179-223.
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Articles from other publishers (23)

Dafni-Alexandra Kavvoura, Michalis K. Stefanakis, Dimitris Kletsas, Haralambos E. Katerinopoulos & Harris Pratsinis. (2023) Biological Activities of Ceratonia siliqua Pod and Seed Extracts: A Comparative Analysis of Two Cretan Cultivars. International Journal of Molecular Sciences 24:15, pages 12104.
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Matteo Vitali, Mónica Gandía, Guadalupe Garcia-Llatas, Juan Antonio Tamayo-Ramos, Antonio Cilla & Amparo Gamero. (2023) Exploring the Potential of Rice, Tiger Nut and Carob for the Development of Fermented Beverages in Spain: A Comprehensive Review on the Production Methodologies Worldwide. Beverages 9:2, pages 47.
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Aylin Kılınç Uğurlu, Aysun Bideci, Elvan Anadol, İpek Süntar, Gülnur Take Kaplanoğlu, Özlem Gülbahar, Zeynep Şafak Teksin, Duygu Dayanır, Tuba Saadet Deveci Bulut, Canan Uluoğlu & Orhun Çamurdan. (2023) Evaluation of The Effects of Carob (Ceratonia siliqua L.) Fruits on the Puberty of Rats. Journal of Clinical Research in Pediatric Endocrinology 15:2, pages 145-153.
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Fouad El Mansouri, Joaquim C. G. Esteves Silva, Francesco Cacciola, Fadoua Asraoui, Hatim Tayeq, Yasmine Mttougui Ben Amar, Miguel Palma Lovillo, Noureddine Chouaibi & Jamal Brigui. (2022) Evaluation of Different Extraction Methods on the Phenolic Profile and the Antioxidant Potential of Ceratonia siliqua L. Pods Extracts. Molecules 27:19, pages 6163.
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Muhammad Usman, Waseem Razzaq Khan, Nousheen Yousaf, Seemab Akram, Ghulam Murtaza, Kamziah Abdul Kudus, Allah Ditta, Zamri Rosli, Muhammad Nawaz Rajpar & Mohd Nazre. (2022) Exploring the Phytochemicals and Anti-Cancer Potential of the Members of Fabaceae Family: A Comprehensive Review. Molecules 27:12, pages 3863.
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Neha Duhan, Sheweta Barak & Deepak Mudgil. 2022. Gums, Resins and Latexes of Plant Origin. Gums, Resins and Latexes of Plant Origin 225 239 .
Eman Mohammed Halawani. (2021) Potential effects of Saudi Shaoka (Fagonia bruguieri) honey against multi-drug-resistant bacteria and cancer cells in comparison to Manuka honey. Saudi Journal of Biological Sciences 28:12, pages 7379-7389.
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Zahra Mehraban, Marefat Gaffari Novin, Mohammad Ghasem Golmohammadi & Hamid Nazarian. (2021) Effect of Ceratonia siliqua L. extract on DNA Fragmentation of Sperm in Adult Male Mice Treated with Cyclophosphamide. Reproductive Sciences 28:4, pages 974-981.
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Foughali Boubkar, Fghire Rachid, Anaya Fatima, Issa Ali Oudou, Tahrouch Saadia & Wahbi Said. (2021) Bioclimatic Impact on the Carob Seeds Morphological Diversity in Morocco. Biosciences Biotechnology Research Asia 18:1, pages 207-217.
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Vahid Pouresmaeil, Shaghayegh Haghighi, Asieh S. Raeisalsadati, Ali Neamati & Masoud Homayouni-Tabrizi. (2021) The Anti-Breast Cancer Effects of Green-Synthesized Zinc Oxide Nanoparticles Using Carob Extracts. Anti-Cancer Agents in Medicinal Chemistry 21:3, pages 316-326.
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Siwar Ben Ayache, Emna Behija Saafi, Fathi Emhemmed, Guido Flamini, Lotfi Achour & Christian D. Muller. (2020) Biological Activities of Aqueous Extracts from Carob Plant (Ceratonia siliqua L.) by Antioxidant, Analgesic and Proapoptotic Properties Evaluation. Molecules 25:14, pages 3120.
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Sara Abidar, Razvan Boiangiu, Gabriela Dumitru, Elena Todirascu-Ciornea, Amina Amakran, Oana Cioanca, Lucian Hritcu & Mohamed Nhiri. (2020) The Aqueous Extract from Ceratonia siliqua Leaves Protects against 6-Hydroxydopamine in Zebrafish: Understanding the Underlying Mechanism. Antioxidants 9:4, pages 304.
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Dalia M. Rasheed, Dina M. El-Kersh & Mohamed A. Farag. 2019. Wild Fruits: Composition, Nutritional Value and Products. Wild Fruits: Composition, Nutritional Value and Products 481 498 .
Kaïs Rtibi, Slimen Selmi, Dhekra Grami, Mohamed Amri, Bruno Eto, Jamel El-benna, Hichem Sebai & Lamjed Marzouki. (2017) Chemical constituents and pharmacological actions of carob pods and leaves (Ceratonia siliqua L.) on the gastrointestinal tract: A review. Biomedicine & Pharmacotherapy 93, pages 522-528.
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Zunlai Sheng, Biying Wang, Jiahong Zhao & Wenhui Yu. (2017) Optimization of Ultrasonic-Assisted Extraction for Pinocembrin from Flos populi Using Response Surface Methodology . International Journal of Food Engineering 13:5.
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Ebtesam M. Al-Olayan, Manal F. El-Khadragy, Reem A. Alajmi, Mohamed S. Othman, Amira A. Bauomy, Shaimaa R. Ibrahim & Ahmed E. Abdel Moneim. (2016) Ceratonia siliqua pod extract ameliorates Schistosoma mansoni-induced liver fibrosis and oxidative stress. BMC Complementary and Alternative Medicine 16:1.
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Aïcha Sassi, Ines Bouhlel, Nadia Mustapha, Imen Mokdad-Bzeouich, Fadwa Chaabane, Kamel Ghedira & Leila Chekir-Ghedira. (2016) Assessment in vitro of the genotoxicity, antigenotoxicity and antioxidant of Ceratonia siliqua L. extracts in murine leukaemia cells L1210 by comet assay. Regulatory Toxicology and Pharmacology 77, pages 117-124.
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Syed M. Nasar-Abbas, Zill- e-Huma, Thi-Huong Vu, Muhammad Kamran Khan, Henry Esbenshade & Vijay Jayasena. (2016) Carob Kibble: A Bioactive-Rich Food Ingredient. Comprehensive Reviews in Food Science and Food Safety 15:1, pages 63-72.
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Kaïs Rtibi, Mohammed-Amine Jabri, Slimen Selmi, Hichem Sebai, Mohamed Amri, Jamel El-Benna & Lamjed Marzouki. (2016) Ceratonia siliqua leaves exert a strong ROS-scavenging effect in human neutrophils, inhibit myeloperoxydase in vitro and protect against intestinal fluid and electrolytes secretion in rats. RSC Advances 6:70, pages 65483-65493.
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Ben Hsouna Anis, Trigui Mohamed, Mezghani Jarraya Raoudha, Damak Mohamed & Jaoua Samir. (2015) Identification of phenolic compounds by high performance liquid chromatography/mass spectrometry (HPLC/MS) and in vitro evaluation of the antioxidant and antimicrobial activities of Ceratonia siliqua leaves extracts. Journal of Medicinal Plants Research 9:14, pages 479-485.
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Luísa B. Roseiro, Luís C. Duarte, Diana L. Oliveira, Ricardo Roque, M. Gabriela Bernardo-Gil, Alice I. Martins, Catarina Sepúlveda, Joana Almeida, Margarida Meireles, Francisco M. Gírio & Amélia Pilar Rauter. (2013) Supercritical, ultrasound and conventional extracts from carob (Ceratonia siliqua L.) biomass: Effect on the phenolic profile and antiproliferative activity. Industrial Crops and Products 47, pages 132-138.
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L. Custódio, E. Fernandes, A. L. Escapa, A. Fajardo, R. Aligué, F. Alberício, N. R. Neng, J. M. F. Nogueira & A. Romano. (2011) Antioxidant and Cytotoxic Activities of Carob Tree Fruit Pulps Are Strongly Influenced by Gender and Cultivar. Journal of Agricultural and Food Chemistry 59:13, pages 7005-7012.
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Luísa Custódio, Ana Luísa Escapa, Eliana Fernandes, Alba Fajardo, Rosa Aligué, Fernando Alberício, Nuno Neng, José Manuel Florêncio Nogueira & Anabela Romano. (2011) Phytochemical Profile, Antioxidant and Cytotoxic Activities of the Carob Tree (Ceratonia siliqua L.) Germ Flour Extracts. Plant Foods for Human Nutrition 66:1, pages 78-84.
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