Antioxidant activity and in vitro inhibition of tumor cell growth by leaf extracts from the carob tree (Ceratonia siliqua)

References

• Alali F, Tawaha K, El-Elimat T, Syouf M, El-Fayad M, Abulaila K, Nielsen S, Wheaton W, Falkinham J, Oberlies N (2007): Antioxidant activity and total phenolic content of aqueous and methanol extracts of Jordanian plants: an ICBG project. Nat Prod Res 21: 1121–1131.
   PubMed Web of Science ®Google Scholar
• Arnous A, Makris D, Kefalas P (2001): Effect of principal polyphenolic components in relation to antioxidant characteristics of aged red wines. J Agric Food Chem 49: 5736–5742.
   PubMed Web of Science ®Google Scholar
• Avallone R, Plessi M, Baraldi M, Monzani A (1997): Determination of chemical composition of carob (Ceratonia siliqua): protein, fat, carbohydrates, and tannins. J Food Comp Anal 10: 166–172.
   Google Scholar
• Avallone R, Cosenza F, Farina F, Baraldi C, Baraldi M (2002): Extraction and purification from Ceratonia siliqua of compounds acting on central and peripheral benzodiazepine receptors. Fitoterapia 73: 390–396.
   PubMed Web of Science ®Google Scholar
• Baumgartner S, Genner-Ritzmann R, Haas J, Amadò R, Neukom H (1986): Isolation and identification of cyclitols in carob pods (Ceratonia siliqua L.). J Agric Food Chem 34: 827–829.
   Web of Science ®Google Scholar
• Brand-Williams W, Cuvelier ME, Berset C (1995): Use of a free radical method to evaluate antioxidant activity. Lebens-Wiss Technol 28: 25–30.
   Web of Science ®Google Scholar
• Cetkovic G, Djilas S, Canadanovic-Brunet J, Tumbas V (2004): Antioxidant properties of marigold extracts. Food Res Int 37: 643–650.
   Web of Science ®Google Scholar
• Chen M, Chen D, Dou Q (2004): Inhibition of proteasome activity by various fruits and vegetables is associated with cancer cell death. In Vivo 18: 73–80.
   PubMedGoogle Scholar
• Choudhary M, Jali, A, Israr M, Rahman A (2006). Inhibition of respiratory burst in human neutrophils an lipoxygenase enzyme by compounds from Haloxylon griffithii. Phytother Res 20: 840–843.
   PubMed Web of Science ®Google Scholar
• Corsi L, Avallone R, Cosenza F, Farina F, Baraldi C, Baraldi, M (2002): Antiproliferative effects of Ceratonia siliqua L. on mouse hepatocellular carcinoma cell line. Fitoterapia 73: 674–684.
   PubMed Web of Science ®Google Scholar
• Emmons C, Peterson D (2001): Antioxidant activity and phenolic content of oat as affected by cultivar and location. Crop Sci 41: 1676–1681.
   Web of Science ®Google Scholar
• Gattuso G, Barreca D, Caristi C, Gargiulli C, Leuzzi U (2007): Distribution of flavonoids and furocoumarins in juices from cultivars of Citrus bergamia Risso. J Agric Food Chem 55: 9921–9927.
   PubMed Web of Science ®Google Scholar
• Goldin A, Venditt JM, MacDonald JS, Muggia FM, Henney JE, Devita VT (1981): Current results of the screening program at the division of cancer treatment, National Cancer Institute. Eur J Cancer 17: 129–142.
   PubMed Web of Science ®Google Scholar
• Greenspan P, Bauer J, Pollock S, Gangemi J, Mayer E, Ghaffar A, Hargrove J, Hartle D (2005): Antiinflammatory properties of the muscadine grape (Vitis rotundifolia). J Agric Food Chem 53: 8481–8484.
   PubMed Web of Science ®Google Scholar
• Houghton PJ, Fang R, Techatanawat I, Steventon GJ, Hylands PJ, Lee CC (2007): The sulphorhodamine (SRB) assay and other approaches to testing plant extracts and derived compounds for activities related to reputed anticancer activity. Methods 42: 377–387.
   PubMed Web of Science ®Google Scholar
• Julkunen-Tiitto R (1985): Phenolic constituents in the leaves of northern willows: Methods for the analysis of certain phenolics. J Agric Food Chem 33: 213–217.
   Web of Science ®Google Scholar
• Kähkönen MP, Hopia AI, Vuorela HJ, Rauha JP, Pihlaja K, Kujala TS, Heinonen M (1999): Antioxidant activity of plant extracts containing phenolic compounds. J Agri Food Chem 47: 3954–3962.
   PubMed Web of Science ®Google Scholar
• Kivçak B, Mert T, öztürk H (2002): Antimicrobial and cytotoxic activities of Ceratonia siliqua L. extracts. Turk J Biol 26: 197–200.
   Google Scholar
• Kris-Etherton P, Hecker K, Bonanome A, Coval S, Binkoski A, Hilpert K, Griel A, Etherton T (2002): Bioactive compounds in foods: Their role in the prevention of cardiovascular disease and cancer. Am J Med 113: 71–88.
   PubMed Web of Science ®Google Scholar
• Kumazawa S, Taniguchi M, Susuki Y, Shimura M, Kwon M-S, Nakayama T (2002): Antioxidant activity of polyphenols in carob pods. J Agric Food Chem 50: 373–377.
   PubMed Web of Science ®Google Scholar
• Kwon Y-I, Apostolidis E, Shetty A (2008): In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 3 diabetes and hypertension. Bioresource Technol 99: 2981–2988.
   PubMed Web of Science ®Google Scholar
• Lamaison L, Carnat A. (1990): Teneurs en acide rosmarinique, en dérivés hydroxycinnamiques totaux et activités antioxydantes chez les Apiacées, les Borraginacées et les Lamiacées médicinales. Pharm Acta Helv 65: 315–320.
   Google Scholar
• Lambert J, Hong J, Yang G-Y, Liao J, Yang C (2005): Inhibition of carcinogenesis by polyphenols: Evidence from laboratory studies. Am J Clin Nutr 81: 284S–291S.
   PubMed Web of Science ®Google Scholar
• Lazzè M, Savio M, Pizzala R, Cazzalini O, Perucca P, Scovassi A, Stivala L, Bianchi L (2004): Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines. Carcinogenesis 25: 1427–1433.
   PubMed Web of Science ®Google Scholar
• Li W, Gao Y, Zhao J, Wang Q (2007): Phenolic, flavonoid, and lutein ester content and antioxidant activity of 11 cultivars of Chinese marigold. J Agric Food Chem 255: 8478–8484.
   Google Scholar
• Lila M (2006): The nature-versus-nurture debate on bioactive phytochemicals: The genome versus terroir. J Sci Food Agric 86: 2510–2515.
   Web of Science ®Google Scholar
• Loeb H, Vandenplas Y, Wursch P, Guesry P (1989): Tannin-rich carob pod for the treatment of acute-onset diarrhea. J Pediatr Gastr Nutr 8: 480–485.
   PubMedGoogle Scholar
• Maksimović Z, Malenčić D, Kovačević N (2005): Polyphenol contents and antioxidant activity of Maydis stigma extracts. Bioresource Technol 96: 873–877.
   PubMed Web of Science ®Google Scholar
• Makris D, Kefalas P (2004): Carob pods (Ceratonia siliqua L.) as a source of polyphenolic antioxidants. Food Technol Biotechnol 42: 105–108.
   Web of Science ®Google Scholar
• Moreno S, Scheyer T, Romano C, Vojnov A (2006): Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition. Free Radic Res 40: 223–231.
   PubMed Web of Science ®Google Scholar
• Owen R, Haubner R, Hull W, Erben G, Spiegelhalder B, Bartsch H, Haber B (2003): Isolation and structure elucidation of the major individual polyphenols in carob fibre. Food Chem Toxicol 41: 1727–1738.
   PubMed Web of Science ®Google Scholar
• Papagiannopoulos M, Wollseifen H, Mellenthin A, Haber B, Galensa R (2004): Identification and quantification of polyphenols in carob fruits (Ceratonia siliqua L.) and derived products by HPLC-UV-ESI/MS. J Agric Food Chem 52: 3784–3791.
   PubMed Web of Science ®Google Scholar
• Parejo I, Viladomata F, Bastida J, Rosas-Romero A, Saavedra G, Murcia M. Jiménez A, Codina C (2003): Investigation of Bolivian plant extracts for their radical scavenging activity and antioxidant activity. Life Sci 73: 1667–1681.
   PubMed Web of Science ®Google Scholar
• Pietta PG (2000): Flavonoids as antioxidants. J Nat Prod 63: 1035–1042.
   PubMed Web of Science ®Google Scholar
• Ramos S, Alia M, Bravo L, Goya L (2005): Comparative effects of food-derived polyphenols on the viability and apoptosis of a human hepatoma cell line (HepG2). J Agric Food Chem 53: 1271–1280.
   PubMed Web of Science ®Google Scholar
• Song J, Park K, Lee K, Byun Y, Park J, Kim S, Kim J, Seong B (2007): Biological evaluation of anti-influenza viral activity of semi-synthetic catechin derivates. Antiviral Res 76: 178–185.
   PubMedGoogle Scholar
• Sugihara N, Arakawa T, Ohnishi M, Furuno K (1999): Anti- and pro-oxidative effects of flavonoids on metal induced lipid hydroperoxide-dependent lipid peroxidation in cultured hepatocytes located with α-linolenic acid. Free Radic Biol Med 27: 1313–1323.
   PubMed Web of Science ®Google Scholar
• Tepe B, Akpulat A, Sokmen M, Daferera D, Yumrutas O, Aydin E, Polissiou M, Sokmen A (2006): Screening of the antioxidative and antimicrobial properties of the essential oils of Pimpinella anisetum and Pimpinella flabellifolia from Turkey. Food Chem 97: 719–724.
   Web of Science ®Google Scholar
• Valko M, Leibfritz D, Moncol J, Cronin M, Mazur M, Telser J (2007): Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39: 44–84.
   PubMed Web of Science ®Google Scholar
• Yamagishi M, Natsume M, Nagaki A, Adachi T, Osakabe N, Takizawa T. Kumon H, Osawa T (2000): Antimutagenic activity of cacao: inhibitory effect of cacao liquor polyphenols on the mutagenic action of heterocyclic amines. J Agric Food Chem 48: 5074–5078.
   PubMed Web of Science ®Google Scholar
• Wang Y, Deng T, Lin L, Pan Y, Zheng X (2006): Bioassay-guided isolation of antiatherosclerotic phytochemicals from Artocarpus altilis. Phytother Res 20: 1052–1055.
   PubMed Web of Science ®Google Scholar
• Wedge D, Meepagala K, Magee J, Smith S, Huang G, Larcom L (2001): Anticarcinogenic activity of strawberry, blueberry, and raspberry extracts to breast and cervical cancer cells. J Med Food 4: 49–51.
   PubMedGoogle Scholar
• Wenzel U, Kuntz S, Brendel M, Daniel H (2000): Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. Cancer Res 60: 3823–3831.
   PubMed Web of Science ®Google Scholar