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Editorial

Riluzole for ALS: what is the evidence?

Page 135 | Received 13 May 2003, Accepted 13 May 2003, Published online: 10 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Svitlana Garbuzova-Davis, Avery Thomson, Crupa Kurien, R. Douglas Shytle & Paul R. Sanberg. (2016) Potential new complication in drug therapy development for amyotrophic lateral sclerosis. Expert Review of Neurotherapeutics 16:12, pages 1397-1405.
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Dilara Pirhan, Nurşen Yüksel, Esra Emre, Abdulkadir Cengiz & Demir Kürşat Yıldız. (2016) Riluzole- and Resveratrol-Induced Delay of Retinal Ganglion Cell Death in an Experimental Model of Glaucoma. Current Eye Research 41:1, pages 59-69.
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Radhia Benmohamed, Anthony C. Arvanites, Jinho Kim, Robert J. Ferrante, Richard B. Silverman, Richard I. Morimoto & Donald R. Kirsch. (2011) Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis 12:2, pages 87-96.
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Daniel J. Amante, Jinho Kim, Samantha T. Carreiro, Andrew C. Cooper, Steven W. Jones, Ting Li, Jennifer P. Moody, Christina K. Edgerly, Olivia L. Bordiuk, Kerry Cormier, Karen Smith, Robert J. Ferrante & James Rusche. (2010) Uridine ameliorates the pathological phenotype in transgenic G93A-ALS mice. Amyotrophic Lateral Sclerosis 11:6, pages 520-530.
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Andrew P. Smith & Nancy M. Lee. (2007) Role of zinc in ALS. Amyotrophic Lateral Sclerosis 8:3, pages 131-143.
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Kirsten L. Gruis, Devin L. Brown, Kevin J. Weatherwax, Eva L. Feldman & Ronald D. Chervin. (2006) Evaluation of sham non‐invasive ventilation for randomized, controlled trials in ALS. Amyotrophic Lateral Sclerosis 7:2, pages 96-99.
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Articles from other publishers (26)

Angelica Benavides-Serrato, Jacquelyn T. Saunders, Brent Holmes, Robert N. Nishimura, Alan Lichtenstein & Joseph Gera. (2020) Repurposing Potential of Riluzole as an ITAF Inhibitor in mTOR Therapy Resistant Glioblastoma. International Journal of Molecular Sciences 21:1, pages 344.
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Atif J. Khan, Stephanie LaCava, Monal Mehta, Devora Schiff, Aditya Thandoni, Sachin Jhawar, Shabbar Danish, Bruce G. Haffty & Suzie Chen. (2019) The glutamate release inhibitor riluzole increases DNA damage and enhances cytotoxicity in human glioma cells, in vitro and in vivo . Oncotarget 10:29, pages 2824-2834.
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Janice M. Mehnert, Ann W. Silk, J. H. Lee, Liesel Dudek, Byeong-Seon Jeong, Jiadong Li, Jason M. Schenkel, Evita Sadimin, Michael Kane, Hongxia Lin, Weichung J. Shih, Andrew Zloza, Suzie Chen & James S. Goydos. (2018) A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor 1 (GRM1) signaling, in patients with advanced melanoma. Pigment Cell & Melanoma Research 31:4, pages 534-540.
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E. Srinivasan & R. Rajasekaran. (2017) Cysteine to Serine Conversion at 111th Position Renders the Disaggregation and Retains the Stabilization of Detrimental SOD1 A4V Mutant Against Amyotrophic Lateral Sclerosis in Human—A Discrete Molecular Dynamics Study. Cell Biochemistry and Biophysics 76:1-2, pages 231-241.
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Vishwambhar Bhandare & Amutha Ramaswamy. (2016) Structural Dynamics of Human Argonaute2 and Its Interaction with siRNAs Designed to Target Mutant tdp43. Advances in Bioinformatics 2016, pages 1-13.
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Florie BorelGwladys GernouxBrynn CardozoJake P. MettervilleGabriela T. CabreraLina SongQin SuGuang Ping GaoMai K. ElmallahRobert H. BrownJr.Jr. & Christian Mueller. (2016) Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1 G93A Mice and Nonhuman Primates . Human Gene Therapy 27:1, pages 19-31.
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Ji-Seon Seo, Juli Choi, Yea-Hyun Leem & Pyung-Lim Han. (2015) Rosmarinic Acid Alleviates Neurological Symptoms in the G93A-SOD1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis. Experimental Neurobiology 24:4, pages 341-350.
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Diane MoujalledAnthony R White. (2014) Heterogeneous nuclear ribonucleoproteins in amyotrophic 
lateral sclerosis: what do we know?. Future Neurology 9:2, pages 173-185.
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Hyun Young KimChanil MoonKyung Suk KimKi Wook OhSeong-il OhJuhan KimSeung Hyun Kim. (2014) Recombinant Human Erythropoietin in Amyotrophic Lateral Sclerosis: A Pilot Study of Safety and Feasibility. Journal of Clinical Neurology 10:4, pages 342.
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Yongchao WuKajana SatkunendrarajahYang TengDiana S.-L. ChowJosef ButtigiegMichael G. Fehlings. (2013) Delayed Post-Injury Administration of Riluzole Is Neuroprotective in a Preclinical Rodent Model of Cervical Spinal Cord Injury. Journal of Neurotrauma 30:6, pages 441-452.
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M.C. Evans, Y. Couch, N. Sibson & M.R. Turner. (2013) Inflammation and neurovascular changes in amyotrophic lateral sclerosis. Molecular and Cellular Neuroscience 53, pages 34-41.
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Mauro CozzolinoMaria Grazia PesaresiValeria GerbinoJulian GrosskreutzMaria Teresa Carrì. (2012) Amyotrophic Lateral Sclerosis: New Insights into Underlying Molecular Mechanisms and Opportunities for Therapeutic Intervention. Antioxidants & Redox Signaling 17:9, pages 1277-1330.
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Hyun Soo Park. (2012) A Case of Motor Neuron Disease Presenting as Dyspnea in the Emergency Department. Korean Journal of Family Medicine 33:2, pages 110.
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Tommaso Iannitti & Beniamino Palmieri. (2012) Clinical and Experimental Applications of Sodium Phenylbutyrate. Drugs in R&D 11:3, pages 227-249.
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Atif J. Khan, Brian Wall, Stuti Ahlawat, Camille Green, Devora Schiff, Janice M. Mehnert, James S. Goydos, Suzie Chen & Bruce G. Haffty. (2011) Riluzole Enhances Ionizing Radiation–Induced Cytotoxicity in Human Melanoma Cells that Ectopically Express Metabotropic Glutamate Receptor 1 In Vitro and In Vivo . Clinical Cancer Research 17:7, pages 1807-1814.
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Kewal K. JainKewal K. Jain. 2011. The Handbook of Neuroprotection. The Handbook of Neuroprotection 385 408 .
Maithao N. Le, Joseph L.-K. Chan, Stephen A. Rosenberg, Adam S. Nabatian, Kim T. Merrigan, Karine A. Cohen-Solal & James S. Goydos. (2010) The Glutamate Release Inhibitor Riluzole Decreases Migration, Invasion, and Proliferation of Melanoma Cells. Journal of Investigative Dermatology 130:9, pages 2240-2249.
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Paul GrantJane Y. SongSusan E. Swedo. (2010) Review of the Use of the Glutamate Antagonist Riluzole in Psychiatric Disorders and a Description of Recent Use in Childhood Obsessive-Compulsive Disorder. Journal of Child and Adolescent Psychopharmacology 20:4, pages 309-315.
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Dana Yip, Maithao N. Le, Joseph L.-K. Chan, Jonathan H. Lee, Janice A. Mehnert, Anthony Yudd, Jeffery Kempf, Weichung J. Shih, Suzie Chen & James S. Goydos. (2009) A Phase 0 Trial of Riluzole in Patients with Resectable Stage III and IV Melanoma. Clinical Cancer Research 15:11, pages 3896-3902.
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Daniel A. Bruestle, Roy G. Cutler, Richard S. Telljohann & Mark P. Mattson. (2009) Decline in Daily Running Distance Presages Disease Onset in a Mouse Model of ALS. NeuroMolecular Medicine 11:2, pages 58-62.
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Mauro CozzolinoAlberto FerriMaria Teresa Carrì. (2008) Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Implications. Antioxidants & Redox Signaling 10:3, pages 405-444.
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Lauren B. Elman, Leo McCluskey & Murray Grossman. (2008) Motor Neuron Disease and Frontotemporal Lobar Degeneration: A Tale of Two Disorders Linked To TDP-43. Neurosignals 16:1, pages 85-90.
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Autumn M. Klein & Robert J. Ferrante. 2007. Creatine and Creatine Kinase in Health and Disease. Creatine and Creatine Kinase in Health and Disease 205 243 .
Mark P. Mattson. (2006) Neuronal Life-and-Death Signaling, Apoptosis, and Neurodegenerative Disorders. Antioxidants & Redox Signaling 8:11-12, pages 1997-2006.
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Marcus Rattray & Caterina Bendotti. (2006) Does excitotoxic cell death of motor neurons in ALS arise from glutamate transporter and glutamate receptor abnormalities?. Experimental Neurology 201:1, pages 15-23.
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Da Wei Zang, Qing Yang, Hong Xin Wang, Gary Egan, Elizabeth C Lopes & Surindar S Cheema. (2004) Magnetic resonance imaging reveals neuronal degeneration in the brainstem of the superoxide dismutase 1G93A G1H transgenic mouse model of amyotrophic lateral sclerosis. European Journal of Neuroscience 20:7, pages 1745-1751.
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