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REVIEW ARTICLE

Excitotoxicity and ALS: What is unique about the AMPA receptors expressed on spinal motor neurons?

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Pages 131-144 | Received 28 Oct 2004, Accepted 21 Mar 2005, Published online: 10 Jul 2009

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Articles from other publishers (39)

Yukun Yuan, Jordan M. Bailey, Gretchen M. Rivera-Lopez & William D. Atchison. (2023) Preferential potentiation of AMPA-mediated currents in brainstem hypoglossal motoneurons by subchronic exposure of mice expressing the human superoxide dismutase 1 G93A gene mutation to neurotoxicant methylmercury in vivo.. NeuroToxicology.
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Marina N. Vukolova, Laura Y. Yen, Margarita I. Khmyz, Alexander I. Sobolevsky & Maria V. Yelshanskaya. (2023) Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors. Frontiers in Cell and Developmental Biology 11.
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Klaudia Jomova, Marianna Makova, Suliman Y. Alomar, Saleh H. Alwasel, Eugenie Nepovimova, Kamil Kuca, Christopher J. Rhodes & Marian Valko. (2022) Essential metals in health and disease. Chemico-Biological Interactions 367, pages 110173.
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Jocelyn Widagdo, Saumya Udagedara, Nishita Bhembre, Jing Zhi Anson Tan, Lara Neureiter, Jie Huang, Victor Anggono & Mihwa Lee. (2022) Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons . Open Biology 12:9.
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Megumi Akamatsu, Takenari Yamashita, Sayaka Teramoto, Zhen Huang, Janet Lynch, Tatsushi Toda, Li Niu & Shin Kwak. (2022) Testing of the therapeutic efficacy and safety of AMPA receptor RNA aptamers in an ALS mouse model. Life Science Alliance 5:4, pages e202101193.
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Jinmeng Liu, Fenghua Zhou, Yingjun Guan, Fandi Meng, Zhenhan Zhao, Qi Su, Weiwei Bao, Xuemei Wang, Jiantao Zhao, Zijun Huo, Lingyun Zhang, Shuanhu Zhou, Yanchun Chen & Xin Wang. (2022) The Biogenesis of miRNAs and Their Role in the Development of Amyotrophic Lateral Sclerosis. Cells 11:3, pages 572.
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Changyong Guo & Yao-Ying Ma. (2021) Calcium Permeable-AMPA Receptors and Excitotoxicity in Neurological Disorders. Frontiers in Neural Circuits 15.
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Pedro Henrique Costa Cruz & Yukio Kawahara. 2021. RNA Editing. RNA Editing 309 330 .
Giovanna Morello, Giulia Gentile, Rossella Spataro, Antonio Gianmaria Spampinato, Maria Guarnaccia, Salvatore Salomone, Vincenzo La Bella, Francesca Luisa Conforti & Sebastiano Cavallaro. (2020) Genomic Portrait of a Sporadic Amyotrophic Lateral Sclerosis Case in a Large Spinocerebellar Ataxia Type 1 Family. Journal of Personalized Medicine 10:4, pages 262.
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Vijay Kumar, Preeti Gupta & Md. Imtaiyaz Hassan. (2019) Mechanism and implications of traditional Chinese medicine in amyotrophic lateral sclerosis therapy. Journal of Proteins and Proteomics.
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Hussain Jinnah & Randi J. Ulbricht. (2019) Using mouse models to unlock the secrets of non-synonymous RNA editing. Methods 156, pages 40-45.
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Klara Valko & Lukasz Ciesla. 2019. 63 117 .
Vijay Kumar, Tara Kashav & Md. Imtaiyaz Hassan. 2019. Pathology, Prevention and Therapeutics of Neurodegenerative Disease. Pathology, Prevention and Therapeutics of Neurodegenerative Disease 207 224 .
Dorota Studniarczyk, Elizabeth L. Needham, Hannah M. Mitchison, Mark Farrant & Stuart G. Cull-Candy. (2018) Altered Cerebellar Short-Term Plasticity but No Change in Postsynaptic AMPA-Type Glutamate Receptors in a Mouse Model of Juvenile Batten Disease. eneuro 5:2, pages ENEURO.0387-17.2018.
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Masataka Nakano & Miki Nakajima. (2018) Significance of A-to-I RNA editing of transcripts modulating pharmacokinetics and pharmacodynamics. Pharmacology & Therapeutics 181, pages 13-21.
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Vijay Kumar, Asimul Islam, Md. Imtaiyaz Hassan & Faizan Ahmad. (2016) Therapeutic progress in amyotrophic lateral sclerosis-beginning to learning. European Journal of Medicinal Chemistry 121, pages 903-917.
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Cigdem Acioglu, Ersilia Mirabelli, Ahmet Tarik Baykal, Li Ni, Ayomi Ratnayake, Robert F. Heary & Stella Elkabes. (2016) Toll like receptor 9 antagonism modulates spinal cord neuronal function and survival: Direct versus astrocyte-mediated mechanisms. Brain, Behavior, and Immunity 56, pages 310-324.
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Megumi Akamatsu, Takenari Yamashita, Naoki Hirose, Sayaka Teramoto & Shin Kwak. (2016) The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice. Scientific Reports 6:1.
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Dinesh C. Joshi, Bhanu P. Tewari, Mahendra Singh, Preeti G. Joshi & Nanda B. Joshi. (2015) AMPA receptor activation causes preferential mitochondrial Ca2+ load and oxidative stress in motor neurons. Brain Research 1616, pages 1-9.
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Andrew Wu, Congzhou Wang & Li Niu. (2014) Mechanism of Inhibition of the GluA1 AMPA Receptor Channel Opening by the 2,3-Benzodiazepine Compound GYKI 52466 and a N -Methyl-Carbamoyl Derivative . Biochemistry 53:18, pages 3033-3041.
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Shoichi Sasaki, Takenari Yamashita, Takuto Hideyama & Shin Kwak. (2014) Unique nuclear vacuoles in the motor neurons of conditional ADAR2-knockout mice. Brain Research 1550, pages 36-46.
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Pierre-François Pradat & Luc Dupuis. 2014. Handbook of Neurotoxicity. Handbook of Neurotoxicity 1417 1434 .
Congzhou Wang & Li Niu. (2013) Mechanism of Inhibition of the GluA2 AMPA Receptor Channel Opening by Talampanel and Its Enantiomer: The Stereochemistry of the 4-Methyl Group on the Diazepine Ring of 2,3-Benzodiazepine Derivatives. ACS Chemical Neuroscience 4:4, pages 635-644.
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Daiana Silva Avila, Robson Luiz Puntel & Michael Aschner. 2013. Interrelations between Essential Metal Ions and Human Diseases. Interrelations between Essential Metal Ions and Human Diseases 199 227 .
Angela Gallo & Franco Locatelli. (2011) ADARs: allies or enemies? The importance of A‐to‐I RNA editing in human disease: from cancer to HIV‐1. Biological Reviews 87:1, pages 95-110.
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E.P.Sica Roberto. (2012) Sporadic Amyotrophic Lateral Sclerosis: Brief Pathogenic Review and a New Causal Hypothesis. Biocybernetics and Biomedical Engineering 32:4, pages 17-32.
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Dinesh C. Joshi, Mahendra Singh, Karthik Krishnamurthy, Preeti G. Joshi & Nanda B. Joshi. (2011) AMPA induced Ca2+ influx in motor neurons occurs through voltage gated Ca2+ channel and Ca2+ permeable AMPA receptor. Neurochemistry International 59:6, pages 913-921.
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Roberto E.P. Sica, Alejandro F. De Nicola, María C. González Deniselle, Gabriel Rodriguez, Gisella M. Gargiulo Monachelli, Liliana Martinez Peralta & Mariela Bettini. (2011) Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent. Arquivos de Neuro-Psiquiatria 69:4, pages 699-706.
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Takuto Hideyama, Takenari Yamashita, Takeshi Suzuki, Shoji Tsuji, Miyoko Higuchi, Peter H. Seeburg, Ryosuke Takahashi, Hidemi Misawa & Shin Kwak. (2010) Induced Loss of ADAR2 Engenders Slow Death of Motor Neurons from Q/R Site-Unedited GluR2. The Journal of Neuroscience 30:36, pages 11917-11925.
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Hitoshi Aizawa, Jun Sawada, Takuto Hideyama, Takenari Yamashita, Takayuki Katayama, Naoyuki Hasebe, Takashi Kimura, Osamu Yahara & Shin Kwak. (2010) TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2. Acta Neuropathologica 120:1, pages 75-84.
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Ian R Mellor. (2010) The AMPA receptor as a therapeutic target: current perspectives and emerging possibilities. Future Medicinal Chemistry 2:5, pages 877-891.
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Shin Kwak, Takuto Hideyama, Takenari Yamashita & Hitoshi Aizawa. (2010) AMPA receptor-mediated neuronal death in sporadic ALS. Neuropathology 30:2, pages 182-188.
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Takuto Hideyama, Takenari Yamashita, Yoshinori Nishimoto, Takeshi Suzuki & Shin Kwak. (2010) Novel Etiological and Therapeutic Strategies for Neurodiseases: RNA Editing Enzyme Abnormality in Sporadic Amyotrophic Lateral Sclerosis. Journal of Pharmacological Sciences 113:1, pages 9-13.
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Kathryn Duncan. (2009) The role of AMPA receptor-mediated excitotoxicity in ALS: Is deficient RNA editing to blame?. Current Anaesthesia & Critical Care 20:5-6, pages 227-235.
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Mark P. Mattson. (2008) Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease. Annals of the New York Academy of Sciences 1144:1, pages 97-112.
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Olga Pulido. (2008) Domoic Acid Toxicologic Pathology: A Review. Marine Drugs 6:2, pages 180-219.
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Luis B. Tovar-y-Romo, Angélica Zepeda & Ricardo Tapia. (2007) Vascular Endothelial Growth Factor Prevents Paralysis and Motoneuron Death in a Rat Model of Excitotoxic Spinal Cord Neurodegeneration. Journal of Neuropathology and Experimental Neurology 66:10, pages 913-922.
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Mei Du, Henning Ulrich, Xiurong Zhao, Jaroslaw Aronowski & Vasanthi Jayaraman. (2007) Water soluble RNA based antagonist of AMPA receptors. Neuropharmacology 53:2, pages 242-251.
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Shin Kwak & John H Weiss. (2006) Calcium-permeable AMPA channels in neurodegenerative disease and ischemia. Current Opinion in Neurobiology 16:3, pages 281-287.
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