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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 20, 2005 - Issue 5
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Research Article

Evaluation of O3α-, O21-Di-(N1-methyloxycarbonyl-2, 4-dioxo-5-fluoropyrimidinyl)17α-hydroxy-5β-pregnan-20-one as a novel potential antiangiogenic codrug

Michelle Howard-Sparks University of Kentucky, College of Pharmacy, Chandler Medical Center, Lexington, Kentucky, 40536, USA
,
Abeer M. Al-Ghananeem University of Kentucky, College of Pharmacy, Chandler Medical Center, Lexington, Kentucky, 40536, USA
,
Andrew P. Pearson University of Kentucky, Department of Ophthalmology, Chandler Medical Center, Lexington, Kentucky, 40536, USA
&
Peter A. Crooks University of Kentucky, College of Pharmacy, Chandler Medical Center, Lexington, Kentucky, 40536, USA
Pages 417-428 | Received 15 Mar 2005, Accepted 21 Jun 2005, Published online: 04 Oct 2008

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Michelle Howard-Sparks, Abeer M. Al-Ghananeem, Peter A. Crooks & Andrew P. Pearson. (2007) A Novel Chemical Delivery System Comprising an Ocular Sustained Release Formulation of a 3α, 17α, 21-trihydroxy-5β-pregnan-20-one-BIS-5-Flourouracil Codrug. Drug Development and Industrial Pharmacy 33:6, pages 677-682.
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He-Ping Li, Zhou-dong Wang & Tao Yu. (2009) Microwave irradiation synthesis of novel ramose chitosan-based-5-fluorouracil and research on its in vitro release. Medicinal Chemistry Research 20:1, pages 67-73.
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Peter A. Crooks, Harpreet K. Dhooper & Ujjwal Chakraborty. 2010. Prodrugs and Targeted Delivery. Prodrugs and Targeted Delivery 345 383 .
M. Berdugo Polak & F. Behar-Cohen. (2008) Dégénérescence maculaire liée à l’âge exsudative : efficacité et limites des différents traitements. Journal Français d'Ophtalmologie 31:5, pages 537-556.
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Abeer Al-Ghananeem & Peter Crooks. (2007) Phase I and Phase II Ocular Metabolic Activities and the Role of Metabolism in Ophthalmic Prodrug and Codrug Design and Delivery. Molecules 12:3, pages 373-388.
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Mohamed O. Hamad, Paul K. Kiptoo, Audra L. Stinchcomb & Peter A. Crooks. (2006) Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6β-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents. Bioorganic & Medicinal Chemistry 14:20, pages 7051-7061.
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