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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 20, 2005 - Issue 5
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Research Article

Structure–activity relationship studies of 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A2α-mediated arachidonic acid release in intact platelets: variation of the keto moiety

Afshin Ghasemi Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Hittorfstrasse 58-62, D-48149, Münster, Germany
,
Alwine Schulze Elfringhoff Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Hittorfstrasse 58-62, D-48149, Münster, Germany
&
Matthias Lehr Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Hittorfstrasse 58-62, D-48149, Münster, Germany
Pages 429-437 | Received 04 May 2005, Published online: 04 Oct 2008

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Mark Hess, Alwine Schulze Elfringhoff & Matthias Lehr. (2008) Design and synthesis of 3-pyrrol-3-yl-3H-isobenzofuran-1-ones as inhibitors of human cytosolic phospholipase A2α. Journal of Enzyme Inhibition and Medicinal Chemistry 23:6, pages 946-957.
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Articles from other publishers (4)

MATTHIAS LEHR. 2012. Anti-Inflammatory Drug Discovery. Anti-Inflammatory Drug Discovery 35 57 .
Edward A. Dennis, Jian Cao, Yuan-Hao Hsu, Victoria Magrioti & George Kokotos. (2011) Phospholipase A 2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention . Chemical Reviews 111:10, pages 6130-6185.
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Katherine L. Lee, Megan A. Foley, Lihren Chen, Mark L. Behnke, Frank E. Lovering, Steven J. Kirincich, Weiheng Wang, Jaechul Shim, Steve Tam, Marina W. H. Shen, SooPeang Khor, Xin Xu, Debra G. Goodwin, Manjunath K. Ramarao, Cheryl Nickerson-Nutter, Frances Donahue, M. Sherry Ku, James D. Clark & John C. McKew. (2007) Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α 2 α . Journal of Medicinal Chemistry 50:6, pages 1380-1400.
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Joachim Ludwig, Stefanie Bovens, Carsten Brauch, Alwine Schulze Elfringhoff & Matthias Lehr. (2006) Design and Synthesis of 1-Indol-1-yl-propan-2-ones as Inhibitors of Human Cytosolic Phospholipase A 2 α . Journal of Medicinal Chemistry 49:8, pages 2611-2620.
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