Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 21, 2006 - Issue 2
Submit an article Journal homepage
1,417
Views
30
CrossRef citations to date
0
Altmetric
Research Article

Berberine potently inhibits protein tyrosine phosphatase 1B: Investigation by docking simulation and experimental validation

Yasser Bustanji University of Jordan, Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Amman, Jordan
,
Mutasem O. Taha University of Jordan, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Amman, Jordan
,
Al-Motassem Yousef University of Jordan, Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Amman, Jordan
&
Amal G. Al- Bakri University of Jordan, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Amman, Jordan
Pages 163-171 | Received 28 Jul 2005, Accepted 27 Nov 2005, Published online: 04 Oct 2008

Citations (30)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Akhilesh Kumar Tamrakar, Chandan K Maurya & Amit K Rai. (2014) PTP1B inhibitors for type 2 diabetes treatment: a patent review (2011 – 2014). Expert Opinion on Therapeutic Patents 24:10, pages 1101-1115.
Read now
Ihab M. Al-masri, Mohammad K. Mohammad & Mutasem O. Tahaa. (2009) Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine. Journal of Enzyme Inhibition and Medicinal Chemistry 24:5, pages 1061-1066.
Read now

Articles from other publishers (28)

Yasser BustanjiNadia QuqazehMoahmmad MohammadMohammad HudaibKhaled TawahaBashaer Abu-IrmailehBasil AlbustanjiHana Bajes. (2023) Screening of some medicinal plant extracts for their lipoprotein lipase inhibition activity. Research Journal of Pharmacy and Technology, pages 4786-4790.
Crossref
Paolo Bellavite, Serafino Fazio & Flora Affuso. (2023) A Descriptive Review of the Action Mechanisms of Berberine, Quercetin and Silymarin on Insulin Resistance/Hyperinsulinemia and Cardiovascular Prevention. Molecules 28:11, pages 4491.
Crossref
Noor Tarawneh, Lama Hamadneh, Bashaer Abu-Irmaileh, Ziad Shraideh, Yasser Bustanji & Shtaywy Abdalla. (2023) Berberine Inhibited Growth and Migration of Human Colon Cancer Cell Lines by Increasing Phosphatase and Tensin and Inhibiting Aquaporins 1, 3 and 5 Expressions. Molecules 28:9, pages 3823.
Crossref
Ayed M. Al-Abdallat, Batool K. Adayileh, Jamal S. Sawwan, Rida Shibli, Tamara S. Al-Qudah, Bashaer Abu-Irmaileh, Randa N. Albdaiwi, Jehad Almaliti & Yasser Bustanji. (2023) Secondary Metabolites Profiling, Antimicrobial and Cytotoxic Properties of Commiphora gileadensis L. Leaves, Seeds, Callus, and Cell Suspension Extracts. Metabolites 13:4, pages 537.
Crossref
Hana BajesSawsan OranBustanji Yasser. (2023) Phytochemical Analysis, In vitro Assessment of Antioxidant Properties and Cytotoxic Potential of Thymus capitatus Essential Oil. Research Journal of Pharmacy and Technology, pages 1100-1108.
Crossref
Duaa Eliwa, Abdel-Rahim S. Ibrahim, Amal Kabbash, Mona El-Aasr, Michał Tomczyk, Yousef A. Bin Jardan, Gaber El-Saber Batiha & Amany E. Ragab. (2022) Biotransformation of Modified Benzylisoquinoline Alkaloids: Boldine and Berberine and In Silico Molecular Docking Studies of Metabolites on Telomerase and Human Protein Tyrosine Phosphatase 1B. Pharmaceuticals 15:10, pages 1195.
Crossref
Sukhbir Singh, Ajmer Singh Grewal, Rupanshi Grover, Neelam Sharma, Bhawna Chopra, Ashwani Kumar Dhingra, Sandeep Arora, Sonika Redhu & Viney Lather. (2022) Recent updates on development of protein-tyrosine phosphatase 1B inhibitors for treatment of diabetes, obesity and related disorders. Bioorganic Chemistry 121, pages 105626.
Crossref
Ankit Kumar, Sonali Aswal, Ruchi Badoni Semwal, Ashutosh Chauhan, Sunil Kumar Joshi & Deepak Kumar Semwal. (2019) Role of plant-derived alkaloids against diabetes and diabetes-related complications: a mechanism-based approach. Phytochemistry Reviews 18:5, pages 1277-1298.
Crossref
Pranav K. Prabhakar & Ponnurengam M. Sivakumar. (2019) Protein Tyrosine Phosphatase 1B Inhibitors: A Novel Therapeutic Strategy for the Management of type 2 Diabetes Mellitus. Current Pharmaceutical Design 25:23, pages 2526-2539.
Crossref
Qian Ran, Jin Wang, Lin Wang, Hai-rong Zeng, Xiang-bo Yang & Qin-wan Huang. (2019) Rhizoma coptidis as a Potential Treatment Agent for Type 2 Diabetes Mellitus and the Underlying Mechanisms: A Review. Frontiers in Pharmacology 10.
Crossref
Jie Ming, Shaoyong Xu, Chun Liu, Xiangyang Liu, Aihua Jia & Qiuhe Ji. (2018) Effectiveness and safety of bifidobacteria and berberine in people with hyperglycemia: study protocol for a randomized controlled trial. Trials 19:1.
Crossref
Hamid R. Nasiri, Philipp Mracek, Steffen K. Grimm, Janine Gastaldello, Adrian Kolodzik & Dirk Ullmann. (2017) PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B. MedChemComm 8:6, pages 1220-1224.
Crossref
Wei Zou. (2016) Type 2 Diabetes Mellitus and Protein-Tyrosine Phosphatase 1B1. Journal of Diabetes, Metabolic Disorders & Control 3:8.
Crossref
Shanshan Zhang, Xiaohong Wang, Weicheng Yin, Zhenbao Liu, Mi Zhou, Daipeng Xiao, Yanfei Liu & Dongming Peng. (2016) Synthesis and hypoglycemic activity of 9- O -(lipophilic group substituted) berberine derivatives. Bioorganic & Medicinal Chemistry Letters 26:19, pages 4799-4803.
Crossref
Jae Sue Choi, Md. Yousof Ali, Hyun Ah Jung, Sang Ho Oh, Ran Joo Choi & Eon Ji Kim. (2015) Protein tyrosine phosphatase 1B inhibitory activity of alkaloids from Rhizoma Coptidis and their molecular docking studies. Journal of Ethnopharmacology 171, pages 28-36.
Crossref
Yuanyuan Gao, Yong Zhang, Jianming Zhu, Bo Li, Zhao Li, Weiliang Zhu, Jiye Shi, Qi Jia & Yiming Li. (2015) Recent progress in natural products as DPP-4 inhibitors. Future Medicinal Chemistry 7:8, pages 1079-1089.
Crossref
Li-Jun Wang, Bo Jiang, Ning Wu, Shuai-Yu Wang & Da-Yong Shi. (2015) Natural and semisynthetic protein tyrosine phosphatase 1B (PTP1B) inhibitors as anti-diabetic agents. RSC Advances 5:60, pages 48822-48834.
Crossref
Eric YarnellKathy Abascal. (2014) Herbs for Diabetes: Update—Part 1. Alternative and Complementary Therapies 20:6, pages 328-333.
Crossref
Ghadeer A. R. Y. Suaifan, Mayadah B. Shehadeh, Hebah A. N. Al-Ijel, Khuloud T. Al-Jamal & Mutasem O. Taha. (2014) Ritodrine inhibits neuronal nitric oxide synthase, a potential link between tocolysis and autism. Medicinal Chemistry Research 23:12, pages 5102-5109.
Crossref
Hui Wang, Wei Mu, Hongcai Shang, Jia Lin & Xiang Lei. (2014) The Antihyperglycemic Effects of Rhizoma Coptidis and Mechanism of Actions: A Review of Systematic Reviews and Pharmacological Research. BioMed Research International 2014, pages 1-10.
Crossref
Kubra KaraosmanogluNihat Alpagu SayarIsil Aksan KurnazBerna Sariyar Akbulut. (2014) Assessment of Berberine as a Multi-target Antimicrobial: A Multi-omics Study for Drug Discovery and Repositioning. OMICS: A Journal of Integrative Biology 18:1, pages 42-53.
Crossref
Arnaud S. Karaboga, Jesús M. Planesas, Florent Petronin, Jordi Teixidó, Michel Souchet & Violeta I. Pérez-Nueno. (2013) Highly SpecIfic and Sensitive Pharmacophore Model for Identifying CXCR4 Antagonists. Comparison with Docking and Shape-Matching Virtual Screening Performance. Journal of Chemical Information and Modeling 53:5, pages 1043-1056.
Crossref
Mohammad Mohammad, Ihab M. Al-masri, Ala Issa, Ayman Khdair & Yasser Bustanji. (2012) Inhibition of pancreatic lipase by berberine and dihydroberberine: an investigation by docking simulation and experimental validation. Medicinal Chemistry Research 22:5, pages 2273-2278.
Crossref
Cheng-shi Jiang, Lin-fu Liang & Yue-wei Guo. (2012) Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades. Acta Pharmacologica Sinica 33:10, pages 1217-1245.
Crossref
Jesús M. Planesas, Violeta I. Pérez-Nueno, José I. Borrell & Jordi Teixidó. (2012) Impact of the CXCR4 structure on docking-based virtual screening of HIV entry inhibitors. Journal of Molecular Graphics and Modelling 38, pages 123-136.
Crossref
Suresh Thareja, Saurabh Aggarwal, T. R. Bhardwaj & Manoj Kumar. (2010) Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes Mellitus. Medicinal Research Reviews 32:3, pages 459-517.
Crossref
Chunhua Chen, Yuebo Zhang & Cheng Huang. (2010) Berberine inhibits PTP1B activity and mimics insulin action. Biochemical and Biophysical Research Communications 397:3, pages 543-547.
Crossref
Yasser Bustanji, Mutasem Omar Taha, Ihab Mustafa Al-masri & Mohammad Khalil Mohammad. (2009) Docking Simulations and in Vitro Assay Unveil Potent Inhibitory Action of Papaverine against Protein Tyrosine Phosphatase 1B. Biological and Pharmaceutical Bulletin 32:4, pages 640-645.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.