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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 23, 2008 - Issue 1
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Research Article

Targeting human DNA polymerase α for the inhibition of keratinocyte proliferation. Part 1. Homology model, active site architecture and ligand binding

Anja Richartz Institute of Pharmacy, Department of Pharmacology and Toxicology, Free University of Berlin, Berlin, Germany
,
Monika Höltje Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine-University of Düsseldorf, Düsseldorf, Germany
,
Birte Brandt Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine-University of Düsseldorf, Düsseldorf, Germany
,
Monika Schäfer-Korting Institute of Pharmacy, Department of Pharmacology and Toxicology, Free University of Berlin, Berlin, Germany
&
Hans-Dieter Höltje Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine-University of Düsseldorf, Düsseldorf, Germany
Pages 94-100 | Received 24 Jan 2007, Accepted 29 Mar 2007, Published online: 04 Oct 2008

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Read on this site (2)

Barbara Zdrazil, Anja Schwanke, Birte Schmitz, Monika Schäfer-Korting & Hans-Dieter Höltje. (2011) Molecular modelling studies of new potential human DNA polymerase α inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 26:2, pages 270-279.
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Monika Höltje, Anja Richartz, Barbara Zdrazil, Anja Schwanke, Branislav Dugovic, Caterina Murruzzu, Hans-Ulrich Reißig, Hans Christian Korting, Burkhard Kleuser, Hans-Dieter Höltje & Monika Schäfer-Korting. (2010) Human polymerase α inhibitors for skin tumors. Part 2. Modeling, synthesis and influence on normal and transformed keratinocytes of new thymidine and purine derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 25:2, pages 250-265.
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Articles from other publishers (4)

Christopher Maffeo, Han‐Yi Chou & Aleksei Aksimentiev. (2019) Molecular Mechanisms of DNA Replication and Repair Machinery: Insights from Microscopic Simulations. Advanced Theory and Simulations 2:5, pages 1800191.
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Alexey Yu. Nyporko. 2014. Application of Computational Techniques in Pharmacy and Medicine. Application of Computational Techniques in Pharmacy and Medicine 95 135 .
Anja Schwanke, Caterina Murruzzu, Barbara Zdrazil, Ralf Zuhse, Maja Natek, Monika Höltje, Hans Christian Korting, Hans-Ulrich Reissig, Hans-Dieter Höltje & Monika Schäfer-Korting. (2010) Antitumor effects of guanosine-analog phosphonates identified by molecular modelling. International Journal of Pharmaceutics 397:1-2, pages 9-18.
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Anthony J. Berdis. (2009) Mechanisms of DNA Polymerases. Chemical Reviews 109:7, pages 2862-2879.
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