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Research Article

Chlorpromazine oligomer is a potentially active substance that inhibits human D-amino acid oxidase, product of a susceptibility gene for schizophrenia

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Pages 901-911 | Received 02 May 2007, Accepted 31 Jul 2007, Published online: 20 Oct 2008

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Andra Mihali, Shreya Subramani, Genevieve Kaunitz, Stephen Rayport & Inna Gaisler-Salomon. (2012) Modeling resilience to schizophrenia in genetically modified mice: a novel approach to drug discovery. Expert Review of Neurotherapeutics 12:7, pages 785-799.
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Taiki Kohiki, Yusuke Nishikawa, Tsubasa Inokuma, Akira Shigenaga & Akira Otaka. (2017) Chemical Synthetic Platform for Chlorpromazine Oligomers That Were Reported as Photo-degradation Products of Chlorpromazine. CHEMICAL & PHARMACEUTICAL BULLETIN Chemical and Pharmaceutical Bulletin 65:12, pages 1161-1166.
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Miho Shishikura, Hitomi Hakariya, Sumiko Iwasa, Takashi Yoshio, Hideaki Ichiba, Kazuko Yorita, Kiyoshi Fukui & Takeshi Fukushima. (2014) Evaluation of human D-amino acid oxidase inhibition by anti-psychotic drugs in vitro. BioScience Trends 8:3, pages 149-154.
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Silvia Sacchi, Laura Caldinelli, Pamela Cappelletti, Loredano Pollegioni & Gianluca Molla. (2012) Structure–function relationships in human d-amino acid oxidase. Amino Acids 43:5, pages 1833-1850.
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Panos Roussos, Stella G Giakoumaki, Eva Adamaki, Georgakopoulos Anastasios, Robakis K Nikos & Panos Bitsios. (2011) The Association of Schizophrenia Risk D-Amino Acid Oxidase Polymorphisms With Sensorimotor Gating, Working Memory and Personality in Healthy Males. Neuropsychopharmacology 36:8, pages 1677-1688.
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Sumiko IWASA, Hiroshi TABARA, Ziyu SONG, Moe NAKABAYASHI, Yuusaku YOKOYAMA & Takeshi FUKUSHIMA. (2011) Inhibition of D-Amino Acid Oxidase Activity by Antipsychotic Drugs Evaluated by a Fluorometric Assay Using D-Kynurenine as Substrate. YAKUGAKU ZASSHI 131:7, pages 1111-1116.
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Glen B. Baker, Jaime E.C. Hallak, Alexandria F. Dilullo, Lisa Burback & Serdar M. Dursun. 2011. Handbook of Schizophrenia Spectrum Disorders, Volume I. Handbook of Schizophrenia Spectrum Disorders, Volume I 253 262 .
S. P. Chung, K. Sogabe, H. K. Park, Y. Song, K. Ono, R. M. Abou El-Magd, Y. Shishido, K. Yorita, T. Sakai & K. Fukui. (2010) Potential cytotoxic effect of hydroxypyruvate produced from D-serine by astroglial D-amino acid oxidase. Journal of Biochemistry 148:6, pages 743-753.
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Rabab M. Abou El-Magd, Chizuru Sasaki, Tomoya Kawazoe, Salah M. El-Sayed, Kazuko Yorita, Yuji Shishido, Takashi Sakai, Yoshitoshi Nakamura & Kiyoshi Fukui. (2010) Bioprocess development of the production of the mutant P-219-L human d-amino acid oxidase for high soluble fraction expression in recombinant Escherichia coli. Biochemical Engineering Journal 52:2-3, pages 236-247.
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Masumi Katane, Yasuaki Saitoh, Toshihiko Hanai, Masae Sekine, Takemitsu Furuchi, Nobuhiro Koyama, Izumi Nakagome, Hiroshi Tomoda, Shuichi Hirono & Hiroshi Homma. (2010) Thiolactomycin inhibits d-aspartate oxidase: A novel approach to probing the active site environment. Biochimie 92:10, pages 1371-1378.
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RM Abou El-Magd, HK Park, T. Kawazoe, S. Iwana, K. Ono, SP Chung, M. Miyano, K. Yorita, T. Sakai & K. Fukui. (2009) The effect of risperidone on D-amino acid oxidase activity as a hypothesis for a novel mechanism of action in the treatment of schizophrenia. Journal of Psychopharmacology 24:7, pages 1055-1067.
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L Verrall, P W J Burnet, J F Betts & P J Harrison. (2009) The neurobiology of D-amino acid oxidase and its involvement in schizophrenia. Molecular Psychiatry 15:2, pages 122-137.
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Ziyu Song, Tadahiro Ogaya, Kana Ishii, Hideaki Ichiba, Hideaki Iizuka & Takeshi Fukushima. (2010) Utilization of Kynurenic Acid Produced from D-kynurenine in an in Vitro Assay of D-Amino Acid Oxidase Activity. Journal of Health Science 56:3, pages 341-346.
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