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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 23, 2008 - Issue 6
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Research Article

Enzyme kinetic and molecular modelling studies of sulphur-containing substrates of phenylalanine 4-monooxygenase

N. G. Patel Pharmaceutical Sciences Division, School of Biomedical and Health Sciences, King's College London, Franklin Wilkins Building, 150 Stamford StreetLondon, SE1 9NH, UK
,
C. Iliadou Pharmaceutical Sciences Division, School of Biomedical and Health Sciences, King's College London, Franklin Wilkins Building, 150 Stamford StreetLondon, SE1 9NH, UK
,
B. Boonyapiwat Pharmaceutical Sciences Division, School of Biomedical and Health Sciences, King's College London, Franklin Wilkins Building, 150 Stamford StreetLondon, SE1 9NH, UK
,
D. J. Barlow Pharmaceutical Sciences Division, School of Biomedical and Health Sciences, King's College London, Franklin Wilkins Building, 150 Stamford StreetLondon, SE1 9NH, UK
,
B. Forbes Pharmaceutical Sciences Division, School of Biomedical and Health Sciences, King's College London, Franklin Wilkins Building, 150 Stamford StreetLondon, SE1 9NH, UK
,
S. C. Mitchell Faculty of Medicine, Department of Biomolecular Medicine, Imperial College London, Sir Alexander Fleming Building, South KensingtonLondon, SW7 2AZ, UK
&
G. B. Steventon Pharmaceutical Sciences Division, School of Biomedical and Health Sciences, King's College London, Franklin Wilkins Building, 150 Stamford StreetLondon, SE1 9NH, UKCorrespondence[email protected]
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Pages 958-963 | Received 09 Jul 2007, Accepted 26 Oct 2007, Published online: 20 Oct 2008

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Read on this site (7)

Stephen C. Mitchell & Glyn B. Steventon. (2020) Phenylalanine 4-monooxygenase: the “sulfoxidation polymorphism”. Xenobiotica 50:1, pages 51-63.
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Glyn B. Steventon & Stephen C. Mitchell. (2019) The S-oxidation of S-carboxymethyl-L-cysteine in hepatic cytosolic fractions from BTBR and phenylketonuria enu1 and enu2 mice. Xenobiotica 49:4, pages 495-502.
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Evita Vandenbossche, Christopher Lucas, Lata Mistry, Emma Garfield, Stephen C. Mitchell & Glyn B. Steventon. (2016) Phenylalanine monooxygenase and the sulfur oxygenation of S-carboxymethyl-l-cysteine in mice. Xenobiotica 46:4, pages 379-384.
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Panayotis Panagopoulos, Stephen C. Mitchell & Glyn B. Steventon. (2015) S-carboxymethyl-l-cysteine and it (R/S)-S-oxides in beagle dog plasma and hepatic cytosol. Xenobiotica 45:12, pages 1047-1053.
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Steve C. Mitchell & Glyn B. Steventon. (2012) S-Carboxymethyl-L-cysteine. Drug Metabolism Reviews 44:2, pages 129-147.
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A. Antypa, C. Rebello, A. Biernacka, K. Krajewski, J. Cassam, S. C. Mitchell & G. B. Steventon. (2010) Post-translational activation of human phenylalanine 4-monooxygenase from an endobiotic to a xenobiotic enzyme by reactive oxygen and reactive nitrogen species. Xenobiotica 40:5, pages 319-330.
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Glyn B Steventon & Stephen C Mitchell. (2009) Phenylalanine 4-monooxygenase and the role of endobiotic metabolism enzymes in xenobiotic biotransformation. Expert Opinion on Drug Metabolism & Toxicology 5:10, pages 1213-1221.
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Articles from other publishers (4)

Glyn B. Steventon & Stephen C. Mitchell. (2018) Phenylalanine hydroxylase: A biomarker of disease susceptibility in Parkinson’s disease and Amyotrophic lateral sclerosis. Medical Hypotheses 118, pages 29-33.
Crossref
Boontarika Boonyapiwat, Stephen C Mitchell & Glyn B Steventon. (2011) Recombinant heteromeric phenylalanine monooxygenase and the oxygenation of carbon and sulfur substrates. Journal of Pharmacy and Pharmacology 63:4, pages 558-564.
Crossref
Glyn B. Steventon & Stephen C. Mitchell. 2001. Current Protocols in Toxicology. Current Protocols in Toxicology.
Glyn B. Steventon, Stephen C. Mitchell, Belen Pérez, Lourdes R. Desviat & Magdalena Ugarte. (2009) The activity of wild type and mutant phenylalanine hydroxylase with respect to the C-oxidation of phenylalanine and the S-oxidation of S-carboxymethyl-l-cysteine. Molecular Genetics and Metabolism 96:1, pages 27-31.
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