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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 24, 2009 - Issue 2
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Research Article

Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis

Nikolaos A. A. Balatsos
,
Dimitrios AnastasakisDepartment of Biochemistry and Biotechnology, University of Thessaly, 26 Ploutonos st., 412 21 Larissa, Greece
&
Constantinos StathopoulosCorrespondence[email protected]
Pages 516-523 | Received 12 Dec 2007, Accepted 15 May 2008, Published online: 01 Apr 2009

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Costas Delis, Afrodite Krokida, Anastasia Tomatsidou, Daniela Tsikou, Rafailia A.A. Beta, Maria Tsioumpekou, Julietta Moustaka, Georgios Stravodimos, Demetres D. Leonidas, Nikolaos A. A. Balatsos & Kalliope K. Papadopoulou. (2016) AtHESPERIN: a novel regulator of circadian rhythms with poly(A)-degrading activity in plants. RNA Biology 13:1, pages 68-82.
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Articles from other publishers (11)

Lydia Borgelt & Peng Wu. (2023) Targeting Ribonucleases with Small Molecules and Bifunctional Molecules. ACS Chemical Biology 18:10, pages 2101-2113.
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Thao Ngoc Huynh, Siddharth Shukla, Philip Reigan & Roy Parker. (2023) Identification of PARN nuclease activity inhibitors by computational-based docking and high-throughput screening. Scientific Reports 13:1.
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Rafailia A. A. Beta, Athanasios Kyritsis, Veroniki Douka, Eirini Papanastasi, Marianna Rizouli, Demetres D. Leonidas, Dimitrios Vlachakis & Nikolaos A. A. Balatsos. (2022) Biochemical and in silico identification of the active site and the catalytic mechanism of the circadian deadenylase HESPERIN . FEBS Open Bio 12:5, pages 1036-1049.
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Dimitrios Anastasakis, Ilias Skeparnias, Athanasios-Nasir Shaukat, Katerina Grafanaki, Alexandra Kanellou, Stavros Taraviras, Dionysios J. Papachristou, Athanasios Papakyriakou & Constantinos Stathopoulos. (2016) Mammalian PNLDC1 is a novel poly(A) specific exonuclease with discrete expression during early development. Nucleic Acids Research 44:18, pages 8908-8920.
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Taslimahemad T. Khatri & Viresh H. Shah. (2014) One Pot Synthesis of Novel Cyanopyridones as an Intermediate of Bioactive Pyrido[2,3-d]Pyrimidines. Journal of the Korean Chemical Society 58:4, pages 366-376.
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Alan R. Godwin, Shihoko Kojima, Carla B. Green & Jeffrey Wilusz. (2013) Kiss your tail goodbye: The role of PARN, Nocturnin, and Angel deadenylases in mRNA biology. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829:6-7, pages 571-579.
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Dimitrios Vlachakis, Athanasia Pavlopoulou, Georgia Tsiliki, Dimitri Komiotis, Constantinos Stathopoulos, Nikolaos A. A. Balatsos & Sophia Kossida. (2012) An Integrated In Silico Approach to Design Specific Inhibitors Targeting Human Poly(A)-Specific Ribonuclease. PLoS ONE 7:12, pages e51113.
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Guang-Jun He & Yong-Bin Yan. (2012) A Deadenylase Assay by Size-Exclusion Chromatography. PLoS ONE 7:3, pages e33700.
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Nikolaos Balatsos, Dimitrios Vlachakis, Vassiliki Chatzigeorgiou, Stella Manta, Dimitri Komiotis, Metaxia Vlassi & Constantinos Stathopoulos. (2012) Kinetic and in silico analysis of the slow-binding inhibition of human poly(A)-specific ribonuclease (PARN) by novel nucleoside analogues. Biochimie 94:1, pages 214-221.
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Guang-Jun He, Wei-Feng Liu & Yong-Bin Yan. (2011) Dissimilar Roles of the Four Conserved Acidic Residues in the Thermal Stability of Poly(A)-Specific Ribonuclease. International Journal of Molecular Sciences 12:5, pages 2901-2916.
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Nikolaos A. A. Balatsos, Dimitrios Vlachakis, Panagiotis Maragozidis, Stella Manta, Dimitrios Anastasakis, Athanasios Kyritsis, Metaxia Vlassi, Dimitri Komiotis & Constantinos Stathopoulos. (2009) Competitive Inhibition of Human Poly(A)-Specific Ribonuclease (PARN) by Synthetic Fluoro-Pyranosyl Nucleosides. Biochemistry 48:26, pages 6044-6051.
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