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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 23, 2008 - Issue 5
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Research Article

β-Lactam type molecular scaffolds for antiproliferative activity: Synthesis and cytotoxic effects in breast cancer cells

Mary J. Meegan School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Centre for Synthesis and Chemical Biology, Dublin 2, IrelandCorrespondence[email protected]
,
Miriam Carr School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Centre for Synthesis and Chemical Biology, Dublin 2, Ireland
,
Andrew J. S. Knox
,
Daniela M. Zisterer School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
&
David G. Lloyd School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
Pages 668-685 | Received 02 Jan 2008, Accepted 21 Mar 2008, Published online: 20 Oct 2008

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Miriam Carr, Andrew J. S. Knox, David G. Lloyd, Daniela M. Zisterer & Mary J. Meegan. (2016) Development of the β-lactam type molecular scaffold for selective estrogen receptor α modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup3, pages 117-130.
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Articles from other publishers (16)

Márton Kalabay, Zsófia Szász, Orsolya Láng, Eszter Lajkó, Éva Pállinger, Cintia Duró, Tamás Jernei, Antal Csámpai, Angéla Takács & László Kőhidai. (2022) Investigation of the Antitumor Effects of Tamoxifen and Its Ferrocene-Linked Derivatives on Pancreatic and Breast Cancer Cell Lines. Pharmaceuticals 15:3, pages 314.
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Bimal Krishna Banik & Alberto Boretti. (2021) Hypotheses for synthesis of novel chiral beta-amino-beta-lactams through amidines. Results in Chemistry 3, pages 100158.
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Xinfen Zhang & Yanshu Jia. (2020) Recent Advances in β-lactam Derivatives as Potential Anticancer Agents. Current Topics in Medicinal Chemistry 20:16, pages 1468-1480.
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Subhajit Makar, Tanmay Saha, Rayala Swetha, Gopichand Gutti, Ashok Kumar & Sushil K. Singh. (2020) Rational approaches of drug design for the development of selective estrogen receptor modulators (SERMs), implicated in breast cancer. Bioorganic Chemistry 94, pages 103380.
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Niamh M. O’Boyle, Jade K. Pollock, Miriam Carr, Andrew J. S. Knox, Seema M. Nathwani, Shu Wang, Laura Caboni, Daniela M. Zisterer & Mary J. Meegan. (2014) β-Lactam Estrogen Receptor Antagonists and a Dual-Targeting Estrogen Receptor/Tubulin Ligand. Journal of Medicinal Chemistry 57:22, pages 9370-9382.
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Sebastian Stecko, Bartłomiej Furman & Marek Chmielewski. (2014) Kinugasa reaction: an ‘ugly duckling’ of β-lactam chemistry. Tetrahedron 70:43, pages 7817-7844.
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Marcin Śnieżek, Sebastian Stecko, Irma Panfil, Bartłomiej Furman, Zofia Urbańczyk-Lipkowska & Marek Chmielewski. (2013) Thermal and Sc(OTf)3 catalyzed 1,3-dipolar cycloaddition of open-chain nitrones to α,β-unsaturated lactones: combined experimental and computational studies. Tetrahedron: Asymmetry 24:2-3, pages 89-103.
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Jiaxi Xu. (2012) Synthesis of ?-lactams with ? electron-withdrawing substituents. Tetrahedron 68:52, pages 10696-10747.
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Bimal K. Banik & Maghar S. Manhas. (2012) Stereospecific novel glycosylation of hydroxy ?-lactams via iodine-catalyzed reaction: a new method for optical resolution. Tetrahedron 68:52, pages 10769-10779.
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Micha Michalak, Maciej Stodulski, Sebastian Stecko, Magdalena Wonica, Olga Staszewska-Krajewska, Przemysaw Kalicki, Bartomiej Furman, Jadwiga Frelek & Marek Chmielewski. (2012) Synthesis of N,4-diaryl substituted ?-lactams via Kinugasa cycloaddition/rearrangement reaction. Tetrahedron 68:52, pages 10806-10817.
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Michał Michalak, Maciej Stodulski, Sebastian Stecko, Adam Mames, Irma Panfil, Magdalena Soluch, Bartłomiej Furman & Marek Chmielewski. (2011) A Formal Synthesis of Ezetimibe via Cycloaddition/Rearrangement Cascade Reaction. The Journal of Organic Chemistry 76:16, pages 6931-6936.
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Cheng-Pei Chung, Chih-Ying Hsu, Jing-Hui Lin, Yueh-Hsiung Kuo, Wenchang Chiang & Yun-Lian Lin. (2011) Antiproliferative Lactams and Spiroenone from Adlay Bran in Human Breast Cancer Cell Lines. Journal of Agricultural and Food Chemistry 59:4, pages 1185-1194.
Crossref
Niamh M. O’Boyle, Miriam Carr, Lisa M. Greene, Orla Bergin, Seema M. Nathwani, Thomas McCabe, David G. Lloyd, Daniela M Zisterer & Mary J. Meegan. (2010) Synthesis and Evaluation of Azetidinone Analogues of Combretastatin A-4 as Tubulin Targeting Agents. Journal of Medicinal Chemistry 53:24, pages 8569-8584.
Crossref
Miriam Carr, Lisa M. Greene, Andrew J.S. Knox, David G. Lloyd, Daniela M. Zisterer & Mary J. Meegan. (2010) Lead identification of conformationally restricted β-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects. European Journal of Medicinal Chemistry 45:12, pages 5752-5766.
Crossref
Bimal K. Banik, Indrani Banik & Frederick F. Becker. 2010. Heterocyclic Scaffolds I. Heterocyclic Scaffolds I 349 373 .
Luigino Troisi, Catia Granito & Emanuela Pindinelli. 2010. Heterocyclic Scaffolds I. Heterocyclic Scaffolds I 101 209 .

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