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Research Article

Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro

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Pages 1138-1140 | Received 01 Jul 2008, Accepted 12 Nov 2008, Published online: 23 Sep 2009

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Xiao Ma, Yan-ling Zhao, Yun Zhu, Zhe Chen, Jia-bo Wang, Rui-yu Li, Chang Chen, Shi-zhang Wei, Jian-yu Li, Bing Liu, Rui-lin Wang, Yong-gang Li, Li-fu Wang & Xiao-he Xiao. (2015) Paeonia lactiflora Pall. protects against ANIT-induced cholestasis by activating Nrf2 via PI3K/Akt signaling pathway. Drug Design, Development and Therapy 9, pages 5061-5074.
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Kyung-Ran Park, Hanna Lee, Soo Hyun Kim & Hyung-Mun Yun. (2022) Paeoniflorigenone regulates apoptosis, autophagy, and necroptosis to induce anti-cancer bioactivities in human head and neck squamous cell carcinomas. Journal of Ethnopharmacology 288, pages 115000.
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Yichao Wu, Yuanyuan Jiang, Li Zhang, Jing Zhou, Yan Yu, Yonghong Zhou & Tairan Kang. (2021) Chemical Profiling and Antioxidant Evaluation of Paeonia lactiflora Pall. “Zhongjiang” by HPLC–ESI–MS Combined with DPPH Assay . Journal of Chromatographic Science 59:9, pages 795-805.
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Mi Na Nam, Ji-Hyun Kim, Ah Young Lee & Eun Ju Cho. (2021) Neuroprotective effects of Paeonia lactiflora and its active compound paeoniflorin against Aβ 25-35 -induced neurotoxicity in SH-SY5Y cells . Journal of Applied Biological Chemistry 64:2, pages 105-112.
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Lijun Zhu, Shanshan Sun, Xin Li, Yanxi Hu, Yancheng Li & Yufeng Liu. (2020) Comparative Pharmacokinetic Studies of Paeoniflorin, Albiflorin and Oxypaeoniflorin Between Normal and Cerebral Ischemia–Reperfusion Rats Based on the Simultaneous Determinations Using an UPLC-MS–MS Method. Chromatographia 83:11, pages 1345-1354.
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Ah Young Lee, Mi Na Nam, Hyun Young Kim & Eun Ju Cho. (2020) Protective role of paeoniflorin from hydrogen peroxide-mediated oxidative damage in C6 glial cells. Journal of Applied Biological Chemistry 63:2, pages 137-145.
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Yang Pan, Zhen Gao, Xiao-Yan Huang, Ji-Jun Chen & Chang-An Geng. (2020) Chemical and biological comparison of different parts of Paeonia suffruticosa (Mudan) based on LCMS-IT-TOF and multi-evaluation in vitro. Industrial Crops and Products 144, pages 112028.
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Adem Demir, Halbay Turumtay, Mustafa Emirik, Cemal Sandalli, Şeyda Kanbolat, Ufuk Özgen & Emine Akyuz Turumtay. (2019) Paeoniflorigenone purified from Paeonia daurica roots potently inhibits viral and bacterial DNA polymerases: investigation by experimental validation and docking simulation. Medicinal Chemistry Research 28:12, pages 2232-2245.
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I-Cheng Chen, Te-Hsien Lin, Yu-Hsuan Hsieh, Chih-Ying Chao, Yih-Ru Wu, Kuo-Hsuan Chang, Ming-Chung Lee, Guey-Jen Lee-Chen & Chiung-Mei Chen. (2018) Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation. Oxidative Medicine and Cellular Longevity 2018, pages 1-16.
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Shujuan Li, Yanjie Chu, Ruowen Zhang, Linjia Sun & Xiaohui Chen. (2018) Prophylactic Neuroprotection of Total Glucosides of Paeoniae Radix Alba against Semen Strychni-Induced Neurotoxicity in Rats: Suppressing Oxidative Stress and Reducing the Absorption of Toxic Components. Nutrients 10:4, pages 514.
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Odontuya Gendaram, Daowan Lai, Purevdorj Erdenetsogt & Peter Proksch. (2017) Pancreatic lipase inhibitory and antioxidative constituents from the aerial parts of Paeonia lactiflora Pall. (Ranunculaceae). Phytochemistry Letters 21, pages 240-246.
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Chuanqi Zhou & Xiaoke Wang. (2017) Rapid Determination of Isomeric Benzoylpaeoniflorin and Benzoylalbiflorin in Rat Plasma by LC-MS/MS Method. International Journal of Analytical Chemistry 2017, pages 1-9.
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Dan-Dan Zhao, Li-Li Jiang, Hong-Yi Li, Peng-Fei Yan & Yan-Long Zhang. (2016) Chemical Components and Pharmacological Activities of Terpene Natural Products from the Genus Paeonia. Molecules 21:10, pages 1362.
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Jun-Jun Shi, Jian-Guo Zhang, Yu-Han Sun, Qi-Xin Xu, Ling Li, Chandan Prasad & Zhao-Jun Wei. (2016) The rheological properties of polysaccharides sequentially extracted from peony seed dreg. International Journal of Biological Macromolecules 91, pages 760-767.
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Jun-Jun Shi, Jian-Guo Zhang, Yu-Han Sun, Jie Qu, Ling Li, Chandan Prasad & Zhao-Jun Wei. (2016) Physicochemical properties and antioxidant activities of polysaccharides sequentially extracted from peony seed dreg. International Journal of Biological Macromolecules 91, pages 23-30.
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Shefton Parker, Brian May, Claire Zhang, Anthony Lin Zhang, Chuanjian Lu & Charlie Changli Xue. (2016) A Pharmacological Review of Bioactive Constituents of Paeonia lactiflora Pallas and Paeonia veitchii Lynch . Phytotherapy Research 30:9, pages 1445-1473.
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LINGWEN KONG, SHANGSHANG WANG, XIAO WU, FUGUO ZUO, HAIHONG QIN & JINFENG WU. (2016) Paeoniflorin attenuates ultraviolet B-induced apoptosis in human keratinocytes by inhibiting the ROS-p38-p53 pathway. Molecular Medicine Reports 13:4, pages 3553-3558.
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Xiaoyan Xu, Feng Li, Xin Zhang, Pengcheng Li, Xing Zhang, Zhaoxi Wu & Dapeng Li. (2014) In Vitro Synergistic Antioxidant Activity and Identification of Antioxidant Components from Astragalus membranaceus and Paeonia lactiflora. PLoS ONE 9:5, pages e96780.
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Yanling Zhao, Guangde Zhou, Jiabo Wang, Lei Jia, Ping Zhang, Ruisheng Li, Limei Shan, Bing Liu, Xueai Song, Shijing Liu & Xiaohe Xiao. (2013) Paeoniflorin protects against ANIT-induced cholestasis by ameliorating oxidative stress in rats. Food and Chemical Toxicology 58, pages 242-248.
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Jing Yu, Xiaoyun Zhu, Xin Qi, Juanjuan Che & Bangwei Cao. (2013) Paeoniflorin protects human EA.hy926 endothelial cells against gamma-radiation induced oxidative injury by activating the NF-E2-related factor 2/heme oxygenase-1 pathway. Toxicology Letters 218:3, pages 224-234.
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Wei Zhang & Sheng-Ming Dai. (2012) Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis. International Immunopharmacology 14:1, pages 27-31.
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Lili Zhang & Shulan Zhang. (2011) Modulating Bcl-2 Family Proteins and Caspase-3 in Induction of Apoptosis by Paeoniflorin in Human Cervical Cancer Cells. Phytotherapy Research 25:10, pages 1551-1557.
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