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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Research Paper

Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors

Adel S. El-Azaba Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7197-1515View further author information
ORCID Icon,
Alaa A.-M. Abdel-Aziza Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0002-3362-9337View further author information
ORCID Icon,
Hany E. A. Ahmedb Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo, Egypt;c Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi ArabiaView further author information
,
Sivia Buad Department of Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, ItalyView further author information
,
Alessio Nocentinid Department of Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, ItalyView further author information
,
Nawaf A. AlSaifa Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaView further author information
,
Ahmad J. Obaidullaha Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaView further author information
,
Mohamed M. Hefnawya Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaView further author information
&
Claudiu T. Supurand Department of Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4262-0323View further author information
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Pages 598-609 | Received 21 Dec 2019, Accepted 09 Jan 2020, Published online: 02 Feb 2020

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Maan T. Khayat, Hany E. A. Ahmed, Abdelsattar M. Omar, Yosra A. Muhammad, Khadijah A. Mohammad, Azizah M. Malebari, Ahdab N. Khayyat, Ahmed H. Halawa, Hamada S. Abulkhair, Ahmed A. Al-Karmalawy, Mohammed Almaghrabi, Majed Alharbi, Anfal S. Aljahdali & Ahmed M. El-Agrody. (2023) A novel class of phenylpyrazolone-sulphonamides rigid synthetic anticancer molecules selectively inhibit the isoform IX of carbonic anhydrases guided by molecular docking and orbital analyses. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-19.
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Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Nawaf A. AlSaif, Mohammed M. Alanazi, Manal A. El-Gendy, Hany E. A. Ahmed & Claudiu T. Supuran. (2020) S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 733-743.
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Walaa M. El-Husseiny, Magda A.-A. El-Sayed, Adel S. El-Azab, Nawaf A. AlSaif, Mohammed M. Alanazi & Alaa A.-M. Abdel-Aziz. (2020) Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 744-758.
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Articles from other publishers (9)

Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Ahmed H. Bakheit, Hamad M. Alkahtani, Mohamed M. Hefnawy & Claudiu T. Supuran. (2023) Design, synthesis, and carbonic anhydrase inhibition activities of Schiff bases incorporating benzenesulfonamide scaffold: Molecular docking application. Saudi Pharmaceutical Journal 31:12, pages 101866.
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Adel S. El-Azab, Hamad M. Alkahtani, Nawaf A. AlSaif, Ibrahim A. Al-Suwaidan, Ahmad J. Obaidullah, Mohammed M. Alanazi, Abdulrahman M. Al-Obaid, Mohamed H.M. Al-Agamy & Alaa A.-M. Abdel-Aziz. (2023) Synthesis, antiproliferative and enzymatic inhibition activities of quinazolines incorporating benzenesulfonamide: Cell cycle analysis and molecular modeling study. Journal of Molecular Structure 1278, pages 134928.
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Feyzi Sinan Tokalı, Zuhal Alım & Ümit Yırtıcı. (2023) Carboxylate‐ and Sulfonate‐Containing Quinazolin‐4(3H)‐one Rings: Synthesis, Characterization, and Carbonic Anhydrase I–II and Acetylcholinesterase Inhibition Properties. ChemistrySelect 8:8.
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Reihane Ghomashi, Shakila Ghomashi, Hamidreza Aghaei & Ahmad Reza Massah. (2023) Recent Advances in Biological Active Sulfonamide based Hybrid Compounds Part A: Two-Component Sulfonamide Hybrids. Current Medicinal Chemistry 30:4, pages 407-480.
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Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Hazem A. Ghabbour, Silvia Bua, Alessio Nocentini, Hamad M. Alkahtani, Nawaf A. Alsaif, Mohamed H. M. Al-Agamy & Claudiu T. Supuran. (2022) Carbonic Anhydrase Inhibition Activities of Schiff’s Bases Based on Quinazoline-Linked Benzenesulfonamide. Molecules 27:22, pages 7703.
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Adel S. El-Azab, Nasr Y. Khalil & Alaa A.-M. Abdel-Aziz. (2021) Remarkable Conversion of 2-Thioxo-2,3-dihydroquinazolin-4(1H)-ones into the Corresponding Quinazoline-2,4(1H,3H)-diones: Spectroscopic Analysis and X-Ray Crystallography. Journal of Chemistry 2021, pages 1-8.
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Keyvan Pedrood, Maedeh Sherafati, Maryam Mohammadi-Khanaposhtani, Mohammad Sadegh Asgari, Samanesadat Hosseini, Hossein Rastegar, Bagher Larijani, Mohammad Mahdavi, Parham Taslimi, Yavuz Erden, Sevilay Günay & İlhami Gulçin. (2021) Design, synthesis, characterization, enzymatic inhibition evaluations, and docking study of novel quinazolinone derivatives. International Journal of Biological Macromolecules 170, pages 1-12.
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Shubham Kumar, Sandeep Rulhania, Shalini Jaswal & Vikramdeep Monga. (2021) Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors. European Journal of Medicinal Chemistry 209, pages 112923.
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Abdallah Turky, Ashraf H. Bayoumi, Adel Ghiaty, Adel S. El-Azab, Alaa A.-M. Abdel-Aziz & Hamada S. Abulkhair. (2020) Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects. Bioorganic Chemistry 101, pages 104019.
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