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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 37, 2022 - Issue 1
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Research Papers

New pyrazolylpyrazoline derivatives as dual acting antimalarial-antileishamanial agents: synthesis, biological evaluation and molecular modelling simulations

Adnan A. Bekhita Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt;b Pharmacy Program, Allied Health Department, College of Health and Sport Sciences, University of Bahrain, Zallaq, Kingdom of Bahrain;c Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0003-3865-0677
ORCID Icon,
Eskedar T. Lodeboc Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia;d Department of Chemistry, Kotebe Metropolitan University, Addis Ababa, Ethiopia
,
Ariaya Hymetec Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia
,
Hanan M. Ragaba Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
,
Salma A. Bekhite High Institute of Public Health, Alexandria University, Alexandria, Egypt
,
Kikuko Amagasef Laboratory of Pharmacology & Pharmacotherapeutics, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Japan
,
Afnan Batubarag Department of Pharmaceutical Chemistry, College of Pharmacy, Umm Al-Qurra University, Makkah, Saudi Arabia
,
Mohammed A. S. Abourehabh Department of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia;i Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Minia University, Minia, Egypt
,
Alaa El-Din A. Bekhitj Food Sciences, University of Otago, Dunedin, New ZealandORCID Iconhttps://orcid.org/0000-0003-2569-8620
ORCID Icon &
Tamer M. Ibrahimk Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafr El-Sheikh, EgyptCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0003-1016-8950
ORCID Icon show all
Pages 2320-2333 | Received 08 Jun 2022, Accepted 21 Aug 2022, Published online: 29 Aug 2022

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Mounir A. A. Mohamed, Asmaa M. Kadry, Salma A. Bekhit, Mohammed A. S. Abourehab, Kikuko Amagase, Tamer M. Ibrahim, Ahmed M. M. El-Saghier & Adnan A. Bekhit. (2023) Spiro heterocycles bearing piperidine moiety as potential scaffold for antileishmanial activity: synthesis, biological evaluation, and in silico studies. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 330-342.
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Huma Khan, Muhammad Waqas, Beenish Khurshid, Nazif Ullah, Asaad Khalid, Ashraf N. Abdalla, Mubarak A. Alamri & Abdul Wadood. (2023) Investigating the role of Sterol C24-Methyl transferase mutation on drug resistance in leishmaniasis and identifying potential inhibitors. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-14.
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Fabian Audu Ugbe, Gideon Adamu Shallangwa, Adamu Uzairu, Ibrahim Abdulkadir, Emmanuel Israel Edache, Wafa Abdullah I. Al-Megrin, Samia T. Al-Shouli, Ying Wang & Mohnad Abdalla. Cheminformatics-based discovery of new organoselenium compounds with potential for the treatment of cutaneous and visceral leishmaniasis. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-24.
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Articles from other publishers (1)

Ahmed Sabt, Wagdy M. Eldehna, Tamer M. Ibrahim, Adnan A. Bekhit & Rasha Z. Batran. (2023) New antileishmanial quinoline linked isatin derivatives targeting DHFR-TS and PTR1: Design, synthesis, and molecular modeling studies. European Journal of Medicinal Chemistry 246, pages 114959.
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