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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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Research Paper

Towards safer anti-inflammatory therapy: synthesis of new thymol–pyrazole hybrids as dual COX-2/5-LOX inhibitors

Mostafa M. M. El-Miligya Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4832-0719View further author information
ORCID Icon,
Ahmed K. Al-Kubeisib Pharmacy Department, Alnukhba University College, Baghdad, IraqView further author information
,
Mohamed G. Bekhitc Pharmaceutical Chemistry Department, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, EgyptView further author information
,
Saad R. El-Zemityd Department of Chemistry and Technology of Pesticides, Faculty of Agriculture, Alexandria University, Alexandria, EgyptView further author information
,
Rasha A. Nassrae Medical Biochemistry Department, Faculty of Medicine, Alexandria University, Alexandria, EgyptView further author information
&
Aly A. Hazzaaa Pharmaceutical Chemistry Department, Faculty of Pharmacy, Alexandria University, Alexandria, EgyptView further author information
Pages 294-308 | Received 25 Aug 2022, Accepted 08 Nov 2022, Published online: 21 Nov 2022

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Read on this site (2)

Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Rasha A. Nassra, Saad R. El-Zemity & Aly A. Hazzaa. (2024) Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with in vivo proof. Journal of Enzyme Inhibition and Medicinal Chemistry 39:1.
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Fengmei Zhang, Guonian Zhu, Yangqian Li, Yawen Qi, Zhoufeng Wang & Weimin Li. (2023) Dual-Target Inhibitors Based on COX-2: A Review from Medicinal Chemistry Perspectives. Future Medicinal Chemistry 15:23, pages 2209-2233.
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Articles from other publishers (6)

Bhupender Nehra, Manoj Kumar, Pooja A. Chawla & Viney Chawla. (2024) Therapeutic Potential of Natural Metabolites Coupled Pyrazole and Its Bio‐Isosteres: Medicinal Perspectives and SAR Studies. ChemistrySelect 9:13.
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Djebar Hadji & Toufik Bensafi. (2024) Deeper Insights on the Nonlinear Optical Properties of O-acylated Pyrazoles. Journal of Electronic Materials 53:4, pages 1868-1883.
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Yong-Qiang Tian, Jing Liu, Peng Cheng, Jian Zou, Hui-Fang Xu, Xin-Hua Shi, Yi-Sheng Zhang & Ling Mei. (2024) Dual COX-2/5-LOX inhibitors from Zanthoxylum simulans inhibit gastric cancer cells by cross-mediating thyroid, estrogen, and oxytocin signaling pathways. Frontiers in Chemistry 11.
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Viola Noti, Eleni Pontiki & Dimitra Hadjipavlou-Litina. (2023) Development of Novel Pyrrole Derivatives and Their Cinnamic Hybrids as Dual COX-2/LOX Inhibitors. Molecules 28:24, pages 7958.
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Jingjie Fang, Ziyi Shang, Kumaravel Kaliaperumal, Zhiran Ju & Fen‐Er Chen. (2023) Design of Balanced Cyclooxygenase Inhibitors Based on Natural Anti‐inflammatory Ascidian Metabolites and Celecoxib. ChemMedChem 18:23.
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Metin Yildirim, Samet Poyraz & Mehmet Ersatir. (2023) Recent advances on biologically active coumarin-based hybrid compounds. Medicinal Chemistry Research 32:4, pages 617-642.
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