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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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Research Paper

Novel piperine-carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway

Lamya H. Al-Wahaibia Department of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8039-6989View further author information
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Mohamed A. Mahmoudb Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, EgyptView further author information
,
Yaser A. Mostafab Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, EgyptView further author information
,
Ali E. Raslanc Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut, EgyptORCID Iconhttps://orcid.org/0000-0002-8567-3970View further author information
ORCID Icon &
Bahaa G. M. Youssifb Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, EgyptCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-6834-6548View further author information
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Pages 376-386 | Received 27 Aug 2022, Accepted 20 Nov 2022, Published online: 30 Nov 2022

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Mohamed A. Mahmoud, Anber F. Mohammed, Ola I. A. Salem, Tahani Mazyad Almutairi, Stefan Bräse & Bahaa G. M. Youssif. (2024) Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 39:1.
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Ibrahim Ali Al-Hakami, Amina El-Shaibany, Hassan Al-Mahbashi, Ahmed S. Abdelkhalek, Mahmoud M. Elaasser & Ali E. Raslan. (2023) GC-MS profiling and evaluation of acute oral toxicity, anti-tumour, antimicrobial and antioxidant activities of Croton socotranus Balf.f. aerial parts: in-vitro, in-vivo and in-silico studies. Natural Product Research 0:0, pages 1-10.
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Bahaa G. M. Youssif, Martha M. Morcoss, Stefan Bräse, Mohamed Abdel-Aziz, Hamdy M. Abdel-Rahman, Dalal A. Abou El-Ella & El Shimaa M. N. Abdelhafez. (2024) Benzimidazole-Based Derivatives as Apoptotic Antiproliferative Agents: Design, Synthesis, Docking, and Mechanistic Studies. Molecules 29:2, pages 446.
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Chunlong Zheng, Yan Chu, Nian Zhang, Ting Jia, Yuanyuan Li, Tao Jiang & Jianyong Sun. (2024) Pan-Cancer Analysis of the LOX Family Reveals that LOX Affects Tumor Prognosis by Affecting Immune Infiltration. Critical Reviews in Eukaryotic Gene Expression 34:2, pages 87-100.
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Frias Obaid Arhema Frejat, Bingbing Zhao, Nooruldeen Furaijit, Lihong Wang, Hesham A. Abou‐Zied, Hazem M. Fathy, Fatma A. M. Mohamed, Bahaa G. M. Youssif & Chunli Wu. (2023) New pyrrolidine‐carboxamide derivatives as dual antiproliferative EGFR / CDK2 inhibitors . Chemical Biology & Drug Design 103:1.
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Alaa A. Hassan, Nasr K. Mohamed, Ashraf A. Aly, Mohamed Ramadan, Hesham A. M. Gomaa, Ahmed T. Abdel-Aziz, Bahaa G. M. Youssif, Stefan Bräse & Olaf Fuhr. (2023) Synthesis and Antiproliferative Potential of Thiazole and 4-Thiazolidinone Containing Motifs as Dual Inhibitors of EGFR and BRAFV600E. Molecules 28:24, pages 7951.
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Hesham A.M. Gomaa, Mohamed E. Shaker, Sami I. Alzarea, Tariq G. Alsahli, Omnia Hendawy, Yasser Khamis Mohammed, M. Khaled Younes, Fatema El-Zahraa S. Abdel Rahman, Fatma A.M. Mohamed, Gehan Fawzy Abdel Raoof, Mohamed A. Mahmoud, Ahmed M. Gouda, Adel G. Bakr & Bahaa G.M. Youssif. (2023) Design, synthesis, and biological evaluation of indole-2-carboxamides as SARS CoV-2 main protease inhibitors. Tetrahedron 146, pages 133628.
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Lamya H. Al-Wahaibi, Hesham A. Abou-Zied, Mohamed Hisham, Eman A. M. Beshr, Bahaa G. M. Youssif, Stefan Bräse, Alaa M. Hayallah & Mohamed Abdel-Aziz. (2023) Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAFV600E Inhibitory Pathways. Molecules 28:18, pages 6586.
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Essmat M. El-Sheref, Stefan Bräse, Hendawy N. Tawfeek, Fatmah Ali Alasmary & Bahaa G. M. Youssif. (2023) Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl)quinolin-2(1H)-ones as Multi-Target Inhibitors. International Journal of Molecular Sciences 24:17, pages 13300.
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Lamya H. Al-Wahaibi, Anber F. Mohammed, Mostafa H. Abdelrahman, Laurent Trembleau & Bahaa G. M. Youssif. (2023) Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents. Pharmaceuticals 16:7, pages 1039.
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Lalmohan Maji, Ghanshyam Teli, Nulgumnalli Manjunathaiah Raghavendra, Sindhuja Sengupta, Rohit Pal, Abhishek Ghara & Gurubasavaraja Swamy Purawarga Matada. (2023) An updated literature on BRAF inhibitors (2018–2023). Molecular Diversity.
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Lamya H. Al-Wahaibi, Essmat M. El-Sheref, Alaa A. Hassan, S. Bräse, M. Nieger, Bahaa G. M. Youssif, Mahmoud A. A. Ibrahim & Hendawy N. Tawfeek. (2023) Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAFV600E Dual Inhibitors Endowed with Antiproliferative Activity. Pharmaceuticals 16:7, pages 1014.
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Mohamed A. Mahmoud, Anber F. Mohammed, Ola I.A. Salem, Safwat M. Rabea & Bahaa G.M. Youssif. (2023) Design, synthesis, and antiproliferative properties of new 1,2,3-triazole-carboximidamide derivatives as dual EGFR/VEGFR-2 inhibitors. Journal of Molecular Structure 1282, pages 135165.
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Lamya H. Al-Wahaibi, Anber F. Mohammed, Mostafa H. Abdelrahman, Laurent Trembleau & Bahaa G. M. Youssif. (2023) Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFRT790M/BRAFV600E Pathways. Molecules 28:3, pages 1269.
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